Mohamed Hashim - Academia.edu (original) (raw)

Papers by Mohamed Hashim

Background: Chronic hepatitis C virus (HCV) infection is the most frequent cause of progressive l... more Background: Chronic hepatitis C virus (HCV) infection is the most frequent cause of progressive liver disease and hepatocellular carcinoma (HCC) in Egypt. Risk of HCC can be affected by the exposure to endogenous or environmental toxins. Genetic polymorphism of the carcinogensmetabolizing enzymes, were suggested as modifiers of cancer risk. So, the present study aimed to investigate the association between xenobiotic metabolizing enzymes [cytochrome P450 (CYP2D6), N-acetyl transferase 2 (NAT2) and UDP-glucuronosyltransferase 1A7 (UGT1A7)] gene polymorphism and the risk of HCC in patients with chronic HCV-induced cirrhosis compared to normal and chronic HCV infected subjects. Subjects and Methods: 354 subjects, divided into 3 groups, (group I: 150 patients had chronic hepatitis C with HCC, group II: 104 patients had chronic hepatitis C without HCC and group III: 100 healthy controls. The studied genes were genotyped using polymerase chain reaction-restriction fragment length polymorp...

The main objective of the project is to design robust, fast, and practical controllers for tower ... more The main objective of the project is to design robust, fast, and practical controllers for tower cranes to transfer loads from point to point in a short time as fast as possible and at the same time, keep the load swing small during the transfer process and completely eliminate it at the load destination. Moreover variations of the system parameters, such as the load weight are taken into account.

Introduction: Cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacin... more Introduction: Cardiac resynchronization therapy (CRT) with multipoint left ventricular (LV) pacing (MultiPoint Pacing, MPP) has been shown to improve CRT response, although MPP response using automated pacing vector programming has not been demonstrated in the Middle East. Objective: Compare the impact of MPP to conventional biventricular pacing (BiV) using echocardiographic and clinical changes at 6 months post-implant. Methods: This prospective, randomized study was conducted at 13 Middle Eastern centers. After de novo CRT-D implant (Abbott Unify Quadra MP or Quadra Assura MP) with quadripolar LV lead (Abbott Quartet), patients were randomized to either BiV or MPP therapy. In BiV patients, the LV pacing vector was selected per standard practice; in MPP patients, the two LV pacing vectors were selected automatically using VectSelect. CRT response was defined at 6 months post-implant by a reduction in LV end-systolic volume (ESV) [?]15%. Results: One-hundred and forty-two patients (61 years old, 68% male, NYHA class II/III/IV 19%/75%/6%, 33% ischemic, 57% hypertension, 52% diabetes, 158 ms QRS, 25.8% ejection fraction [EF]) were randomized to either BiV (N=69) or MPP (N=73). After 6 months,

Annals of Hepatology, 2020

Introduction and aim: The interleukin-2 receptor antagonist; basiliximab is used to allow delayed... more Introduction and aim: The interleukin-2 receptor antagonist; basiliximab is used to allow delayed introduction of Calcineurin inhibitors (CNI) after liver transplantation and thus delay their renal insult. However, there is only little evidence for the safety and the efficacy of this regimen. This study aimed to evaluate the effectiveness and safety of basiliximab induction in liver transplantation. Materials and methods: This study included 89 patients who were classified into two groups: standard triple immunosuppression (IS) regimen of steroid, tacrolimus (TAC) and mycophenolate mofetil (MMF) (n=47) and induction IS regimen of basiliximab, low dose steroids and MMF with delayed introduction of CNI (n=42). All patients were followed after liver transplantation for at least six months or until death. Results: There were no significant differences in patient survival, graft dysfunction, infection rate or type, or wound healing between both groups. The acute rejection rate was equiva...

Mesentery and Peritoneum, 2018

Background: Medicine is a fallible science. There is an inherently pervasive uncertainty within m... more Background: Medicine is a fallible science. There is an inherently pervasive uncertainty within medicine generally and within pain medicine in particular. It is uncertainty itself that inspires many aspects of medicine from patients seeking medical help to conducting medical research. Uncertainty themes are related to poor pain outcomes. The study aim was to investigate uncertainty in patients attending a chronic pain clinic for the first time. Methods: The sample consisted of 100 consecutive adult patients (51 women and 49 men) with chronic pain attending a pain clinic. Results: Average patient age was 55 years; 51% were female. The uncertainty questionnaire scores were clinically severe for uncertainty in 69% of the sample. Of these, trauma and road traffic accidents accounted for the largest group. Pain Anxiety scores were strongly correlated with uncertainty. Pain intensity scores using the Numeric Pain Rating Scale (NPRS) were weakly correlated with uncertainty scores. Conclusions: The consequences of uncertainty are extensive with the potential to influence a multitude of issues such as patient expectations, diagnosis, treatment decisions, patient confidence and satisfaction and ultimately patient compliance. Uncertainty affects chronic pain patients' outcomes and should be assessed routinely.

European journal of gastroenterology & hepatology, Jan 18, 2018

Insulin resistance (IR) is a common complication in chronic hepatitis C virus (HCV) patients. The... more Insulin resistance (IR) is a common complication in chronic hepatitis C virus (HCV) patients. The impact of IR on outcome of therapy with direct antivirals has not been studied. The aim was to assess the impact of direct-acting antiviral (DAA) therapy on IR status in chronic HCV patients. A total of 511 patients [mean age: 50.7±10.4 years, 29.7% pegylated interferon and ribavirin (RBV) experienced] were enrolled. Patients with uncontrolled diabetes, decompensated liver disease, or previous nonresponse to DAAs were excluded. Homeostatic model assessment (HOMA) was calculated before and 12 weeks after treatment, and IR was defined as HOMA greater than 1.9. Patients were treated according to the treating physician's choice, and received 12 weeks of either ombitasvir/ritonavir/paritaprevir/RBV (n=28); sofosbuvir (SOF)/simeprevir (n=36); SOF/ravidasvir (n=101); SOF/pegylated interferon/RBV (n=192); or 24 weeks of SOF/RBV (n=154). Most patients received IR pretreatment (80.6%); 51.3% ...

Journal of Materials Science and Chemical Engineering, 2017

This paper used a new approach of preparing poly-composites by covalent linkage between the MWCNT... more This paper used a new approach of preparing poly-composites by covalent linkage between the MWCNT's by imine group. The Poly (Imine)/MWCNT Composite was synthesized by the solution blending method from reacted amino multi-walled carbon nanotubes (MWCNT-NH 2) with Terephthalaldehyde (TPAL). The obtained poly-composite was characterized by FT-IR, UV-Vis, XRD, TEM, SEM, TGA, DSC and DC electrical conductivity. The formation of Poly (Imine)/MWCNT composite was confirmed. The DC electrical conductivity of poly-composites was within the range 2.3 × 10 −4-5.3 × 10 −4 S/cm due to the interaction between the nanotubes.

Communications in Computer and Information Science, 2012

Light has been shed recently on the usage ofrequirements-based testing where requirements-based m... more Light has been shed recently on the usage ofrequirements-based testing where requirements-based models, specifically UML models, are used in proposing test cases’ generation models. In this paper, an automated prototype called “Test Cases Automatic Generator” (TCAG) is proposed, implementing an introduced enhanced technique for generating reduced, hybrid coverage and multi-testing types test cases from activity diagrams with a minimum user intervention. After their generation, the final test cases are captured using one of the well known automatic capture-replay tools and are executed generating summary reports. A traceability matrix called “Test cases Traceability Matrix” (TTM) is proposed and used by one of the well known requirements management tools to trace the final generated test cases to their initial requirements. Qualitative and quantitative evaluation of the proposed prototype is made, under different processing speeds, showing the improved performance over its previous releases and over a closely related prototype as well.

Egyptian Journal of Medical Human Genetics, 2014

Background: Liver cancer is the fifth most common cancer in men and the seventh in women. Hepatoc... more Background: Liver cancer is the fifth most common cancer in men and the seventh in women. Hepatocellular carcinoma (HCC) is responsible for significant morbidity and mortality in patients with liver cirrhosis and accounts for 90% of primary liver cancer. Synovial sarcoma X chromosome (SSX) genes belong to cancer testis antigens (CTA) family; expressed only in germ cell tumors. There have been some studies about the SSX genes expression in the HCC. To the best of our knowledge no reports included these genes expression in the Egyptian patients with HCC. Aim: This study aims to evaluate the SSX-1 and SSX-5 mRNA expression in tumor cells circulating in the peripheral blood (PB) of a cohort of Egyptian patients with HCC and to find out any possible associations between these genes expression and different clinical/laboratory parameters. Subjects and methods: This study included 100 subjects; 52 HCC cases, 25 with post viral hepatitis liver cirrhosis and 23 apparently healthy controls. Expression of SSX-1 and SSX-5 mRNA in PB was tested by reverse transcription polymerase chain reaction (RT-PCR).

Egyptian Informatics Journal, 2012

ABSTRACT The World Wide Web has become the largest library through the history of the humanity. H... more ABSTRACT The World Wide Web has become the largest library through the history of the humanity. Having such a huge library made the search process more complex as the syntactic search engines offer an overwhelming amount of search results. Vocabulary problems like polysemy and synonymy can make the search results of traditional search engines irrelevant to users. Such problems trigger a strong need for personalizing the web search results based on user preferences. In this paper, we propose a new multi-agent system based approach for personalizing the web search results. The proposed approach introduces a model to build a user profile from initial and basic information, and maintain it through implicit user feedback to establish a complete, dynamic and up-to-date user profile. In the web search process, the model semantically optimizes the user query in two steps: query optimization using user profile preferences and query optimization using the WordNet ontology. The model builds on the advantages of the current search engines by utilizing them for retrieving the web search results. We present a detailed case study and simulation results evaluation to illustrate how the proposed model works and its expected value in increasing the precision of the traditional search engines and solving the vocabulary problems.

The 2011 International Conference on Computer Engineering & Systems, 2011

Test case generation is a core phase in any testing process, therefore automating it plays a trem... more Test case generation is a core phase in any testing process, therefore automating it plays a tremendous role in reducing the time and effort spent during the testing process. This paper proposes an enhanced XML-based automated approach for generating test cases from activity diagrams. The proposed architecture creates a special table called Activity Dependency Table (ADT) for each XML file.

PLoS ONE, 2014

Introduction: Several hepatocellular carcinoma (HCC) staging systems are available. Although the ... more Introduction: Several hepatocellular carcinoma (HCC) staging systems are available. Although the European Association for Study of Liver Diseases (EASL) and American Association for the Study of Liver Diseases (AASLD) recommended the use of Barcelona Clinic Liver Cancer (BCLC), many studies in different populations revealed heterogeneous results. The aim of this study was to compare different staging systems for predicting prognosis and survival, and for stratifying HCC patients for treatment at a national referral centre for liver disease in Egypt. Methods: 2000 Patients were included in this study. Baseline demographic, clinical, laboratory, and radiological data were determined at diagnosis. Patients were stratified using the Okuda, BCLC, Cancer of the Liver Italian Program (CLIP), and Japan Integrated Staging (JIS). Patients' survival in different stages within each staging system and the validity of the system in predicting survival were compared. Results: The overall survival was 15 months. The 1-, 2-, 3-and 4-year survival of the entire cohort was 56%, 34%, 25% and 15% respectively. The presence of ascites, multiple focal lesions, large tumour size .5 cm, portal vein thrombosis, extrahepatic spread, AFP$200 ng/ml and poor Child score were independent predictors of survival (p,0.001). All staging systems were significant in determining overall survival in univariate and multivariate analyses. BCLC was the most predictive staging system for the whole cohort (p,0.001). Among the subgroup of patients offered potentially curative therapy, BCLC was the most informative system in predicting patient survival (p,0.001). For patients with advanced HCC not amenable for specific therapy, CLIP was the best staging system for predicting prognosis (p,0.001). Conclusion: BCLC staging system provided the best prognostic stratification for HCC patients. However, CLIP score has the highest stratification ability in patients with advanced HCC highlighting the importance of including AFP in best staging system.

Organic Letters, 2013

N-Indolyltriethylborate was found to be a useful reagent for dearomatizing C3-alkylation of 3-sub... more N-Indolyltriethylborate was found to be a useful reagent for dearomatizing C3-alkylation of 3-substituted indoles with both activated and nonactivated alkyl halides to give C3-quaternary indolenines, pyrroloindolines, furoindoline, and hexahydropyridoindoline under mild reaction conditions. The utility of these reagents was demonstrated in the syntheses of a pyrroloindoline-4-cholestene hybrid and debromoflustramine B.

IEEE Transactions on Wireless Communications, 2006

Page 1. IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS, VOL. 5, NO. 5, MAY 2006 1055 Measurements a... more Page 1. IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS, VOL. 5, NO. 5, MAY 2006 1055 Measurements and Modelling of Wind Influence on Radiowave Propagation Through Vegetation Mohamed H. Hashim and Stavros Stavrou ...

IEEE Antennas and Wireless Propagation Letters, 2005

The impact of moving vegetation on propagating radio waves under the influence of wind had been i... more The impact of moving vegetation on propagating radio waves under the influence of wind had been investigated. It was found that the fast-fading component of the vegetation-shadowed signal, originating from a line-of-sight (LOS) transmitter, resembles a Rician distribution. From the measured data, a new empirical model at 1.8 GHz of the Rician-factor has been proposed. The model characterizes the dynamic impact of the wind influence for radio waves propagating through vegetation. The proposed model was then assessed against a different set of measured data and was found to be in close agreement.

Chemosphere, 2006

Recent monitoring investigations have shown that antimicrobial agents used in veterinary medicine... more Recent monitoring investigations have shown that antimicrobial agents used in veterinary medicine can cause nonpoint source contamination of soils through manure spreading. In the present study, the effect of the antimicrobial agent sulfamethazine (sulfadimidine) on degradation and sorption of the herbicide metolachlor in a sandy loam soil was studied. In soil samples treated with sulfamethazine at two concentrations (15 and 150 lg kg À1 soil), metolachlor persistence was not different than of that observed in untreated samples. These results were supported by the absence of effects of both sulfamethazine concentration levels on the size of the culturable soil bacteria population. Equilibrating soil samples with metolachlor solutions containing equivalent sulfamethazine concentrations did not lead to any significant effects on metolachlor sorption, suggesting that, under the conditions of the present experiment, sulfamethazine did not affect metolachlor bioavailability in soil. This laboratory investigation showed that concentrations of sulfamethazine in the lg kg À1 range did not cause significant effects on metolachlor degradation and sorption thus not affecting the main processes ruling its environmental fate in soil.

British Dental Journal, 2011

to the gingival sulcus may lead to endodontic-periodontal problems through contamination of the p... more to the gingival sulcus may lead to endodontic-periodontal problems through contamination of the perforation with bacteria from the oral cavity through the sulcus. 3 It is important that the level of crestal bone and epithelial attachment is taken into consideration. 1 If the perforation lies coronal of the crestal bone it will be easy to treat and have a good prognosis. Perforations near the crestal bone are susceptible to epithelial migration and rapid pocket formation and treatment of these has a low success rate. 4,5 Different materials have been used to seal perforations: amalgam, zinc oxide eugenol-based materials, calcium hydroxide, resin monomer, glass-ionomer, MTA, super-EBA etc. 2,6,7 Important properties of an ideal furcation repair material have been cited as the following: good sealability, 8-10 biocompatibility, 11 sufficient antibacterial effect 10,12 and good handling properties. Mineral trioxide aggregate (MTA) has received particular attention as a perforation repair material. Several forms of MTA are available on the market, of which ProRoot® MTA Original and ProRoot® MTA tooth-coloured are widely used (Table 1).