Mohamed Radwan - Academia.edu (original) (raw)
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Papers by Mohamed Radwan
Journal of Alloys and Compounds, 2009
Medicinal Chemistry, Apr 30, 2013
Acs Medicinal Chemistry Letters, Sep 11, 2014
Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is... more Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is an important goal. Herein, we report two strategies, using the nonacidic propyphenazone structure, with potential to overcome the side effects of NSAIDs. Propyphenazone was employed to temporarily mask the free acid group of the widely used NSAIDs ibuprofen, diclofenac, and ketoprofen to develop three mutual prodrugs hypothesized to have minimal GI irritation. The three prodrugs exhibit in vivo anti-inflammatory and analgesic activities with improved potency over each parent drug when compared to a nonhydrolyzable control betahistine-propyphenazone (BET-MP). Additionally, ANT-MP formed by the irreversible coupling of propyphenazone and 4-aminoantipyrine, displayed exceptional COXII selectivity (COXII IC50 of 0.97 ± 0.04 μM, compared to no observed inhibition of COXI at 160 μM). Inhibition of COXII suppresses inflammatory diseases without affecting COXI-mediated GI tract events. ANT-MP exhibited maximal analgesic effect when tested in vivo in an abdominal writhing assay (100% protection) and its anti-inflammatory activity showed a peak at 2 h in a carrageenan-induced paw edema model. Its unique selectivity toward the COXII enzyme was investigated using molecular modeling techniques.
Natural Product Research, Sep 10, 2013
Transactions of J W R I, 2002
Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **... more Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **>^ ^0/í****' & j><\^ 40 - ^*^^ ^^* Л ^t//>^^ Ы) à^^^ 20 - SiC^-"^^ 0 - ' 1 ' 1 ' 1 ' 1 ' 0.2 0.4 0.6 Y (mole) 0.8 Fig. 3 Change of composition in the synthesized Si2N20-SiC composites. . 99 - ...
Ceramics International, 2009
Indian Journal of Physiotherapy and Occupational Therapy an International Journal, 2012
The Journal of the Egyptian Medical Association, 1989
European Journal of Medicinal Chemistry, Apr 1, 2008
The Journal of Nervous and Mental Disease, 1992
J Eur Ceram Soc, 2003
A new approach for synthesis and sintering of silicon oxynitride starting from a unique natural r... more A new approach for synthesis and sintering of silicon oxynitride starting from a unique natural raw material, desert sand is described. The sand in a mixture with silicon metal is combusted under pressurized nitrogen gas into pure silicon oxynitride powder. Then, this powder is densified in the presence of 5 wt.% calcia-alumina mixture to a compact with about 99% of theoretical density within 6 min heating up and holding by using the spark plasma sintering technique. The dense silicon oxynitride has 18.7 GPa Vickers hardness, 3.3 MPa m1/2 fracture toughness, and 363 MPa strength. Morphology of a fractured surface shows that the grains are equiaxed and the fracture occurs in transgranular mode. The material exhibited excellent oxidation resistance at high temperatures up to 1500 °C as well as outstanding chemical resistance in acidic, alkaline and salt mediums at room temperature.
Transactions of Jwri, Sep 1, 2002
Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **... more Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **>^ ^0/í****' & j><\^ 40 - ^*^^ ^^* Л ^t//>^^ Ы) à^^^ 20 - SiC^-"^^ 0 - ' 1 ' 1 ' 1 ' 1 ' 0.2 0.4 0.6 Y (mole) 0.8 Fig. 3 Change of composition in the synthesized Si2N20-SiC composites. . 99 - ...
Journal of Natural Products, Aug 1, 2008
Transactions of Jwri, Dec 1, 2006
Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi, 2008
New Egyptian Journal of Medicine, 1992
Records of Natural Products
New Egyptian journal of medicine
Journal of Alloys and Compounds, 2009
Medicinal Chemistry, Apr 30, 2013
Acs Medicinal Chemistry Letters, Sep 11, 2014
Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is... more Improving the gastrointestinal safety profile of nonsteroidal anti-inflammatory drugs (NSAIDs) is an important goal. Herein, we report two strategies, using the nonacidic propyphenazone structure, with potential to overcome the side effects of NSAIDs. Propyphenazone was employed to temporarily mask the free acid group of the widely used NSAIDs ibuprofen, diclofenac, and ketoprofen to develop three mutual prodrugs hypothesized to have minimal GI irritation. The three prodrugs exhibit in vivo anti-inflammatory and analgesic activities with improved potency over each parent drug when compared to a nonhydrolyzable control betahistine-propyphenazone (BET-MP). Additionally, ANT-MP formed by the irreversible coupling of propyphenazone and 4-aminoantipyrine, displayed exceptional COXII selectivity (COXII IC50 of 0.97 ± 0.04 μM, compared to no observed inhibition of COXI at 160 μM). Inhibition of COXII suppresses inflammatory diseases without affecting COXI-mediated GI tract events. ANT-MP exhibited maximal analgesic effect when tested in vivo in an abdominal writhing assay (100% protection) and its anti-inflammatory activity showed a peak at 2 h in a carrageenan-induced paw edema model. Its unique selectivity toward the COXII enzyme was investigated using molecular modeling techniques.
Natural Product Research, Sep 10, 2013
Transactions of J W R I, 2002
Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **... more Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **>^ ^0/í****' & j><\^ 40 - ^*^^ ^^* Л ^t//>^^ Ы) à^^^ 20 - SiC^-"^^ 0 - ' 1 ' 1 ' 1 ' 1 ' 0.2 0.4 0.6 Y (mole) 0.8 Fig. 3 Change of composition in the synthesized Si2N20-SiC composites. . 99 - ...
Ceramics International, 2009
Indian Journal of Physiotherapy and Occupational Therapy an International Journal, 2012
The Journal of the Egyptian Medical Association, 1989
European Journal of Medicinal Chemistry, Apr 1, 2008
The Journal of Nervous and Mental Disease, 1992
J Eur Ceram Soc, 2003
A new approach for synthesis and sintering of silicon oxynitride starting from a unique natural r... more A new approach for synthesis and sintering of silicon oxynitride starting from a unique natural raw material, desert sand is described. The sand in a mixture with silicon metal is combusted under pressurized nitrogen gas into pure silicon oxynitride powder. Then, this powder is densified in the presence of 5 wt.% calcia-alumina mixture to a compact with about 99% of theoretical density within 6 min heating up and holding by using the spark plasma sintering technique. The dense silicon oxynitride has 18.7 GPa Vickers hardness, 3.3 MPa m1/2 fracture toughness, and 363 MPa strength. Morphology of a fractured surface shows that the grains are equiaxed and the fracture occurs in transgranular mode. The material exhibited excellent oxidation resistance at high temperatures up to 1500 °C as well as outstanding chemical resistance in acidic, alkaline and salt mediums at room temperature.
Transactions of Jwri, Sep 1, 2002
Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **... more Trans. JWRI, Vol.31, (2002), No.l 1UU £ 80 - Si2N20 *_^^ ^**"*#^^ a s. о 60 - ^\^ . и **>^ ^0/í****' & j><\^ 40 - ^*^^ ^^* Л ^t//>^^ Ы) à^^^ 20 - SiC^-"^^ 0 - ' 1 ' 1 ' 1 ' 1 ' 0.2 0.4 0.6 Y (mole) 0.8 Fig. 3 Change of composition in the synthesized Si2N20-SiC composites. . 99 - ...
Journal of Natural Products, Aug 1, 2008
Transactions of Jwri, Dec 1, 2006
Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi, 2008
New Egyptian Journal of Medicine, 1992
Records of Natural Products
New Egyptian journal of medicine