Mohamed zarrouk - Academia.edu (original) (raw)
Papers by Mohamed zarrouk
Prerequis: Le syndrome de Sweet est une affection classiquement caracterisee par des placards ery... more Prerequis: Le syndrome de Sweet est une affection classiquement caracterisee par des placards erythemateux douloureux associes a une fievre, une hyperleucocytose neutrophilique et un infiltrat dermique dense constitue essentiellement de polynucleaires neutrophiles. II est souvent idiopathique. Toutefois, son association a des affections inflammatoires et surtout malignes (20% des cas), impose une enquete etiologique rigoureuse. But: Nous rapportons les caracteristiques epidemiologiques, cliniques, therapeutiques et evolutives d'une serie hospitaliere. Methodes: II s'agit d'une etude retrospective concemant les malades ayant consulte pour un syndrome de Sweet au service de Dermatologie de l'hopital Habib Thameur durant 7 ans (entre 1997 et 2003). Nous avons inclus les patients repondant au moins a 2 criteres majeurs et a 2 criteres mineurs des criteres diagnostiques de Su et Liu modifies par Von Der Driesch. Resultats: Nous avons collige 8 patients. Tous etaient de se...
Prerequis : Le syndrome de SWEET (SS) ou dermatose aigue febrile neutrophilique est une inflammat... more Prerequis : Le syndrome de SWEET (SS) ou dermatose aigue febrile neutrophilique est une inflammation non infectieuse du derme. Il est associe a une hemopathie maligne dans 85% des cas, generalement une leucemie aigue myeloide. But : Rapporter de nouvelles obseravtions de syndrome de SWEET Observations : Nous rapportons deux cas de SS d'evolution favorable lies a la prise de G-CSF (Granulocyte Colony Stimilating Factor) dans un cas et a la prise d'acide tout trans-retinoique (ATRA) dans l'autre chez 2 patientes âgees respectivement de 46 et 35 ans. L'examen histologique est capital dans ce contexte pour eliminer une localisation specifique leucemique ou infectieuse.
Journal of Arts and Social Sciences [JASS], 2018
This paper explores the question of identity, in terms of self and historical construction in a s... more This paper explores the question of identity, in terms of self and historical construction in a sample of Omani women’s novel, by looking specifically at the ways the narratives focused on the local and the borrowed, the free and slave, the tribal and non- tribal and articulated their vision of their individual selves, their actions and established relationships resulting from of their historical circumstances. The research focuses on the narrative viewpoint, on the way the speaking subject self-seeing and its focalization, on the narrator view of the other, be it different or similar. The resources from which the research started are structured on feminine identities that have a standpoint from their historical evolution and from the formation of their identities. It also has an attitude. about the other whether it is different in terms of gender, race or descent.
Mathematical Modelling and Analysis, 2020
This work deals with the numerical solution of a nonlinear degenerate parabolic equation arising ... more This work deals with the numerical solution of a nonlinear degenerate parabolic equation arising in a model of reactive solute transport in porous media, including equilibrium sorption. The model is a simplified, yet representative, version of multicomponents reactive transport models. The numerical scheme is based on an operator splitting method, the advection and diffusion operators are solved separately using the upwind finite volume method and the mixed finite element method (MFEM) respectively. The discrete nonlinear system is solved by the Newton–Krylov method, where the linear system at each Newton step is itself solved by a Krylov type method, avoiding the storage of the full Jacobian matrix. A critical aspect of the method is an efficient matrix-free preconditioner. Our aim is, on the one hand to analyze the convergence of fixed-point algorithms. On the other hand we introduce preconditioning techniques for this system, respecting its block structure then we propose an alte...
Blood, 2008
We have performed a study in 137 adult pts who were transplanted with BFA (busulfan 8 mg/kg, flud... more We have performed a study in 137 adult pts who were transplanted with BFA (busulfan 8 mg/kg, fludarabine 150 mg/m^2 and ATG (Thymoglobuline Genzyme)) conditioning regimen in our centre between 11/1998 and 12/2007. The aim of the study was to evaluate the prognostic factors in this cohort of pts. The group consisted of 87 men and 50 women, median age was 54.5 yo (17–66). The diagnosis was AML (43), Myelodysplasia/Myeloproliferative disease (20), CML (2) (Myeloid group, MG: 65), ALL (14), Multiple Myeloma (MM: 30), Lymphoma (LYM: 28). Pts had received a median of 2 lines of treatment before transplantation (0–6). Sixty-four pts (47%) had previous autologous transplants (50 pts one and 14 pts 2 autologous transplants). At time of transplant, 80 pts were in CR, 38 in PR and 19 refractory or in relapse. The donor was a sibling for 85 and a MUD in 52 pts with HLA compatibility 10/10 in 37pts and 9/10 in 15 pts (2 one A mm, 2 one B mm, 10 one C mm and 1 one DQ mm). Graft consisted of PBSC ...
Blood, 2011
4271 Background: In Tunisia, before 1998, ATRA was not available in APL, and we reported CR rates... more 4271 Background: In Tunisia, before 1998, ATRA was not available in APL, and we reported CR rates of 37.5% (unpublished results). The ATRA era began in 1998 with the consecutive use of two regimens combining ATRA and an anthracycline with AraC (APL93 trial), and without AraC (LPA99 trial). We report outcome of those clinical trials in our country, whose yearly GDP is about 8000 USD/inhabitant (ranking n°55 in the world). Methods: Between 1998 and 2010, consecutive patients with genetically confirmed APL were treated, until 2004 (n= 27 patients, median age, 27 years) with the European APL93 trial induction treatment with ATRA 45 mg/m2 from day (D)1 and DNR (60mg/m2/d x3)+ AraC (200mg/m2/d x7) started from D1 if WBC ≥ 5G/L and D3 if WBC < 5G/L.Patients achieving CR received a first consolidation course with the same CT and a second with DNR at 45 mg/m2/dx3 and AraC 1g/m2/12h x8. Maintenance treatment consisted of a combination of ATRA 45 mg/m2 for 15 days every 3 months,6MP at 50 m...
Blood, 2016
Background: High dose Melphalan (HDM) and autologous stem cell transplantation (ASCT) is a standa... more Background: High dose Melphalan (HDM) and autologous stem cell transplantation (ASCT) is a standard care for Myeloma ≤ 65 years. Studies have demonstrated that depth of response prior to ASCT does not impact outcome post ASCT, e.g. solely depth of response post ASCT matters. However, with improving induction regimens, the questions remains whether patients achieving a deeper response at completion of induction would not perform better post ASCT. ASCT can only be performed in Tunisia if newly diagnosed Multiple Myeloma (NDMM) achieves at least PR; we therefore sought to report the national Tunisian experience. Patients and Methods: NDMM aged ≤65 years received three cycles of Thalidomide (200mg daily) and Dexamethasone, followed by HDM and ASCT.52% received maintenance therapy for 12 months with Thalidomide, from 3 months post transplantation. Non responders to TD induction were salvaged with Lenalidomide or Bortezomib-based regimen. The response was assessed based on IMWG response c...
Blood, 2012
4297 Background: In Tunisia children with acute lymphoblastic leukemia (ALL) are treated accordin... more 4297 Background: In Tunisia children with acute lymphoblastic leukemia (ALL) are treated according to the EORTC 58951 protocol with complete remission rate (CR) of 84% and long-term survivals reaching 80% at 5 years. Survivals of adult ALL remain disappointing mainly because of the high rate of early deaths, the limited number of allografted patients performed only for those aged < 40y, and lack of access to the international bone marrow donors registry. Are the improvements made in the last decades in developed countries in the treatment of adult ALL transposable for patients diagnosed in developing countries? The aim of the present study is to report the experience of a Tunisian hematology center in the management of adult ALL. Patients and methods: Fifty one adult ALL patients were treated with three consecutive trials in the hematology department of Aziza Othmana university hospital of Tunis between January 2005 and July 2011.18 patients were treated with Tunisian LALA03 prot...
Estudios de Historia Novohispana, 2009
Puntual relación de las reformas militares implantadas por el segundo conde de Revillagigedo en l... more Puntual relación de las reformas militares implantadas por el segundo conde de Revillagigedo en la Nueva España, especialmente en lo referente a las milicias no profesionales, que necesitaban una urgente modernización y reglamentación. Estas reformas se implantaron como parte de los planes de la monarquía para crear un ejército colonial capaz de defender las fronteras y litorales del virreinato y de controlar los principales centros urbanos y regiones socioeconómicas. Parte esencial de este proyecto fue la redacción de reglamentos específicos para las milicias provinciales y urbanas (ciudades de México y Puebla) de acuerdo con las circunstancias regionales y las posibilidades reales de organizar eficientes cuerpos militares.
Indian Journal of Hematology and Blood Transfusion, 2015
Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associ... more Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.
Annales de biologie clinique
Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) i... more Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) in the treatment of the acute lymphoblastic leukemia (ALL). To prevent potential toxicity, MTX is usually administered following the application of preventive measures. We report a case of an accidental shortening time for high dose MTX infusion and a literature review of accidental intoxications by the MTX. This case illustrates the importance of the respect of MTX high dose infusion time and the major role played by the therapeutic drug monitoring.
La Tunisie médicale, 2007
Sweet's syndrome is a dermatosis classically determined by painful erythematous plaques or no... more Sweet's syndrome is a dermatosis classically determined by painful erythematous plaques or nodules associated with fever, neutrophilia and dense neutrophilic dermal infiltrate. In most cases, Sweet's syndrome may occur in the absence of other diseases. However, it can be associated with an inflammatory disease and essentially with malignant conditions in 20% of cases requiring a careful investigation. We report herein, the epidemiological, clinical, therapeutic and evolutive features of a hospital serie. We retrospectively reviewed all the files of patients conforming with the diagnosis of SS, seen at the dermatology departement of Habib Thameur hospital during a 7-year period (from 1997 to 2003). All patients fulfilled at least two major criteria and two minor criteria of Su et Liu's diagnostic criteria modified by Von Den Driesch. 8 cases of .Sweet's syndrome were diagnosed. All patients were females. The mean age was 51.62 years. The lesions occurred on the upper ...
Annales de biologie clinique
Leukemia Research, 2008
Cytogenetic analysis was performed on 224 bone marrow (BM) of Tunisian patients with de novo myel... more Cytogenetic analysis was performed on 224 bone marrow (BM) of Tunisian patients with de novo myelodysplastic syndrome (MDS) at our institution from January 1993 to December 2006. According to French-American-British (FAB) criteria, there were 36% of patients with refractory anaemia (RA), 26% with refractory anaemia with excess of blasts (RAEB), 10% with refractory anaemia with ringed sideroblasts (RARS), 12% with chronic myelomonocytic leukaemia (CMML), 9% refractory anaemia with excess of blasts in transformation (RAEB-t) and 7% of unclassified MDS. A clonal chromosomal abnormality was observed in 51% of the patients. The most frequent karyotypic change was 5q- in 30 cases (13%), followed by -7/7q- in 17 cases (8%), del(12p) in 8 cases (4%), del(20q) and trisomy 8 in 7 cases each (3%), i(17q) in 2 cases (1%) and -y in only one case (0.4%). This is the first large comparative series of MDS from an Arab country, with cytogenetic analysis showing haematological and cytogenetic features similar to those of MDS population of European or mixed European-subsaharian African origin (like Brazil), but different from those seen in Eastern populations.
Clinical Lymphoma Myeloma and Leukemia, 2015
e126 relapse of 23,8 months [6-69]. One patient had CNS MM at diagnosis and 4 patients in first r... more e126 relapse of 23,8 months [6-69]. One patient had CNS MM at diagnosis and 4 patients in first relapse. Three patients presented intraparenchymal focal lesions, 1 CNC myelomatosis and 1 intraparenchymal focal lesion associated with leptomenigeal infiltration. The patient, who presented CNS MM at diagnosis, received VCD followed by ASCT and he is in CR with a follow up of 19 months. Four patients presented CNS MM in relapse: 2 were treated with Lenalidomide and dexamethasone (Len+Dex) with an overall survival of 1 and 2 months since the diagnosis of CNS MM and 2 were treated with VCD (1 patient had an overall survival of 12 months and 1 is in VGPR with a follow up of 14 months since the diagnosis of CNS MM). Conclusion: There are no treatment guidelines for CNS MM and few new drugs cross the blood-brain barrier. The median overall survival from the time of diagnosis of SNC MM ranges from 2 to 6 months. Clinical results seem better when CNS involvement occurs at diagnosis compared to relapse setting. Clinical trials involving these patients are essential to improve outcomes.
Prerequis: Le syndrome de Sweet est une affection classiquement caracterisee par des placards ery... more Prerequis: Le syndrome de Sweet est une affection classiquement caracterisee par des placards erythemateux douloureux associes a une fievre, une hyperleucocytose neutrophilique et un infiltrat dermique dense constitue essentiellement de polynucleaires neutrophiles. II est souvent idiopathique. Toutefois, son association a des affections inflammatoires et surtout malignes (20% des cas), impose une enquete etiologique rigoureuse. But: Nous rapportons les caracteristiques epidemiologiques, cliniques, therapeutiques et evolutives d'une serie hospitaliere. Methodes: II s'agit d'une etude retrospective concemant les malades ayant consulte pour un syndrome de Sweet au service de Dermatologie de l'hopital Habib Thameur durant 7 ans (entre 1997 et 2003). Nous avons inclus les patients repondant au moins a 2 criteres majeurs et a 2 criteres mineurs des criteres diagnostiques de Su et Liu modifies par Von Der Driesch. Resultats: Nous avons collige 8 patients. Tous etaient de se...
Prerequis : Le syndrome de SWEET (SS) ou dermatose aigue febrile neutrophilique est une inflammat... more Prerequis : Le syndrome de SWEET (SS) ou dermatose aigue febrile neutrophilique est une inflammation non infectieuse du derme. Il est associe a une hemopathie maligne dans 85% des cas, generalement une leucemie aigue myeloide. But : Rapporter de nouvelles obseravtions de syndrome de SWEET Observations : Nous rapportons deux cas de SS d'evolution favorable lies a la prise de G-CSF (Granulocyte Colony Stimilating Factor) dans un cas et a la prise d'acide tout trans-retinoique (ATRA) dans l'autre chez 2 patientes âgees respectivement de 46 et 35 ans. L'examen histologique est capital dans ce contexte pour eliminer une localisation specifique leucemique ou infectieuse.
Journal of Arts and Social Sciences [JASS], 2018
This paper explores the question of identity, in terms of self and historical construction in a s... more This paper explores the question of identity, in terms of self and historical construction in a sample of Omani women’s novel, by looking specifically at the ways the narratives focused on the local and the borrowed, the free and slave, the tribal and non- tribal and articulated their vision of their individual selves, their actions and established relationships resulting from of their historical circumstances. The research focuses on the narrative viewpoint, on the way the speaking subject self-seeing and its focalization, on the narrator view of the other, be it different or similar. The resources from which the research started are structured on feminine identities that have a standpoint from their historical evolution and from the formation of their identities. It also has an attitude. about the other whether it is different in terms of gender, race or descent.
Mathematical Modelling and Analysis, 2020
This work deals with the numerical solution of a nonlinear degenerate parabolic equation arising ... more This work deals with the numerical solution of a nonlinear degenerate parabolic equation arising in a model of reactive solute transport in porous media, including equilibrium sorption. The model is a simplified, yet representative, version of multicomponents reactive transport models. The numerical scheme is based on an operator splitting method, the advection and diffusion operators are solved separately using the upwind finite volume method and the mixed finite element method (MFEM) respectively. The discrete nonlinear system is solved by the Newton–Krylov method, where the linear system at each Newton step is itself solved by a Krylov type method, avoiding the storage of the full Jacobian matrix. A critical aspect of the method is an efficient matrix-free preconditioner. Our aim is, on the one hand to analyze the convergence of fixed-point algorithms. On the other hand we introduce preconditioning techniques for this system, respecting its block structure then we propose an alte...
Blood, 2008
We have performed a study in 137 adult pts who were transplanted with BFA (busulfan 8 mg/kg, flud... more We have performed a study in 137 adult pts who were transplanted with BFA (busulfan 8 mg/kg, fludarabine 150 mg/m^2 and ATG (Thymoglobuline Genzyme)) conditioning regimen in our centre between 11/1998 and 12/2007. The aim of the study was to evaluate the prognostic factors in this cohort of pts. The group consisted of 87 men and 50 women, median age was 54.5 yo (17–66). The diagnosis was AML (43), Myelodysplasia/Myeloproliferative disease (20), CML (2) (Myeloid group, MG: 65), ALL (14), Multiple Myeloma (MM: 30), Lymphoma (LYM: 28). Pts had received a median of 2 lines of treatment before transplantation (0–6). Sixty-four pts (47%) had previous autologous transplants (50 pts one and 14 pts 2 autologous transplants). At time of transplant, 80 pts were in CR, 38 in PR and 19 refractory or in relapse. The donor was a sibling for 85 and a MUD in 52 pts with HLA compatibility 10/10 in 37pts and 9/10 in 15 pts (2 one A mm, 2 one B mm, 10 one C mm and 1 one DQ mm). Graft consisted of PBSC ...
Blood, 2011
4271 Background: In Tunisia, before 1998, ATRA was not available in APL, and we reported CR rates... more 4271 Background: In Tunisia, before 1998, ATRA was not available in APL, and we reported CR rates of 37.5% (unpublished results). The ATRA era began in 1998 with the consecutive use of two regimens combining ATRA and an anthracycline with AraC (APL93 trial), and without AraC (LPA99 trial). We report outcome of those clinical trials in our country, whose yearly GDP is about 8000 USD/inhabitant (ranking n°55 in the world). Methods: Between 1998 and 2010, consecutive patients with genetically confirmed APL were treated, until 2004 (n= 27 patients, median age, 27 years) with the European APL93 trial induction treatment with ATRA 45 mg/m2 from day (D)1 and DNR (60mg/m2/d x3)+ AraC (200mg/m2/d x7) started from D1 if WBC ≥ 5G/L and D3 if WBC < 5G/L.Patients achieving CR received a first consolidation course with the same CT and a second with DNR at 45 mg/m2/dx3 and AraC 1g/m2/12h x8. Maintenance treatment consisted of a combination of ATRA 45 mg/m2 for 15 days every 3 months,6MP at 50 m...
Blood, 2016
Background: High dose Melphalan (HDM) and autologous stem cell transplantation (ASCT) is a standa... more Background: High dose Melphalan (HDM) and autologous stem cell transplantation (ASCT) is a standard care for Myeloma ≤ 65 years. Studies have demonstrated that depth of response prior to ASCT does not impact outcome post ASCT, e.g. solely depth of response post ASCT matters. However, with improving induction regimens, the questions remains whether patients achieving a deeper response at completion of induction would not perform better post ASCT. ASCT can only be performed in Tunisia if newly diagnosed Multiple Myeloma (NDMM) achieves at least PR; we therefore sought to report the national Tunisian experience. Patients and Methods: NDMM aged ≤65 years received three cycles of Thalidomide (200mg daily) and Dexamethasone, followed by HDM and ASCT.52% received maintenance therapy for 12 months with Thalidomide, from 3 months post transplantation. Non responders to TD induction were salvaged with Lenalidomide or Bortezomib-based regimen. The response was assessed based on IMWG response c...
Blood, 2012
4297 Background: In Tunisia children with acute lymphoblastic leukemia (ALL) are treated accordin... more 4297 Background: In Tunisia children with acute lymphoblastic leukemia (ALL) are treated according to the EORTC 58951 protocol with complete remission rate (CR) of 84% and long-term survivals reaching 80% at 5 years. Survivals of adult ALL remain disappointing mainly because of the high rate of early deaths, the limited number of allografted patients performed only for those aged < 40y, and lack of access to the international bone marrow donors registry. Are the improvements made in the last decades in developed countries in the treatment of adult ALL transposable for patients diagnosed in developing countries? The aim of the present study is to report the experience of a Tunisian hematology center in the management of adult ALL. Patients and methods: Fifty one adult ALL patients were treated with three consecutive trials in the hematology department of Aziza Othmana university hospital of Tunis between January 2005 and July 2011.18 patients were treated with Tunisian LALA03 prot...
Estudios de Historia Novohispana, 2009
Puntual relación de las reformas militares implantadas por el segundo conde de Revillagigedo en l... more Puntual relación de las reformas militares implantadas por el segundo conde de Revillagigedo en la Nueva España, especialmente en lo referente a las milicias no profesionales, que necesitaban una urgente modernización y reglamentación. Estas reformas se implantaron como parte de los planes de la monarquía para crear un ejército colonial capaz de defender las fronteras y litorales del virreinato y de controlar los principales centros urbanos y regiones socioeconómicas. Parte esencial de este proyecto fue la redacción de reglamentos específicos para las milicias provinciales y urbanas (ciudades de México y Puebla) de acuerdo con las circunstancias regionales y las posibilidades reales de organizar eficientes cuerpos militares.
Indian Journal of Hematology and Blood Transfusion, 2015
Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associ... more Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.
Annales de biologie clinique
Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) i... more Methotrexate (MTX) is a folic acid antagonist used at high-dose intravenously on 24 hours (24h) in the treatment of the acute lymphoblastic leukemia (ALL). To prevent potential toxicity, MTX is usually administered following the application of preventive measures. We report a case of an accidental shortening time for high dose MTX infusion and a literature review of accidental intoxications by the MTX. This case illustrates the importance of the respect of MTX high dose infusion time and the major role played by the therapeutic drug monitoring.
La Tunisie médicale, 2007
Sweet's syndrome is a dermatosis classically determined by painful erythematous plaques or no... more Sweet's syndrome is a dermatosis classically determined by painful erythematous plaques or nodules associated with fever, neutrophilia and dense neutrophilic dermal infiltrate. In most cases, Sweet's syndrome may occur in the absence of other diseases. However, it can be associated with an inflammatory disease and essentially with malignant conditions in 20% of cases requiring a careful investigation. We report herein, the epidemiological, clinical, therapeutic and evolutive features of a hospital serie. We retrospectively reviewed all the files of patients conforming with the diagnosis of SS, seen at the dermatology departement of Habib Thameur hospital during a 7-year period (from 1997 to 2003). All patients fulfilled at least two major criteria and two minor criteria of Su et Liu's diagnostic criteria modified by Von Den Driesch. 8 cases of .Sweet's syndrome were diagnosed. All patients were females. The mean age was 51.62 years. The lesions occurred on the upper ...
Annales de biologie clinique
Leukemia Research, 2008
Cytogenetic analysis was performed on 224 bone marrow (BM) of Tunisian patients with de novo myel... more Cytogenetic analysis was performed on 224 bone marrow (BM) of Tunisian patients with de novo myelodysplastic syndrome (MDS) at our institution from January 1993 to December 2006. According to French-American-British (FAB) criteria, there were 36% of patients with refractory anaemia (RA), 26% with refractory anaemia with excess of blasts (RAEB), 10% with refractory anaemia with ringed sideroblasts (RARS), 12% with chronic myelomonocytic leukaemia (CMML), 9% refractory anaemia with excess of blasts in transformation (RAEB-t) and 7% of unclassified MDS. A clonal chromosomal abnormality was observed in 51% of the patients. The most frequent karyotypic change was 5q- in 30 cases (13%), followed by -7/7q- in 17 cases (8%), del(12p) in 8 cases (4%), del(20q) and trisomy 8 in 7 cases each (3%), i(17q) in 2 cases (1%) and -y in only one case (0.4%). This is the first large comparative series of MDS from an Arab country, with cytogenetic analysis showing haematological and cytogenetic features similar to those of MDS population of European or mixed European-subsaharian African origin (like Brazil), but different from those seen in Eastern populations.
Clinical Lymphoma Myeloma and Leukemia, 2015
e126 relapse of 23,8 months [6-69]. One patient had CNS MM at diagnosis and 4 patients in first r... more e126 relapse of 23,8 months [6-69]. One patient had CNS MM at diagnosis and 4 patients in first relapse. Three patients presented intraparenchymal focal lesions, 1 CNC myelomatosis and 1 intraparenchymal focal lesion associated with leptomenigeal infiltration. The patient, who presented CNS MM at diagnosis, received VCD followed by ASCT and he is in CR with a follow up of 19 months. Four patients presented CNS MM in relapse: 2 were treated with Lenalidomide and dexamethasone (Len+Dex) with an overall survival of 1 and 2 months since the diagnosis of CNS MM and 2 were treated with VCD (1 patient had an overall survival of 12 months and 1 is in VGPR with a follow up of 14 months since the diagnosis of CNS MM). Conclusion: There are no treatment guidelines for CNS MM and few new drugs cross the blood-brain barrier. The median overall survival from the time of diagnosis of SNC MM ranges from 2 to 6 months. Clinical results seem better when CNS involvement occurs at diagnosis compared to relapse setting. Clinical trials involving these patients are essential to improve outcomes.