Mohammad Reza Safarinejad - Academia.edu (original) (raw)

Papers by Mohammad Reza Safarinejad

BJUI, Feb 14, 2011

= 0.88). • We found that the frequency of the AA genotype was significantly higher in patients wi... more = 0.88). • We found that the frequency of the AA genotype was significantly higher in patients with CCRCC than in controls (odds ratio [OR] = 4.62, 95% confidence interval [CI] = 3.41-7.42, P = 0.001). • The A allele had a gene dose effect in increasing the risk of CCRCC (OR = 4.75, 95% CI = 3.64-7.64, P = 0.001). • The distribution of IGFBP-3 genotypes was also significantly associated with the histological grade (P = 0.001) and clinical stage (P = 0.001). CONCLUSION • In the Iranian population, the polymorphism of the IGFBP-3 gene plays a pivotal role in the development of CCRCC. KEYWORDS kidney, renal cell carcinoma, insulin-like growth factor binding protein-3, polymorphism What's known on the subject? and What does the study add? Renal cell carcinoma (RCC) is the third leading cause of death among urological tumours. Insulin-like growth factors (IGFs) regulate cellular proliferation and differentiation. IGFB proteins (IGFBPs) regulate the action of IGFs. Polymorphism of the IGFBP-3 gene affects mean circulating IGFBP-3 concentrations. In this study, the AA genotype was significantly higher in patients with RCC than in controls. In addition, IGFBP-3 serum level was significantly higher in carriers of the A allele compared with non-carriers. OBJECTIVE • To evaluate the A to C nucleotide change located 202 bp upstream to the transcription start site, (-202 A/C polymorphism), in the insulin-like growth factor (IGF) binding protein-3 (IGFBP-3) gene, and its association with renal carinogenesis and with clinicopathological characteristics. PATIENTS AND METHODS • We matched 158 male patients with clearcell renal cell carcinoma (CCRCC) to 316 healthy controls, and genotyped one single nucleotide polymorphism (rs2854744) using the polymerase chain reaction restriction fragment length polymorphism technique. RESULTS • The alleles and genotypes differed significantly between patients with CCRCC

PubMed, 2012

Purpose: To determine the role of glutathione S-transferases (GSTs; GSTM1, GSTT1, and GSTP1) gene... more Purpose: To determine the role of glutathione S-transferases (GSTs; GSTM1, GSTT1, and GSTP1) gene polymorphisms in susceptibility to male factor infertility. Materials and methods: We report a pooled analysis of 11 studies on the association of GSTM1, GSTT1, and GSTP1 polymorphisms and male factor infertility, including 1323 cases and 1054 controls. Results: An overall significant association was determined between the GSTM1 null genotype [odds ratio (OR), 2.74; 95% confidence interval (CI), 1.72 to 3.84; P = .003], GSTT1 null genotype (OR, 1.54; 95% CI, 1.43 to 3.47; P = .02), and male factor infertility. The GSTP1 Ile/Val genotype had overall protective effect against development of infertility (OR, 0.48; 95% CI, 0.27 to 0.77), while there was significant heterogeneity between studies. In sensitivity analysis, two studies were excluded; the association and direction between GSTM1 and GSTT1 null genotypes and GSTP1 Ile/Val genotype and male infertility remained unchanged. There was no significant interaction between smoking status and studied genotypes on male infertility risk (P = .26). Conclusion: These results demonstrated that amongst populations studied to date, GSTM1 and GSTT1 null genotypes are associated with strong and modest increase in the risk of male infertility, respectively. On the contrary, GSTP1 Ile/Val genotype has protective effect.

Archives of Medical Research, Aug 1, 2010

Table 1). Lack of receipt of chemotherapy and hematopoietic cell transplant were associated with ... more Table 1). Lack of receipt of chemotherapy and hematopoietic cell transplant were associated with worse OS. OS was significantly better in women (HR 0.96; 95% CI 0.93-0.98; p¼0.001), and with higher annual income (p<0.0001). OS did not differ based on race, and education status. Conclusion: Various socioeconomic and health system factors are associated with varying OS in older patients with AML. Deeper understanding of such factors and improved delivery of care have potential to improve outcomes.

The Journal of Steroid Biochemistry and Molecular Biology, Oct 1, 2010

This article appeared in a journal published by Elsevier. The attached copy is furnished to the a... more This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues. Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. In most cases authors are permitted to post their version of the article (e.g. in Word or Tex form) to their personal website or institutional repository. Authors requiring further information regarding Elsevier's archiving and manuscript policies are encouraged to visit: http://www.elsevier.com/copyright

Journal of Diabetes and Its Complications, Jul 1, 2004

To determine the efficacy and safety of oral sildenafil citrate in the treatment of erectile dysf... more To determine the efficacy and safety of oral sildenafil citrate in the treatment of erectile dysfunction (ED) in diabetic men. In a randomized, double-blind, placebo-controlled, and fixed-dose study, a total of 282 men (mean age, 46.4 years) with ED (mean duration, 3.6 years) and diabetes (mean duration, 11 years) were randomly assigned to receive 100 mg sildenafil (n=144) or placebo (n=138) approximately 1 h before planned sexual activity, but not more than once daily, for 16 weeks. The efficacy of two treatments was assessed using responses to the International Index of Erectile Function (IIEF) questionnaire. Two hundred sixty-two (93%) of men completed the study (134/144 in the sildenafil group, 128/138 in the placebo group). Positive clinical results were obtained in 68 (51%) of 134 patients in the sildenafil group compared with 14 (11%) of 128 patients in the placebo group (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.003). Fifty-nine percent of the patients reported at least one successful attempt at sexual intercourse in the sildenafil group as compared with 21% successful attempts for the placebo group (P&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;.002). Drug-related adverse effects occurred in 32 (22%) of 144 patients taking sildenafil and 4 (3%) of 138 patients receiving placebo. The most common adverse events were headache (20% sildenafil, 2% placebo), flushing (19% sildenafil, 0% placebo), dyspnea (9% sildenafil, 2% placebo), rhinitis (6% sildenafil, 0% placebo), and cardiovascular effects (7% sildenafil, 0% placebo). Of patients taking sildenafil, four (2.7%) developed new chest pains, with documented myocardial infarction in two. Oral sildenafil is a moderately effective treatment for ED in men with diabetes. The response rate was lower and cardiovascular events were higher than previously reported in nondiabetic patients.

Journal of Human Genetics, May 27, 2010

The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been we... more The effects of the GST genes (GSTM1, GSTT1 and GSTP1) on male factor infertility have not been well elucidated. A casecontrol study was performed to investigate the association between functionally important polymorphisms in GST genes and idiopathic male infertility. The study group consisted of 166 men suffering from idiopathic oligoasthenoteratozoospermia (OAT) and an equal number of age-matched healthy fertile male controls. Genomic DNA extracted from the peripheral blood, was analyzed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Multivariate regression analysis showed an increase in risk to infertility in the patients with null genotype of GSTM1 (OR: 2.18; 95% CI: 1.64-3.32; P¼0.001) or GSTT1 (OR: 1.88; 95% CI:1.12-2.52; P¼0.04). Our data further showed that combination of deletion genotypes of GST (GSTM1 and GSTT1) pose an even higher risk of infertility. In addition, GSTP1 wild-type genotype in combination with GSTM1 null or GSTT1 null genotype increased probability for infertility (OR: 2.47, 95% CI: 1.46-4.17: and OR: 2.69, 95% CI: 1.39-5.32, respectively). Similarly a much higher risk for infertility was noted in the patients carrying a genotype combination of GSTM1 null, GSTT1 null and GSTP1 (Ile/Ile) (OR: 4.45; 95% CI: 1.59-12.24; P¼0.002). The variant genotypes of GSTP1 (Ile/Val and Val/Val) resulted in a significant decreased risk to infertility in the cases (OR: 0.44; 95% CI: 0.29-0.78, P¼0.004). These results support the hypothesis of increased risk of GSTM1 or GSTT1null genotypes for developing infertility, but the nondeletion GSTM1 and GSTT1genotypes emerged as protective factors.

International Journal of Impotence Research, Aug 1, 2003

This study aims to estimate the prevalence of erectile dysfunction (ED) in a population-based sam... more This study aims to estimate the prevalence of erectile dysfunction (ED) in a population-based sample of Korean men aged 45 or over, and to study its correlation with the socio-demographic, medical and lifestyle factors. Materials and Methods: 385 men in Chunchon City were evaluated by clinical measures and questionnaires. All the participants were evaluated for erectile dysfunction. In conjunction with this evaluation, all the men were asked to complete the International Prostate Symptom Score (IPSS), and they underwent health examinations that included blood pressure, body mass index and waist-to-hip ratio, and the laboratory studies included the fasting blood glucose and total cholesterol levels. The subjects' medical history and health behaviors were investigated. Results: Out of the 385 men who visited our hospital, 285 completed the questionnaires. The prevalence of moderate or severe ED increased from 5.3% in men aged 45 to 54 years to 87.3% in men aged 75 or over. The standardized prevalence of ED was 41.5%. The IPSS were strongly correlated with ED (age adjusted partial R= 0.246, p＜0.001). An increasing risk of ED was observed among those subjects with total cholesterol higher than 240mg/dl (adjusted odds ratio [aOR]=1.8), hypertension (aOR=2.2) and the ex-smokers (aOR=5.2). Education and family income were not correlated with ED (p＞0.05). Conclusions: The results of this community-based survey confirmed the strong correlation between advancing age and the prevalence of ED. Lower urinary tract symptoms are the major factors affecting erectile function. High blood pressure, high cholesterol levels and ex-smokers are significant risk factors for ED.

European Urology Supplements, Mar 1, 2009

The Journal of Urology, Jan 10, 2023

Journal of Clinical Gastroenterology, 2009

The multikinase inhibitor sorafenib provides survival benefit for patients with advanced hepatoce... more The multikinase inhibitor sorafenib provides survival benefit for patients with advanced hepatocellular carcinoma (HCC) and liver cirrhosis (LCI) Child-Pugh A. We report our experiences with sorafenib in advanced HCC, particularly in patients with LCI Child-Pugh B/C, where only limited data are available in regard to safety and efficacy of sorafenib. Thirty-four patients with advanced HCC were treated with sorafenib regardless of liver function and prior anticancer therapy. Adverse events (AEs) were graded using Common Toxicity Criteria version 3.0, tumor response was assessed according to Response Evaluation Criteria in Solid Tumors. Fifteen patients presented without LCI or with LCI Child- Pugh A, 15/4 patients had LCI Child-Pugh B/C. Barcelona Clinic Liver Cancer stage was B/C/D in 4/22/8 patients. During treatment period (median 2.2 mo), therapy was discontinued in 61.8% of patients due to tumor progression (32.3%), death (17.6%), AEs (8.8%), or noncompliance (2.9%). Most common grade 3/4 AEs included liver dysfunction (23.5%), diarrhea (14.7%), increased lipase (8.8%), fatigue (8.8%), and hand-foot skin reaction (5.9%). Worsening liver dysfunction/failure was more frequent (P=0.036) in patients with LCI Child-Pugh B/C compared with patients with maintained liver function (no LCI/LCI Child-Pugh A). Median overall survival was 7.2 months for patients with maintained liver function versus 3.3/3.4 months for patients with LCI Child-Pugh B/C. These data do not support the use of sorafenib in patients with LCI Child-Pugh C, and patients with LCI Child-Pugh B should be treated with caution until larger trials provide more safety data and a clinically relevant survival benefit under sorafenib therapy.

European Urology, 2005

Glutathione-S-transferases (GSTs) are active in the detoxification of wide variety of endogenous ... more Glutathione-S-transferases (GSTs) are active in the detoxification of wide variety of endogenous or exogenous carcinogens. We examined the association of the GST gene polymorphism with sporadic bladder cancer patients in Northern India. The study constituted of 106 bladder cancer cases and 370 age-matched controls. The GSTT1 and GSTM1 null genotypes were identified by multiplex PCR and GSTP1313 A/G by Polymerase Chain Reaction/Restriction Fragment Length Polymorphism method (PCR/RFLP). We observed non-significant association in null alleles of the GSTM1 (p = 0.611, OR = 1.12, 95% CI = 0.72-1.74 and GSTT1 (p = 0.135, OR = 1.45, 95% CI = 0.89-2.37) with risk of bladder cancer. However, the G/G genotype of the GSTP1 gene polymorphism was highly significant when compared to controls (p=0.000, OR = 7.12, 95% CI = 3.14-16.16). The combined analysis of the three risk genotypes demonstrated further increase in the risk of bladder cancer (p = 0.000, OR = 7.29 95% CI = 2.81-18.93). Our study demonstrated that GSTP1313 G/G polymorphism is a strong predisposing risk factor for bladder cancer. Combination of three GST genotypes association exhibiting gene-gene interaction further substantiates the increased risk of bladder cancer.

arXiv (Cornell University), Mar 4, 2018

Objectives: To mathematically investigate urethral pressure and influencing parameters of stress ... more Objectives: To mathematically investigate urethral pressure and influencing parameters of stress urinary incontinence (SUI) in women, with focus on the clinical aspects of the mathematical modeling. Method: Several patients' data are extracted from UPP and urodynamic documents and their relation and affinities are modeled using an artificial neural network (ANN) model. The studied parameter is urethral pressure as a function of two variables: the age of the patient and the position in which the pressure was measured across the urethra (normalized length). Results: The ANN-generated surface, showing the relation between the chosen parameters and the urethral pressure in the studied patients, is more efficient than the surface generated by conventional mathematical methods for clinical analysis, with multi-sample analysis being obtained. For example, in elderly people, there are many low-pressure zones throughout the urethra length, indicating that there is more incontinence in old age. Conclusion: The predictions of urethral pressure made by the trained neural network model in relation to the studied effective parameters can be used to build a medical assistance system in order to help clinicians diagnose urinary incontinence problems more efficiently.

European Urology Supplements, Mar 1, 2008

Introduction & Objectives: Female sexual dysfunction (FSD) are a common feature in women with chr... more Introduction & Objectives: Female sexual dysfunction (FSD) are a common feature in women with chronic renal failure. The majority of pre-menopausal women, undergoing long-term dialysis, experience anovulation, abnormal menstrual cycles, often associated with amenorrhoea, loss of libido and inability to reach orgasm. The genesis of FSD is multifactorial and it is primarily organic in origin. After renal transplantation (RT) the majority of pre-menopausal women restored their to determine if sexual function improve after RT as well as hormonal status, comparing a group of pre-menopausal women in dialysis with an age-matched group of women after RT with fully functioning allograft. Material & Methods: urogynecological examination, a Female Sexual Dysfunction Index (FSFI) and a Back Depression Inventory questionnaire (BDI) were administered to all of them. The results of questionnaires were analyzed with unpaired Wilcoxon test. The number of pts with an active sexual life in the two groups were analyzed with Fisher's exact test. Results: The mean time after RT was 26 months (range 14-75) all RT pts were under 6 months (sexual desire disorder, sexual arousal disorder, orgasmic and sexual pain disorder). 8/10 RT pts complained of a sexual desire disorder, 7/10 complained of a sexual arousal disorder associated with a reduction of vaginal lubrication. 10/10 had an orgasmic phase disorder, with delayed orgasm desire disorder and an orgasmic disorder, 7 had a sexual arousal disorder, and 2 had a sexual pain disorder. The mean score of BDI questionnaire was 7 (range 6-11) and 11 (range 7-19) in RT and Conclusions: This study demonstrate, although the small number of patients, that a successful renal transplantation should improve sexual function in women.

BJUI, Aug 1, 2009

OBJECTIVETo evaluate the safety and efficacy of sildenafil citrate for treating erectile dysfunct... more OBJECTIVETo evaluate the safety and efficacy of sildenafil citrate for treating erectile dysfunction (ED) in patients with combat‐related post‐traumatic stress disorder (PTSD).PATIENTS AND METHODSIn all, 266 combat‐exposed war veterans with ED (aged 37–59 years) were recruited. They met the Diagnostic and Statistical Manual of Mental Disorders‐IV criteria for PTSD according to the Structured Clinical Interview for Patients, Investigator Version. The patients were also evaluated with the Clinician‐Administered PTSD Scale, both to establish the diagnosis of PTSD and to measure symptom severity. Only patients with psychogenic ED were included in the study. Patients with comorbid conditions (diabetes mellitus, hypercholesterolaemia, hypertension, Peyronie’s disease) and smokers of more than five cigarettes daily were excluded. The patients were randomly divided into a group of 133 who received 100 mg of on‐demand sildenafil 0.75–2 h before sexual stimulation, and 133 who received placebo. Patients were asked to use ≥16 doses or attempts at home. The efficacy of the treatments was assessed every four attempts during treatment, and at the end of the study, using responses to the 15‐question International Index of Erectile Function (IIEF), Sexual Encounter Profile diary questions 2 and 3, Erectile Dysfunction Inventory of Treatment Satisfaction questionnaire, patients’ event logs of sexual activity, and a Global Assessment Question about erections.RESULTSSildenafil did not produce significantly and substantially greater improvement than placebo in each of the primary and secondary outcome measures (P = 0.08). A normal EF domain score (≥26) at endpoint was reported by 13 (9.8%), and 11 (8.3%) of patients on the sildenafil and placebo regimens, respectively (P = 0.09). Patients treated with sildenafil had no statistically significantly greater improvement in the five sexual function domains of the IIEF questionnaire than those treated with placebo (P = 0.08). The incidences of treatment‐emergent adverse events were significantly greater in the sildenafil arm than in the placebo group (P = 0.01).CONCLUSIONSSildenafil is no better than placebo in treating PTSD‐emergent ED. Further randomized clinical trials are warranted in combat veterans and other populations with PTSD to better elucidate the role of phosphodiesterase type 5 inhibitors in treating PTSD‐emergent ED.

Journal of Herbal Pharmacotherapy, 2005

ABSTRACT

arXiv (Cornell University), Aug 4, 2017

Stress Urinary Incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdo... more Stress Urinary Incontinence (SUI) or urine leakage from urethra occurs due to an increase in abdominal pressure resulting from stress like a cough or jumping height. SUI is more frequent among postmenopausal women. In the absence of bladder contraction, vesical pressure exceeds from urethral pressure leading to urine leakage. Despite a large number of patients diagnosed with this problem, few studies have investigated its function and mechanics. The main goal of this study is to model bladder and urethra computationally under an external pressure like sneezing. Finite Element Method and Fluid-Structure Interactions are utilized for simulation. Linear mechanical properties assigned to the bladder and urethra and pressure boundary conditions are indispensable in this model. The results show good accordance between the clinical data and predicted values of the computational models, such as the pressure at the center of the bladder. This indicates that numerical methods and simplified physics of biological systems like inferior urinary tract are helpful to achieve the results similar to clinical results, in order to investigate pathological conditions.

Journal of Archives in Military Medicine, May 3, 2014

European Urology Supplements, Sep 1, 2010

Serum lipid concentration as a part of the metabolic syndrome is supposed to be linked to prostat... more Serum lipid concentration as a part of the metabolic syndrome is supposed to be linked to prostate cancer risk. However, few epidemiological studies have assessed the relation between serum triglyceride level and risk of prostate cancer. This study sought to further evaluate the probable association between serum triglyceride level and prostate cancer risk. material & methods: Using data from a prospective hospital-based multicenter case-control study, serum triglyceride concentration as well as thorough demographic and medical characteristics were determined in 194 cases with the newly diagnosed, clinicopathologically confirmed PC and 317 controls, without any malignant disease, admitted to the same network of hospitals. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were obtained after adjustment for major potential confounders, including age, body mass index, smoking, alcohol, education, occupation and family history of PC. results: The mean (±SD) serum triglyceride level in case and control groups were 141.24±74.39 mg/dl and 143.38±71.51 mg/dl, respectively; the difference was not statistically significant (p=0.76). Comparing the highest with the lowest tertile, serum triglyceride concentration was not associated with the increased risk of prostate cancer (OR: 1.24, 95% CI: 0.08-3.12; P=0.18). conclusions: Our findings do not support the hypothesis that serum triglyceride level may be involved in the pathogenesis of prostate cancer.