Mohammad Samadian - Academia.edu (original) (raw)

Papers by Mohammad Samadian

Caspian Journal of Internal Medicine, 2021

Background: Germinoma is a rare lesion found commonly in the pineal and suprasellar regions of th... more Background: Germinoma is a rare lesion found commonly in the pineal and suprasellar regions of the brain. Clinical presentation mainly involves the location and size of the tumor and the patient age. Endocrine abnormalities are the most common symptom. Case Presentation: The patient was a 26-year-old Iranian female who suffered from germinoma for a long time and was referred to Loghman Hakim Hospital for amenorrhea, polyuria, and polydipsia. Despite diagnostic challenges, she was finally diagnosed with suprasellar germinoma after endoscopic transsphenoidal surgery, followed by radiotherapy and medical interventions to complement the surgery. Conclusion: It is important to be able to diagnose the patient's problem at an early stage based on their history, hormonal profile, laboratory results and radiological view.

Clinical Neurology and Neurosurgery, 2021

OBJECTIVES The telovelar approach is a surgical method performed through natural corridors of the... more OBJECTIVES The telovelar approach is a surgical method performed through natural corridors of the brain to access the fourth ventricle. The aim of this study is to assess the results of this approach as well as the role of neuroendoscopy in surgical management of fourth ventricle tumors. MATERIAL AND METHODS A retrospective study was designed, and a series of 52 consecutive patients (32 male, 20 female) with fourth ventricle tumor undergoing telovelar approach was undertaken. In 10 patients (19 %) with a tumor invading the rostral fourth ventricle, an adjustable angle endoscope was also used to ensure total resection of the tumor. RESULTS Complete resection was obtained in majority of patients (94 %). 30 patients (57 %) required insertion of an external ventricular drain which was discontinued in all patients after 72 h. 2 patients (4 %) underwent permanent ventriculoperitoneal shunt. The postoperative complications included meningitis (8 %), transient facial nerve paralysis (8 %), transient sixth cranial nerve paralysis (6 %) and transient unilateral absence of the gag reflex (4 %). No patient experienced mutism and there was a mortality rate of 2 % (1 case) in current study. CONCLUSION In our experience, a high rate of total resection of the fourth ventricle tumors could be achieved with the telovelar approach associated with a low risk of surgical morbidity and mortality. Moreover, the use of an adjustable angle endoscope could be useful in patients with a tumor involving the rostral fourth ventricle to ensure total resection of the tumor and also to minimize the extent of telovelar dissection.

Archives of Iranian medicine, 2015

Congenital absence of posterior elements of the lumbar column is an extremely uncommon anomaly an... more Congenital absence of posterior elements of the lumbar column is an extremely uncommon anomaly and we found no any reported cases of incomplete congenital absence of the posterior elements of lumbar vertebra in the literature. Here, we present a case with congenital absence of posterior elements of lumbar vertebra. The patient was a 51-year-old man with a history of 20 years of back pain. Imaging of the lumbar spine revealed instability in L2 and L3 and there was evidence of retrolisthesis, agenesis of pars interarticularis, spinous processes, lamina, transverse processes and facets at L2 and L3. The patient underwent lumbar discectomy and posterior spinal fixation and instrumentation was then done using pedicle screw fixation. Four pedicle screws, two rods, and one cross link were employed to bilaterally fix the L2 and L3 and then we used autograft and allograft bone for interbody fusion, substitutes from iliac crest for posterior fusion. There were no postoperative complications,...

European Journal of Oncology, 2015

Association of primary hyperparathyroidism with various malignancies is a known phenomenon. Howev... more Association of primary hyperparathyroidism with various malignancies is a known phenomenon. However, hyperparathyroidism presenting as a result of parathyroid carcinoma in association with Nonmedullary thyroid carcinoma is quite rare. In this report a rare case of primary hyperparathyroidism is presented in which paraplegia and radicular pain of lower limbs were the presenting symptoms. The patient was histopathologically diagnosed with concurrent papillary cancer of the thyroid gland and parathyroid carcinoma. The characteristics of the patient’s vertebral lesion were suggestive of Brown tumor. Ten days after parathyroidectomy, the patient exhibited delayed hungry bone syndrome.

Clinical Neurology and Neurosurgery, 2020

A primary intraventricular hydatid cyst is a very rare phenomenon, which is mostly located in the... more A primary intraventricular hydatid cyst is a very rare phenomenon, which is mostly located in the lateral ventricle. To the best of our knowledge, only two cases of third ventricle hydatid cyst have been reported. Herein, we present a very rare case of third ventricle hydatid cyst in a four-year-old boy with nausea, vomiting, and progressive drowsiness. Neuroradiological examination revealed a large, spherical, well-defined cystic lesion within the third ventricle. The patient underwent surgery using the anterior interhemispheric transcallosal approach, and the cyst was successfully removed using the Dowling's technique. In this case report, we described the first case of transcallosal removal of a rare third ventricle hydatid cyst, which can be considered in the differential diagnosis of suprasellar arachnoid cysts. Caution must be taken in determining the best surgical approach to prevent unexpected complications.

JPO Journal of Prosthetics and Orthotics, 2017

Background The aim of this study was to develop a new stance control knee-ankle-foot orthosis (SC... more Background The aim of this study was to develop a new stance control knee-ankle-foot orthosis (SCKAFO) and determine its efficacy on specific spatiotemporal and kinematic parameters. Method Seven healthy volunteer subjects participated in this study. After orthotic gait training, subjects participated in a four-part data collection session that consisted of gait evaluation with normal walking, SCKAFO with locked knee joint, SCKAFO without initial flexion (IF) mode, and SCKAFO with IF mode. Results Walking with any of the control knee-ankle-foot orthoses (KAFOs) produced a significant reduction in walking speed compared with normal walking. There was no significant difference in walking speed between the SCKAFO with and without IF. There was significantly higher knee flexion in stance phase when walking with the SCKAFO with IF compared with the other types of KAFO, but there was no significant difference between normal walking and SCKAFO with IF. In wearing SCKAFO with IF, the mean o...

Spinal Cord, 2016

Objective: Orthoses for various joints sections are considered to greatly influence the gait func... more Objective: Orthoses for various joints sections are considered to greatly influence the gait function and energy expenditure in spinal cord-injured (SCI) patients. The aim of this review was to determine the influence of orthoses characteristics and options on the improvement of walking in patients with SCI. Methods: A search was performed using the Population Intervention Comparison Outcome (PICO) method, based on selected keywords; studies were identified electronically in the Science Direct, Google Scholar, Scopus, Web of Knowledge and PubMed databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method was used to report the results. Assessment of the quality of all articles was performed based on the Physiotherapy Evidence Database (PEDro scale). Results: Twelve studies evaluated the effects of different hip joint options on walking parameters and energy expenditure. Five studies investigated the role of knee joint options on gait parameters and compensatory trunk motion. Only five studies analyzed modified ankle joints on gait parameters in SCI patients. Nine studies analyzed gait parameters in SCI patients as powered orthoses and exoskeleton. These studies had a low level of evidence according to the PEDro score (2/10). Conclusion: The various joint types of orthoses appear to be critical in the improvement of walking in patients with SCI. In particular, 'user friendly' orthoses that support the related structure such as the hip joint with a reciprocating mechanism, activated knee joint and movable ankle joint with dorsiflexion assist enable SCI patients to optimize their walking pattern when wearing an orthoses system.

Spinal Cord Series and Cases, 2015

The aim of this study was to evaluate the effect of walking with isocentric reciprocating gait or... more The aim of this study was to evaluate the effect of walking with isocentric reciprocating gait orthoses (IRGOs) utilizing two designs of ankle foot orthoses (AFOs) on specific outcome measures in people with spinal cord injury (SCI). METHODS: Four volunteer SCI subjects participated in this study, and were fitted with an IRGO equipped with either solid or dorsiflexion-assisted AFOs in a randomized order. Subjects walked at their self-selected speed along a flat walkway to enable a comparison of walking speed, endurance and the resulting physiological cost index (PCI) to be performed. RESULTS: Increased walking speed, increased distance walked and less PCI were demonstrated in walking with the IRGO incorporating dorsiflexion-assisted AFOs as compared to walking with an IRGO plus solid AFO as a control condition. CONCLUSION: This study demonstrated that people with SCI could walk at relatively higher speeds and with greater endurance and a reduced PCI when utilizing an IRGO with dorsiflexion-assisted AFO components compared to solid ones. It is therefore concluded that the IRGO incorporating dorsiflexion-assisted AFOs may be an effective alternative in helping to reduce the energy consumption experienced by people with SCI.

Epidermoid cyst in the spinal cord is a rare condition. It constitutes of only 0.6-1.1% of all sp... more Epidermoid cyst in the spinal cord is a rare condition. It constitutes of only 0.6-1.1% of all spinal tumors. When they occur, the typical location is in the subdural, extramedullary space of the lumbo-sacral region.We report a forty-two -year-old female who presented with left extremity radicular pain and myelopathy. MRI of the thoracic spine,illustrated a focal fusiform enlargement of the thoracic cord at T4 and T5.Histopathological examination confirmed the diagnosis of epidermoid cyst. The lesion was surgically resected and the pathology revealed we discuss the clinical features, MR imaging characteristics and surgical findings of this rare tumor and review the associated literature.

Journal of Oncology, 2021

Ovarian cancer is the major cause of gynecologic cancer-related mortality. Regardless of outstand... more Ovarian cancer is the major cause of gynecologic cancer-related mortality. Regardless of outstanding advances, which have been made for improving the prognosis, diagnosis, and treatment of ovarian cancer, the majority of the patients will die of the disease. Late-stage diagnosis and the occurrence of recurrent cancer after treatment are the most important causes of the high mortality rate observed in ovarian cancer patients. Unraveling the molecular mechanisms involved in the pathogenesis of ovarian cancer may help find new biomarkers and therapeutic targets for ovarian cancer. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression, mostly at the posttranscriptional stage, through binding to mRNA targets and inducing translational repression or degradation of target via the RNA-induced silencing complex. Over the last two decades, the role of miRNAs in the pathogenesis of various human cancers, including ovarian cancer, has been documented in multiple studies. Con...

Neurological Sciences, 2020

Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central ne... more Multiple sclerosis (MS) as chronic autoimmune inflammatory neurological disease of the central nervous system (CNS) occurs due to several environmental and genetic factors, whose pathogenesis is associated with genes with regulatory role in the immune system. Long non-coding RNAs (LncRNAs) are able to reportedly regulate responses of immune systems and expression of genes, and show the tissue specificity and complexity of biofunctions. Various studies have suggested that the aberrant LncRNA expression is an underlying factor involved in the incidence of MS and that the analysis of the expression profile of these molecules can be a specific biomarker of MS for preventing the course of the disease or responding to treatment. The purpose of this research was to review the recent studies for exploring the functions of LncRNAs in the processes leading to MS disease.

Journal of Holistic Nursing And Midwifery

Introduction: Cushing disease is a rare problem that usually has an important effect on the quali... more Introduction: Cushing disease is a rare problem that usually has an important effect on the quality of life (QoL). Objective: This survey aimed to evaluate patients’ QoL and determine predictors of improving QoL scores in patients. Materials and Methods: In this before-after study, basic characteristics were collected from 56 patients with Cushing disease who underwent endoscopic transsphenoidal surgery, and their QoL score during one year was assessed. Finally, predictor factors of QoL score improvement were identified. To compare the QoL scores before, 6 months, and 12 months after surgery, repeated measures ANOVA and for determining predictors of QoL score improvement, multivariable logistic regression analysis was used. P<0.05 was considered significant in all tests. Results: The mean±SD age of the samples was 33.92±12.82 years, and 43 (76.8%) were female. In all 56 patients who underwent endoscopic transsphenoidal surgery, the QoL score significantly improved. In multivariab...

Clinical Neurology and Neurosurgery, Apr 1, 2022

BACKGROUND AND AIM Colloid cysts are uncommon benign lesions. There is a lack of consensus regard... more BACKGROUND AND AIM Colloid cysts are uncommon benign lesions. There is a lack of consensus regarding the preferred surgical strategy for colloid cyst resection; the technique with the optimal rates of remission, recurrence, mortality, and complications is debatable. MATERIALS AND METHODS To determine surgical outcomes, we performed a systematic review of the published literature on Colloid cysts. Eligible studies (n = 63) with a prospective or retrospective evaluation of endoscopic or microscopic resection of third ventricle colloid cysts were included, which contained data describing extents of resection, seizures, meningitis, and tumor recurrence. A total of 3143 patients (1741 microscopically and 1402 endoscopically operated) were included in the final analysis. RESULTS According to the results of the meta-analysis, there was a higher rate of gross total resection (GTR) (98.15% versus 91.29%, p = 0.00), need for shunting (4.75% versus 1.46%, p = 0.04), postoperative complications (20.68% versus 10.42%, P = 0.03), mean operating time (194.18 versus 113.04 min), and duration of hospitalization (7.85 versus 4.69 days) for microscopic resection compared with endoscopic resection. While endoscopic resection is associated with a higher rate of cyst recurrence (1.78% versus 0.00%, P = 0.00), there was no difference in reoperation rate (0.49% for endoscopic versus 0.09% for microscopic resection). CONCLUSION Microsurgical resection of third ventricle colloid cysts was associated with a higher rate of GTR and a lower rate of recurrence, while there was a lower rate of postoperative complications, duration of surgery, and shorter hospitalization period in the endoscopic group.

PubMed, Oct 1, 2007

Background: Endoscopic third ventriculostomy has become the preferred treatment for obstructive h... more Background: Endoscopic third ventriculostomy has become the preferred treatment for obstructive hydrocephalus. The purpose of this paper is to present our experience with ventriculostomy at our center. Methods: Twenty-four patients underwent ventriculostomy for the treatment of obstructive hydrocephalus between May 2000 and May 2006. The follow-up period lasted between one and 51 (median: four) months. The mean age of the patients was 31 (range: 0.5 - 67) years. It was determined that the obstructive hydrocephalus was caused by space-occupying lesions in nine patients (eight tumors and one with calcified arteriovenous malformation), aqueductal stenosis in 14 patients, and shunt infection and entrapped fourth ventricle in one patient. Kaplan-Meier survival analysis showed that the proportion of functioning ventriculostomies became stable at rates of 80% to 90% after the third postoperative month. Results: There was no statistically significant difference in the aqueductal stenosis and tumor subgroups (P=0.716). A high rate of functioning ventriculostomies was found in both subgroups: 12 of 14 in the aqueductal stenosis subgroup and eight of nine in the tumor subgroup. In cases of intraventricular tumors, in addition to ventriculostomy, biopsy was performed that successfully helped the patient management. In the present study, the procedure failed in three patients (13%). Ventriculostomy failures occurred within three months after the operation. The cases of treatment failure were one with aqueductal stenosis, one with Chiari I, and one with pineocytoma. There was no permanent morbidity after ventriculostomy in our patients. Conclusion: The results indicated that ventriculostomy is an effective treatment in cases of obstructive hydrocephalus that is caused by aqueductal stenosis and space-occupying lesions. This procedure is worthy for controlling hydrocephalus without shunt and its complications. Early clinical picture after the operation plays an important role in predicting patient's outcome after endoscopic third ventriculostomy.

PubMed, 2009

Cholesterol granuloma (CG) of the petrous apex is an inflammatory reaction to the by-products of ... more Cholesterol granuloma (CG) of the petrous apex is an inflammatory reaction to the by-products of eroded marrow cavities secondary to chronic obstruction of air cells within the petrous pyramid. We report a case of cholesterol granuloma in the left petrous bone occurring in a 28-year-old woman with an unusual presentation. The woman presented with a 6-month history of intermittent left hemicranial headache and diplopia. CT scan of petrous bone and skull base showed an expansile mass of the left petrous apex. For surgical removal we used the transrostral transsphenoid approach. After surgery, all the symptoms and signs of the patient completely recovered. In this report, the indications and merits of the endoscopic transsphenoidal drainage procedure are illustrated through a case presentation.

Clinical Neurology and Neurosurgery, Sep 1, 2019

Highlights  Endoscopic approach to manage the pineal region tumors is associated with a low rate... more Highlights  Endoscopic approach to manage the pineal region tumors is associated with a low rate of morbidity and mortality.  A high rate of positive diagnosis is achievable in endoscopic approach to biopsy the pineal region tumors.  Coexisting hydrocephalus could be successfully treated with single entry approach to the pineal region tumors.  A higher number of biopsy samples could be obtained with single entry approach leading to lower rate of sampling error.

Research Square (Research Square), Mar 7, 2022

Background Brain abscess (BA) is recognized as a potentially fatal neurological infection requiri... more Background Brain abscess (BA) is recognized as a potentially fatal neurological infection requiring appropriate and prompt treatment. Improvements in diagnostic imaging and patient care have recently changed clinical symptoms, epidemiology, and outcomes. Therefore, we aimed to review all BA patients in our referral center. Method This study retrospectively reviewed all con rmed cases of BA referred to an academic teaching hospital and tertiary referral center between 2009 and 2021. Result The study included 119 clinically and radiologically con rmed brain abscesses (84% male vs. 16% female) with a mean age of 38.6 ± 16 years (range:1-79 years). The cause of BA in most cases (71.4%) was unknown. Only 11 patients had positive smears. Approximately 42.9% of patients were treated with surgery and antibiotic therapy, and the rest were treated with antibiotic therapy. The mortality rate in our study was 31.1%. Based on our analysis, HIV patients (P: 0.003), IV drug users (P: 0.025), and patients with loss of consciousness at the time of admission (P < 0.001) had a high mortality rate. On the other hand, patients treated with surgical intervention exhibited a low mortality rate (P: 0.02). The most common site of BA in our patients was the parietal (27.2%). Conclusion In our experience, HIV patients, IV drug users, and unconscious people on admission had higher mortality rates. The mortality rate of patients who underwent surgery was also low. The source of BA in most patients was unknown.

Research in Medicine, Dec 10, 2019

be at high risk of recurrence and could be candidates for adjuvant chemotherapy. Keywords Gastric... more be at high risk of recurrence and could be candidates for adjuvant chemotherapy. Keywords Gastric cancer • Adjuvant chemotherapy • Gastrectomy • T3N0 which were published in 2007 revealed that adjuvant chemotherapy had a significant impact on survival [4]; subsequently, S-1 adjuvant therapy has become a standard treatment for pathological Stage II or III gastric cancer patients in Japan, as mentioned in the guidelines. However, it seems confusing that although patients with T3N0M0, T1N2M0, and T1N3M0 disease are classified as Stage II in the third English edition of the Japanese classification of gastric carcinoma (JCGC) [5], they are excluded from the indications for adjuvant chemotherapy. This is because the ACTS-GC

DOAJ (DOAJ: Directory of Open Access Journals), Apr 1, 2014

Purpose: The aim of this study was to investigate the feasibility and effectiveness of endoscopic... more Purpose: The aim of this study was to investigate the feasibility and effectiveness of endoscopic neurosurgery for patients with third ventricular colloid cysts without ventriculomegaly. Methods: Seventy-one patients with third ventricular colloid cysts were identified and recruited to this study. Eighteen of these patients did not have concomitant hydrocephalus and underwent primary endoscopic surgery for cyst resection. The surgical technique, the success rate, and patients' outcome were assessed and compared with 53 hydrocephalic patients who underwent similar procedures. Results: The ventricular compartments were successfully cannulated and gross total resectin of the colloid cysts was achieved in all patients. There were no operative complications related to the endoscopic procedure. Two patients required subsequent intervention for hydrocephalus. The success rate for endoscopic surgery in non-hydrocephalic patients was similar to its value in patients with hydrocephalus. Conclusion: Endoscopic resection of third ventricular colloid cyst in patients without hydrocephalus seems to be feasible, effective and not contraindicated.