Mohammed Saad - Academia.edu (original) (raw)

Papers by Mohammed Saad

Journal of Clinical Medicine

Background: Active infective endocarditis (IE) is a serious disease associated with high mortalit... more Background: Active infective endocarditis (IE) is a serious disease associated with high mortality. The current study represents our experience over 18 years with surgical treatment for active infective native and prosthetic valve endocarditis (INVE, IPVE). Method: Analysis of 413 patients (171 with IPVE vs. 242 with INVE) who underwent cardiac surgery due to IE between 2002 and 2020. Results: Patients with IPVE were significantly older (64.9 ± 13.2 years vs. 58.3 ± 15.5 years; p < 0.001) with higher EuroSCORE II (21.2 (12.7; 41.8) vs. 6.9 (3.0; 17.0); p < 0.001)) and coronary heart disease (50.6% vs. 38.0%; p < 0.011). Preoperative embolization was significantly higher within INVE (35.5% vs. 16.4%; p < 0.001) with high incidence of cerebral embolization (18.6% vs. 7.6%; p = 0.001) and underwent emergency curative surgery than the IPVE group (19.6% vs. 10.6%; p < 0.001). However, patients with IPVE were significantly represented with intracardiac abscess (44.4% vs.15....

Journal of X-Ray Science and Technology

BACKGROUND: Computed Tomographic (CT) imaging procedures have been reported as the main source of... more BACKGROUND: Computed Tomographic (CT) imaging procedures have been reported as the main source of radiation in diagnostic procedures compared to other modalities. To provide the optimal quality of CT images at the minimum radiation risk to the patient, periodic inspections and calibration tests for CT equipment are required. These tests involve a series of measurements that are time consuming and may require specific skills and highly-trained personnel. OBJECTIVE: This study aims to develop a new computational tool to estimate the dose of CT radiation outputs and assist in the calibration of CT scanners. It may also provide an educational resource by which radiological practitioners can learn the influence of technique factors on both patient radiation dose and the produced image quality. METHODS: The computational tool was developed using MATLAB in order to estimate the CT radiation dose parameters for different technique factors. The CT radiation dose parameters were estimated fro...

King Khalid University Journal of Health Sciences

Industry and Higher Education

The role of higher education institutions (HEIs) in developing the innovative capacity of societi... more The role of higher education institutions (HEIs) in developing the innovative capacity of societies is well recognised. That role is accomplished through the creation and dissemination of knowledge, the success of which is dependent on the types and extent of interactions that can exist between HEIs and industry. Yet this topic remains insufficiently explored in African countries. This paper investigates the extent of the role of Algerian HEIs in cooperating with industry. The main enablers and inhibitors of such activity are also examined.

Journal of Educational and Psychological Sciences

This study aimed at identifying the evaluation competencies of commercial secondary school teache... more This study aimed at identifying the evaluation competencies of commercial secondary school teachers as well as identifying a suggested training program to developing these competencies. To achieve these objectives, the researchers have prepared: ó∏ÛG 4 Oó©dG 3 ôÑªàÑ°S 2003 á«°ùØaedGh ájƒHÎdG Ωƒ∏©dG á∏› …QÉéàdG º«∏©àdG »ª∏©e iód Ëƒ≤àdG äÉjÉØc á«ªaeàd ìÎ≤e »ÑjQóJ èeÉfôH OGó`````YE G ójRƒHC G º©aeŸGóÑY »bÉÑdGóÑY .O óªfi ó©°S óªfi .O ègÉaeŸG IQGOE ÉH »°UÉ°üàNG (k É≤HÉ°S) ègÉaeŸG IQGOE ÉH »°UÉ°üàNG º«∏©àdGh á«HÎdG IQGRh º«∏©àdGh á«HÎdG IQGRh øjôëÑdG áµ∏ ‡ øjôëÑdG áµ∏ ‡ :áeó≤ŸG ' ¬à«ªgC G OGOõà°S É¡fC G ∂°T'h ,π«ãe ¬d ≥Ñ°ùj ⁄ ƒëf ≈∏Y Ωƒ«dG º∏©ŸG á«ªgC G â∏OE ó≤d ójó÷G ¿ô≤dG äÉÑ∏£àe á¡LGƒe ' k ÓYÉa k ÉaôW ó©j ¬fC ' ;∂dPh ,øjô°û©dGh …OÉ◊G ¿ô≤dG óFÉ≤dGh ,á«ª«∏©àdG á«∏ª©∏d á«°SÉ°SC 'G Iõ«côdG A∞µdG º∏©ŸG ó©j å«M ,(1997,ƒµ°ùfƒ«dG) …òdG ƒgh ,•É°ûaedGh ,ájƒ«◊G É¡«∏Y »Ø° †jh ,IOƒ°ûaeŸG É¡aGógC G ≥«≤-¤E G É¡H Ò°ùj …òdG .∫É©ØdG º∏©àdG áÄ«H ™ae°üj øe äÉfÉµeE 'Gh ègÉaeŸG âfÉc Éª¡ªa :

World Journal of Gastrointestinal Pharmacology and Therapeutics

Scientific Reports

Postprocedural aortic regurgitation (AR) has negative impact on patient outcome after transcathet... more Postprocedural aortic regurgitation (AR) has negative impact on patient outcome after transcatheter aortic valve replacement (TAVR). Standard assessment of AR severity by echocardiography is hampered after TAVR. Measurement of pressure half-time (PHT) by echocardiography is not limited in these patients but it may be affected by concomitant left ventricular hypertrophy (LVH). This study sought to evaluate distinct cut-off values of PHT differentiating between patients without and with more than mild LVH for grading of AR after TAVR with cardiac magnetic resonance (CMR) as the reference method for comparison. 71 patients (age 81 ± 6 years) with severe aortic stenosis undergoing TAVR were included into the study. Transthoracic echocardiography (TTE) and CMR were performed after TAVR. Left ventricular mass index was calculated by TTE. PHT was measured by continuous-wave Doppler echocardiography of aortic regurgitation jet. In 18 patients (25%) PHT could not be obtained due to no or ver...

American Journal of Gastroenterology

Benha Veterinary Medical Journal

Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of... more Foot-and-mouth disease (FMD) is a highly contagious and economically devastating viral disease of cloven-hoofed animals. In Egypt, the local commercial (trivalent O Panasia-2/A Iran-05/ SAT2/EGY-A-2012) and imported (trivalent O Manisa /A Iran-05/ SAT2/EGY-A-2012) inactivated vaccines were used for rapid control of the disease. We aimed to determine the cross protection between FMD virus serotypes O and A local Egyptian isolate with vaccinal strains in the local commercial and imported vaccines using challenge experiment. By the 7th day post challenge with either O/EGY-4-2012 or A/EGY/1/2012 isolates, the vaccinated cattle with either local commercial or imported vaccine were clinically protected by 100% with local commercial vaccine and 80% with imported vaccine for O/EGY-4-2012. The protection values were 100% and 80% with cattle challenged with A/EGY/1/2012 and vaccinated with a local commercial or imported vaccine respectively. In conclusion, FMD virus Egyptian isolates O and A was antigenically similar to that of vaccinal strains in local commercial and imported vaccines which provide good protection.

International Journal of Cardiology

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Industrial & engineering chemistry research, Jan 8, 2018

A common problem that faces the oil and gas industry is the formation of iron sulfide scale in va... more A common problem that faces the oil and gas industry is the formation of iron sulfide scale in various stages of production. Recently an effective chemical formulation was proposed to remove all types of iron sulfide scales (including pyrite), consisting of a chelating agent diethylenetriaminepentaacetic acid (DTPA) at high pH using potassium carbonate (KCO). The aim of this molecular modeling study is to develop insight into the thermodynamics and kinetics of the chemical reactions during scale removal. A cluster approach was chosen to mimic the overall system. Standard density functional theory (B3LYP/6-31G*) was used for all calculations. Low spin KFe(II)(SH) and KFe(II)(SH) clusters were derived from the crystal structure of pyrite and used as mimics for surface scale FeS. In addition, KDTPA was used as a starting material too. High spin KFe(II)DTPA, and KS were considered as products. A series of K Fe(II)(SH) complexes ( = -2, = 5-0) with various carboxylate and glycinate ligan...

International journal of cardiology, Jan 15, 2018

Mechanisms underlying increased mortality in patients with chronic total occlusion (CTO) of a non... more Mechanisms underlying increased mortality in patients with chronic total occlusion (CTO) of a non-infarct-related artery (non-IRA) are unknown. Cardiac magnetic resonance (CMR) is uniquely suited to provide important mechanistic and pathophysiological information on myocardial damage and reperfusion injury. Aim of this study was to investigate the association of a CTO in a non-IRA with myocardial damage assessed by CMR in patients with ST-elevation myocardial infarction (STEMI). STEMI patients (n = 791) were stratified according to the presence of single-vessel disease (SVD), multivessel disease (MVD) without a CTO and MVD with a concomitant CTO in a non-IRA. CMR parameters of myocardial injury and clinical outcome after 12 months (major adverse cardiac events [MACE]: death, re-infarction, readmission for heart failure) were compared between groups. A CTO in a non-IRA was present in 74 patients (9%), whereas 372 (47%) had MVD without a CTO and 345 (44%) had SVD. Patients with a CTO ...

JACC. Cardiovascular interventions, Jan 8, 2018

International journal of cardiology, Apr 2, 2018

The most prominent procedure-related and thus modifiable risk factor for contrast-induced acute k... more The most prominent procedure-related and thus modifiable risk factor for contrast-induced acute kidney injury is contrast media (CM) volume. The DyeVert™ system has been designed to reduce the amount of CM. The primary objective of this randomised controlled trial was thus to examine whether the novel DyeVert™ contrast reduction system (Osprey Medical Inc., Minnetonka, MN, USA) leads to a reduction in CM volume in patients undergoing diagnostic coronary angiography. Patients scheduled for a diagnostic coronary angiogram were randomised to angiography with or without the DyeVert™ system. The primary efficacy endpoint was mean CM volume. Image quality was evaluated by an independent reviewer blinded to treatment allocation. A total of 96 patients underwent randomisation. Baseline characteristics were well balanced between groups. Use of the DyeVert™ system resulted in a significant 41.0% reduction in CM volume (36.9±10.9mL versus 62.5±12.7mL, p<0.001). Image quality using the DyeVe...

Circulation. Cardiovascular imaging, 2018

Atrial fibrillation (AF) is frequently observed in patients with ST-segment-elevation myocardial ... more Atrial fibrillation (AF) is frequently observed in patients with ST-segment-elevation myocardial infarction and associated with worse clinical outcome. However, the mechanisms for this increased risk are not fully understood. The purpose of this study was to investigate the relationship of the presence of AF to cardiac magnetic resonance (CMR) derived myocardial salvage and damage as well as clinical outcomes. This multicenter CMR study enrolled 786 patients with ST-segment-elevation myocardial infarction. CMR parameters (infarct size, myocardial salvage index, microvascular obstruction, and myocardial function) were assessed 3 (interquartile range [IQR], 2-4) days post-ST-segment-elevation myocardial infarction and compared between patients with or without AF during hospitalization. Major adverse cardiac events were assessed as a composite of all-cause death, reinfarction, and new congestive heart failure at 12 months. AF was documented in 48 (6.1%) patients. There was no significa...

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, Jun 5, 2017

To investigate the impact of a chronic total occlusion (CTO) in a non-infarct-related coronary ar... more To investigate the impact of a chronic total occlusion (CTO) in a non-infarct-related coronary artery (non-IRA) on 1-year mortality and occurrence of cardiac arrhythmia in patients with cardiogenic shock (CS) complicating acute myocardial infarction (AMI). In a retrospective sub-analysis of the Intraaortic Balloon Pump in Cardiogenic Shock II trial (IABP-SHOCK II) and its accompanying registry, 201 (26%) of 761 patients had a CTO in a non-IR major coronary artery. Mortality was significantly higher in the CTO group at day of admission (19% vs. 11%; p=0.005), 30 days (53% vs. 41%, p=0.002), and 12 months (63% vs. 51%, p=0.002). In the adjusted multivariate Cox regression analysis, a CTO in a non-IRA was an independent predictor of mortality at 12 months (hazard ratio 1.30, 95% confidence interval [CI] 1.02-1.67, p=0.03). At 30-day follow-up, ventricular arrhythmias requiring defibrillation occurred more frequently in patients with non-IRA CTO in the univariate analysis (33% vs. 21%, ...

Journal of diabetes and its complications, Jan 7, 2017

Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). To id... more Urinary microRNAs (miRNAs) play a role in the pathogenesis of chronic kidney disease (CKD). To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and assess their relation to the degree of albuminuria, glycemic control and carotid intimal thickness (CIMT) as an index of atherosclerosis. Diabetic subjects were divided into normoalbuminuric and microalbuminuric groups according to urinary albumin creatinine ration (UACR). Urinary miRNAs were assessed using real time polymerase chain reaction. CIMT was measured using high resolution carotid ultrasound. The expression of urinary miR-377 was significantly higher in patients with microalbumiuria (median, 3.8) compared with 2.65 and 0.98 in normoalbuminic patients and healthy controls, respectively (p<0.05). Urinary miR-216a was significantly lower in all patients with type 1 diabetes and the lowest levels were among the microalbumiuric gro...

Canadian Journal of Electrical and Computer Engineering