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Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat pe... more Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat penyembuhan luka banyak dilakukan terutama pada penyembuhan luka disertai komplikasi, salah satunya dengan memberikan membran amnion. Membran amnion mempunyai sifat anti-inflamasi, anti-bakteri, anti-fibrosis dan anti-scarring dengan imunogenitas rendah, efek reepitelisasi dan mengandung berbagai macam growth factor. Tujuan: Membuktikan pemberian sponge amnion terhadap peningkatan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar. Metode: Sponge amnion dibuat dengan mencampur freeze–dried amnion membrane dengan gelatin 1% dan dilakukan freeze drying. Jumlah sampel 20 tikus Wistar dibagi menjadi 4 kelompok. Kelompok 1 dilakukan pencabutan gigi dan tidak diberi aplikasi bahan disebut kelompok kontrol. Kelompok 2 dilakukan pencabutan gigi kemudian diaplikasi sponge amnion disebut kelompok perlakuan. Masing-masing kelompok dibagi menjadi 2 kelompok kecil yaitu tikus dikorbankan pada hari ke-3 dan ke-5. Kemudian dihitung ekspresi VEGF dan jumlah pembuluh darah baru. Analisis statistik menggunakan uji t. Hasil: Jumlah ekspresi VEGF hari ke-3 dan hari ke-5 menunjukkan terdapat perbedaan yang bermakna antara kelompok kontrol dan perlakuan dengan nilai p sebesar 0,000 (p 0,05). Kesimpulan: Pemberian sponge amnion dapat meningkatkan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar.
B-Dent, Jul 7, 2023
Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to... more Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to individual or to object. Candida albicans is one of the infectious pathogens that can cause cross-infection in dentistry. One example is the manufacture of working models of gypsum material, which can cause cross-infection from patients to dentists or technicians, so it is necessary to control infection by means of disinfection of type III gypsum material work models. Objective: To determine the effectiveness of soaking type III Gypsum in a 0.5% Sodium hypochlorite and 2% Povidone Iodine solution against the growth of Candida albicans. Methods: A laboratory experiment with a total of 21 samples, consisting of 7 samples for each group. The sample is made of a type III gypsum plate measuring 2 x 1 x 0.5 cm. The sample consisted of 3 groups: treatment 1, treatment 2, and treatment 3. The study used the diffusion method. Gypsum plate type III was contaminated with Candida albicans and then immersed in a solution of sterile distilled water (C), 0.5% sodium hypochlorite (P1), and 2% povidone-iodine (P2). The soaking results were planted in SDA media, incubated for 2x24 hours, and then counted using a colony counter. The data were analyzed using Kruskal-Wallis and Mann-Whitney post hoc analyses. Results: In the Kruskal-Wallis analysis of significance (p), between each group, there was a significant difference (p<0.05). The Mann-Whitney post hoc analysis test showed a correlation between group K and P1 and P2 (p<0.05). Conclusion: 0.5% Sodium Hypochlorite and 2% Povidone Iodine solutions are effective as disinfectants using the immersion method in Type III Gypsum against the growth of Candida albicans.
Dental Journal: Majalah Kedokteran Gigi, Mar 31, 2018
Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially ... more Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, antifibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). it also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects' post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p<0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p <0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.
DENTA
Background: Calcium is a material that is mostly contained in the Anadara-granose shell. Beta-TCP... more Background: Calcium is a material that is mostly contained in the Anadara-granose shell. Beta-TCP can be obtained from the hydrothermal process from the Anadara-granose shell. Beta-TCP has a chemical composition that approximates the structure of bones and teeth. Objective:The microencapsulation technique aims to increase stability, reduce side effects and toxic effects of drugs, and prolong the release of ingredients. The encapsulation process is an attempt to inhibit the dissolution speed of Calcium to prevent tunnel defects. Methods: Anadara-granose shell powder was subjected to hydrothermal processing for 18 hours and sintering for 3 hours. The beta-TCP powder was dissolved with aquadest using a magnetic stirrer until it was homogeneous, Na-alginate was dissolved in aquadest until it was homogeneous with a magnetic stirrer then the two solutions were mixed and the CaCl2 solution was dropped. The sample was divided into 3 groups; Pure Beta-TCP(K-); 7 hours stirring (P1); 8 hours ...
Prosiding Applying Advanced Clinical Sciences in Conservative Dentistry, JW Marriott Hotel Surabaya, 23-25 November 2012, 2012
Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat pe... more Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat penyembuhan luka banyak dilakukan terutama pada penyembuhan luka disertai komplikasi, salah satunya dengan memberikan membran amnion. Membran amnion mempunyai sifat anti-inflamasi, anti-bakteri, anti-fibrosis dan anti-scarring dengan imunogenitas rendah, efek reepitelisasi dan mengandung berbagai macam growth factor. Tujuan: Membuktikan pemberian sponge amnion terhadap peningkatan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar. Metode: Sponge amnion dibuat dengan mencampur freeze–dried amnion membrane dengan gelatin 1% dan dilakukan freeze drying. Jumlah sampel 20 tikus Wistar dibagi menjadi 4 kelompok. Kelompok 1 dilakukan pencabutan gigi dan tidak diberi aplikasi bahan disebut kelompok kontrol. Kelompok 2 dilakukan pencabutan gigi kemudian diaplikasi sponge amnion disebut kelompok perlakuan. Masing-masing kelompok dibagi menjadi 2 kelompok kecil...
Dental Journal, 2018
Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially ... more Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar...
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva
The prevalence of dental caries in Indonesia is still high. One of the dental caries treatments i... more The prevalence of dental caries in Indonesia is still high. One of the dental caries treatments is direct restoration. Biomaterial, often used as a restorative material, is glass ionomer cement which has a silica content of 35%. Silica is found in Penaeus monodon shells which have been a waste of production. This research aims to study the characteristic of Penaeus monodon shell powder extracts as candidates for dental materials restoration. The research sample used was Penaeus monodon shell powder extract which was then carried out by a depigmentation process by mixing acetone 1:10 (w/v) ≤ 20 hours. Samples were tested with the XRD test (x-ray diffraction). SEM assessment was performed to evaluate the morphology of the particle. Data were analyzed using Mann-Whitney. The result demonstrated a significant silica content in Penaeus monodon shell powder extract before and after the depigmentation process with a p-value of 0,00 (p0,05). The depigmentation process can decrease silica co...
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah
Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to... more Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to individual or to object. Candida albicans is one of the infectious pathogens that can cause cross-infection in dentistry. One example is the manufacture of working models of gypsum material, which can cause cross-infection from patients to dentists or technicians, so it is necessary to control infection by means of disinfection of type III gypsum material work models. Objective: To determine the effectiveness of soaking type III Gypsum in a 0.5% Sodium hypochlorite and 2% Povidone Iodine solution against the growth of Candida albicans. Methods: A laboratory experiment with a total of 21 samples, consisting of 7 samples for each group. The sample is made of a type III gypsum plate measuring 2 x 1 x 0.5 cm. The sample consisted of 3 groups: treatment 1, treatment 2, and treatment 3. The study used the diffusion method. Gypsum plate type III was contaminated with Can...
ABSTRAK Hormon bekerja melalui pengikatan dengan reseptor spesifik. Pengikatan dari hormon ke res... more ABSTRAK Hormon bekerja melalui pengikatan dengan reseptor spesifik. Pengikatan dari hormon ke reseptor ini pada umumnya memicu suatu perubahan penyesuaian pada reseptor sedemikian rupa sehingga menyampaikan informasi kepada unsur spesifik lain dari sel. Adanya reseptor merupakan determinan (penentu) pertama apakah jaringan akan memberikan respon terhadap hormon. Saat ini di seluruh dunia, khususnya di negara-negara maju sedang ramai membicarakan masalah pencemaran lingkungan yang disebakan oleh hormone disruptors, Salah satu hormone disruptors tersebut yaitu Polychlorinated biphenyls (PCBs). PCBs merupakan endocrine disrupter yang berasal dari lingkungan, senyawa lingkungan yang dapat menimbulkan efek pada manuisa dan spesies lain terutama adanya gangguan pada endocrine signaling. PCBs dan hydroxyl PCBs dapat menimbulkan efek yang sangat besar terhadap sistem hormon steroid. PCBs dan hydroxyl PCBs meningkatkan efek gangguan pada bermacam macam mekanisme, termasuk perubahan dalam produksi hormon, receptor level dan metabolisme hormon steroid dengan berperan sebagai agonist bagi beberapa reseptor hormon steroid. ABSTRACT Hormones work by binding to specific receptors. The binding of the hormone to the receptor is generally trigger an adjustment change in the receptor such that convey information to other specific elements of the cell. Receptor is the first determinant of whether the network will provide a response to the hormone. Currently around the world, especially in developed countries are busy discussing the problem of environmental pollution caused by the hormone disruptors, hormone disruptors One of these is Polychlorinated biphenyls (PCBs). PCBs are endocrine disrupter that come from the environment, environmental compounds that can cause effects in humans and other species, especially disturbance in endocrine signaling. Hydroxyl PCBs and PCBs can cause a very large effect on steroid hormone system. PCBs and PCBs hydroxyl increasing interference effects on a variety of mechanisms, including changes in production of the hormone, receptor steroid hormone levels and metabolism by acting as an agonist for several steroid hormone receptors.
Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat pe... more Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat penyembuhan luka banyak dilakukan terutama pada penyembuhan luka disertai komplikasi, salah satunya dengan memberikan membran amnion. Membran amnion mempunyai sifat anti-inflamasi, anti-bakteri, anti-fibrosis dan anti-scarring dengan imunogenitas rendah, efek reepitelisasi dan mengandung berbagai macam growth factor. Tujuan: Membuktikan pemberian sponge amnion terhadap peningkatan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar. Metode: Sponge amnion dibuat dengan mencampur freeze–dried amnion membrane dengan gelatin 1% dan dilakukan freeze drying. Jumlah sampel 20 tikus Wistar dibagi menjadi 4 kelompok. Kelompok 1 dilakukan pencabutan gigi dan tidak diberi aplikasi bahan disebut kelompok kontrol. Kelompok 2 dilakukan pencabutan gigi kemudian diaplikasi sponge amnion disebut kelompok perlakuan. Masing-masing kelompok dibagi menjadi 2 kelompok kecil yaitu tikus dikorbankan pada hari ke-3 dan ke-5. Kemudian dihitung ekspresi VEGF dan jumlah pembuluh darah baru. Analisis statistik menggunakan uji t. Hasil: Jumlah ekspresi VEGF hari ke-3 dan hari ke-5 menunjukkan terdapat perbedaan yang bermakna antara kelompok kontrol dan perlakuan dengan nilai p sebesar 0,000 (p 0,05). Kesimpulan: Pemberian sponge amnion dapat meningkatkan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar.
B-Dent, Jul 7, 2023
Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to... more Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to individual or to object. Candida albicans is one of the infectious pathogens that can cause cross-infection in dentistry. One example is the manufacture of working models of gypsum material, which can cause cross-infection from patients to dentists or technicians, so it is necessary to control infection by means of disinfection of type III gypsum material work models. Objective: To determine the effectiveness of soaking type III Gypsum in a 0.5% Sodium hypochlorite and 2% Povidone Iodine solution against the growth of Candida albicans. Methods: A laboratory experiment with a total of 21 samples, consisting of 7 samples for each group. The sample is made of a type III gypsum plate measuring 2 x 1 x 0.5 cm. The sample consisted of 3 groups: treatment 1, treatment 2, and treatment 3. The study used the diffusion method. Gypsum plate type III was contaminated with Candida albicans and then immersed in a solution of sterile distilled water (C), 0.5% sodium hypochlorite (P1), and 2% povidone-iodine (P2). The soaking results were planted in SDA media, incubated for 2x24 hours, and then counted using a colony counter. The data were analyzed using Kruskal-Wallis and Mann-Whitney post hoc analyses. Results: In the Kruskal-Wallis analysis of significance (p), between each group, there was a significant difference (p<0.05). The Mann-Whitney post hoc analysis test showed a correlation between group K and P1 and P2 (p<0.05). Conclusion: 0.5% Sodium Hypochlorite and 2% Povidone Iodine solutions are effective as disinfectants using the immersion method in Type III Gypsum against the growth of Candida albicans.
Dental Journal: Majalah Kedokteran Gigi, Mar 31, 2018
Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially ... more Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, antifibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). it also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar rats were then divided into two groups. In Group 1, referred to as the control group, the post-extraction wounds of the rats received no treatment. Meanwhile, in Group 2, the treatment group, the subjects' post-extraction wounds were treated with sponge amnion. The rats of both groups were sacrificed on day 3 to allow observation of the number of VEGF expressions and new blood vessels. A statistical analysis test, a t-test, was subsequently conducted. Results: There was a significant difference in the number of new blood vessels in the control group and that of the treatment group with a p value of 0.018 (p<0.05). There was also a significant difference in VEGF expression between the two groups with a p value of 0.000 (p <0.05). Conclusion: Sponge amnion can generate a number of VEGF expressions and new blood vessels in the post-extraction wounds of Wistar rats.
DENTA
Background: Calcium is a material that is mostly contained in the Anadara-granose shell. Beta-TCP... more Background: Calcium is a material that is mostly contained in the Anadara-granose shell. Beta-TCP can be obtained from the hydrothermal process from the Anadara-granose shell. Beta-TCP has a chemical composition that approximates the structure of bones and teeth. Objective:The microencapsulation technique aims to increase stability, reduce side effects and toxic effects of drugs, and prolong the release of ingredients. The encapsulation process is an attempt to inhibit the dissolution speed of Calcium to prevent tunnel defects. Methods: Anadara-granose shell powder was subjected to hydrothermal processing for 18 hours and sintering for 3 hours. The beta-TCP powder was dissolved with aquadest using a magnetic stirrer until it was homogeneous, Na-alginate was dissolved in aquadest until it was homogeneous with a magnetic stirrer then the two solutions were mixed and the CaCl2 solution was dropped. The sample was divided into 3 groups; Pure Beta-TCP(K-); 7 hours stirring (P1); 8 hours ...
Prosiding Applying Advanced Clinical Sciences in Conservative Dentistry, JW Marriott Hotel Surabaya, 23-25 November 2012, 2012
Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat pe... more Pencabutan gigi dapat memicu terjadinya respon penyembuhan luka oleh tubuh. Metode mempercepat penyembuhan luka banyak dilakukan terutama pada penyembuhan luka disertai komplikasi, salah satunya dengan memberikan membran amnion. Membran amnion mempunyai sifat anti-inflamasi, anti-bakteri, anti-fibrosis dan anti-scarring dengan imunogenitas rendah, efek reepitelisasi dan mengandung berbagai macam growth factor. Tujuan: Membuktikan pemberian sponge amnion terhadap peningkatan ekspresi VEGF dan jumlah pembuluh darah baru pada luka pasca pencabutan gigi tikus wistar. Metode: Sponge amnion dibuat dengan mencampur freeze–dried amnion membrane dengan gelatin 1% dan dilakukan freeze drying. Jumlah sampel 20 tikus Wistar dibagi menjadi 4 kelompok. Kelompok 1 dilakukan pencabutan gigi dan tidak diberi aplikasi bahan disebut kelompok kontrol. Kelompok 2 dilakukan pencabutan gigi kemudian diaplikasi sponge amnion disebut kelompok perlakuan. Masing-masing kelompok dibagi menjadi 2 kelompok kecil...
Dental Journal, 2018
Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially ... more Background: Tooth extraction is the process of removing a tooth from the oral cavity potentially triggering a wound healing response in the body. As a result, many methods have been applied to improve the wound healing process, especially in wounds resulting in complications. One such method involves the application of amniotic membrane which has anti-inflammatory, anti-bacterial, anti-fibrosis, anti-scarring properties with low immunogenicity, epithelialization effects, and secretory leukocyte protease inhibitor (SLPI). It also contains collagen, various growth factors, transferrin, fibronectin, nidogen, proteoglycans, hyaluronan, and laminin. Purpose: This study aimed to determine the effects of sponge amnion on the number of VEGF expressions and new blood vessels in post-tooth extraction wounds of Wistar rats. Methods: Sponge amnion was produced by mixing freeze-dried amnion membrane from the Tissue Bank at RSUD Dr. Soetomo with 1% gelatin before freeze drying the mixture. Wistar...
Insisiva Dental Journal: Majalah Kedokteran Gigi Insisiva
The prevalence of dental caries in Indonesia is still high. One of the dental caries treatments i... more The prevalence of dental caries in Indonesia is still high. One of the dental caries treatments is direct restoration. Biomaterial, often used as a restorative material, is glass ionomer cement which has a silica content of 35%. Silica is found in Penaeus monodon shells which have been a waste of production. This research aims to study the characteristic of Penaeus monodon shell powder extracts as candidates for dental materials restoration. The research sample used was Penaeus monodon shell powder extract which was then carried out by a depigmentation process by mixing acetone 1:10 (w/v) ≤ 20 hours. Samples were tested with the XRD test (x-ray diffraction). SEM assessment was performed to evaluate the morphology of the particle. Data were analyzed using Mann-Whitney. The result demonstrated a significant silica content in Penaeus monodon shell powder extract before and after the depigmentation process with a p-value of 0,00 (p0,05). The depigmentation process can decrease silica co...
B-Dent: Jurnal Kedokteran Gigi Universitas Baiturrahmah
Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to... more Introduction: Cross-infection is the transfer of microorganisms that can occur from individual to individual or to object. Candida albicans is one of the infectious pathogens that can cause cross-infection in dentistry. One example is the manufacture of working models of gypsum material, which can cause cross-infection from patients to dentists or technicians, so it is necessary to control infection by means of disinfection of type III gypsum material work models. Objective: To determine the effectiveness of soaking type III Gypsum in a 0.5% Sodium hypochlorite and 2% Povidone Iodine solution against the growth of Candida albicans. Methods: A laboratory experiment with a total of 21 samples, consisting of 7 samples for each group. The sample is made of a type III gypsum plate measuring 2 x 1 x 0.5 cm. The sample consisted of 3 groups: treatment 1, treatment 2, and treatment 3. The study used the diffusion method. Gypsum plate type III was contaminated with Can...
ABSTRAK Hormon bekerja melalui pengikatan dengan reseptor spesifik. Pengikatan dari hormon ke res... more ABSTRAK Hormon bekerja melalui pengikatan dengan reseptor spesifik. Pengikatan dari hormon ke reseptor ini pada umumnya memicu suatu perubahan penyesuaian pada reseptor sedemikian rupa sehingga menyampaikan informasi kepada unsur spesifik lain dari sel. Adanya reseptor merupakan determinan (penentu) pertama apakah jaringan akan memberikan respon terhadap hormon. Saat ini di seluruh dunia, khususnya di negara-negara maju sedang ramai membicarakan masalah pencemaran lingkungan yang disebakan oleh hormone disruptors, Salah satu hormone disruptors tersebut yaitu Polychlorinated biphenyls (PCBs). PCBs merupakan endocrine disrupter yang berasal dari lingkungan, senyawa lingkungan yang dapat menimbulkan efek pada manuisa dan spesies lain terutama adanya gangguan pada endocrine signaling. PCBs dan hydroxyl PCBs dapat menimbulkan efek yang sangat besar terhadap sistem hormon steroid. PCBs dan hydroxyl PCBs meningkatkan efek gangguan pada bermacam macam mekanisme, termasuk perubahan dalam produksi hormon, receptor level dan metabolisme hormon steroid dengan berperan sebagai agonist bagi beberapa reseptor hormon steroid. ABSTRACT Hormones work by binding to specific receptors. The binding of the hormone to the receptor is generally trigger an adjustment change in the receptor such that convey information to other specific elements of the cell. Receptor is the first determinant of whether the network will provide a response to the hormone. Currently around the world, especially in developed countries are busy discussing the problem of environmental pollution caused by the hormone disruptors, hormone disruptors One of these is Polychlorinated biphenyls (PCBs). PCBs are endocrine disrupter that come from the environment, environmental compounds that can cause effects in humans and other species, especially disturbance in endocrine signaling. Hydroxyl PCBs and PCBs can cause a very large effect on steroid hormone system. PCBs and PCBs hydroxyl increasing interference effects on a variety of mechanisms, including changes in production of the hormone, receptor steroid hormone levels and metabolism by acting as an agonist for several steroid hormone receptors.