Mojgan Mortazavi - Academia.edu (original) (raw)
Papers by Mojgan Mortazavi
Successful prevention of tunneled, central catheter infection by antibiotic lock therapy using cefotaxime
PubMed, Mar 1, 2011
Background: Chronic hemodialysis patients frequently require vascular access through central veno... more Background: Chronic hemodialysis patients frequently require vascular access through central venous catheters (CVCs). The most significant complication of these catheters is infection. This risk can be lowered by the use of an antibiotic-Heparin lock. This study focuses on hemodialysis patients using Tunneled-cuffed catheters (TCC), to assess the rate of catheter-related infections (CRI) in catheter-restricted filling with Cefotaxime and Heparin in end stage renal disease patients. Methods: A double-blind randomized study was conducted to compare 5000 U/ml Heparin plus10 mg/ml cefotaxime (CE/HS) as catheter-lock solutions, with Heparin (5000 U/ml) alone. A total of 30 patients with end-stage renal disease and different etiologies, were enrolled for chronic hemodialysis with permanent catheters from December 2009 to March 2010. These patients were randomly assigned to two groups of 15 members. Blood samples were collected for culture, sensitivity, and colony count, from the catheter lumen and the peripheral vein. CRI was considered as the end point. Results: The rate of CRI was significantly lower in the cefotaxime group versus control group (p < 0.001). No exit site infection was occurred in both groups. Infection-free survival rates at 180 days were 100% for the CE/HS group, and 56% for the HS group. Conclusions: Antibiotic lock therapy using cefotaxime reduces the risk of CRI in hemodialysis patients.
Journal of nephropathology, Mar 18, 2012
Granulomatosis with polyangiitis (Wegener's) is a systemic necrotizing vasculitis, rarely present... more Granulomatosis with polyangiitis (Wegener's) is a systemic necrotizing vasculitis, rarely presented with ventricular masses and also multiple echo-free lesions in the spleen. Cardiac masses and spleen lesions completely resolved after corticosteroid pulse therapy. GPA should be considered in the differential diagnosis of any nonspecific illnesses with cardiac involvement.
Outcome Of Rapamycin Therapy For Post Transplant- Lymphoproliferative Disorder After Kidney Transplantation: Case Series
Blood, Nov 15, 2013
The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients
DOAJ (DOAJ: Directory of Open Access Journals), 2022
Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisp... more Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment. The aim of study was to develop a general consensus statement for CP therapy in clinic to limit the drug-induced nephrotoxicity. Methods: A total of 30 oncologist-hematologists, adult and pediatric nephrologists, radiation oncologists, clinical pathologist clinical pharmacologist, and renal physiologist participated in a workshop, and in order to reduce the incidence of CP-induced nephrotoxicity, a general consensus was developed. Results: The developed general consensus was focused on some items such as age, sex, female hormone, nonsteroidal anti-inflammatory drugs (NSAID), renin–angiotensin system inhibitor drugs, glomerular filtration rate, hydration methods, contrasts, antioxidants, dextrose, and magnesium. Conclusion: The agreement between participants for CP therapy in clinic was achieved, and this general consensus was announced to be implemented in the hospitals.
Dietary and sleep quality association in hemodialysis patients
Advanced Biomedical Research
BMJ Open
ObjectivesPhysical inactivity is a major adjustable lifestyle risk factor in renal patients; neve... more ObjectivesPhysical inactivity is a major adjustable lifestyle risk factor in renal patients; nevertheless, research on the association of physical activity (PA) with chronic kidney disease (CKD) is unclear.DesignCross-sectional.SettingWe evaluated the secondary care related to the nephrology specialists.ParticipantsWe evaluated PA in 3374 Iranian patients with CKD aged ≥18 years. Exclusion criteria were current or prior kidney transplantation, dementia, institutionalisation, expected to start renal replacement therapy or leave the area within study duration, participation in a clinical trial or inability to undergo the informed consent process.Primary and secondary outcomeThe renal function parameters were measured and compared with PA, assessed by the Baecke questionnaire. Estimated glomerular filtration rate, haematuria and/or albuminuria were used to estimate decreased kidney function and the incidence of CKD. To estimate the relationship between PA and CKD, we used the multinomi...
Is Chronic Kidney Disease, a Predictor of In-Hospital Mortality in Coronavirus Disease 2019 (COVID-19) Patients?
Advanced Biomedical Research, 2023
Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 ... more Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 (COVID-19) patients considering its high prevalence. We aimed to figure out the relationship between CKD and COVID-19 mortality in this study. Materials and methods: In total, 116 CKD patients (estimated glomerular filtration rate [eGFR] lower than 60 mL/min/1.73 m2) and 147 control subjects confirmed with COVID-19 were studied. Data regarding demographics, sign and symptoms, laboratory findings, and chest computed tomography were collected. Association between CKD and in-hospital mortality were analyzed using logistic regression models adjusted for confounders. Results: Mortality rate was significantly higher in CKD than non-CKD (30.17 vs 4.76, P < 0.001) COVID-19 patients. Multivariate logistic regression showed that CKD was significantly correlated with in-hospital mortality in the total sample (Odds ratio (OR) = 8.64, confidence interval (CI): 3.67-20.35) and gender subgroups (females: OR = 4.77, CI: 1.38-16.40, males: OR = 13.43, CI: 3.85-46.87) (P < 0.05) of COVID-19 patients in the crude model. Whereas, the correlation did not remain significant in the fully adjusted model in the total sample (OR = 1.70, CI: 0.35-8.19) and gender subgroups (females: OR = 1.07 CI: 0.06-19.82, males: OR = 0.87, CI: 0.07-10.33) (P > 0.05) of COVID-19 patients. Conclusion: This study suggested an independent association between CKD and in-hospital mortality in COVID-19 patients. Therefore, more intensive surveillance of COVID-19 patients with CKD is to be warranted.
Chronic Kidney Disease in Isfahan Province, Action Plan for Screening in A Population-based Study
Iranian Journal of Kidney Diseases, Nov 1, 2022
Chronic kidney disease and COVID-19 infection: A case–Control study
Advanced Biomedical Research
Evaluation of magnesium level and associated factors in patients under peritoneal dialysis
Journal of Isfahan Medical School, 2020
One-Year Renal Function in Patients with Chronic Renal Failure and Metabolic Syndrome
مجله دانشکده پزشکی اصفهان, 2018
Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk fa... more Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk factor to end-stage renal diseases. The incidence of metabolic syndrome (MS) and its cardiovascular complications is common in patients CRF, too. In this study, we compared renal function in patients with CRF and with or without metabolic syndrome. Methods: This study was conducted in 2017 among 100 patient with CRF with glomerular filtration rate (GFR) of 15-60 ml/min/1.73m2, 50 patients with and 50 without metabolic syndrome. Metabolic syndrome criteria, as well as serum creatinine were measured in all the patients each 3 months till 1 year. Findings: 42 patients were women and 58 were men. The mean GFR was not significantly different among the patients with or without metabolic syndrome (P = 0.322) in 1-year follow up. In 3-month follow ups, only there was a significant association between systolic blood pressure and GFR with metabolic syndrome (P = 0.028, P = 0.030, P = 0.020, and P = ...
Sleep Science, 2021
Dietary nutrients' intake and sleep quality in peritoneal dialysis patients Dietary nutrients' in... more Dietary nutrients' intake and sleep quality in peritoneal dialysis patients Dietary nutrients' intake and sleep quality in peritoneal dialysis patients SHORT COMMUNICATIONS
Is There Any Difference Between Use of Gentamycin and Mupirocin Ointments in Decrease Exit Site Infection Ratio in Peritoneal Dialysis Patients
The Effect of Pentoxyphiline for Reduce of Erythropoietin Needs in Hemodialysis Patients
Does Intraperitoneal Heparin Affect the Level of CA125 in Peritoneal Dialysis Effluent of Peritoneal Dialysis Patients
Effect of L-Carrnitine on Albomin in Hemodialysis Patient (Poster Presentations: P218)
Outcome and Clinical Findings of Peritoneal Dialysis Patients in Isfahan, Iran
Demographic Characteristics of Peritoneal Dialysis Patients in Isfahan
Blood, 2013
Background Post transplant lymphoproliferative disorders (PTLD) , are a complication of c... more Background Post transplant lymphoproliferative disorders (PTLD) , are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored. Methods A detailed retrospective analysis was performed according to data collected from thirteen patients with PTLD. At the time of PTLD diagnosis, immunosuppressive therapy was decreased and rapamycin administered. Overall survival and disease free survival of patients and graft survival were determined. Results Among 590 kidney transplant recipients, thirteen adult patients with PTLD were included in this study. The mean age of the patients was 42.15 (range: 25-58) years at the time of PTLD diagnosis, and 9 patients were male. Histology was distributed in 9 diffuse large B cell, 1 Malt lymphoma, 1 Burkitt lymphoma, 2 Hodgkin-like PTLD. The response rate to rapamycin alone was 30.8%. The mean overall survival period is 27.4...
Journal of Nephropathology, 2012
The prevalence and clinical picture of IgA nephropathy (IgAN) varies from region to region. There... more The prevalence and clinical picture of IgA nephropathy (IgAN) varies from region to region. There is a limited knowledge about the morphological features of this disease according to recent Oxford-MEST classification in Iran and Middle East. In this study higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/tubular atrophy as the two of four variables of this classification in male patients further attests that male gender is a risk factor in this kind of disease. Significant correlation between serum creatinine and extracapillary proliferation was in an agreement with previous studies and was suggested for the probable accommodation of crescent as a new variable in the MEST system.
Successful prevention of tunneled, central catheter infection by antibiotic lock therapy using cefotaxime
PubMed, Mar 1, 2011
Background: Chronic hemodialysis patients frequently require vascular access through central veno... more Background: Chronic hemodialysis patients frequently require vascular access through central venous catheters (CVCs). The most significant complication of these catheters is infection. This risk can be lowered by the use of an antibiotic-Heparin lock. This study focuses on hemodialysis patients using Tunneled-cuffed catheters (TCC), to assess the rate of catheter-related infections (CRI) in catheter-restricted filling with Cefotaxime and Heparin in end stage renal disease patients. Methods: A double-blind randomized study was conducted to compare 5000 U/ml Heparin plus10 mg/ml cefotaxime (CE/HS) as catheter-lock solutions, with Heparin (5000 U/ml) alone. A total of 30 patients with end-stage renal disease and different etiologies, were enrolled for chronic hemodialysis with permanent catheters from December 2009 to March 2010. These patients were randomly assigned to two groups of 15 members. Blood samples were collected for culture, sensitivity, and colony count, from the catheter lumen and the peripheral vein. CRI was considered as the end point. Results: The rate of CRI was significantly lower in the cefotaxime group versus control group (p < 0.001). No exit site infection was occurred in both groups. Infection-free survival rates at 180 days were 100% for the CE/HS group, and 56% for the HS group. Conclusions: Antibiotic lock therapy using cefotaxime reduces the risk of CRI in hemodialysis patients.
Journal of nephropathology, Mar 18, 2012
Granulomatosis with polyangiitis (Wegener's) is a systemic necrotizing vasculitis, rarely present... more Granulomatosis with polyangiitis (Wegener's) is a systemic necrotizing vasculitis, rarely presented with ventricular masses and also multiple echo-free lesions in the spleen. Cardiac masses and spleen lesions completely resolved after corticosteroid pulse therapy. GPA should be considered in the differential diagnosis of any nonspecific illnesses with cardiac involvement.
Outcome Of Rapamycin Therapy For Post Transplant- Lymphoproliferative Disorder After Kidney Transplantation: Case Series
Blood, Nov 15, 2013
The Prevention of Cisplatin-Induced Nephrotoxicity: A General Consensus Statement of a Group of Oncologist-Hematologists, Adult and Pediatric Nephrologists, Radiation Oncologists, Clinical Pathologists, Clinical Pharmacologists, and Renal Physiologists on Cisplatin Therapy in Cancer Patients
DOAJ (DOAJ: Directory of Open Access Journals), 2022
Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisp... more Backgrounds: Most of the cancer patients with solid tumor are subjected to chemotherapy with cisplatin (CP) in clinic. However, the most side effect of CP is nephrotoxicity, which limits the treatment. The aim of study was to develop a general consensus statement for CP therapy in clinic to limit the drug-induced nephrotoxicity. Methods: A total of 30 oncologist-hematologists, adult and pediatric nephrologists, radiation oncologists, clinical pathologist clinical pharmacologist, and renal physiologist participated in a workshop, and in order to reduce the incidence of CP-induced nephrotoxicity, a general consensus was developed. Results: The developed general consensus was focused on some items such as age, sex, female hormone, nonsteroidal anti-inflammatory drugs (NSAID), renin–angiotensin system inhibitor drugs, glomerular filtration rate, hydration methods, contrasts, antioxidants, dextrose, and magnesium. Conclusion: The agreement between participants for CP therapy in clinic was achieved, and this general consensus was announced to be implemented in the hospitals.
Dietary and sleep quality association in hemodialysis patients
Advanced Biomedical Research
BMJ Open
ObjectivesPhysical inactivity is a major adjustable lifestyle risk factor in renal patients; neve... more ObjectivesPhysical inactivity is a major adjustable lifestyle risk factor in renal patients; nevertheless, research on the association of physical activity (PA) with chronic kidney disease (CKD) is unclear.DesignCross-sectional.SettingWe evaluated the secondary care related to the nephrology specialists.ParticipantsWe evaluated PA in 3374 Iranian patients with CKD aged ≥18 years. Exclusion criteria were current or prior kidney transplantation, dementia, institutionalisation, expected to start renal replacement therapy or leave the area within study duration, participation in a clinical trial or inability to undergo the informed consent process.Primary and secondary outcomeThe renal function parameters were measured and compared with PA, assessed by the Baecke questionnaire. Estimated glomerular filtration rate, haematuria and/or albuminuria were used to estimate decreased kidney function and the incidence of CKD. To estimate the relationship between PA and CKD, we used the multinomi...
Is Chronic Kidney Disease, a Predictor of In-Hospital Mortality in Coronavirus Disease 2019 (COVID-19) Patients?
Advanced Biomedical Research, 2023
Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 ... more Background: Chronic kidney disease (CKD) is an important comorbidity in Coronavirus Disease 2019 (COVID-19) patients considering its high prevalence. We aimed to figure out the relationship between CKD and COVID-19 mortality in this study. Materials and methods: In total, 116 CKD patients (estimated glomerular filtration rate [eGFR] lower than 60 mL/min/1.73 m2) and 147 control subjects confirmed with COVID-19 were studied. Data regarding demographics, sign and symptoms, laboratory findings, and chest computed tomography were collected. Association between CKD and in-hospital mortality were analyzed using logistic regression models adjusted for confounders. Results: Mortality rate was significantly higher in CKD than non-CKD (30.17 vs 4.76, P < 0.001) COVID-19 patients. Multivariate logistic regression showed that CKD was significantly correlated with in-hospital mortality in the total sample (Odds ratio (OR) = 8.64, confidence interval (CI): 3.67-20.35) and gender subgroups (females: OR = 4.77, CI: 1.38-16.40, males: OR = 13.43, CI: 3.85-46.87) (P < 0.05) of COVID-19 patients in the crude model. Whereas, the correlation did not remain significant in the fully adjusted model in the total sample (OR = 1.70, CI: 0.35-8.19) and gender subgroups (females: OR = 1.07 CI: 0.06-19.82, males: OR = 0.87, CI: 0.07-10.33) (P > 0.05) of COVID-19 patients. Conclusion: This study suggested an independent association between CKD and in-hospital mortality in COVID-19 patients. Therefore, more intensive surveillance of COVID-19 patients with CKD is to be warranted.
Chronic Kidney Disease in Isfahan Province, Action Plan for Screening in A Population-based Study
Iranian Journal of Kidney Diseases, Nov 1, 2022
Chronic kidney disease and COVID-19 infection: A case–Control study
Advanced Biomedical Research
Evaluation of magnesium level and associated factors in patients under peritoneal dialysis
Journal of Isfahan Medical School, 2020
One-Year Renal Function in Patients with Chronic Renal Failure and Metabolic Syndrome
مجله دانشکده پزشکی اصفهان, 2018
Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk fa... more Background: Recently, chronic renal failure (CRF) has increased worldwide. CRF is a major risk factor to end-stage renal diseases. The incidence of metabolic syndrome (MS) and its cardiovascular complications is common in patients CRF, too. In this study, we compared renal function in patients with CRF and with or without metabolic syndrome. Methods: This study was conducted in 2017 among 100 patient with CRF with glomerular filtration rate (GFR) of 15-60 ml/min/1.73m2, 50 patients with and 50 without metabolic syndrome. Metabolic syndrome criteria, as well as serum creatinine were measured in all the patients each 3 months till 1 year. Findings: 42 patients were women and 58 were men. The mean GFR was not significantly different among the patients with or without metabolic syndrome (P = 0.322) in 1-year follow up. In 3-month follow ups, only there was a significant association between systolic blood pressure and GFR with metabolic syndrome (P = 0.028, P = 0.030, P = 0.020, and P = ...
Sleep Science, 2021
Dietary nutrients' intake and sleep quality in peritoneal dialysis patients Dietary nutrients' in... more Dietary nutrients' intake and sleep quality in peritoneal dialysis patients Dietary nutrients' intake and sleep quality in peritoneal dialysis patients SHORT COMMUNICATIONS
Is There Any Difference Between Use of Gentamycin and Mupirocin Ointments in Decrease Exit Site Infection Ratio in Peritoneal Dialysis Patients
The Effect of Pentoxyphiline for Reduce of Erythropoietin Needs in Hemodialysis Patients
Does Intraperitoneal Heparin Affect the Level of CA125 in Peritoneal Dialysis Effluent of Peritoneal Dialysis Patients
Effect of L-Carrnitine on Albomin in Hemodialysis Patient (Poster Presentations: P218)
Outcome and Clinical Findings of Peritoneal Dialysis Patients in Isfahan, Iran
Demographic Characteristics of Peritoneal Dialysis Patients in Isfahan
Blood, 2013
Background Post transplant lymphoproliferative disorders (PTLD) , are a complication of c... more Background Post transplant lymphoproliferative disorders (PTLD) , are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored. Methods A detailed retrospective analysis was performed according to data collected from thirteen patients with PTLD. At the time of PTLD diagnosis, immunosuppressive therapy was decreased and rapamycin administered. Overall survival and disease free survival of patients and graft survival were determined. Results Among 590 kidney transplant recipients, thirteen adult patients with PTLD were included in this study. The mean age of the patients was 42.15 (range: 25-58) years at the time of PTLD diagnosis, and 9 patients were male. Histology was distributed in 9 diffuse large B cell, 1 Malt lymphoma, 1 Burkitt lymphoma, 2 Hodgkin-like PTLD. The response rate to rapamycin alone was 30.8%. The mean overall survival period is 27.4...
Journal of Nephropathology, 2012
The prevalence and clinical picture of IgA nephropathy (IgAN) varies from region to region. There... more The prevalence and clinical picture of IgA nephropathy (IgAN) varies from region to region. There is a limited knowledge about the morphological features of this disease according to recent Oxford-MEST classification in Iran and Middle East. In this study higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/tubular atrophy as the two of four variables of this classification in male patients further attests that male gender is a risk factor in this kind of disease. Significant correlation between serum creatinine and extracapillary proliferation was in an agreement with previous studies and was suggested for the probable accommodation of crescent as a new variable in the MEST system.