Monika Ola - Academia.edu (original) (raw)

Papers by Monika Ola

Langmuir, 1998

The recently discovered isotropic/nematic phase transition in κ-carrageenan was further examined ... more The recently discovered isotropic/nematic phase transition in κ-carrageenan was further examined by macroscopic observations and by NMR. A state diagram, which is the equivalent of a phase diagram but including also nonequilibrium states (in our case a gel), was established in the mixed salt solutions of NaI/CsI where the competition between phase separation and gelation could be studied. The phase boundaries of the nematic phase depended on molecular weight and ionic strength qualitatively as expected for a charged rigid polymer. From these data the persistence length of the κ-carrageenan helix was estimated as 60-90 nm. The volume fraction of the nematic phase depended sensitively on the overall helical content. In coexisting phases, the helical content was larger in the nematic than in the isotropic phase.

Journal of Drug Delivery and Therapeutics

Sometimes immediate onset of action is required than conventional treatment in many patients. Amo... more Sometimes immediate onset of action is required than conventional treatment in many patients. Among all dosage forms tablet is the most popular dosage form existing today because of its convenience of self-administration, compactness and easy manufacturing. to overcome these drawbacks, immediate release dosage form has emerged as alternative oral dosage forms. Immediate drug release dosage forms disintegrate quickly after administration with enhanced rate of dissolution. The basic approach used in development tablets is the use of superdisintegrants like Cross linked Polyvinylpyrrolidone or crospovidone (Polyplasdone), Sodium starch glycolate (Primogel, Explotab), carboxymethylcellulose (Croscarmellose) etc. In this field immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form.

Food is a basic necessity of life it helps to stay healthy and be active. Your body needs all the... more Food is a basic necessity of life it helps to stay healthy and be active. Your body needs all the nutrient in adequate amount and in a correct proportion to work and to make healthy body cells is called balanced nutrition, so well balance diets include the basic five foods carbohydrates, protein, milk, fruits, vegetables and fats and oil. Malnutrition truly means 'bad nourishment'. Herbal dietary supplements are frequently taken into consideration harmless. Natural vitamins are the best it increases immunity. However, in case you are poor in a specific nutrient, then taking dietary supplements is beneficial.

International Journal Of All Research Writings, May 22, 2019

International Journal of Computational Biology and Bioinformatics, Sep 17, 2020

Bioanalytical method development plays importance role in the pre-clinical and clinical studies. ... more Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pharmacokinetics of any drug and its metabolite can be recognized by bioanalytical studies. The quantitative analysis of drugs and their metabolite sin the biological media is done by bioanalytical studies. Physical-chemical and biological techniques are used for these studies. Every bioanalytical method should be selective, sensitive and reliable for the quantitative estimation in drug discovery process. Bioanalytical method development consists of sample preparation, chromatographic separation and detection by using proper analytical method. Each developed method should be validated as per the regulatory authorities, so as to give reliable and reproducible method for the intended use. Many analytical techniques can be used for bioanalysis; LCMS/MS is one of them. In Liquid chromatography-mass spectrometry [LC-MS/MS] the separation of analyte is done by LC and detection is carried out by MS. LC-MS/MS obviously used in estimation and understanding of bioavailability, bioequivalence and pharmacokinetic data. This review additionally centered on different validation parameters such as:

Quality is an important prerequisite when we consider any product. Therefore the drug must be man... more Quality is an important prerequisite when we consider any product. Therefore the drug must be manufactured to the highest quality levels. End product testing by itself does not guarantee of product quality. Every step of manufacturing procedure should be validated. Process validation performs this task to build quality in to the product. Process validation had proven to be an important tool for quality management soon emerged several regulatory guidelines and publication on validation and today for the pharmaceutical industry successful validation is prerequisite. The principles of planning, organizing and performing process validation are similar to those for qualification. It should be done in accordance with process validation protocols; data should be collected and reviewed against predetermined acceptance criteria, and reflected in process validation reports.

Journal of Drug Delivery and Therapeutics, 2020

Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and nor... more Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may be unbalanced in people with depression. It is used to treat major depressive disorder, anxiety and panic disorder. The present review assesses the various approaches for analysis of Venlafaxine in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of Venlafaxine in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on Venlafaxine. Keywords: Venlafaxine; Analytical Profile; HPLC; HPTLC; Bioanalytical; Stability indicating

The oral cavity has been investigated as a site of drug delivery for an extended amount of your t... more The oral cavity has been investigated as a site of drug delivery for an extended amount of your time. In 1847 Sobrero found that Nitro glycerine was absorbed from the oral cavity (Ponchel 1993). Since ABSTRACT Nicotine is associate organic compound found within e ligneous plant family of plants (Solanaceae) t hat acts as a nicotinic neurotransmitter receptor agonist. And po sseses completely different medical specialty activ ities like, system Stimulant. Completely different preparation of nicotine in market like Nicogum and Nicolette ex c pt buccal film. Buccle film having varios blessings like Conv enient dosing, No water required, No risk chocking, Taste masking therefore in presence study we tend to conc eive to formulate buccal film of nicotine. The main aim of the study was to look at varied polymers thought-about t possess dissolving properties for the preparatio n of buccal films of nicotine and to guage the films for varied physical and chemical parameters and subject the s...

Seminars in Cancer Biology, 2021

It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of can... more It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of cancer cells and the gradual manifestation of resistance. Specific action, adverse effects and development of resistance has prompted the urgent requirement of exploring alternative anti-tumour treatment therapies. The naturally derived microbial toxins as a therapy against cancer cells are a promisingly new dimension. Various important microbial toxins such as Diphtheria toxin, Vibrio cholera toxin, Aflatoxin, Patulin, Cryptophycin-55, Chlorella are derived from several bacterial, fungal and algal species. These agents act on different biotargets such as inhibition of protein synthesis, reduction in cell growth, regulation of cell cycle and many cellular processes. Bacterial toxins produce actions primarily by targeting protein moieties and some immunomodulation and few acts through DNA. Fungal toxins appear to have more DNA damaging activity and affect the cell cycle. Algal toxins produce alteration in mitochondrial phosphorylation. In conclusion, microbial toxins and their metabolites appear to have a great potential to provide a promising option for the treatment and management to combat cancer.

Agglomerative phase of comminution (APOC) is a relatively newer granulation cum particle size red... more Agglomerative phase of comminution (APOC) is a relatively newer granulation cum particle size reduction technique in which agglomeration of the fine coherent particles take place into loose granular structure. Agglomeration of the fine cohesive particles produced during grinding particularly with rotating or oscillating ball mills. Reduction of particle size during prolonged grinding by a ball mill has been used as a novel means of producing a pharmaceutical granulation. When compared with conventional granulation methods, this method produced mechanically stronger tablets with a higher dissolution rate than those compacted from granules made by a conventional wet granulation method. It is suggested that binderless tablets may be prepared by using this method, thus simplifying tablet formulation and enhancing stability. A possible mechanism for the increased dissolution rate is the increased internal surface area of the particles produced by the prolonged grinding method. As the com...

Current Research in Green and Sustainable Chemistry, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Indian Journal of Pharmaceutical and Biological Research, 2018

The advantages of oral dosage form that are responsible for its popularity are its ease of admini... more The advantages of oral dosage form that are responsible for its popularity are its ease of administration, patient compliance and stability of formulation. The most popular oral dosage forms beings tablets and capsules, but one important drawback of the dosage forms however is the difficulty to swallow especially when a dosage form is developed for pediatric and geriatric patient. The modern scientific and technological advancement in the pharmaceutical field had created bank of interest in reconstitutable oral suspension dosage form in the recent year. The reconstituted system is the formulation of choice when the drug stability is a major concern. Reconstitutable oral systems show the adequate chemical stability of the drug during shelf life and also reduce the weight of the final product. Dry syrup form of the drug is also useful in case of bioavailability as it has high bioavailability rather than tablets and capsules as it disintegrates in water outside of the oral cavity and d...

Indian Journal of Pharmaceutical and Biological Research, 2018

Nearly 40% of novel drugs comes in pharmaceutical industries are showing poor capability of solub... more Nearly 40% of novel drugs comes in pharmaceutical industries are showing poor capability of solubilization in water. Therefore enhancing the solubilization of such drugs in water to enhance their bioavailability be the major challenge to formulation scientists. So the preparation of solid dispersion from the drug which shows poor solubility in water with carriers having good water solubility has decrease the occurrence of such problems and increase dissolution. Hence solid dispersion found to be attention-grabbing method for solubility enhancing of drugs which showing poor solubility in water. This review, shows an overview on the different solid dispersion types, rationale, their advantages, limitations, manufacturing processes as well as its characterization methods.

Journal of Drug Delivery and Therapeutics, Jan 15, 2013

As significant number of products manufactured for personal care/health care, either in the final... more As significant number of products manufactured for personal care/health care, either in the final stage or at some stage of their production, dispersion of particulate materials dispersed into liquid or solid vehicles, often at high volume fraction. The vast array of cosmetics/personal care and pharmaceutical products reveal the importance of adequate dispersion. With active pharmaceutical ingredients possessing poor aqueous solubility, optimal dispersion is necessary for maximizing the bioavailability and uniformity of dose. Fine particulate dry powders always contain agglomerates that require deagglomeration and stabilization to obtain optimal dispersion. All particulate dispersion systems are inherently thermodynamically unstable. Unless properly stabilized, through the random motion of the particles over time, they will get aggregate due to the natural and dominant tendency to decrease the large specific surface area and excess surface energy. Adequate concentrations of wetting agents, de-agglomerating agents and stabilizers are required to produce stable particulate dispersions. The dispersion process is accomplished via three distinct steps: wetting the particulate material, de-agglomeration of the particles and stabilization of the same, and these steps should be performed in the correct order to get a stable product.

Journal of Drug Delivery and Therapeutics, 2020

The stability of a new drug substances and new drug products is a vital parameter which may affec... more The stability of a new drug substances and new drug products is a vital parameter which may affect purity, safety & potency. Changes in drug stability can threat patient safety by formation of toxic degradation products or deliver to lower dose than expected. Therefore it is to know the purity profile & behaviour of a drug substances under the various environmental condition. Forced Degradation studies show the chemical behavior of the molecule which in turn helps in the development of new formulation & package . Degradation study is required to the design of a regulatory compliant stability program for the both drug substances & products, and formalized as a regulatory requirement in ICH Guideline Q1A in 1993. Forced degradation studies (chemical and physical stress testing) of new chemical entities and drug product which is required to develop and demonstrate the specificity i.e stability indicating method. Forced degradation studies used to determination of the degradation pat...

Journal of Drug Discovery And Therapeutics, 2019

The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmac... more The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most popular pharmaceutical application of cyclodextrin is to increase the solubility, stability, safety and bioavailability of drug molecules. The idea of this review article is to solve and study any of the findings and application of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This review article introduce the molecular structure, properties like complexation, solubility etc. of cyclodextrins and targeted on its use for parenteral, oral, ophthalmic and nasal drug delivery. Other routes including dermal, rectal, sublingual and pulmonary delivery are again briefly addressed. The aim of this contribution is to focus on the potential application of chemically altared cyclodextrins as high-performance drug carriers in drug delivery systems with emphasis on the other ...

Materials Today Chemistry, 2020

Despite the adverse effects of microbial hazards on public health, major pharmaceutical firms hav... more Despite the adverse effects of microbial hazards on public health, major pharmaceutical firms have left the field of anti-infective development and a dramatic reduction in the number of researcher'sintricated in the quest for new specific anti-infective leads. In the non-existence of an efficient forum for antibiotics development and over usage in human beings and animals, bacteria have demoralized this potential by gradually establishing the resistance toward most of the antibiotics used. Thus, the production of novel and successful anti-infectivedrugs is urgently required to combat this resistance. Hydrazones and hydrazides have mounted as a key-skeleton for the development of active drugs, due to their important biological and pharmacological profiles.Hydrazones are being manufactured as medicines by various investigators to fight against the ailments with maximal effects and minimal toxicity.This paper focuses on the outline of the literature results of recent years, incorporating the work on the anti-infective profileof Manuscript File Click here to view linked References 2 hydrazoneanalogues. This review may also act as an excellent basisfor the development of new derivatives of hydrazone as potential anti-infective mediators.

The Pharma Innovation Journal, 2015

The present study illustrates development of site specific delivery of metoprolol succinate in tr... more The present study illustrates development of site specific delivery of metoprolol succinate in treatment of hypertension. Formulations were developed by utilizing polymers such as HPMC and Chitosan along with plasticizer (PEG-400) by solvent technique. The calibration curve of metoprolol succinate was developed in PBS pH 6.8 at 223 nm in the range of 5 to 25 µg/ml. Compatibility study were carried out by FT-IR and Differential scanning colorimetry. The formulations were evaluated for thickness, folding endurance, weight variation, drug content, percent moisture loss, percent moisture absorption, tensile strength, SEM. In vitro drug diffusion study was also carried out using franz diffusion cell with PBS pH 6.8 and the samples were analyzed by UV-spectrophotometrically at 223 nm. FT-IR and DSC study revealed no interaction between drug and polymers. Formulations shown good uniformity of drug content more than 90%, there is little effect on moisture loss test due to hydrophilic polyme...

In present study, LCs were formulated and evaluate for desirable properties, Sonication condition... more In present study, LCs were formulated and evaluate for desirable properties, Sonication conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of liquid crystals and optimized according probe sonication condition (Ultra Tarrux T25), liquid crystals with reproducible narrow particle size distribution and mean particle size of 168.0 ± 2.1 nm were obtained. The structure of the dispersed cubosomes was revealed by XRD (X-ray diffraction) and SEM (scanning electron microscopy) as a liquid crystalline phase. To overcome the dose frequency and increase drug loading rate, in vitro-dissolution, method, ultracentrifuge be firstly develop liquid crystals containing Rifampicin. The encapsulation efficiency determined by UV spectroscopy was 93.86 ± 0.11% and stability studies in pH 6.8 phosphate buffer solutions further confirmed that Rifampicin was successfully encapsulated in liquid crystals.

Langmuir, 1998

The recently discovered isotropic/nematic phase transition in κ-carrageenan was further examined ... more The recently discovered isotropic/nematic phase transition in κ-carrageenan was further examined by macroscopic observations and by NMR. A state diagram, which is the equivalent of a phase diagram but including also nonequilibrium states (in our case a gel), was established in the mixed salt solutions of NaI/CsI where the competition between phase separation and gelation could be studied. The phase boundaries of the nematic phase depended on molecular weight and ionic strength qualitatively as expected for a charged rigid polymer. From these data the persistence length of the κ-carrageenan helix was estimated as 60-90 nm. The volume fraction of the nematic phase depended sensitively on the overall helical content. In coexisting phases, the helical content was larger in the nematic than in the isotropic phase.

Journal of Drug Delivery and Therapeutics

Sometimes immediate onset of action is required than conventional treatment in many patients. Amo... more Sometimes immediate onset of action is required than conventional treatment in many patients. Among all dosage forms tablet is the most popular dosage form existing today because of its convenience of self-administration, compactness and easy manufacturing. to overcome these drawbacks, immediate release dosage form has emerged as alternative oral dosage forms. Immediate drug release dosage forms disintegrate quickly after administration with enhanced rate of dissolution. The basic approach used in development tablets is the use of superdisintegrants like Cross linked Polyvinylpyrrolidone or crospovidone (Polyplasdone), Sodium starch glycolate (Primogel, Explotab), carboxymethylcellulose (Croscarmellose) etc. In this field immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, a wide range of drugs e.g., anticoagulant and other drugs can be considered candidates for this dosage form.

Food is a basic necessity of life it helps to stay healthy and be active. Your body needs all the... more Food is a basic necessity of life it helps to stay healthy and be active. Your body needs all the nutrient in adequate amount and in a correct proportion to work and to make healthy body cells is called balanced nutrition, so well balance diets include the basic five foods carbohydrates, protein, milk, fruits, vegetables and fats and oil. Malnutrition truly means 'bad nourishment'. Herbal dietary supplements are frequently taken into consideration harmless. Natural vitamins are the best it increases immunity. However, in case you are poor in a specific nutrient, then taking dietary supplements is beneficial.

International Journal Of All Research Writings, May 22, 2019

International Journal of Computational Biology and Bioinformatics, Sep 17, 2020

Bioanalytical method development plays importance role in the pre-clinical and clinical studies. ... more Bioanalytical method development plays importance role in the pre-clinical and clinical studies. Pharmacokinetics of any drug and its metabolite can be recognized by bioanalytical studies. The quantitative analysis of drugs and their metabolite sin the biological media is done by bioanalytical studies. Physical-chemical and biological techniques are used for these studies. Every bioanalytical method should be selective, sensitive and reliable for the quantitative estimation in drug discovery process. Bioanalytical method development consists of sample preparation, chromatographic separation and detection by using proper analytical method. Each developed method should be validated as per the regulatory authorities, so as to give reliable and reproducible method for the intended use. Many analytical techniques can be used for bioanalysis; LCMS/MS is one of them. In Liquid chromatography-mass spectrometry [LC-MS/MS] the separation of analyte is done by LC and detection is carried out by MS. LC-MS/MS obviously used in estimation and understanding of bioavailability, bioequivalence and pharmacokinetic data. This review additionally centered on different validation parameters such as:

Quality is an important prerequisite when we consider any product. Therefore the drug must be man... more Quality is an important prerequisite when we consider any product. Therefore the drug must be manufactured to the highest quality levels. End product testing by itself does not guarantee of product quality. Every step of manufacturing procedure should be validated. Process validation performs this task to build quality in to the product. Process validation had proven to be an important tool for quality management soon emerged several regulatory guidelines and publication on validation and today for the pharmaceutical industry successful validation is prerequisite. The principles of planning, organizing and performing process validation are similar to those for qualification. It should be done in accordance with process validation protocols; data should be collected and reviewed against predetermined acceptance criteria, and reflected in process validation reports.

Journal of Drug Delivery and Therapeutics, 2020

Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and nor... more Venlafaxine is an antidepressant belonging to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). Venlafaxine affects chemicals in the brain that may be unbalanced in people with depression. It is used to treat major depressive disorder, anxiety and panic disorder. The present review assesses the various approaches for analysis of Venlafaxine in bulk drug as well as various formulations. A concise review represents the compilation and discussion of about more than 35 analytical methods which includes HPLC, HPTLC, UPLC, LC-MS and UV-Spectrophotometry methods implemented for investigation of Venlafaxine in biological matrices, bulk samples and in different dosage formulations. This detailed review will be of great help to the researcher who is working on Venlafaxine. Keywords: Venlafaxine; Analytical Profile; HPLC; HPTLC; Bioanalytical; Stability indicating

The oral cavity has been investigated as a site of drug delivery for an extended amount of your t... more The oral cavity has been investigated as a site of drug delivery for an extended amount of your time. In 1847 Sobrero found that Nitro glycerine was absorbed from the oral cavity (Ponchel 1993). Since ABSTRACT Nicotine is associate organic compound found within e ligneous plant family of plants (Solanaceae) t hat acts as a nicotinic neurotransmitter receptor agonist. And po sseses completely different medical specialty activ ities like, system Stimulant. Completely different preparation of nicotine in market like Nicogum and Nicolette ex c pt buccal film. Buccle film having varios blessings like Conv enient dosing, No water required, No risk chocking, Taste masking therefore in presence study we tend to conc eive to formulate buccal film of nicotine. The main aim of the study was to look at varied polymers thought-about t possess dissolving properties for the preparatio n of buccal films of nicotine and to guage the films for varied physical and chemical parameters and subject the s...

Seminars in Cancer Biology, 2021

It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of can... more It is a major concern to treat cancer successfully, due to the distinctive pathophysiology of cancer cells and the gradual manifestation of resistance. Specific action, adverse effects and development of resistance has prompted the urgent requirement of exploring alternative anti-tumour treatment therapies. The naturally derived microbial toxins as a therapy against cancer cells are a promisingly new dimension. Various important microbial toxins such as Diphtheria toxin, Vibrio cholera toxin, Aflatoxin, Patulin, Cryptophycin-55, Chlorella are derived from several bacterial, fungal and algal species. These agents act on different biotargets such as inhibition of protein synthesis, reduction in cell growth, regulation of cell cycle and many cellular processes. Bacterial toxins produce actions primarily by targeting protein moieties and some immunomodulation and few acts through DNA. Fungal toxins appear to have more DNA damaging activity and affect the cell cycle. Algal toxins produce alteration in mitochondrial phosphorylation. In conclusion, microbial toxins and their metabolites appear to have a great potential to provide a promising option for the treatment and management to combat cancer.

Agglomerative phase of comminution (APOC) is a relatively newer granulation cum particle size red... more Agglomerative phase of comminution (APOC) is a relatively newer granulation cum particle size reduction technique in which agglomeration of the fine coherent particles take place into loose granular structure. Agglomeration of the fine cohesive particles produced during grinding particularly with rotating or oscillating ball mills. Reduction of particle size during prolonged grinding by a ball mill has been used as a novel means of producing a pharmaceutical granulation. When compared with conventional granulation methods, this method produced mechanically stronger tablets with a higher dissolution rate than those compacted from granules made by a conventional wet granulation method. It is suggested that binderless tablets may be prepared by using this method, thus simplifying tablet formulation and enhancing stability. A possible mechanism for the increased dissolution rate is the increased internal surface area of the particles produced by the prolonged grinding method. As the com...

Current Research in Green and Sustainable Chemistry, 2021

This is a PDF file of an article that has undergone enhancements after acceptance, such as the ad... more This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

Indian Journal of Pharmaceutical and Biological Research, 2018

The advantages of oral dosage form that are responsible for its popularity are its ease of admini... more The advantages of oral dosage form that are responsible for its popularity are its ease of administration, patient compliance and stability of formulation. The most popular oral dosage forms beings tablets and capsules, but one important drawback of the dosage forms however is the difficulty to swallow especially when a dosage form is developed for pediatric and geriatric patient. The modern scientific and technological advancement in the pharmaceutical field had created bank of interest in reconstitutable oral suspension dosage form in the recent year. The reconstituted system is the formulation of choice when the drug stability is a major concern. Reconstitutable oral systems show the adequate chemical stability of the drug during shelf life and also reduce the weight of the final product. Dry syrup form of the drug is also useful in case of bioavailability as it has high bioavailability rather than tablets and capsules as it disintegrates in water outside of the oral cavity and d...

Indian Journal of Pharmaceutical and Biological Research, 2018

Nearly 40% of novel drugs comes in pharmaceutical industries are showing poor capability of solub... more Nearly 40% of novel drugs comes in pharmaceutical industries are showing poor capability of solubilization in water. Therefore enhancing the solubilization of such drugs in water to enhance their bioavailability be the major challenge to formulation scientists. So the preparation of solid dispersion from the drug which shows poor solubility in water with carriers having good water solubility has decrease the occurrence of such problems and increase dissolution. Hence solid dispersion found to be attention-grabbing method for solubility enhancing of drugs which showing poor solubility in water. This review, shows an overview on the different solid dispersion types, rationale, their advantages, limitations, manufacturing processes as well as its characterization methods.

Journal of Drug Delivery and Therapeutics, Jan 15, 2013

As significant number of products manufactured for personal care/health care, either in the final... more As significant number of products manufactured for personal care/health care, either in the final stage or at some stage of their production, dispersion of particulate materials dispersed into liquid or solid vehicles, often at high volume fraction. The vast array of cosmetics/personal care and pharmaceutical products reveal the importance of adequate dispersion. With active pharmaceutical ingredients possessing poor aqueous solubility, optimal dispersion is necessary for maximizing the bioavailability and uniformity of dose. Fine particulate dry powders always contain agglomerates that require deagglomeration and stabilization to obtain optimal dispersion. All particulate dispersion systems are inherently thermodynamically unstable. Unless properly stabilized, through the random motion of the particles over time, they will get aggregate due to the natural and dominant tendency to decrease the large specific surface area and excess surface energy. Adequate concentrations of wetting agents, de-agglomerating agents and stabilizers are required to produce stable particulate dispersions. The dispersion process is accomplished via three distinct steps: wetting the particulate material, de-agglomeration of the particles and stabilization of the same, and these steps should be performed in the correct order to get a stable product.

Journal of Drug Delivery and Therapeutics, 2020

The stability of a new drug substances and new drug products is a vital parameter which may affec... more The stability of a new drug substances and new drug products is a vital parameter which may affect purity, safety & potency. Changes in drug stability can threat patient safety by formation of toxic degradation products or deliver to lower dose than expected. Therefore it is to know the purity profile & behaviour of a drug substances under the various environmental condition. Forced Degradation studies show the chemical behavior of the molecule which in turn helps in the development of new formulation & package . Degradation study is required to the design of a regulatory compliant stability program for the both drug substances & products, and formalized as a regulatory requirement in ICH Guideline Q1A in 1993. Forced degradation studies (chemical and physical stress testing) of new chemical entities and drug product which is required to develop and demonstrate the specificity i.e stability indicating method. Forced degradation studies used to determination of the degradation pat...

Journal of Drug Discovery And Therapeutics, 2019

The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmac... more The cyclodextrins have a wide range of applications in various areas of drug delivery and pharmaceutical industry due to their complexation ability and other versatile characteristics. The most popular pharmaceutical application of cyclodextrin is to increase the solubility, stability, safety and bioavailability of drug molecules. The idea of this review article is to solve and study any of the findings and application of cyclodextrin (CD) and their derivatives in different areas of drug delivery. This review article introduce the molecular structure, properties like complexation, solubility etc. of cyclodextrins and targeted on its use for parenteral, oral, ophthalmic and nasal drug delivery. Other routes including dermal, rectal, sublingual and pulmonary delivery are again briefly addressed. The aim of this contribution is to focus on the potential application of chemically altared cyclodextrins as high-performance drug carriers in drug delivery systems with emphasis on the other ...

Materials Today Chemistry, 2020

Despite the adverse effects of microbial hazards on public health, major pharmaceutical firms hav... more Despite the adverse effects of microbial hazards on public health, major pharmaceutical firms have left the field of anti-infective development and a dramatic reduction in the number of researcher'sintricated in the quest for new specific anti-infective leads. In the non-existence of an efficient forum for antibiotics development and over usage in human beings and animals, bacteria have demoralized this potential by gradually establishing the resistance toward most of the antibiotics used. Thus, the production of novel and successful anti-infectivedrugs is urgently required to combat this resistance. Hydrazones and hydrazides have mounted as a key-skeleton for the development of active drugs, due to their important biological and pharmacological profiles.Hydrazones are being manufactured as medicines by various investigators to fight against the ailments with maximal effects and minimal toxicity.This paper focuses on the outline of the literature results of recent years, incorporating the work on the anti-infective profileof Manuscript File Click here to view linked References 2 hydrazoneanalogues. This review may also act as an excellent basisfor the development of new derivatives of hydrazone as potential anti-infective mediators.

The Pharma Innovation Journal, 2015

The present study illustrates development of site specific delivery of metoprolol succinate in tr... more The present study illustrates development of site specific delivery of metoprolol succinate in treatment of hypertension. Formulations were developed by utilizing polymers such as HPMC and Chitosan along with plasticizer (PEG-400) by solvent technique. The calibration curve of metoprolol succinate was developed in PBS pH 6.8 at 223 nm in the range of 5 to 25 µg/ml. Compatibility study were carried out by FT-IR and Differential scanning colorimetry. The formulations were evaluated for thickness, folding endurance, weight variation, drug content, percent moisture loss, percent moisture absorption, tensile strength, SEM. In vitro drug diffusion study was also carried out using franz diffusion cell with PBS pH 6.8 and the samples were analyzed by UV-spectrophotometrically at 223 nm. FT-IR and DSC study revealed no interaction between drug and polymers. Formulations shown good uniformity of drug content more than 90%, there is little effect on moisture loss test due to hydrophilic polyme...

In present study, LCs were formulated and evaluate for desirable properties, Sonication condition... more In present study, LCs were formulated and evaluate for desirable properties, Sonication conditions were firstly investigated to determine their effects on the morphological and dimensional characteristics of liquid crystals and optimized according probe sonication condition (Ultra Tarrux T25), liquid crystals with reproducible narrow particle size distribution and mean particle size of 168.0 ± 2.1 nm were obtained. The structure of the dispersed cubosomes was revealed by XRD (X-ray diffraction) and SEM (scanning electron microscopy) as a liquid crystalline phase. To overcome the dose frequency and increase drug loading rate, in vitro-dissolution, method, ultracentrifuge be firstly develop liquid crystals containing Rifampicin. The encapsulation efficiency determined by UV spectroscopy was 93.86 ± 0.11% and stability studies in pH 6.8 phosphate buffer solutions further confirmed that Rifampicin was successfully encapsulated in liquid crystals.