Monika Chrzanowska - Profile on Academia.edu (original) (raw)
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Papers by Monika Chrzanowska
Background: Systemic sclerosis is a rare multisystem inflammatory connective tissue disorder of u... more Background: Systemic sclerosis is a rare multisystem inflammatory connective tissue disorder of unclear etiology, characterized by progressive fibrosis of skin and internal organs as well as systemic vascular dysfunction. Disease severity is determined by the degree of internal organ involvement, especially pulmonary hypertension, interstitial lung disease, and peripheral vasculopathy. Objectives: Th e aim of this study was to analyze a group of patients diagnosed with systemic sclerosis. Methods: We retrospectively analyzed a group of 70 patients (42 women and 28 men) treated in the Department of Internal Medicine and Rheumatology, SUM, Katowice, Poland between 2013 and 2016. Patients were an average of 54.0 years old (+/–, range). Our study examined the incidence of cardiovascular and musculoskeletal symptoms as well as basic blood chemistry and imaging studies. We also assessed the degree of skin thickness by the Modified Rodnan Skin score (mRSS). Results: Among study group parti...
Folia Morphologica
The arrangement of autonomic fibres was studied in the cardiac atrioventricular valves of small c... more The arrangement of autonomic fibres was studied in the cardiac atrioventricular valves of small chinchillas. The dissected valves were stained entirely using the modified histochemical acetylcholine esterase technique (AChE) and the SPG-De la Torre method. Double immunocytochemical staining was also used for the expression of vesicular acetylcholine transporter (VAChT) and dopamine beta hydroxylase (DBH). The study showed the presence of both cholinergic and adrenergic fibres, forming a kind of network on all cusps of both valves. The adrenergic network is always more strongly represented than the cholinergic network. The cholinergic nerve network of the "parietal" part formed mainly the parallel arrangement. As we move towards the free parts of the cusps, the arrangement becomes netted and radiant. The adrenergic fibres formed only the netted arrangement, which was the most dense in the peripheral (parietal) part of the cusps. Some of the fibres in the vicinity of tendinous cords extended as far as the papillary muscles. Double immunocytochemical tests confirmed the presence and distribution of DBH-and VAChT-positive fibres. Some fibres (especially within the tendinous cords) show VAChT and DBH colocalisation.
Reumatologia/Rheumatology
Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painf... more Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body. The deposits occur histologically as lipomas and are associated with overweight or obesity and a variety of psychiatric disturbances (anxiety, depression, sleep disturbances). Classification of Dercum's disease is related to size and location of adipose nodules (generalized diffuse, generalized nodular, localized nodular and juxta-articular forms). Diagnosis in based on clinical presentation and exclusion of a number of other disorders associated with lipomas. There is no generally accepted management of the patients. Liposuction or lidocaine application has been reported successful in some cases. Other therapeutic methods have been reported but their effectiveness is based on anecdotal descriptions only, and were not confirmed in clinical trials.
Forum Reumatologiczne
Erectile dysfunctions are a common feature in patients with systemic sclerosis. They are resulted... more Erectile dysfunctions are a common feature in patients with systemic sclerosis. They are resulted from a complex pathomechanism. The main role is attributed to vascular alterations and fibrosis of the carvernous bodies. Depression and disturbed autonomy nervous system function may be additional factors for development of erectile dysfunctions. Diagnosis is based on subjective patient's data and functional tests. Treatment of erectile dysfunctions in scleroderma patients is difficult, multifactorial and sometimes ineffective.
Background: Systemic sclerosis is a rare multisystem inflammatory connective tissue disorder of u... more Background: Systemic sclerosis is a rare multisystem inflammatory connective tissue disorder of unclear etiology, characterized by progressive fibrosis of skin and internal organs as well as systemic vascular dysfunction. Disease severity is determined by the degree of internal organ involvement, especially pulmonary hypertension, interstitial lung disease, and peripheral vasculopathy. Objectives: Th e aim of this study was to analyze a group of patients diagnosed with systemic sclerosis. Methods: We retrospectively analyzed a group of 70 patients (42 women and 28 men) treated in the Department of Internal Medicine and Rheumatology, SUM, Katowice, Poland between 2013 and 2016. Patients were an average of 54.0 years old (+/–, range). Our study examined the incidence of cardiovascular and musculoskeletal symptoms as well as basic blood chemistry and imaging studies. We also assessed the degree of skin thickness by the Modified Rodnan Skin score (mRSS). Results: Among study group parti...
Folia Morphologica
The arrangement of autonomic fibres was studied in the cardiac atrioventricular valves of small c... more The arrangement of autonomic fibres was studied in the cardiac atrioventricular valves of small chinchillas. The dissected valves were stained entirely using the modified histochemical acetylcholine esterase technique (AChE) and the SPG-De la Torre method. Double immunocytochemical staining was also used for the expression of vesicular acetylcholine transporter (VAChT) and dopamine beta hydroxylase (DBH). The study showed the presence of both cholinergic and adrenergic fibres, forming a kind of network on all cusps of both valves. The adrenergic network is always more strongly represented than the cholinergic network. The cholinergic nerve network of the "parietal" part formed mainly the parallel arrangement. As we move towards the free parts of the cusps, the arrangement becomes netted and radiant. The adrenergic fibres formed only the netted arrangement, which was the most dense in the peripheral (parietal) part of the cusps. Some of the fibres in the vicinity of tendinous cords extended as far as the papillary muscles. Double immunocytochemical tests confirmed the presence and distribution of DBH-and VAChT-positive fibres. Some fibres (especially within the tendinous cords) show VAChT and DBH colocalisation.
Reumatologia/Rheumatology
Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painf... more Dercum's disease (adiposis dolorosa) is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body. The deposits occur histologically as lipomas and are associated with overweight or obesity and a variety of psychiatric disturbances (anxiety, depression, sleep disturbances). Classification of Dercum's disease is related to size and location of adipose nodules (generalized diffuse, generalized nodular, localized nodular and juxta-articular forms). Diagnosis in based on clinical presentation and exclusion of a number of other disorders associated with lipomas. There is no generally accepted management of the patients. Liposuction or lidocaine application has been reported successful in some cases. Other therapeutic methods have been reported but their effectiveness is based on anecdotal descriptions only, and were not confirmed in clinical trials.
Forum Reumatologiczne
Erectile dysfunctions are a common feature in patients with systemic sclerosis. They are resulted... more Erectile dysfunctions are a common feature in patients with systemic sclerosis. They are resulted from a complex pathomechanism. The main role is attributed to vascular alterations and fibrosis of the carvernous bodies. Depression and disturbed autonomy nervous system function may be additional factors for development of erectile dysfunctions. Diagnosis is based on subjective patient's data and functional tests. Treatment of erectile dysfunctions in scleroderma patients is difficult, multifactorial and sometimes ineffective.