Suzan Morsy - Academia.edu (original) (raw)

Papers by Suzan Morsy

Curēus, Apr 17, 2024

Introduction Gestational diabetes mellitus (GDM) is a common disease affecting pregnant females, ... more Introduction Gestational diabetes mellitus (GDM) is a common disease affecting pregnant females, and it carries a major risk of short and long-term health problems for both mothers and their offspring. Multiple factors like advanced maternal age, obesity, and unhealthy lifestyle can increase the risk of GDM. The current guidelines recommend screening all pregnant females for risk factors during the first trimester with subsequent testing of the blood glucose level at 24 weeks gestation. Lack of awareness about GDM is a main contributing factor in the delay in screening and diagnosis of GDM with subsequent fetal and maternal complications. This study aims to identify the level of knowledge about GDM among the adult population in the Kingdom of Saudi Arabia (KSA). Material and methods A descriptive cross-sectional questionnaire-based study was conducted to identify the level of knowledge about risk factors, prevention, and treatment of GDM in a community sample from Saudi Arabia. A selfadministered electronic questionnaire was designed, tested for validity and reliability, and distributed through social media platforms. It consisted of 18 questions asking about the socio-demographic characteristics, the type of hospital in which the participant receives their medical care, whether the participant heard about GDM or not, and if they know someone with GDM, in addition to questions to assess the level of knowledge about risk factors, complications, prevention, and treatment of GDM. The total score of knowledge was calculated. The multivariate regression analysis test was employed to analyze the relationship between various demographic variables and the level of knowledge about GDM among the study population. A p-value of 0.05 or less was considered statistically significant. Results A total of 539 (100%) participants completed the questionnaire: 263 (48.8%) of them were in the age category (18-25 years), 440 (81.6%) of them were females, 307 (57%) had a bachelor's degree, 275 (51%) were single, 454 (84.2%) had heard about GDM, and 258 (47.9%) of them have or know someone with GDM. The total score of knowledge revealed excellent, good, fair, and poor levels among 334 (62%), 140 (26%), 49 (9%), and 16 (3%) of participants, respectively. The multivariable linear regression model revealed that participants who received health care from governmental hospitals heard about GDM and had or knew someone with GDM were positively associated with a higher level of knowledge. Conclusions The findings revealed that among participants, 62% showed excellent knowledge about GDM, although, the other 38% had non-optimal levels of knowledge. Awareness campaigns are recommended to improve the level of knowledge about this disease, its risk factors, treatment, and complications.

Journal of Neuroimmune Pharmacology, Jan 17, 2024

Neuroinflammation occurs in response to different injurious triggers to limit their hazardous eff... more Neuroinflammation occurs in response to different injurious triggers to limit their hazardous effects. However, failure to stop this process can end in multiple neurological diseases. Doxycycline (DX) is a tetracycline, with potential antioxidant and anti-inflammatory properties. The current study tested the effects of free DX, DX-loaded calcium phosphate (DX@ CaP), and pectin-coated DX@CaP (Pec/DX@CaP) nanoparticles on the lipopolysaccharide (LPS)-induced neuroinflammation in mice and to identify the role of adenosine monophosphate-activated protein kinase (AMPK) in this effect. The present study was conducted on 48 mice, divided into 6 groups, eight mice each. Group 1 (normal control), Group 2 (blank nanoparticles-treated), Group 3 (LPS (untreated)), Groups 4, 5, and 6 received LPS, then Group 4 received free DX, Group 5 received DX-loaded calcium phosphate nanoparticles (DX@CaP), and Group 6 received DX-loaded calcium phosphate nanoparticles with a pectin coat (Pec/DX@CaP). At the end of the experimentation period, behavioral tests were carried out. Then, mice were sacrificed, and brain tissue was extracted and used for histological examination, and assessment of interleukin-6 positive cells in different brain areas, in addition to biochemical measurement of SOD activity, TLR-4, AMPK and Nrf2. LPS can induce prominent neuroinflammation. Treatment with (Pec/DX@CaP) can reverse most behavioral, histopathological, and biochemical changes caused by LPS. The findings of the current study suggest that (Pec/DX@CaP) exerts a significant reverse of LPS-induced neuroinflammation by enhancing SOD activity, AMPK, and Nrf2 expression, in addition to suppression of TLR-4.

Archives of Medical Sciences, Oct 15, 2023

Introduction: Self-medication (SM) is defined as drug utilization based on a patient's self-diagn... more Introduction: Self-medication (SM) is defined as drug utilization based on a patient's self-diagnosis, without consultation of any healthcare members. Despite being common among most communities, it carries a risk of medication errors. The current study aimed to assess the prevalence, awareness, and practices related to SM, including risky practices among adults in Kingdom of Saudi Arabia (KSA). Material and methods: A cross-sectional survey-based study was conducted in Jeddah KSA. The sample size was 312 participants (as calculated by using the Epi-info CDC software calculator). They were recruited by volunteer sampling technique, through online propagation of a questionnaire, which was designed and assessed for validity and reliability. It was composed of 3 sections: demographics, assessment of awareness, and practices related to SM, including risky practices. Data were analysed using IBM SPSS-25. Results: SM was practiced by 83% of the studied population. The prevalence of excellent, fair, and poor levels of awareness about SM were 12.4%, 45.6%, and 42%, respectively. Risky practices like using expired SMs, using SMs without checking expiry dates or without reading the instructions, using SMs during pregnancy or lactation, and continued use of SMs despite lack of improvement were identified among 5%, 12%, 39%, 11%, and 33% of participants, respectively. Conclusions: An inappropriate level of awareness and a high prevalence of risky practices related to SM were identified among the studied sample of adults in KSA. It is critical to raise public awareness of SM to avoid SM-related health concerns.

Tissue and Cell

Background: Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury. Neurode... more Background: Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury. Neurodegeneration can result from I/R, but the mechanisms are still challenging. We studied the implications of bilateral renal I/R on brain and potential involvement of the oxidative stress (OS) driven extracellular signal-regulated kinase1/2, c-Jun N-terminal kinase (ERK1/2, JNK) and Galectin-3 (Gal-3)/nuclear factor Kappa B (NF-қB)/tumor necrosis factor-alpha (TNF-α), high mobility group box-1 (HMGB-1), and caspase-3 paths upregulation. We tested the impact of Nano-trimetazidine (Nano-TMZ) on these pathways being a target of its neuroprotective effects. Methods: Study groups; Sham, I/R, TMZ+I/R, and Nano-TMZ+I/R. Kidney functions, cognition, hippocampal OS markers, Gal-3, NF-қB, p65 and HMGB-1 gene expression, TNF-α level, t-JNK/p-JNK and t-ERK/p-ERK proteins, caspase-3, glial fibrillary acidic protein (GFAP) and ionized calcium binding protein-1 (Iba-1) were assessed. Results: Nano-TMZ averted renal I/R-induced hippocampal impairment by virtue of its anti: oxidative, inflammatory, and apoptotic properties. Conclusion: Nano-TMZ is more than anti-ischemic.

International Journal of Medicine in Developing Countries, 2023

Objective: This study aimed to assess the knowledge, attitude, and practice regarding personal hy... more Objective: This study aimed to assess the knowledge, attitude, and practice regarding personal hygiene among primary school children in Jeddah, Kingdom of Saudi Arabia. Methods: This community-based cross-sectional study was conducted by in-person interview of primary school children from grades II to VI at the selected school in Jeddah, Saudi Arabia. Each child was interviewed using a structured questionnaire. The questionnaire was drawn up in English, translated into Arabic (the local language), and back-translated into English to check the translation. The study was conducted between 2019 and 2022. Results: The study included 492 children from 39 schools and most of the participants were females (54.7%). The most common grade among participants was grade 4 (34.1%), and the majority of participants were 11 years old (29.9%). Further, most participants had excellent academic achievement (39.2%). Most of the participants could identify the correct definition of personal hygiene (56.1%). About 63.4% could recognize the correct components of personal hygiene. Most students (51.2%) received their knowledge about personal hygiene from their parents. Around 52.6% of students totally agreed that personal hygiene and clean surroundings are important for a healthy life. Conclusion: The current study concluded that primary school students in Jeddah have an excellent level of knowledge, practice, and attitude toward personal hygiene. Some of the assessed points were poor among some participants. Thus, intervention programs to increase schoolchildren's awareness about these points are needed to improve pediatric well-being among school children in Jeddah.

World family medicine journal, 2020

Background: Assessing children with autism and the effect of different modalities in management o... more Background: Assessing children with autism and the effect of different modalities in management of autism is a critical issue as the disease is a lifelong disorder that has a negative effect on the social health of the families. Aim of the work: Evaluate the pharmacotherapy for children with au-tism spectrum disorder in Jeddah. Method: The current study is a descriptive cross sectional study that was conducted in three private hospitals in Jeddah (KSA); Ibn Sina Hospital, Al Jeddain Gholeel and AlJeddaani AlSafaa. The study included 152 children aged 2-18 years diagnosed with autism according to DSM V criteria. The collected data and the designed questionnaire were filled out by the care giver. Children with concomitant other chronic disease and parents who refused to participate or did not complete the questionnaire were excluded from the study. The collected data were analyzed by SPSS version 20. Results: The mean age of the children was 4.5±3.2 and the source of the data was mainly from the mother (69.1%). Children were mainly males (75.7%) and the majority of families had only one child with autism (85.5%) and about (45.5%) were diagnosed in the second year of life. The majority of children complained of social withdrawal (85.5%), distraction of attention and repetitive behavior (75%). About (36.2%) of the studied children received combined treatment modalities and the most common pharmacological line used was SSRIs and kebra. Conclusion: Nowadays management of autism depends on a combination of behavioral management, pharmacotherapy, family and educational therapy for the best outcome. The most common pharmacological line used was SSRIs and kebra and about 75% of children who took drugs complained of side effects.

International Journal of Medicine in Developing Countries

Medical Science, 2022

Backgroud: The goal of this study was to see how the COVID-19 pandemic affected children's vaccin... more Backgroud: The goal of this study was to see how the COVID-19 pandemic affected children's vaccination in Saudi Arabia. During the COVID-19 pandemic, we investigated the population's commitment to routine immunization of their children as well as the prevalence of vaccine misconceptions. Methods: A cross-sectional study was done on 586 parents of children under 6 years of age. An online questionnaire was used that included items to collect data about parents' demographics, knowledge about childhood vaccination and its side effects, practice toward vaccination of their children before and after the COVID-19 pandemic. Results: Approximately 67.2% of parents reported having good knowledge about the benefits of vaccines for their children, and 7.2% had ever declined to vaccinate their infant, with the most common reason being concern about vaccine side effects. Prior to this pandemic, 88% of parents had their children's vaccinations scheduled on a regular basis, while 25.3% had missed or postponed their children's vaccinations. 26.8% of the participants and their families were willing to take a coronavirus vaccine if one was available. During the epidemic, non-Saudi participants had a significantly greater percentage of those who missed or delayed a child's immunization. Participants who had one or two children and those with ages ranging from 18-25 years had a higher percentage of those who were willing to take a vaccine against the coronavirus. Conclusions: Addressing parents about the need of protecting their children from vaccine-preventable diseases is vital even as the COVID-19 pandemic persists.

World Family Medicine Journal/Middle East Journal of Family Medicine, 2020

Food and Waterborne Parasitology