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Papers by Mounika Katyayani

Research paper thumbnail of Evaluation of a Neck Mass in a Six-Month-Old Infant: A Case Report

Research paper thumbnail of A rare case of metabolic disorder- Alkaptonuria

Journal of Case Reports and Scientific Images, 2021

Alkaptonuria is a rare genetic disorder of tyrosine metabolism, due to deficiency of the enzyme h... more Alkaptonuria is a rare genetic disorder of tyrosine metabolism, due to deficiency of the enzyme homogentisate 1, 2 dioxygenase. This results in characteristic features like blackish urine discoloration, ochronosis, arthropathy, cardiac valve deterioration. In this paper, the authors presenta case report of a 4-month-old boy who was brought by his mother to the well-baby clinic, with a chief complaint of black staining of nappy, a few hours after voiding. A qualitative examination of urine after an hour of the collection showed dark black discoloration, Quantitative examination reveals the presence of homogentisic acid to the extent of200mg/dl. The Diagnosis of Alkaptonuria was confirmed and the infant was started on Vitamin C and put under regular follow-up.

Research paper thumbnail of Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India

International Journal of Paediatrics and Geriatrics

To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormo... more To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1 st and 2 nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.

Research paper thumbnail of Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India

International Journal of Paediatrics and Geriatrics, 2020

To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormo... more To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1 st and 2 nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.

Research paper thumbnail of Evaluation of a Neck Mass in a Six-Month-Old Infant: A Case Report

Research paper thumbnail of A rare case of metabolic disorder- Alkaptonuria

Journal of Case Reports and Scientific Images, 2021

Alkaptonuria is a rare genetic disorder of tyrosine metabolism, due to deficiency of the enzyme h... more Alkaptonuria is a rare genetic disorder of tyrosine metabolism, due to deficiency of the enzyme homogentisate 1, 2 dioxygenase. This results in characteristic features like blackish urine discoloration, ochronosis, arthropathy, cardiac valve deterioration. In this paper, the authors presenta case report of a 4-month-old boy who was brought by his mother to the well-baby clinic, with a chief complaint of black staining of nappy, a few hours after voiding. A qualitative examination of urine after an hour of the collection showed dark black discoloration, Quantitative examination reveals the presence of homogentisic acid to the extent of200mg/dl. The Diagnosis of Alkaptonuria was confirmed and the infant was started on Vitamin C and put under regular follow-up.

Research paper thumbnail of Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India

International Journal of Paediatrics and Geriatrics

To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormo... more To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1 st and 2 nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.

Research paper thumbnail of Unfolding the perinatal factors that affect cord blood thyroid stimulating hormone levels- an experience from a rural centre in southern India

International Journal of Paediatrics and Geriatrics, 2020

To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormo... more To evaluate the incidence of congenital hypothyroidism using cord blood thyroid stimulating hormone (CB-TSH) levels and examining the influence of maternal and perinatal factors on these levels in our cohort of babies. Design: A cross-sectional study. Setting: Tertiary care teaching hospital, China Kakani, A.P. Methods: CB-TSH levels were measured in 2012 live-born neonates using electro chemiluminescence immunoassay. The effect of various maternal and perinatal factors on CB-TSH levels was analyzed statistically by multivariate analysis. Results: The mean CB-TSH was 8.86 micro IU/ml (ranged between 0.23 to 100micro IU/ml). The incidence of high CB-TSH (>20microIU/ml) was 4.82%. CB-TSH levels were significantly raised in neonates delivered in 1 st and 2 nd birth order, assisted vaginal deliveries, need for emergency section, and who were born with low APGAR scores (p<0.01 and Cron-bach's alfa 0.932). Maternal hypothyroidism or maternal hypertension, weight appropriateness for gestation, birth weight and gestational age had no significance. Conclusion: Upon multivariate analysis, the need for resuscitation, mode of delivery, and birth order were found to be significant factors affecting CB-TSH levels. Hence, these factors must be considered cautiously while interpreting CB-TSH values.