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Papers by Mousa Magharbeh
Pharmacognosy Journal, 2011
The present research work was carried out to study the antioxidant potential of methanolic extrac... more The present research work was carried out to study the antioxidant potential of methanolic extract of Jawarish amla using various in vitro tests including Reducing power assay, Superoxide anion scavenging activity assay, Hydroxyl radical scavenging activity assay, Nitric oxide scavenging activity assay, DPPH free radical scavenging assay, and hydrogen peroxide method. These various antioxidant activities were compared to standard ascorbic acid. Preliminary methods, using aluminum chloride method and Folin Ciocalteu reagent respectively. The results indicated that methanolic extract of Jawarish amla possess antioxidant property.
Journal of Applied Pharmaceutical Science
Azo dyes account for 70% of dye chemistry, and their importance may grow in the future. Empaglifl... more Azo dyes account for 70% of dye chemistry, and their importance may grow in the future. Empagliflozin is a sodiumglucose co-transporter-2 (SGLT2) inhibitor. SGLT2 transporters are primarily responsible for glucose reabsorption in the kidney. In 2014, empagliflozin was approved for medical use in the United States and the European Union. With over 4 million prescriptions in 2019, it was the 146th most commonly prescribed medication in the United States in 2019. The spectrophotometric determination of empagliflozin is described using coupling agents such as 3-chloro-4nitroaniline or sulfanilamide. These methods are straightforward and are based on the reaction of empagliflozin with diazotized products of 3-chloro-4-nitroaniline or sulfanilamide to produce colored azo dyes with absorption maxima at 470 and 480 nm. Empagliflozin was linear from 1.2 to 26.6 µgml −1 or 0.8 to 20.4 µgml −1 when combined with diazotized 3-chloro-4-nitroaniline or sulfanilamide, respectively. Empagliflozin's molar absorptivity and Sandell's sensitivity to 3-chloro-4-nitroaniline or sulfanilamide azo dyes were 3.179 × 10 4 l mol −1 cm −1 or 4.367 × 10 4 l mol −1 cm −1 and 1.149 × 10 −2 µgcm −2 or 8.368 × 10 −3 µgcm −2 , respectively. The formed colored azo dyes are stable for more than 12 hours. The optimal reaction conditions and other analytical parameters are assessed. Foreign organic compound interference has been studied. The method has been successfully used to determine empagliflozin in pharmaceutical samples.
![Research paper thumbnail of Studying the Complex Formation of Sulfonatocalix[4]naphthalene and Meloxicam towards Enhancing Its Solubility and Dissolution Performance](https://attachments.academia-assets.com/79562207/thumbnails/1.jpg)
](Pharmaceutics, 2021
The interaction between meloxicam and sulfonatocalix[4]naphthalene was investigated to improve th... more The interaction between meloxicam and sulfonatocalix[4]naphthalene was investigated to improve the meloxicam solubility and its dissolution performance. Solubility behavior was investigated in distilled water (DW) and at different pH conditions. Besides, solid systems were prepared in a 1:1 molar ratio using coevaporate, kneading, and simple physical mixture techniques. Further, they were characterized by PXRD, FT-IR, DCS, and TGA. In vitro dissolution rate for coevaporate, kneaded, and physical mixture powders were also investigated. Solubility study revealed that meloxicam solubility significantly increased about 23.99 folds at phosphate buffer of pH 7.4 in the presence of sulfonatocalix[4]naphthalene. The solubility phase diagram was classified as AL type, indicating the formation of 1:1 stoichiometric inclusion complex. PXRD, FT-IR, DCS, and TGA pointed out the formation of an inclusion complex between meloxicam and sulfonatocalix[4]naphthalene solid powders prepared using coeva...
Biomedical and Pharmacology Journal, 2021
The objective of the two pharmacokinetic studies reported here was to compare the relative bioava... more The objective of the two pharmacokinetic studies reported here was to compare the relative bioavailability and bioequivalence of an ibuprofen 400 mg tablet from National Company (SDI) as a test with a reference formulation. Evaluation of two open, randomized, cross-over studies, one single dose in healthy male volunteers. 20 healthy volunteers were randomized in a cross-over design to single dose of Profedin 400 mg produced from National Company, ibuprofen formulation, as a test and a reference formulation produced from Pharmacia & Upjohn, Ibuprofen 400 mg. Ibuprofen and standard of ibuprofen were analyzed by utilizing HPLC, the sample extracted from 0.5ml of plasma with an organic solution of isooctane and 2-propanol. The mobile phase consisted of 44% acetonitrile and 0.1% phosphoric acid. The flow rate was 1 ml/min. The analytical column was a C-18, 5um packing size. Detection of Ibuprofen and the internal standard occurred by UV absorbance at wavelength of 220nm. A single-dose st...
Applied Environmental Biotechnology
Phenol is one of the main pollutants that have a serious impact on the environment and can even b... more Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Bacillus simplex was investigated for the first time under different growth conditions. Six different initial concentrations of phenol were used as the primary substrate. Culture conditions had an important effect on these cells' ability to biodegrade phenol. The best growth of this organism and its highest biodegradation level of phenol were noticed at pH 7, temperature 28 °C, and periods of 36 and 96 h, respectively. The GC-MS analysis of the bacterial culture sample revealed that further degradation of the catechol by 1,2-dioxygenase produce a cis, cis-mucconic acid via ortho-pathway and/or by 2,3-dioxygenase into 2-hydroxymucconic semialdehyde via meta-pathway. The highest biodegradation rate was perceived...
The standard reference materials (SRMs) represent a key tool for the quality control of chemical ... more The standard reference materials (SRMs) represent a key tool for the quality control of chemical analyses and the demand on these materials is constantly increasing worldwide. A standard reference material of oil shale (SJL-1) collected from El-lajjun area in Jordan was prepared and certified to be used for quality control of analyses and calibration particularly for the oil shale characterization and testing laboratories. This work was a part of the Arab collaborative projects initiated by Arab Atomic Energy Agency (AAEA) during the period from 2007 to 2009. The paper describes the certification procedure and the inter-laboratory comparison study results, which was carried out through participation of twelve national and international laboratories applying eleven different analytical techniques used to determine the analytes concentration. Details of the production, homogeneity and stability of SJL-1 standard reference material were reviewed as well as the results of certification....
Journal of Ecological Engineering, 2021
Phenol is one of the main pollutants that have a serious impact on the environment and can even b... more Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Pseudomonas fredriksbergsis was investigated for the first time under different growth conditions. Six different initial concentrations of phenol were used as the primary substrate. Culture conditions had an important effect on these cells' ability to biodegrade phenol. The best growth of this organism and its highest biodegradation level of phenol were noticed at pH 7, temperature 28 °C, and periods of 36 and 96 h, respectively. The highest biodegradation rate was perceived at 700 mg/L initial phenol concentration. Approximately 90% of the phenol (700 mg/L) was removed in less than 96 hours of incubation time. It was found that the Haldane model best fitted the relationship between the specific growth rate an...
Biomedical and Pharmacology Journal, 2020
Urinary calculi are stones (urolithiasis) that can form anywhere in urinary tract outside of the ... more Urinary calculi are stones (urolithiasis) that can form anywhere in urinary tract outside of the kidneys and mostly composed of calcium oxalate and phosphate, additionally with elevated throughout the last two decades in the world. Chemical composition plays a major part in nephrolithiasis. Therefore, the high concentrations of lithogenic substances in urine enhance the crystallization method in urine tract system. The most kidney stones form from calcium oxalate, the present study was inspected the effect of the crude aqueous extract as well as the fractionated methanol extract (ethyl acetate, isopropanol, acetone and methanol residue) of paronychia argentea on the crystallization of calcium oxalate salts. The effect of aqueous extract and fractionated methanol extract on the size, number, type of calcium oxalate crystals. Paronychia argentea both the crude aqueous and the fractionated extract, especially ethyl acetate fraction have antiurolithic activity via reducing crystal size ...
The standard reference materials (SRMs) represent a key tool for the quality control of chemical ... more The standard reference materials (SRMs) represent a key tool for the quality control of chemical analyses and the demand on these materials is constantly increasing worldwide. A standard reference material of oil shale (SJL-1) collected from El-lajjun area in Jordan was prepared and certified to be used for quality control of analyses and calibration particularly for the oil shale characterization and testing laboratories. This work was a part of the Arab collaborative projects initiated by Arab Atomic Energy Agency (AAEA) during the period from 2007 to 2009. The paper describes the certification procedure and the inter-laboratory comparison study results, which was carried out through participation of twelve national and international laboratories applying eleven different analytical techniques used to determine the analytes concentration. Details of the production, homogeneity and stability of SJL-1 standard reference material were reviewed as well as the results of certification. The Certificate of Analysis for SJL-1 provides assigned certified values for almnuium oxide, phosphorus pentoxide, calcium oxide, titanium dioxide, magnesium oxide, potassium oxide, ferric oxide, sodium oxide, manganese oxide, sulfur, uranium, vanadium, chromium, zinc, nickel, copper, and strontium. Reference values are provided for Loss on Ignition (LOI), silicon oxide, cadmium, molybdenum, cobalt, lead, barium and arsenic. Finally, range values are assigned for other thirty-seven constituents of oil shale.
Pharmacognosy Journal, 2011
The present research work was carried out to study the antioxidant potential of methanolic extrac... more The present research work was carried out to study the antioxidant potential of methanolic extract of Jawarish amla using various in vitro tests including Reducing power assay, Superoxide anion scavenging activity assay, Hydroxyl radical scavenging activity assay, Nitric oxide scavenging activity assay, DPPH free radical scavenging assay, and hydrogen peroxide method. These various antioxidant activities were compared to standard ascorbic acid. Preliminary methods, using aluminum chloride method and Folin Ciocalteu reagent respectively. The results indicated that methanolic extract of Jawarish amla possess antioxidant property.
Journal of Applied Pharmaceutical Science
Azo dyes account for 70% of dye chemistry, and their importance may grow in the future. Empaglifl... more Azo dyes account for 70% of dye chemistry, and their importance may grow in the future. Empagliflozin is a sodiumglucose co-transporter-2 (SGLT2) inhibitor. SGLT2 transporters are primarily responsible for glucose reabsorption in the kidney. In 2014, empagliflozin was approved for medical use in the United States and the European Union. With over 4 million prescriptions in 2019, it was the 146th most commonly prescribed medication in the United States in 2019. The spectrophotometric determination of empagliflozin is described using coupling agents such as 3-chloro-4nitroaniline or sulfanilamide. These methods are straightforward and are based on the reaction of empagliflozin with diazotized products of 3-chloro-4-nitroaniline or sulfanilamide to produce colored azo dyes with absorption maxima at 470 and 480 nm. Empagliflozin was linear from 1.2 to 26.6 µgml −1 or 0.8 to 20.4 µgml −1 when combined with diazotized 3-chloro-4-nitroaniline or sulfanilamide, respectively. Empagliflozin's molar absorptivity and Sandell's sensitivity to 3-chloro-4-nitroaniline or sulfanilamide azo dyes were 3.179 × 10 4 l mol −1 cm −1 or 4.367 × 10 4 l mol −1 cm −1 and 1.149 × 10 −2 µgcm −2 or 8.368 × 10 −3 µgcm −2 , respectively. The formed colored azo dyes are stable for more than 12 hours. The optimal reaction conditions and other analytical parameters are assessed. Foreign organic compound interference has been studied. The method has been successfully used to determine empagliflozin in pharmaceutical samples.
Pharmaceutics, 2021
The interaction between meloxicam and sulfonatocalix[4]naphthalene was investigated to improve th... more The interaction between meloxicam and sulfonatocalix[4]naphthalene was investigated to improve the meloxicam solubility and its dissolution performance. Solubility behavior was investigated in distilled water (DW) and at different pH conditions. Besides, solid systems were prepared in a 1:1 molar ratio using coevaporate, kneading, and simple physical mixture techniques. Further, they were characterized by PXRD, FT-IR, DCS, and TGA. In vitro dissolution rate for coevaporate, kneaded, and physical mixture powders were also investigated. Solubility study revealed that meloxicam solubility significantly increased about 23.99 folds at phosphate buffer of pH 7.4 in the presence of sulfonatocalix[4]naphthalene. The solubility phase diagram was classified as AL type, indicating the formation of 1:1 stoichiometric inclusion complex. PXRD, FT-IR, DCS, and TGA pointed out the formation of an inclusion complex between meloxicam and sulfonatocalix[4]naphthalene solid powders prepared using coeva...
Biomedical and Pharmacology Journal, 2021
The objective of the two pharmacokinetic studies reported here was to compare the relative bioava... more The objective of the two pharmacokinetic studies reported here was to compare the relative bioavailability and bioequivalence of an ibuprofen 400 mg tablet from National Company (SDI) as a test with a reference formulation. Evaluation of two open, randomized, cross-over studies, one single dose in healthy male volunteers. 20 healthy volunteers were randomized in a cross-over design to single dose of Profedin 400 mg produced from National Company, ibuprofen formulation, as a test and a reference formulation produced from Pharmacia & Upjohn, Ibuprofen 400 mg. Ibuprofen and standard of ibuprofen were analyzed by utilizing HPLC, the sample extracted from 0.5ml of plasma with an organic solution of isooctane and 2-propanol. The mobile phase consisted of 44% acetonitrile and 0.1% phosphoric acid. The flow rate was 1 ml/min. The analytical column was a C-18, 5um packing size. Detection of Ibuprofen and the internal standard occurred by UV absorbance at wavelength of 220nm. A single-dose st...
Applied Environmental Biotechnology
Phenol is one of the main pollutants that have a serious impact on the environment and can even b... more Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Bacillus simplex was investigated for the first time under different growth conditions. Six different initial concentrations of phenol were used as the primary substrate. Culture conditions had an important effect on these cells' ability to biodegrade phenol. The best growth of this organism and its highest biodegradation level of phenol were noticed at pH 7, temperature 28 °C, and periods of 36 and 96 h, respectively. The GC-MS analysis of the bacterial culture sample revealed that further degradation of the catechol by 1,2-dioxygenase produce a cis, cis-mucconic acid via ortho-pathway and/or by 2,3-dioxygenase into 2-hydroxymucconic semialdehyde via meta-pathway. The highest biodegradation rate was perceived...
The standard reference materials (SRMs) represent a key tool for the quality control of chemical ... more The standard reference materials (SRMs) represent a key tool for the quality control of chemical analyses and the demand on these materials is constantly increasing worldwide. A standard reference material of oil shale (SJL-1) collected from El-lajjun area in Jordan was prepared and certified to be used for quality control of analyses and calibration particularly for the oil shale characterization and testing laboratories. This work was a part of the Arab collaborative projects initiated by Arab Atomic Energy Agency (AAEA) during the period from 2007 to 2009. The paper describes the certification procedure and the inter-laboratory comparison study results, which was carried out through participation of twelve national and international laboratories applying eleven different analytical techniques used to determine the analytes concentration. Details of the production, homogeneity and stability of SJL-1 standard reference material were reviewed as well as the results of certification....
Journal of Ecological Engineering, 2021
Phenol is one of the main pollutants that have a serious impact on the environment and can even b... more Phenol is one of the main pollutants that have a serious impact on the environment and can even be very critical to human health. The biodegradation of phenol can be considered an increasingly important pollution control process. In this study, the degradation of phenol by Pseudomonas fredriksbergsis was investigated for the first time under different growth conditions. Six different initial concentrations of phenol were used as the primary substrate. Culture conditions had an important effect on these cells' ability to biodegrade phenol. The best growth of this organism and its highest biodegradation level of phenol were noticed at pH 7, temperature 28 °C, and periods of 36 and 96 h, respectively. The highest biodegradation rate was perceived at 700 mg/L initial phenol concentration. Approximately 90% of the phenol (700 mg/L) was removed in less than 96 hours of incubation time. It was found that the Haldane model best fitted the relationship between the specific growth rate an...
Biomedical and Pharmacology Journal, 2020
Urinary calculi are stones (urolithiasis) that can form anywhere in urinary tract outside of the ... more Urinary calculi are stones (urolithiasis) that can form anywhere in urinary tract outside of the kidneys and mostly composed of calcium oxalate and phosphate, additionally with elevated throughout the last two decades in the world. Chemical composition plays a major part in nephrolithiasis. Therefore, the high concentrations of lithogenic substances in urine enhance the crystallization method in urine tract system. The most kidney stones form from calcium oxalate, the present study was inspected the effect of the crude aqueous extract as well as the fractionated methanol extract (ethyl acetate, isopropanol, acetone and methanol residue) of paronychia argentea on the crystallization of calcium oxalate salts. The effect of aqueous extract and fractionated methanol extract on the size, number, type of calcium oxalate crystals. Paronychia argentea both the crude aqueous and the fractionated extract, especially ethyl acetate fraction have antiurolithic activity via reducing crystal size ...
The standard reference materials (SRMs) represent a key tool for the quality control of chemical ... more The standard reference materials (SRMs) represent a key tool for the quality control of chemical analyses and the demand on these materials is constantly increasing worldwide. A standard reference material of oil shale (SJL-1) collected from El-lajjun area in Jordan was prepared and certified to be used for quality control of analyses and calibration particularly for the oil shale characterization and testing laboratories. This work was a part of the Arab collaborative projects initiated by Arab Atomic Energy Agency (AAEA) during the period from 2007 to 2009. The paper describes the certification procedure and the inter-laboratory comparison study results, which was carried out through participation of twelve national and international laboratories applying eleven different analytical techniques used to determine the analytes concentration. Details of the production, homogeneity and stability of SJL-1 standard reference material were reviewed as well as the results of certification. The Certificate of Analysis for SJL-1 provides assigned certified values for almnuium oxide, phosphorus pentoxide, calcium oxide, titanium dioxide, magnesium oxide, potassium oxide, ferric oxide, sodium oxide, manganese oxide, sulfur, uranium, vanadium, chromium, zinc, nickel, copper, and strontium. Reference values are provided for Loss on Ignition (LOI), silicon oxide, cadmium, molybdenum, cobalt, lead, barium and arsenic. Finally, range values are assigned for other thirty-seven constituents of oil shale.