Moussa Kone - Academia.edu (original) (raw)
Papers by Moussa Kone
Journal of Vector Ecology Journal of the Society For Vector Ecology, Dec 1, 2006
Urban agriculture is common across Africa and contributes to the livelihoods of urban dwellers. S... more Urban agriculture is common across Africa and contributes to the livelihoods of urban dwellers. Some crop systems create suitable mosquito breeding sites and thus might affect malaria transmission. The purpose of this study was to identify, map, and characterize potential mosquito breeding sites in agricultural land use zones in a medium-sized town of western Côte d'Ivoire and to assess risk factors for productive Anopheles breeding sites. Two surveys were carried out; one toward the end of the rainy season and the second one during the dry season. In all identified potential mosquito breeding sites, two experienced entomologists searched for the presence of Anopheles larvae and pupae with a standardized technique. Totals of 369 and 589 sites were found in the rainy and dry seasons, respectively, mainly in vegetable gardens and irrigated rice fields. Anopheles larvae were present in 50.7% and 42.4% of the sites investigated during the rainy and dry seasons, respectively. Typical Anopheles larval habitats were characterized by the presence of algae, the absence of floating vegetation, and the co-occurrence of Culex larvae. The highest Anopheles larval productivity was observed in rice paddies, agricultural trenches between vegetable patches, and irrigation wells. An indirect link could be established between the occurrence of productive Anopheles breeding sites and agricultural land use through specific man-made habitats, in particular agricultural trenches, irrigation wells, and rice paddies. Our findings have important bearings for the epidemiology and control of urban malaria in sub-Saharan Africa.
![Research paper thumbnail of [Intestinal helminthosis in schoolchildren living in rural and urban areas of Tissale, Ivory Coast]](https://attachments.academia-assets.com/45537695/thumbnails/1.jpg)
](Médecine tropicale : revue du Corps de santé colonial, 2008
Lettres Pleurésie hémorragique au cours d'une maladie de Still : à propos d'une observation au Ga... more Lettres Pleurésie hémorragique au cours d'une maladie de Still : à propos d'une observation au Gabon L a maladie de Still (MS) est un rhumatisme inflammatoire rarement diagnostiqué dans la population noire africaine. Un patient de 23 ans, ayant pour antécédent une polyarthrite fébrile non déformante des grosses articulations évoluant par épisodes récurrents depuis deux ans et améliorée par la prise d'anti-inflammatoires non stéroïdiens, est hospitalisé en médecine interne pour une nouvelle poussée invalidante. L'examen clinique retrouve une hyperthermie à 40°C, une polyarthrite prédominant aux poignets, genou droit et cheville gauche avec érythème en regard, et une matité basi-thoracique droite. La CRP est élevée (94 fois la normale), il existe une hyperleucocytose neutrophile à 15 000/mm 3 avec anémie à 6,1 g/dl sans thrombopénie, une hyperferritinémie (40xN ; la ferritine glycosylée n'a pas pu être dosée). Les hémocultures, l'examen cytobactériologique des urines, les sérologies ASLO, VIH, la recherche d'auto-immunité sont négatifs, les bilans hématologique, métabolique, hépato-rénal sont sans anomalie. La radiographie pulmonaire objective une opacité basale droite de type pleural et la ponction confirme la pleurésie du lobe inférieur droit hémorragique, incoagulable, exsudative (protéines 48 g/l). La cytologie ne montre pas de cellules malignes et les cultures restent stériles. L'intradermoréaction à la tuberculine est positive à 5mm. Les radiographies des poignets, genoux et chevilles sont normales. Une ponction articulaire du genou droit est effectuée, le liquide est jaune citrin, exsudatif (protéines 52 g/l) et aseptique. Une échographie trans-oesophagienne objective une péricardite minime sans végétation.
Santé (Montrouge, France)
Malaria is still a major public health problem in Côte d'Ivoire. Both treatment and control t... more Malaria is still a major public health problem in Côte d'Ivoire. Both treatment and control there are hampered by the spread of resistance to common antimalarial drugs, especially in the south where multidrug-resistant malaria is highly prevalent. Recent treatment guidelines require in vitro tests and the adaptation of drug policies according to local resistance rates. In addition to performing clinical assays in the field, we sought to establish a national map of drug resistance by using in vitro tests with clinical surveys. These make it possible to detect changes in susceptibility and are expected to prevent the emergence of resistance against the most recently introduced combined therapy. Isolates of Plasmodium falciparum. Isolates of P. falciparum were collected from symptomatic adults and paediatric patients seen at Anonkoua-Kouté Hospital or at the Pasteur Institute of Côte d'Ivoire. Venous blood samples were collected in heparinized vacutainer tubes (Becton Dickinson...
Pathologie-biologie, 1998
Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used ... more Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used to investigate the Candida albicans strain diversity in twenty nine AIDS patients from Abidjan (Ivory Coast). All patients were monitored for a first episode of oropharyngeal candidiasis and were randomly clustered into three groups of therapy: ketoconazole, amphotericin B or nystatin. Oral swabs were collected before every treatment, 14 and 30 days after the initiation of the therapy; a total of 67 isolates were investigated. No resistant or less susceptible isolate to any antifungal agent was found despite the emergence of clinical relapses, mainly for patients treated with nystatin or amphotericin B. The MEE analysis revealed 27 different electrophoretic types (ETs). Genetic distances between ETs were statistically analyzed and represented on a dendrogram. The 27 ETs clustered into three groups; in each group, ETs represented variants of the same strain. A segregation of the C. albica...
Bulletin de la Société de pathologie exotique (1990), 1990
In vivo tests of Plasmodium falciparum chloroquine sensitivity were conducted in October and Nove... more In vivo tests of Plasmodium falciparum chloroquine sensitivity were conducted in October and November, 1988 with 81 children aged 5 to 9 in several districts of Abidjan, Ivory Coast. The WHO standard scheme covering 7 days on basis of 25 mg per kilo spread over 3 days resulted in a therapeutic failure in 29.6 per cent cases. Nevertheless, a drop in overall parasitemia by over 80 per cent was noted from Day-0 to Day-2 in 70 per cent of visible resistance. Only in vivo tests conducted at a later stage with identification of chloroquine in the blood stream, with together in vitro studies will make it possible to know the actual level of resistance of Plasmodium falciparum strains to chloroquine.
The Lancet. Infectious diseases, Jan 13, 2015
Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria... more Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic settings. We searched PubMed for clinical trials that enrolled and treated patients with artemether-lumefantrine and were published from 1960 to December, 2012. We merged individual patient data from these trials by use of standardised methods. The primary endpoint was the PCR-adjusted risk of Plasmodium falciparum recrudescence by day 28. Secondary endpoints consisted of the PCR-adjusted risk of P falciparum recurrence by day 42, PCR-unadjusted risk of P falciparum recurrence by day 42, early parasite clearance, and gametocyte carriage. Risk factors for PCR-adjusted recrudescence were identified using Cox's regression model with frailty shared across the study sites. We included 61 studies done between...
Médecine tropicale : revue du Corps de santé colonial, 2010
Strongyloides stercoralis is a neglected soil-transmitted helminth species. In Cote d'Ivoire,... more Strongyloides stercoralis is a neglected soil-transmitted helminth species. In Cote d'Ivoire, as elsewhere, there is a lack of parasitologic and epidemiologic data pertaining to this parasite. The purpose of this study was to evaluate the prevalence and impact of sociodemographic factors on anguillulosis among public school children in Abidjan, Cote d'Ivoire. Testing for Strongyloides stercoralis was performed in a random sample of 411 children from 10 public primary schools in Abidjan. Detection methods included direct examination of stool smears, the Baermann test and helminth coproculture study. The overall prevalence of anguillulosis was 2.7% (N=411) (IC95% = 1.34-4.73). The M/F sex-ratio was 1. No correlation was found between prevalence and sex (p = 0.12). Prevalence was higher among children who reported contact with swamps and rivers (respectively 80% and 7.9%) than those who did not report such contact (respectively 1.7% and 1.5%) (p <0.01). Contact with swamps a...
Bulletin de la Société de pathologie exotique (1990), 2007
We comparatively studied the dynamics of malaria transmission in the villages of Zatta (located i... more We comparatively studied the dynamics of malaria transmission in the villages of Zatta (located in close proximity to an irrigated rice perimeter) and Tiémélékro (rural area with traditional agriculture), central Côte d'Ivoire. In the former village, the irrigated rice farming had been interrupted in 2003/2004 due to a farmers' conflict over land. In each village, mosquitoes were collected by human landing catches at night in sentinel houses. Anopheles gambiae was the predominant malaria vector, followed by An. funestus. In Zatta, the return to an irrigated rice farming in January 2005 was paralleled by a significant increase of the entomological inoculation rate (EIR) ranging from 38 infective bites per person per year (ib/ply) in 2003 to 295 ib/ply in 2005. In Tiémélékro high EIRs were found in 2003 (342 ib/ply) and 2005 (572 ib/ply). Our findings confirm that changes in irrigated rice agriculture influence malaria transmission dynamics, and call for control measures that ...
Bulletin de la Société de pathologie exotique (1990), 2004
A parasitological survey on intestinal coccidia, Cryptosporidium sp and Isospora belli, has been ... more A parasitological survey on intestinal coccidia, Cryptosporidium sp and Isospora belli, has been carried out in paediatric service of an teaching hospital in the district of Abidjan (Côte d'Ivoire). 130 children under 5 years old suffering from diarrhoea have been enrolled. Direct stools examination method, simplified Ritchie technique and Ziehl Neelsen modified coloration were used for analysis. Moreover, the AIDS serological status of the patients has been determined. The results show that Cryptosporidium sp and Isospora belli were found respectively with a prevalence of 7.7% and 3.9%. Only one case of mixed infestation between theses two parasites has been found. Coccidia were the most recurrent parasites found in diarrhoea after flagellates. Parasitism by coccidia was not related to AIDS serological status of the children. These results point out the necessity to make common coccidian parasitical diagnosis in children under 5 years old suffering from diarrhoea.
Santé (Montrouge, France)
Antimalarial drug resistance in endemic malaria zones is first detected in vitro; when it reaches... more Antimalarial drug resistance in endemic malaria zones is first detected in vitro; when it reaches a certain threshold, it becomes perceptible and is expressed in therapeutic failure among subjects only slightly or not at all immune. This work conducted in northern Abidjan (Cote d'Ivoire) studied children with uncomplicated malaria, who were followed for 14 days (during the year 2000) in accordance with the WHO protocol for surveillance of antimalarial drug resistance. Concomitantly, the Plasmodium falciparum isolates were cultured in the presence of variable concentrations of chloroquine, pyrimethamine and quinine during in vitro chemosensitivity tests. The RPMI 1640 used as medium for the pyrimethamine did not contain PABA (para-amino benzoic acid) or folic acid. In all, 114 in vitro tests were completed, 33 to chloroquine, 32 to pyrimethamine, and 49 to quinine. Therapeutic efficacy was tested in 65 patients: 33 to chloroquine and 32 to sulfadoxine-pyrimethamine (SP). The resu...
Santé (Montrouge, France)
In order to assess the action scheme of the National Program against Malaria, a study has been co... more In order to assess the action scheme of the National Program against Malaria, a study has been conducted in 25 pharmacies in Bouaké an area of high malaria transmission. The kind and quality of malaria treatments suggested by medical personnel, pharmacy sellers and used in automedication have been studied. The results proved that chloroquine is the molecule most delivered (25.7%) in private pharmacies. The parasitological diagnosis is scarcely requested by medical personnel. As in automedication, posological mistakes are relatively frequent with medical and pharmacy personnel (29.3%). The duration of the treatment is not specified in 14.2% of cases. Training and information actions must be reinforced for a better care of malaria.
Médecine tropicale : revue du Corps de santé colonial, 2004
Otomycosis is frequently encountered in tropical and subtropical zones. In Ivory Coast diagnosis ... more Otomycosis is frequently encountered in tropical and subtropical zones. In Ivory Coast diagnosis of this disease is often based solely on the clinical symptoms. The objectives of this study were to determine the prevalence, predisposing factors, and etiologic agents associated with otomycosis at the Treichville University Hospital Center in Abidjan, Ivory Coast. Mycological examinations were performed on specimens obtained from 115 patients presenting with external otitis at the d'Oto-Rhino-Laryngology Department. Fungi-positive cultures were obtained in 49 patients for an overall otomycosis prevalence of 42.6 (95% Confidence Interval (CI), 34.4-52.2). Univariate analysis showed that the predisposing factors for otomycosis were frequent swimming in natural or artificial pools (Relative Risk (RR) 3.7; CI 1.7-8.1), daily ear cleaning (RR 3.5; CI 1.8-6.8) and excessive use of eardrops containing antibiotics and corticoids (RR = 9.3; IC95% = 4.3-20.1). The most common etiologic agen...
Médecine tropicale : revue du Corps de santé colonial, 2002
Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Wes... more Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Western Côte d'Ivoire demonstrated that clinical failure rates (WHO 14-day test) were 43% for chloroquine and 6% for pyrimethamine-sulfadoxine (PS). Two issues raise serious doubts about the use of PS as a replacement for chloroquine. The first is detection of persistent asymptomatic parasitemia at day 7 in children treated with PS. The second is widespread use of one PS component (sulfadoxine) to prevent opportunistic infection in AIDS patients or to treat infection. Further study will be needed to evaluate the therapeutic and parasitological efficacy of amodiaquine in the region.
Bulletin de la Société de pathologie exotique (1990), 2000
A prospective study in the municipality of Attécoubé (Abidjan, Côte d'Ivoire) evaluated the s... more A prospective study in the municipality of Attécoubé (Abidjan, Côte d'Ivoire) evaluated the sensitivity of P. falciparum to amodiaquine with a posology of 35 mg/kg over 3 days (1st day: 15 mg/kg; 2nd day: 10 mg/kg; 3rd day: 10 mg/kg) as well as its tolerance of this dosage. One hundred five WHO in vivo standard tests were performed over 7 days on subjects aged > 15 years from May to December 1995. The subjects were carriers of varying number of trophozoites: between 1000 to 34,000 trophozoites were recorded with a mean of 5193 trophozoites by microliter. We divided the subjects into two groups: group A with 43 patients to whom we administered medication and group B with 62 subjects who took their medication on their own. Clinical and parasitological verifications were made on D0, D2 and D7. Biological verification was conducted for 31 subjects of group A by mean of SGOT and SGPT quantity determination on D0 and D2. This survey revealed that 1.9% of P. falciparum malaria patie...
Revue de laryngologie - otologie - rhinologie, 1999
The purpose of this study was to collect ENT signs observed during lymphomas. The study was condu... more The purpose of this study was to collect ENT signs observed during lymphomas. The study was conducted in the unit of ENT at the CHU of Treichville, during 15 month from december 1995 to march 1997. Ten cas of lymphomas was enrolled with 6 Hodgkin's lymphomas, 3 acute leukemia and 1 Hodgkin's lymphoma. The diagnosis was based on biopsy and myelogram. There is a wide spectrum and non specific clinical pictures. Pharynx is the common site particularly on the Waldeyer's ring. The disease is common among young people, low socio-economical status. Female are predominant. Most patients died before specific treatment because of the late diagnosis.
Santé (Montrouge, France)
Hair samples from 2,209 children aged between 4 and 15 years were analyzed in March and April 199... more Hair samples from 2,209 children aged between 4 and 15 years were analyzed in March and April 1997 in an epidemiological study. We found that the prevalence of scalp pediculosis in schools in Abidjan was 18.51%. The girls were more frequently infected than the boys (24.88% for girls and 11.85% for boys). The children most frequently affected were those aged 14 to 15 years (24%) or 6 to 7 years (23. 21%). The children least affected were those aged 12 to 13 years (15. 21%) or 10 to 11 years (16.21%). Socioeconomic conditions, particularly the monthly incomes of the parents, cramped conditions and the collective use of washing facilities and bedding affected the prevalence of scalp pediculosis. Measures to deal with scalp pediculosis in schools should take into account socioeconomic and psychological factors, which are as important as the drug treatment for scalp pediculosis.
Médecine tropicale : revue du Corps de santé colonial, 1997
Historically the region of Abengourou is a well-known of sleeping sickness in the forest area of ... more Historically the region of Abengourou is a well-known of sleeping sickness in the forest area of Cote d'Ivoire. However data from epidemiologic studies carried out since 1980 show that this area is currently disease-free. This finding warrants study of glossina vectors to clarify the epidemiology of the disease in this area. Entomologic surveys were carried out over a period of one year. Traps were used to capture glossina in ten natural habitats: villages with or without pigs, coffee, cocoa and rice plantations, grazing lands, camping areas, uncultivated farmlands, trails, forest borderlands and wilderness. Findings documented almost total disappearance of zoophilic glossina (Glossina nigrofusca and Glossina pallicera) which accounted for less than 0.5% of glossina captured only during the rainy season. The apparent trap density (ATD) of Glossina palpalis, the main vector of disease, was low overall. However ATD values tended to be higher in villages with pigs (ATD : 2.07 gloss...
Médecine tropicale : revue du Corps de santé colonial, 1997
Santé (Montrouge, France)
We report the results of epidemiological research carried out using a sample of 1,001 children be... more We report the results of epidemiological research carried out using a sample of 1,001 children between the ages of 4 and 15 in the city of Abidjan. The aim of the study was to explore the relationship between socioeconomic conditions and the occurrence of intestinal helminthiasis. The variables evaluated in this study were the monthly income of the parents, daily food budget per person, number of people sharing accommodation, availability of running water and electricity, availability of food near schools and regular anti-parasite treatment.
Bulletin de la Société de pathologie exotique (1990), 1997
Feces of 1001 school children aged from 4 to 15 years were examined as an epidemiological investi... more Feces of 1001 school children aged from 4 to 15 years were examined as an epidemiological investigation. Direct analyses were completed by KATO and RITCHIE methods. The outcome was the global prevalence of intestinal helminthiasis in school age children in the Abidjan area is 36.5%. Male subjects are more infected than females. The most infected group is aged from 12 to 13 years and the less infected from 4 to 5 years. The frequent parasite species are Trichuris trichiura (23.4%), Ascaris lumbricoides (15.5%), Necator americanus (6.3%), Strongyloides stercoralis (1.4%). Hymenolepis nana (1.1%), Schistosoma mansoni (0.8%) and Enterobius vermicularis (0.2%).
Journal of Vector Ecology Journal of the Society For Vector Ecology, Dec 1, 2006
Urban agriculture is common across Africa and contributes to the livelihoods of urban dwellers. S... more Urban agriculture is common across Africa and contributes to the livelihoods of urban dwellers. Some crop systems create suitable mosquito breeding sites and thus might affect malaria transmission. The purpose of this study was to identify, map, and characterize potential mosquito breeding sites in agricultural land use zones in a medium-sized town of western Côte d'Ivoire and to assess risk factors for productive Anopheles breeding sites. Two surveys were carried out; one toward the end of the rainy season and the second one during the dry season. In all identified potential mosquito breeding sites, two experienced entomologists searched for the presence of Anopheles larvae and pupae with a standardized technique. Totals of 369 and 589 sites were found in the rainy and dry seasons, respectively, mainly in vegetable gardens and irrigated rice fields. Anopheles larvae were present in 50.7% and 42.4% of the sites investigated during the rainy and dry seasons, respectively. Typical Anopheles larval habitats were characterized by the presence of algae, the absence of floating vegetation, and the co-occurrence of Culex larvae. The highest Anopheles larval productivity was observed in rice paddies, agricultural trenches between vegetable patches, and irrigation wells. An indirect link could be established between the occurrence of productive Anopheles breeding sites and agricultural land use through specific man-made habitats, in particular agricultural trenches, irrigation wells, and rice paddies. Our findings have important bearings for the epidemiology and control of urban malaria in sub-Saharan Africa.
Médecine tropicale : revue du Corps de santé colonial, 2008
Lettres Pleurésie hémorragique au cours d'une maladie de Still : à propos d'une observation au Ga... more Lettres Pleurésie hémorragique au cours d'une maladie de Still : à propos d'une observation au Gabon L a maladie de Still (MS) est un rhumatisme inflammatoire rarement diagnostiqué dans la population noire africaine. Un patient de 23 ans, ayant pour antécédent une polyarthrite fébrile non déformante des grosses articulations évoluant par épisodes récurrents depuis deux ans et améliorée par la prise d'anti-inflammatoires non stéroïdiens, est hospitalisé en médecine interne pour une nouvelle poussée invalidante. L'examen clinique retrouve une hyperthermie à 40°C, une polyarthrite prédominant aux poignets, genou droit et cheville gauche avec érythème en regard, et une matité basi-thoracique droite. La CRP est élevée (94 fois la normale), il existe une hyperleucocytose neutrophile à 15 000/mm 3 avec anémie à 6,1 g/dl sans thrombopénie, une hyperferritinémie (40xN ; la ferritine glycosylée n'a pas pu être dosée). Les hémocultures, l'examen cytobactériologique des urines, les sérologies ASLO, VIH, la recherche d'auto-immunité sont négatifs, les bilans hématologique, métabolique, hépato-rénal sont sans anomalie. La radiographie pulmonaire objective une opacité basale droite de type pleural et la ponction confirme la pleurésie du lobe inférieur droit hémorragique, incoagulable, exsudative (protéines 48 g/l). La cytologie ne montre pas de cellules malignes et les cultures restent stériles. L'intradermoréaction à la tuberculine est positive à 5mm. Les radiographies des poignets, genoux et chevilles sont normales. Une ponction articulaire du genou droit est effectuée, le liquide est jaune citrin, exsudatif (protéines 52 g/l) et aseptique. Une échographie trans-oesophagienne objective une péricardite minime sans végétation.
Santé (Montrouge, France)
Malaria is still a major public health problem in Côte d'Ivoire. Both treatment and control t... more Malaria is still a major public health problem in Côte d'Ivoire. Both treatment and control there are hampered by the spread of resistance to common antimalarial drugs, especially in the south where multidrug-resistant malaria is highly prevalent. Recent treatment guidelines require in vitro tests and the adaptation of drug policies according to local resistance rates. In addition to performing clinical assays in the field, we sought to establish a national map of drug resistance by using in vitro tests with clinical surveys. These make it possible to detect changes in susceptibility and are expected to prevent the emergence of resistance against the most recently introduced combined therapy. Isolates of Plasmodium falciparum. Isolates of P. falciparum were collected from symptomatic adults and paediatric patients seen at Anonkoua-Kouté Hospital or at the Pasteur Institute of Côte d'Ivoire. Venous blood samples were collected in heparinized vacutainer tubes (Becton Dickinson...
Pathologie-biologie, 1998
Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used ... more Multilocus enzyme electrophoresis (MEE) and in vitro antifungal susceptibility testing were used to investigate the Candida albicans strain diversity in twenty nine AIDS patients from Abidjan (Ivory Coast). All patients were monitored for a first episode of oropharyngeal candidiasis and were randomly clustered into three groups of therapy: ketoconazole, amphotericin B or nystatin. Oral swabs were collected before every treatment, 14 and 30 days after the initiation of the therapy; a total of 67 isolates were investigated. No resistant or less susceptible isolate to any antifungal agent was found despite the emergence of clinical relapses, mainly for patients treated with nystatin or amphotericin B. The MEE analysis revealed 27 different electrophoretic types (ETs). Genetic distances between ETs were statistically analyzed and represented on a dendrogram. The 27 ETs clustered into three groups; in each group, ETs represented variants of the same strain. A segregation of the C. albica...
Bulletin de la Société de pathologie exotique (1990), 1990
In vivo tests of Plasmodium falciparum chloroquine sensitivity were conducted in October and Nove... more In vivo tests of Plasmodium falciparum chloroquine sensitivity were conducted in October and November, 1988 with 81 children aged 5 to 9 in several districts of Abidjan, Ivory Coast. The WHO standard scheme covering 7 days on basis of 25 mg per kilo spread over 3 days resulted in a therapeutic failure in 29.6 per cent cases. Nevertheless, a drop in overall parasitemia by over 80 per cent was noted from Day-0 to Day-2 in 70 per cent of visible resistance. Only in vivo tests conducted at a later stage with identification of chloroquine in the blood stream, with together in vitro studies will make it possible to know the actual level of resistance of Plasmodium falciparum strains to chloroquine.
The Lancet. Infectious diseases, Jan 13, 2015
Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria... more Artemether-lumefantrine is the most widely used artemisinin-based combination therapy for malaria, although treatment failures occur in some regions. We investigated the effect of dosing strategy on efficacy in a pooled analysis from trials done in a wide range of malaria-endemic settings. We searched PubMed for clinical trials that enrolled and treated patients with artemether-lumefantrine and were published from 1960 to December, 2012. We merged individual patient data from these trials by use of standardised methods. The primary endpoint was the PCR-adjusted risk of Plasmodium falciparum recrudescence by day 28. Secondary endpoints consisted of the PCR-adjusted risk of P falciparum recurrence by day 42, PCR-unadjusted risk of P falciparum recurrence by day 42, early parasite clearance, and gametocyte carriage. Risk factors for PCR-adjusted recrudescence were identified using Cox's regression model with frailty shared across the study sites. We included 61 studies done between...
Médecine tropicale : revue du Corps de santé colonial, 2010
Strongyloides stercoralis is a neglected soil-transmitted helminth species. In Cote d'Ivoire,... more Strongyloides stercoralis is a neglected soil-transmitted helminth species. In Cote d'Ivoire, as elsewhere, there is a lack of parasitologic and epidemiologic data pertaining to this parasite. The purpose of this study was to evaluate the prevalence and impact of sociodemographic factors on anguillulosis among public school children in Abidjan, Cote d'Ivoire. Testing for Strongyloides stercoralis was performed in a random sample of 411 children from 10 public primary schools in Abidjan. Detection methods included direct examination of stool smears, the Baermann test and helminth coproculture study. The overall prevalence of anguillulosis was 2.7% (N=411) (IC95% = 1.34-4.73). The M/F sex-ratio was 1. No correlation was found between prevalence and sex (p = 0.12). Prevalence was higher among children who reported contact with swamps and rivers (respectively 80% and 7.9%) than those who did not report such contact (respectively 1.7% and 1.5%) (p <0.01). Contact with swamps a...
Bulletin de la Société de pathologie exotique (1990), 2007
We comparatively studied the dynamics of malaria transmission in the villages of Zatta (located i... more We comparatively studied the dynamics of malaria transmission in the villages of Zatta (located in close proximity to an irrigated rice perimeter) and Tiémélékro (rural area with traditional agriculture), central Côte d'Ivoire. In the former village, the irrigated rice farming had been interrupted in 2003/2004 due to a farmers' conflict over land. In each village, mosquitoes were collected by human landing catches at night in sentinel houses. Anopheles gambiae was the predominant malaria vector, followed by An. funestus. In Zatta, the return to an irrigated rice farming in January 2005 was paralleled by a significant increase of the entomological inoculation rate (EIR) ranging from 38 infective bites per person per year (ib/ply) in 2003 to 295 ib/ply in 2005. In Tiémélékro high EIRs were found in 2003 (342 ib/ply) and 2005 (572 ib/ply). Our findings confirm that changes in irrigated rice agriculture influence malaria transmission dynamics, and call for control measures that ...
Bulletin de la Société de pathologie exotique (1990), 2004
A parasitological survey on intestinal coccidia, Cryptosporidium sp and Isospora belli, has been ... more A parasitological survey on intestinal coccidia, Cryptosporidium sp and Isospora belli, has been carried out in paediatric service of an teaching hospital in the district of Abidjan (Côte d'Ivoire). 130 children under 5 years old suffering from diarrhoea have been enrolled. Direct stools examination method, simplified Ritchie technique and Ziehl Neelsen modified coloration were used for analysis. Moreover, the AIDS serological status of the patients has been determined. The results show that Cryptosporidium sp and Isospora belli were found respectively with a prevalence of 7.7% and 3.9%. Only one case of mixed infestation between theses two parasites has been found. Coccidia were the most recurrent parasites found in diarrhoea after flagellates. Parasitism by coccidia was not related to AIDS serological status of the children. These results point out the necessity to make common coccidian parasitical diagnosis in children under 5 years old suffering from diarrhoea.
Santé (Montrouge, France)
Antimalarial drug resistance in endemic malaria zones is first detected in vitro; when it reaches... more Antimalarial drug resistance in endemic malaria zones is first detected in vitro; when it reaches a certain threshold, it becomes perceptible and is expressed in therapeutic failure among subjects only slightly or not at all immune. This work conducted in northern Abidjan (Cote d'Ivoire) studied children with uncomplicated malaria, who were followed for 14 days (during the year 2000) in accordance with the WHO protocol for surveillance of antimalarial drug resistance. Concomitantly, the Plasmodium falciparum isolates were cultured in the presence of variable concentrations of chloroquine, pyrimethamine and quinine during in vitro chemosensitivity tests. The RPMI 1640 used as medium for the pyrimethamine did not contain PABA (para-amino benzoic acid) or folic acid. In all, 114 in vitro tests were completed, 33 to chloroquine, 32 to pyrimethamine, and 49 to quinine. Therapeutic efficacy was tested in 65 patients: 33 to chloroquine and 32 to sulfadoxine-pyrimethamine (SP). The resu...
Santé (Montrouge, France)
In order to assess the action scheme of the National Program against Malaria, a study has been co... more In order to assess the action scheme of the National Program against Malaria, a study has been conducted in 25 pharmacies in Bouaké an area of high malaria transmission. The kind and quality of malaria treatments suggested by medical personnel, pharmacy sellers and used in automedication have been studied. The results proved that chloroquine is the molecule most delivered (25.7%) in private pharmacies. The parasitological diagnosis is scarcely requested by medical personnel. As in automedication, posological mistakes are relatively frequent with medical and pharmacy personnel (29.3%). The duration of the treatment is not specified in 14.2% of cases. Training and information actions must be reinforced for a better care of malaria.
Médecine tropicale : revue du Corps de santé colonial, 2004
Otomycosis is frequently encountered in tropical and subtropical zones. In Ivory Coast diagnosis ... more Otomycosis is frequently encountered in tropical and subtropical zones. In Ivory Coast diagnosis of this disease is often based solely on the clinical symptoms. The objectives of this study were to determine the prevalence, predisposing factors, and etiologic agents associated with otomycosis at the Treichville University Hospital Center in Abidjan, Ivory Coast. Mycological examinations were performed on specimens obtained from 115 patients presenting with external otitis at the d'Oto-Rhino-Laryngology Department. Fungi-positive cultures were obtained in 49 patients for an overall otomycosis prevalence of 42.6 (95% Confidence Interval (CI), 34.4-52.2). Univariate analysis showed that the predisposing factors for otomycosis were frequent swimming in natural or artificial pools (Relative Risk (RR) 3.7; CI 1.7-8.1), daily ear cleaning (RR 3.5; CI 1.8-6.8) and excessive use of eardrops containing antibiotics and corticoids (RR = 9.3; IC95% = 4.3-20.1). The most common etiologic agen...
Médecine tropicale : revue du Corps de santé colonial, 2002
Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Wes... more Study of children treated for uncomplicated malaria in the sub-prefecture of Zouan Hounien in Western Côte d'Ivoire demonstrated that clinical failure rates (WHO 14-day test) were 43% for chloroquine and 6% for pyrimethamine-sulfadoxine (PS). Two issues raise serious doubts about the use of PS as a replacement for chloroquine. The first is detection of persistent asymptomatic parasitemia at day 7 in children treated with PS. The second is widespread use of one PS component (sulfadoxine) to prevent opportunistic infection in AIDS patients or to treat infection. Further study will be needed to evaluate the therapeutic and parasitological efficacy of amodiaquine in the region.
Bulletin de la Société de pathologie exotique (1990), 2000
A prospective study in the municipality of Attécoubé (Abidjan, Côte d'Ivoire) evaluated the s... more A prospective study in the municipality of Attécoubé (Abidjan, Côte d'Ivoire) evaluated the sensitivity of P. falciparum to amodiaquine with a posology of 35 mg/kg over 3 days (1st day: 15 mg/kg; 2nd day: 10 mg/kg; 3rd day: 10 mg/kg) as well as its tolerance of this dosage. One hundred five WHO in vivo standard tests were performed over 7 days on subjects aged > 15 years from May to December 1995. The subjects were carriers of varying number of trophozoites: between 1000 to 34,000 trophozoites were recorded with a mean of 5193 trophozoites by microliter. We divided the subjects into two groups: group A with 43 patients to whom we administered medication and group B with 62 subjects who took their medication on their own. Clinical and parasitological verifications were made on D0, D2 and D7. Biological verification was conducted for 31 subjects of group A by mean of SGOT and SGPT quantity determination on D0 and D2. This survey revealed that 1.9% of P. falciparum malaria patie...
Revue de laryngologie - otologie - rhinologie, 1999
The purpose of this study was to collect ENT signs observed during lymphomas. The study was condu... more The purpose of this study was to collect ENT signs observed during lymphomas. The study was conducted in the unit of ENT at the CHU of Treichville, during 15 month from december 1995 to march 1997. Ten cas of lymphomas was enrolled with 6 Hodgkin's lymphomas, 3 acute leukemia and 1 Hodgkin's lymphoma. The diagnosis was based on biopsy and myelogram. There is a wide spectrum and non specific clinical pictures. Pharynx is the common site particularly on the Waldeyer's ring. The disease is common among young people, low socio-economical status. Female are predominant. Most patients died before specific treatment because of the late diagnosis.
Santé (Montrouge, France)
Hair samples from 2,209 children aged between 4 and 15 years were analyzed in March and April 199... more Hair samples from 2,209 children aged between 4 and 15 years were analyzed in March and April 1997 in an epidemiological study. We found that the prevalence of scalp pediculosis in schools in Abidjan was 18.51%. The girls were more frequently infected than the boys (24.88% for girls and 11.85% for boys). The children most frequently affected were those aged 14 to 15 years (24%) or 6 to 7 years (23. 21%). The children least affected were those aged 12 to 13 years (15. 21%) or 10 to 11 years (16.21%). Socioeconomic conditions, particularly the monthly incomes of the parents, cramped conditions and the collective use of washing facilities and bedding affected the prevalence of scalp pediculosis. Measures to deal with scalp pediculosis in schools should take into account socioeconomic and psychological factors, which are as important as the drug treatment for scalp pediculosis.
Médecine tropicale : revue du Corps de santé colonial, 1997
Historically the region of Abengourou is a well-known of sleeping sickness in the forest area of ... more Historically the region of Abengourou is a well-known of sleeping sickness in the forest area of Cote d'Ivoire. However data from epidemiologic studies carried out since 1980 show that this area is currently disease-free. This finding warrants study of glossina vectors to clarify the epidemiology of the disease in this area. Entomologic surveys were carried out over a period of one year. Traps were used to capture glossina in ten natural habitats: villages with or without pigs, coffee, cocoa and rice plantations, grazing lands, camping areas, uncultivated farmlands, trails, forest borderlands and wilderness. Findings documented almost total disappearance of zoophilic glossina (Glossina nigrofusca and Glossina pallicera) which accounted for less than 0.5% of glossina captured only during the rainy season. The apparent trap density (ATD) of Glossina palpalis, the main vector of disease, was low overall. However ATD values tended to be higher in villages with pigs (ATD : 2.07 gloss...
Médecine tropicale : revue du Corps de santé colonial, 1997
Santé (Montrouge, France)
We report the results of epidemiological research carried out using a sample of 1,001 children be... more We report the results of epidemiological research carried out using a sample of 1,001 children between the ages of 4 and 15 in the city of Abidjan. The aim of the study was to explore the relationship between socioeconomic conditions and the occurrence of intestinal helminthiasis. The variables evaluated in this study were the monthly income of the parents, daily food budget per person, number of people sharing accommodation, availability of running water and electricity, availability of food near schools and regular anti-parasite treatment.
Bulletin de la Société de pathologie exotique (1990), 1997
Feces of 1001 school children aged from 4 to 15 years were examined as an epidemiological investi... more Feces of 1001 school children aged from 4 to 15 years were examined as an epidemiological investigation. Direct analyses were completed by KATO and RITCHIE methods. The outcome was the global prevalence of intestinal helminthiasis in school age children in the Abidjan area is 36.5%. Male subjects are more infected than females. The most infected group is aged from 12 to 13 years and the less infected from 4 to 5 years. The frequent parasite species are Trichuris trichiura (23.4%), Ascaris lumbricoides (15.5%), Necator americanus (6.3%), Strongyloides stercoralis (1.4%). Hymenolepis nana (1.1%), Schistosoma mansoni (0.8%) and Enterobius vermicularis (0.2%).