Mriganka Saha - Academia.edu (original) (raw)

Papers by Mriganka Saha

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2021

Introduction: Pre-eclampsia is a serious condition complicating pregnancy. It is a multisystem di... more Introduction: Pre-eclampsia is a serious condition complicating pregnancy. It is a multisystem disorder responsible for significant maternal and perinatal morbidity and mortality. Thus, prevention of pre-eclampsia may improve both maternal and foetal outcomes. It has been found that reduced serum calcium level may cause high blood pressure by stimulating parathyroid hormone, rennin release and also by producing vasoconstriction in smooth muscle. Aim: To evaluate the role of high dose (2000 mg/day) calcium compared to normal dose (1000 mg/day) calcium in preventing the incidence and severity of pre-eclampsia. Materials and Methods: This was a pilot study and this prospective interventional study conducted from January 2017 to June 2018 in Kolkata, India with 200 primigravidas. About 100 women were given 1000 mg calcium and 100 women were given 2000 mg (high dose) calcium in a day. Incidence of gestational hypertension, pre-eclampsia, severe pre-eclampsia, neonatal outcome etc were as...

Background: Cervical Carcinoma is the second most leading carcinoma following breast cancer among... more Background: Cervical Carcinoma is the second most leading carcinoma following breast cancer among Indian women. It has been showed that HLA class II DQ is associated in persistent HPV infection and HLA class II DR is responsible for increased clearance of HPV virus from cervix. Methodology: In this study we had included total 96 women (53 women in the control, 31 women in CIN group, and 12 women in cervical carcinoma (CC) group. Result: Our study showed that HLA DRB1 was associated with the healthy and cervical intraepithelial neoplasia population; whereas HLA DQB1 was associated with the invasive cervical carcinoma. Conclusion: HLA DRB1 and HLA DQB1 is useful tool for community based screening and focused HPV vaccination among the risk group to prevent the invasive cervical cancer.

Objective: Evaluation of fetal and maternal outcomes in pregnancy with leiomyoma uteri. Methods: ... more Objective: Evaluation of fetal and maternal outcomes in pregnancy with leiomyoma uteri. Methods: Total 50 pregnant women with uterine myoma attending the department of Obstetrics and Gynecology of IPGME&R, Kolkata were followed during the antenatal, intranatal and postnatal period. Total 200 women of normal uncomplicated pregnancy were recruited as control and matched for age and parity. Results: The women were having 10% submucous, 74% intramural and 16% subserous type of uterine myoma. Highest incidence was in more than 30 yrs age group. Spontaneous miscarriage in 16%, malpresentation in 14%, fetal growth restriction (FGR) in 14%, intra uterine fetal demise (IUFD) in 8% and placental abruption in 8% cases were noted. During intranatal period preterm labour in 18%, prolonged labour in 22%, fetal distress in 22%, retained placenta in 6% and preterm premature rupture of membranes (PPROM) or premature rupture of membranes (PROM) in 16% cases were also seen. Postpartum hemorrhage (PPH)...

Adverse pregnancy outcomes such as preeclampsia are the leading cause of maternal morbidity and m... more Adverse pregnancy outcomes such as preeclampsia are the leading cause of maternal morbidity and mortality in the world and its incidence is increasing. It has been observed in some studies that cell-free fetal DNA (cff DNA) is increased in maternal serum associated with preeclampsia. In the present study, we have tested whether the elevated amount of cff DNA in maternal plasma is associated with PE and development of new marker by the low-cost method to predict preeclampsia. Twenty-one pregnant women within the age group of 20–30 years attending for routine antenatal checkups at (G & O) antenatal OPD after 20 weeks with fulfilling the diagnostic criteria of preeclampsia were included in our study. Age-matched pregnant women without hypertension were included as controls. A complete clinical history and anthropometric observation showed that gravida (total number of pregnancy in a patient including present pregnancy), gestational age, gestational age at birth, birth weight in preecla...

Annals of Pathology and Laboratory Medicine, 2016

Non-Hodgkin Lymphoma is diverse and often subdivided into diffuse large B-cell lymphoma, peripher... more Non-Hodgkin Lymphoma is diverse and often subdivided into diffuse large B-cell lymphoma, peripheral T-cell lymphoma, Burkitt’s lymphoma, mantle cell lymphoma and AIDS-related lymphoma. Primary lymphoma involving the uterine cervix is very rarely encountered. We are presenting here a case with post menopausal bleeding with provisional diagnosis of poorly differentiated cervical carcinoma. Radical hysterectomy (type II) with bilateral pelvic lymph node dissection was done . Specimen is sent for histopathological examination and it was reported as diffuse round cells proliferating in an apparently unorganized fashion, with hyperchromatic nuclei and scanty cytoplasm and prominent nucleoli with possibility of poorly differentiated carcinoma or Non-Hodgkin lymphoma involving cervix. Immunohistochemistry study showed expression of CD 20 and negative expression of CD3 there by confirmed the diagnosis of diffuse large B cell type (DLBCL) Non-Hodgkin lymphoma of uterine cervix. The incidence...

Objective: To evaluate the diagnostic value of maternal serum interleukin 6 (IL-6), for the predi... more Objective: To evaluate the diagnostic value of maternal serum interleukin 6 (IL-6), for the prediction of preterm labor. Association of few major maternal high risk factors and occurrence of preterm labor was also studied. Material and methods: Maternal serum IL-6 were prospectively determined in thirty patients in threatened preterm labor and thirty controls. Data was analyzed in study and control groups. Risk factors studied were maternal age, socioeconomic status, parity, antenatal checkup, history of preterm labor in previous pregnancy, history of 2 or more spontaneous or induced abortion, vaginal infection. Results: The strongest risk factor for preterm birth in our study is a previous preterm birth. In this study 60% mothers with history of preterm birth delivered preterm (p value 0.05). Maternal serum IL-6 levels were significantly higher in the study group than controls. The IL-6 value associated with the highest percent of true positives and true negatives for the predictio...

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2018

Introduction: Osteoporosis has become a serious health threat for women. The osteoporosis related... more Introduction: Osteoporosis has become a serious health threat for women. The osteoporosis related fracture rate as well as treatment cost is increasing in recent times due to aging population. Aim: The aim of the present study was to investigate the risk factors of osteoporosis, identifying the risk group and the changes of Bone Mineral Density (BMD) in aging women.

Journal of SAFOMS, 2018

Massive ovarian tumors are rarely encountered in our clinical practices and the most common reaso... more Massive ovarian tumors are rarely encountered in our clinical practices and the most common reason is ignorance about the pathology and its sequences. Many complications are associated with it starting from the preoperative, intraoperative and postoperative period. Here we are reporting a case of massive bilateral ovarian tumor weighing 35.4 kg (weighted after removal). She underwent a successful operation and discharged from the hospital on tenth postoperative day. Histopathology examination has revealed papillary serous cystadenocarcinoma of one ovary and borderline mucinous tumor of another ovary.

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2019

to 2 nd June 2018. The data was collected from 3 rd September to 2 nd December 2017 and then anal... more to 2 nd June 2018. The data was collected from 3 rd September to 2 nd December 2017 and then analysed. The study was approved by the ethics committee of the Institution (ref. no. F-24/PR/COMJNMH/IEC/17/1310). All pregnant women who were admitted to undergo vaginal or caesarean delivery, had given written consent for CuT 380A insertion and agreed for a follow-up upto three months were included in the study. Exclusion criteria were unresolved PPH, acute purulent discharge, PROM >18 hours, chorioamnionitis, any congenital malformation of the uterus, large fibroid, etc. All women irrespective of maternal age, risk factor and proposed mode of delivery at the antenatal clinic of the institution were counselled about contraceptive options. First 127 mothers who delivered vaginally and the first 127 mothers who underwent caesarean section were regarded as study groups and were followed up for three months.

Journal of SAFOG, 2018

Aim: Study of systemic lupus erythematosus (SLE) with pregnancy to manage them in a multidiscipli... more Aim: Study of systemic lupus erythematosus (SLE) with pregnancy to manage them in a multidisciplinary approach for better pregnancy outcomes. Materials and methods: This study was a prospective cohort study. A total of 100 pregnant women with diagnosed SLE were included in the study and another 100 age-matched normal pregnant women without any obvious complications were recruited as controls. Results: Maternal organ involvement-five patients of renal involvement and seven patients of cardiac and pulmonary involvement in SLE group-was found. Antinuclear antibody (ANA) was positive in all cases and 87 were positive for antidouble-stranded deoxyribonucleic acid (anti-dsDNA) antibody. The disease flare was found only in a single case of planned pregnancy and total nine cases of unplanned pregnancy. Most of the women, 41 (53.25%), in the SLE group were delivered by cesarean section, but only 24 (25%) in the control group underwent cesarean section. Conclusion: The SLE with pregnancy is a high-risk condition where prepregnancy disease-free interval is the most important criteria to minimize complications. Hydroxychloroquine can be used safely throughout the pregnancy. Multidisciplinary approach plays a crucial part in management. Clinical significance: Management of lupus flares and preeclampsia during SLE pregnancy is being treated with difficulties with overlapping clinical features. Presence of antiphospholipid antibodies (APLA) is a major unresolved issue. Adverse events to maternal and fetal well-being with use of appropriate medications are required for optimum outcomes.

Indian Journal of Clinical Biochemistry, 2017

Objective: The purpose of the study was to detect & evaluate the feto-maternal outcome of HELLP s... more Objective: The purpose of the study was to detect & evaluate the feto-maternal outcome of HELLP syndrome & partial HELLP syndrome among preeclamptic mothers. Materials and methods: This cross sectional observational study analysed feto-maternal outcome in 44 patients with HELLP syndrome and 32 patients with partial HELLP syndrome and compared with 556 patients having preeclampsia without features of HELLP syndrome. Results: 600 patients were included in this study. The prevalence of HELLP syndrome and partial HELLP syndrome were found to be 7.3% and 5.3% respectively in preeclampsia. The systolic blood pressure, gestational age at admission and during delivery, haematological and biochemical variables, rate of spontaneous vaginal delivery and type of anaesthesia were significantly different in HELLP syndrome and partial HELLP syndrome than in the preeclampsia group. There were statistically significant difference in perinatal outcome like birth weight, intrauterine death, neonatal death, and admission in NICU. Eclampsia was significantly increased in both HELLP syndrome and partial HELLP syndrome. Conclusion: Both HELLP and partial HELLP syndrome must be diagnosed as soon as possible in pregnant or post partum women with preeclampsia. HELLP syndrome is severe than preeclampsia in terms of maternal and perinatal outcome. Partial HELLP syndrome is almost as grave as HELLP syndrome.

Journal of Evolution of Medical and Dental Sciences, 2013

Geriatric gynaecology deals with gynaecological pathology encountered in postmenopausal women at ... more Geriatric gynaecology deals with gynaecological pathology encountered in postmenopausal women at and above 60 years of age with an intention of early diagnosis and management. A major challenge for the world in the 21st century is the ageing of its population. As the life expectancy of postmenopausal women has risen dramatically, hence this study was taken up to analyze incidence, diagnosis, treatment of gynaecological disorders in females aged 60 years and above. METHODS: It is an retrospective observational study of female patients aged 60 years and above, admitted in the department of Obstetrics and Gynaecology, IPGMER and SSKM Hospital, Kolkata over a period of one year. Data was collected from admission and OT register. Age distribution, spectrum of gynaecological disorder, type of surgeries performed, were noted and analyzed. RESULTS: In our study ninety patients were aged 60 years or more amongst total admission of 811 comprising age related incidence of 11.09%. The mean average age of admission was 64.19 years. Uterovaginal prolapse(51.1%) was the commonest clinical problem followed by malignancy (26.7%). Among the gynaecological malignancies (24 patients) ovarian carcinoma was the most common (50%) followed by endometrial carcinoma(33.3%).Total 36 patients of uterovaginal prolapse were managed surgically. All patients of malignancy were treated surgically. Among Nine cases of stress urinary incontinence, seven managed by TVT/TOT. CONCLUSION: Uterovaginal prolapse and malignancy were the major gynaecological problems in older women. In future geriatric gynaecology will play an important role in India, as the size of elderly population is increasing over time.

Indian Journal of Biochemistry and Biophysics

This gender-independent detection of cell-free fetal DNA in maternal plasma using RASSF1A/-actin... more This gender-independent detection of cell-free fetal DNA in maternal plasma using RASSF1A/-actin has curtained off a new dimension regarding its utility to predict the adverse pregnancy outcomes. Recent efforts have been directed at developing sequences from cell-free fetal DNA (cffDNA) as markers for pregnancy outcomes. The utility of cffDNA using the methylation-dependent DSCR3 and RASSF1A markers along with total cell-free DNA (cf-DNA) in maternal serum by HYP2 marker are useful in predicting adverse pregnancy outcomes. Increased amount (>95 th percentile) of cffDNA fraction in the second trimester is associated with preterm birth. Indigenously developed low-cost method of the gender-independent sequence markers from cffDNA was investigated and evaluated with the standardized commercial kits as predictive markers for adverse pregnancy outcomes. Our results indicated that indigenously developed method for detection of geneder-independent cffDNA can be applicable for screening test of adverse pregnancy outcome.