Ms. Pranali Jadhav - Academia.edu (original) (raw)

Papers by Ms. Pranali Jadhav

In silico pharmacology, Mar 26, 2024

Recent advances in drug delivery and formulation, Dec 14, 2023

Future Pharmacology, Oct 9, 2023

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Irish journal of medical science, Jan 29, 2024

Current Drug Therapy

Background: Recent research has revealed promising antibacterial action for thienopyrimidines. To... more Background: Recent research has revealed promising antibacterial action for thienopyrimidines. To comprehend the underlying molecular features underlying their antibacterial potency, a thorough quantitative structure-activity relationship (QSAR) investigation is required. Objective: In order to clarify the structural parameters for effective antibacterial activity, we conducted QSAR analyses on a variety of thienopyrimidines in this work. Methods: Through the analysis of physicochemical properties and molecular descriptors, we aimed to develop predictive models that can guide the design of novel thienopyrimidine derivatives with enhanced antimicrobial potential. Result: It was discovered through the descriptor importance analysis that specific physicochemical characteristics, including lipophilicity, electronic distribution, and steric effects, significantly influenced the antibacterial efficacy of these drugs. Conclusion: The identified molecular characteristics and descriptors can...

European Journal of Gastroenterology & Hepatology

Non-alcoholic fatty liver disease (NAFLD) is a multifactorial complicated condition, reflected by... more Non-alcoholic fatty liver disease (NAFLD) is a multifactorial complicated condition, reflected by the accumulation of extra fat in the liver. A detailed study of literature throws light on the fascinating connection between gut dysbiosis and NAFLD. The term ‘gut dysbiosis’ describes an imbalance in the harmony and operation of the gut microflora, which can upshoot a number of metabolic disorders. To recognize the underlying mechanisms and determine treatment options, it is essential to comprehend the connection between gut dysbiosis and NAFLD. This in-depth review discusses the normal gut microflora composition and its role in health, alterations in the gut microflora composition that leads to disease state focusing on NAFLD. The potential mechanisms influencing the advent and aggravation of NAFLD suggested disturbance of microbial metabolites, changes in gut barrier integrity, and imbalances in the composition of the gut microflora. Furthermore, it was discovered that gut dysbiosis...

Archives of Pharmacy Practice, 2023

Asian Journal of Pharmaceutical and Clinical Research, Dec 25, 2021

Over the past era, development of small heterocycles as potential therapeutics has been a zone of... more Over the past era, development of small heterocycles as potential therapeutics has been a zone of major interest. A large number of pyrimidine derivatives are of considerable biological and chemical interest. Pyrimidine derivatives have shown numerous biological activities such as antimicrobial, antitubercular, anticancer, anticonvulsant, antidiabetic, antiviral, and anti-inflammatory. Being a heterocyclic compound, Pyrimidine finds its use for designing synthesis of newer biologically active structures, as its aromaticity makes it relatively stable, also reactive sites which allow for functionalization. Several amino derivatives of nitrogen-containing heterocycles such as pyrimidine, pyridine possess an antimicrobial activity. In this review, recent advancements in the antimicrobial activity of pyrimidine derivatives have been reported.

Journal of Research in Pharmacy

Current Traditional Medicine

: Punica granatum L. (Punicaceae) generally identified as pomegranate, seeded or granular fruit, ... more : Punica granatum L. (Punicaceae) generally identified as pomegranate, seeded or granular fruit, has been widely used for centuries in many cultures. P. granatum exhibits a wide variety of medicinal activities, viz., anticancer, antioxidant, antimicrobial, anti-inflammatory, etc. A variety of ethnomedical uses of P. granatum in several formulations, like powder, pulp, decoction and extract on its own or in blend with additional herbs against various diseases, like inflammation, skin disorders, cancer, microbial infections, and asthma, have been recorded. A wide variety of phytochemicals, including polyphenols, terpenoids, fatty acids, sugars, amino acids, tocopherols, sterols, alkaloids, amino acids, etc., have been isolated and identified from P. granatum, amongst which punicalagin, the major polyphenolic component of pomegranate extract, has been well thought of as the main effective component of plant. Thorough information related to P. granatum was gathered using the keywords Punica granatum or pomegranate in various computerized databases, including Pubmed, ACS, Science Direct, Google Scholar, WoS, Springer Link, Sci Finder, and Wiley. All full-text articles and abstracts were reviewed. Additionally, book chapters and monographs were also screened. The current study has highlighted the botany, ethnopharmacology, phytochemical profile, pharmacological activity, and toxicological studies of P. granatum. The ethnopharmacological importance of pomegranate has been discussed in recent pharmacological studies, indicating its medicinal and nutritional benefits in varied human disorders. Moreover, inquiries related to various facets of P. granatum relating to safety, toxicity and quality control are yet unanswered. Additionally, the article has provided a thorough knowledge of the herb, including its mechanism of action, structure activity relationships, safety as well as toxicity, as reported in clinical studies.

Archives of Pharmacy Practice

Logical strategy is the heart of drug investigation. The current work endeavored to foster precis... more Logical strategy is the heart of drug investigation. The current work endeavored to foster precise, straightforward, and delicate techniques for concurrent assessment of rabeprazole and levosulpiride. The overlay range of levosulpiride and rabeprazole display λmax of 288 nm and 282 nm for LEVO and RABE. Standard adjustment bends for levosulpiride and rabeprazole were straight with connection coefficient (r) values in the scope of 0.9998-0.9997 at all chosen frequencies. The precision of the technique was affirmed by recuperation contemplated from the tablet at three distinct degrees of 80%, 100 percent, and 120% recuperation in the scope of 99.97-100 percent legitimizes the exactness of the strategy. Intraday and Interday accuracy was checked for UV strategy, and % RSD was viewed as under 2 for UV technique. The created strategy is a fast device for routine examination of rabeprazole and levosulpiride in the mass and the drug dose structure. Considering the possible general improvement of phony medication portions, the proposed strategy could be important for the quality control research offices in developing countries.

Asian Journal of Pharmaceutical and Clinical Research, 2021