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Papers by Mubina Lakhani

Journal of Rawalpindi Medical College

Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Vol... more Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Volume of Benign Prostatic Hyperplasia patients. Study Design: A Cross- out sectional study was done. Qualitative variables measured by Chi square test and quantitative by ANOVA. Pearson correlation & multinominal regression were applied. P value considered significant at <0.05. It was conducted in a tertiary care hospital, Ziauddin University Hospital Karachi. Methodology: The data was collected from 103 Benign prostatic hyperplasia patients. Prostate Volume of BPH patient were recorded by transabdominal ultrasonography in Radiology department. Severity of symptoms were assessed by IPSS questionnaire. Result: Mean IPSS was found out to be ±13.7. Clinical presentation showed hesitancy & nocturia as most frequently occurring symptoms in benign prostatic hyperplasia patient, these symptoms were found to be statistically significant with prostatic volume. Conclusion: IPSS strongly correlate...

Journal of Rawalpindi Medical College

Objective: To find out the frequency of protrusion of Internal Carotid artery in sphenoid sinus a... more Objective: To find out the frequency of protrusion of Internal Carotid artery in sphenoid sinus and dehiscence of carotid canal in a subset of Karachi population. Study design: This was a Cross-sectional study conducted at Radiology department of Ziauddin university. Methodology: We analyzed 270 head and neck CT scans 270 Head and neck CT scans (540 sides) were analyzed. CT was performed on a 16 slice Toshiba Alexion at Ziauddin Hospital, Karachi —removed for blind review---. SPSS version 20 was used for data analysis. Results: Out of 270 CT scans analyzed, 28 (10.3) scans showed protrusion of ICA in sphenoid sinus. Out of 45 (16.6) of the subjects showed dehiscence of carotid canal. Out of total dehiscence present unilateral cases were more frequent as compared to bilateral. Unilateral protrusion was also more common as compared to bilateral protrusion of ICA. Conclusion: Knowledge of dehiscence and protrusion related to ICA and sphenoid sinus anatomy is essential to avoid com...

Life and Science

Objective: To determine the protective effect of aqueous Neem leaf extract-induced hepatotoxicity... more Objective: To determine the protective effect of aqueous Neem leaf extract-induced hepatotoxicity by Erythromycin.Study Design: Laboratory-based Experimental study.Place and Duration of Study: The study was conducted at the Department of Anatomy and Animal House of Baqai Medical University (BMU) Karachi, Pakistan from January 2019 to March 2019.Materials and Methods: A total of 80 albino Wistar male rats were randomly divided into 4 groups. Control group, marked as Group A with no interventions. Only Erythromycin was administered to the rats in group B. Erythromycin and an aqueous extract of neemleaves were administered to group C rats. Group D only received an extract of aqueous neemleaves. Animals' body weight was noted both before and after experiments. Liver weight was also measured after 14 days when the animals were sacrificed.Results: Histopathological changes in group B include loss of architecture, portal vein observed with congestion, and hemorrhages. In Group C, histo...

Journal of Bahria University Medical and Dental College

Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Sco... more Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Score in BPH patients and healthy adults in a subset of Karachi Population. Study Design and Setting: This is a crossectional study carried out at Ziauddin Hospital, Karachi over a period of 6 months. Methodology: In this study 100 Samples were taken through non probability convenience sampling. Inclusion criteria includes 40years and above. Sample initially was taken on the basis of International Prostatic Symptom Score i.e., less than 8 and greater than 8 score. Ultrasonography was performed. 65 Individuals with International Prostatic Symptom Score > 8 and Prostate volume <25 and individuals having symptom index < 8 and Prostate volume > 25ml went for Uroflowmetry. Mean and standard deviation was taken out for quantitative variables. Univariate analysis and Multiple Linear Regression applied to assess relationship between Uroflowmetry with Prostate volume and International Pr...

Pakistan Journal of Medical and Health Sciences, 2022

Aims: To assess the association of BMD (bone mineral density) with ethnicity and parity in female... more Aims: To assess the association of BMD (bone mineral density) with ethnicity and parity in females of Karachi, Pakistan. Study design: Cross Sectional. Place and duration of study: Department of Anatomy & Nuclear Medicine, Ziauddin Hospital, Clifton Campus, Karachi, Pakistan between March and August 2016. Methods: 200 females aged 40 years and above were included. Average age was 60.7 years (±10.52). BMD assessment was done on DXA scans. Participants were interviewed to obtain baseline demographic characteristics. Statistical Package for Social Sciences (SPSS) version 20 was used to analyze data. Results: No significant association was found between BMD and the different ethnicities or parity in our study population. Conclusion: Bone mineral density is not affected by the number of pregnancies or ethnicity. Keywords: bone mineral density, ethnicity, parity, Karachi.

Journal of Rawalpindi Medical College

Objective: Keros classification based assessment of olfactory fossa depth in different age groups... more Objective: Keros classification based assessment of olfactory fossa depth in different age groups of both genders using computerized tomography (CT) Methodology: Cross sectional study done at Ziauddin university, Clifton, Karachi. Sample size was 270 adults including 160 males & 110 females. The assessment of depth of Olfactory fossa was carried out by measuring the height of lateral lamella of cribriform plate on CT images. Result: Olfactory fossa of 270 patients from both sides of both genders were classified according to Keros classification. We found Type II to be the most frequent on both sides in both genders. No significant difference in olfactory fossa depth was found when compared in different age groups. Conclusion: The present study shows that vast majority of the population comes under Keros type II & type III thus emphasizing the need of pre-operative radiological assessment. Association of right & left olfactory fossa depth in different age groups was found to be insig...

Pakistan Journal of Medical and Health Sciences

Objective: In kidney morphological changes in size are manifested by renal pathologies and are of... more Objective: In kidney morphological changes in size are manifested by renal pathologies and are of great significance in clinical assessment of patients with kidney diseases. Therefore of the objective of this study is to report normative data of renal dimension and its correlation with renal function. Design of the study: It was a cross sectional study Place of study: This study was conducted in a tertiary care hospital, Dr. Ziauddin University Hospital, Karachi from January, 2017 to June, 2017. Material and Methods: Total 250 individuals were included in the study. The participants were recruited through convenient sampling, from Ziauddin University. Study participants were 21 to 60 years of age, who were referred to Radiology department for abdominal contrast CT.All kidney dimensions including kidney length, kidney width and anteroposterior diameter were taken by using 16-slice Multidector computed tomography MDCT scanner. Serum creatinine of study participants was used to calcula...

Pakistan Journal of Medical and Health Sciences

Objective: To determine the diameter of abdominal aorta at T12 vertebral level by the use of Mult... more Objective: To determine the diameter of abdominal aorta at T12 vertebral level by the use of Multidetector Computer Tomography Angiography (MDCTA). Study Design: It is a Cross-sectional study. Place and Duration of Study: This study was executed in Ziauddin University (Hospital) Clifton campus Karachi, at Radiology Department, from March 2017 to August 2017. Materials and Methods: Total 160 individuals were enrolled, 75 (46.9%) were females and 85 (53.1%) were males who do not have any abdominal and arterial or venous problems, approach to Radiology Department, for Abdominal 3D Computed Tomography Angiography. Patients who were enrolled in current study were referred to department of Radiology for different indications like adrenal and renal pathologies altered bowel habits and abdominal aches. In current study abdominal aortic dimension (diameter) was analyzed at T12 vertebral levels in both sexes. The SPSS version used in current study was 20 for statistical analysis. Pearson corr...

International Journal of Medical Research and Health Sciences, 2017

With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have th... more With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have thorough knowledge of anatomy of paranasal sinus (PNS). Regarding this, sphenoid sinuses are the most variable among paranasal sinuses. the anatomical relationship of crucial neurovascular structures for example internal carotid artery (ICA) and optic nerve (ON) is extremely variable and these structures are at a risk during ESS. This article will help readers understand the relationship of neurovascular structures with sphenoid sinus (SS) more precisely.

Objective: To assess the variations in the course of optic nerve (ON) in relation to sphenoid sin... more Objective: To assess the variations in the course of optic nerve (ON) in relation to sphenoid sinus with the help of CT scan. Methodology: A cross-sectional study was carried out using computed tomographic (CT) paranasal sinus scans of two hundred and seventy study participants between January 2017 and May 2017. Non-probability consecutive sampling technique was used and data was entered on SPSS version 23. Inclusion criteria comprised of adults coming for CT head and brain who did not have bony abnormality of sphenoid and ethmoid sinuses or adjacent structures. However, individuals with sinonasal tumors, chronic rhinosinusitis, prior sinus surgery, facial fracture, nasal polyposis and congenital craniofacial anomaly were excluded from this study. Analysis of optic nerve was carried out according to DeLano's classification. Results: Type 1 ON was found to be the most frequent type; 55.93%, followed by type 2 with a frequency of 26.85%. However, type 3 and type 4 appeared less fr...

Journal of Bahria University Medical and Dental College, 2020

Objective: To evaluate the immunohistochemical expression and scoring of HER2/neu in different va... more Objective: To evaluate the immunohistochemical expression and scoring of HER2/neu in different variants of adenocarcinoma of prostate and to compared the association of HER2/neu expression with biological behavior and risk factors of prostate adenocarcinoma. Study Design and Setting: Cross sectional study in which all clinically suspected prostate adenocarcinoma cases received at the laboratory Saddar Karachi during the years 2015 and 2016 were evaluated for morphological features of adenocarcinoma. Methodology: This cross sectional study was carried out using prostate biopsies of clinically suspected prostate adenocarcinoma. The diagnosis of adenocarcinoma was confirmed and histological characterization was done by evaluating the morphological features. The tumors were graded according to the revised 2015 Gleason’s grouping. Immunohistochemical analysis for HER2/neu expression was performed in the most representative tumor block. SPSS version 22 was used for data analysis. Mean fre...

Journal of Bahria University Medical and Dental College, Jun 5, 2017

Journal of Rawalpindi Medical College

Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Vol... more Objective: To evaluate the correlation of International Prostatic Symptom Score with Prostate Volume of Benign Prostatic Hyperplasia patients. Study Design: A Cross- out sectional study was done. Qualitative variables measured by Chi square test and quantitative by ANOVA. Pearson correlation & multinominal regression were applied. P value considered significant at <0.05. It was conducted in a tertiary care hospital, Ziauddin University Hospital Karachi. Methodology: The data was collected from 103 Benign prostatic hyperplasia patients. Prostate Volume of BPH patient were recorded by transabdominal ultrasonography in Radiology department. Severity of symptoms were assessed by IPSS questionnaire. Result: Mean IPSS was found out to be ±13.7. Clinical presentation showed hesitancy & nocturia as most frequently occurring symptoms in benign prostatic hyperplasia patient, these symptoms were found to be statistically significant with prostatic volume. Conclusion: IPSS strongly correlate...

Journal of Rawalpindi Medical College

Objective: To find out the frequency of protrusion of Internal Carotid artery in sphenoid sinus a... more Objective: To find out the frequency of protrusion of Internal Carotid artery in sphenoid sinus and dehiscence of carotid canal in a subset of Karachi population. Study design: This was a Cross-sectional study conducted at Radiology department of Ziauddin university. Methodology: We analyzed 270 head and neck CT scans 270 Head and neck CT scans (540 sides) were analyzed. CT was performed on a 16 slice Toshiba Alexion at Ziauddin Hospital, Karachi —removed for blind review---. SPSS version 20 was used for data analysis. Results: Out of 270 CT scans analyzed, 28 (10.3) scans showed protrusion of ICA in sphenoid sinus. Out of 45 (16.6) of the subjects showed dehiscence of carotid canal. Out of total dehiscence present unilateral cases were more frequent as compared to bilateral. Unilateral protrusion was also more common as compared to bilateral protrusion of ICA. Conclusion: Knowledge of dehiscence and protrusion related to ICA and sphenoid sinus anatomy is essential to avoid com...

Life and Science

Objective: To determine the protective effect of aqueous Neem leaf extract-induced hepatotoxicity... more Objective: To determine the protective effect of aqueous Neem leaf extract-induced hepatotoxicity by Erythromycin.Study Design: Laboratory-based Experimental study.Place and Duration of Study: The study was conducted at the Department of Anatomy and Animal House of Baqai Medical University (BMU) Karachi, Pakistan from January 2019 to March 2019.Materials and Methods: A total of 80 albino Wistar male rats were randomly divided into 4 groups. Control group, marked as Group A with no interventions. Only Erythromycin was administered to the rats in group B. Erythromycin and an aqueous extract of neemleaves were administered to group C rats. Group D only received an extract of aqueous neemleaves. Animals' body weight was noted both before and after experiments. Liver weight was also measured after 14 days when the animals were sacrificed.Results: Histopathological changes in group B include loss of architecture, portal vein observed with congestion, and hemorrhages. In Group C, histo...

Journal of Bahria University Medical and Dental College

Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Sco... more Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Score in BPH patients and healthy adults in a subset of Karachi Population. Study Design and Setting: This is a crossectional study carried out at Ziauddin Hospital, Karachi over a period of 6 months. Methodology: In this study 100 Samples were taken through non probability convenience sampling. Inclusion criteria includes 40years and above. Sample initially was taken on the basis of International Prostatic Symptom Score i.e., less than 8 and greater than 8 score. Ultrasonography was performed. 65 Individuals with International Prostatic Symptom Score > 8 and Prostate volume <25 and individuals having symptom index < 8 and Prostate volume > 25ml went for Uroflowmetry. Mean and standard deviation was taken out for quantitative variables. Univariate analysis and Multiple Linear Regression applied to assess relationship between Uroflowmetry with Prostate volume and International Pr...

Pakistan Journal of Medical and Health Sciences, 2022

Aims: To assess the association of BMD (bone mineral density) with ethnicity and parity in female... more Aims: To assess the association of BMD (bone mineral density) with ethnicity and parity in females of Karachi, Pakistan. Study design: Cross Sectional. Place and duration of study: Department of Anatomy & Nuclear Medicine, Ziauddin Hospital, Clifton Campus, Karachi, Pakistan between March and August 2016. Methods: 200 females aged 40 years and above were included. Average age was 60.7 years (±10.52). BMD assessment was done on DXA scans. Participants were interviewed to obtain baseline demographic characteristics. Statistical Package for Social Sciences (SPSS) version 20 was used to analyze data. Results: No significant association was found between BMD and the different ethnicities or parity in our study population. Conclusion: Bone mineral density is not affected by the number of pregnancies or ethnicity. Keywords: bone mineral density, ethnicity, parity, Karachi.

Journal of Rawalpindi Medical College

Objective: Keros classification based assessment of olfactory fossa depth in different age groups... more Objective: Keros classification based assessment of olfactory fossa depth in different age groups of both genders using computerized tomography (CT) Methodology: Cross sectional study done at Ziauddin university, Clifton, Karachi. Sample size was 270 adults including 160 males & 110 females. The assessment of depth of Olfactory fossa was carried out by measuring the height of lateral lamella of cribriform plate on CT images. Result: Olfactory fossa of 270 patients from both sides of both genders were classified according to Keros classification. We found Type II to be the most frequent on both sides in both genders. No significant difference in olfactory fossa depth was found when compared in different age groups. Conclusion: The present study shows that vast majority of the population comes under Keros type II & type III thus emphasizing the need of pre-operative radiological assessment. Association of right & left olfactory fossa depth in different age groups was found to be insig...

Pakistan Journal of Medical and Health Sciences

Objective: In kidney morphological changes in size are manifested by renal pathologies and are of... more Objective: In kidney morphological changes in size are manifested by renal pathologies and are of great significance in clinical assessment of patients with kidney diseases. Therefore of the objective of this study is to report normative data of renal dimension and its correlation with renal function. Design of the study: It was a cross sectional study Place of study: This study was conducted in a tertiary care hospital, Dr. Ziauddin University Hospital, Karachi from January, 2017 to June, 2017. Material and Methods: Total 250 individuals were included in the study. The participants were recruited through convenient sampling, from Ziauddin University. Study participants were 21 to 60 years of age, who were referred to Radiology department for abdominal contrast CT.All kidney dimensions including kidney length, kidney width and anteroposterior diameter were taken by using 16-slice Multidector computed tomography MDCT scanner. Serum creatinine of study participants was used to calcula...

Pakistan Journal of Medical and Health Sciences

Objective: To determine the diameter of abdominal aorta at T12 vertebral level by the use of Mult... more Objective: To determine the diameter of abdominal aorta at T12 vertebral level by the use of Multidetector Computer Tomography Angiography (MDCTA). Study Design: It is a Cross-sectional study. Place and Duration of Study: This study was executed in Ziauddin University (Hospital) Clifton campus Karachi, at Radiology Department, from March 2017 to August 2017. Materials and Methods: Total 160 individuals were enrolled, 75 (46.9%) were females and 85 (53.1%) were males who do not have any abdominal and arterial or venous problems, approach to Radiology Department, for Abdominal 3D Computed Tomography Angiography. Patients who were enrolled in current study were referred to department of Radiology for different indications like adrenal and renal pathologies altered bowel habits and abdominal aches. In current study abdominal aortic dimension (diameter) was analyzed at T12 vertebral levels in both sexes. The SPSS version used in current study was 20 for statistical analysis. Pearson corr...

International Journal of Medical Research and Health Sciences, 2017

With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have th... more With advances in endoscopic sinus surgery (ESS), radiologist and otolaryngologists should have thorough knowledge of anatomy of paranasal sinus (PNS). Regarding this, sphenoid sinuses are the most variable among paranasal sinuses. the anatomical relationship of crucial neurovascular structures for example internal carotid artery (ICA) and optic nerve (ON) is extremely variable and these structures are at a risk during ESS. This article will help readers understand the relationship of neurovascular structures with sphenoid sinus (SS) more precisely.

Objective: To assess the variations in the course of optic nerve (ON) in relation to sphenoid sin... more Objective: To assess the variations in the course of optic nerve (ON) in relation to sphenoid sinus with the help of CT scan. Methodology: A cross-sectional study was carried out using computed tomographic (CT) paranasal sinus scans of two hundred and seventy study participants between January 2017 and May 2017. Non-probability consecutive sampling technique was used and data was entered on SPSS version 23. Inclusion criteria comprised of adults coming for CT head and brain who did not have bony abnormality of sphenoid and ethmoid sinuses or adjacent structures. However, individuals with sinonasal tumors, chronic rhinosinusitis, prior sinus surgery, facial fracture, nasal polyposis and congenital craniofacial anomaly were excluded from this study. Analysis of optic nerve was carried out according to DeLano's classification. Results: Type 1 ON was found to be the most frequent type; 55.93%, followed by type 2 with a frequency of 26.85%. However, type 3 and type 4 appeared less fr...

Journal of Bahria University Medical and Dental College, 2020

Objective: To evaluate the immunohistochemical expression and scoring of HER2/neu in different va... more Objective: To evaluate the immunohistochemical expression and scoring of HER2/neu in different variants of adenocarcinoma of prostate and to compared the association of HER2/neu expression with biological behavior and risk factors of prostate adenocarcinoma. Study Design and Setting: Cross sectional study in which all clinically suspected prostate adenocarcinoma cases received at the laboratory Saddar Karachi during the years 2015 and 2016 were evaluated for morphological features of adenocarcinoma. Methodology: This cross sectional study was carried out using prostate biopsies of clinically suspected prostate adenocarcinoma. The diagnosis of adenocarcinoma was confirmed and histological characterization was done by evaluating the morphological features. The tumors were graded according to the revised 2015 Gleason’s grouping. Immunohistochemical analysis for HER2/neu expression was performed in the most representative tumor block. SPSS version 22 was used for data analysis. Mean fre...

Journal of Bahria University Medical and Dental College, Jun 5, 2017