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Papers by Muhammad Rahman

Castleman’s disease(CD) is a heterogeneous group of lymphoproliferative disorders of uncertain ca... more Castleman’s disease(CD) is a heterogeneous group of lymphoproliferative disorders of uncertain cause presenting with lymphadenopathy. It is histologically and prognostically distinct from malignant lymph-node hyperplasia. It was first
described in a group of patientswith benign localised hyperplastic lymph-nodes in 1956 by Castleman et al. We report a case of a 70 year old gentleman who was clinically suspected to have lymphoma , but later histologically confirmed to have Castleman’s disease.

Mrs. Chhayarunnessa, 50 years of age, a housewife, hailing from Khadimpara, Sylhet was admitte... more Mrs. Chhayarunnessa, 50 years of age, a housewife, hailing from Khadimpara, Sylhet was admitted in Medicine Unit-IV, Sylhet MAG Osmani Medical College Hospital on 6th February 2007. The patient gave history of episodic Raynaud’s phenomenon typically occurring on exposure to cold with three color phases; pallor – cyanosis – redness for the last one year. She also complained variable features of tingling and numbness of all the digits. She noticed gradual blackening, ulceration and gangrenous transformation of the tip of all fingers. She, then observed auto amputation of all of the digital tips. The patient also stated about skin change in the form of symmetrical thickening involving markedly the distal extremities and face. She also noticed ‘tightness’ of the skin of the hand and face. The skin change in the face was making difficult to open the mouth. She had no feature of systemic upset like dysphagia, dyspnea, palpitation, headache etc.

Cutaneous changes may indicate the presence of or herald the incipient development of internal ma... more Cutaneous changes may indicate the presence of or herald the incipient development of internal malignancies. The authors review 24 cutaneous signs, symptoms, diseases, and syndromes associated with internal malignancies. Early recognition of these cutaneous changes may allow for vigilance for, and prompt detection and management of, the underlying neoplasm.

Probiotics are receiving increasing attention in the medical field. This is partly due to the re... more Probiotics are receiving increasing attention in the medical field. This is partly due to the recognition that microbial resistance to antibiotics presents a serious world-wide problem. In addition, fast growing insight into host-microbe interactions opened new routes in the development of rational alternatives in therapy and prevention of diseases as result of the complex procaryotic-eucaryotic evolutionary symphony. Consequently, long existing aspects of probiotics came into focus, and already provide exciting prospects.

The patient was diagnosed as a case of Still’s disease. First described by Dr. George Still in 18... more The patient was diagnosed as a case of Still’s disease. First described by Dr. George Still in 1897, Still's disease is a form of juvenile rheumatoid arthritis that has systemic features as the major symptoms. A classical case of Still’s disease presented in this article. She had very high fever, joint involvement, and strong laboratory support.

Tuberous Sclerosis is a multi-system genetic disease in which there are tuber-like growths in the... more Tuberous Sclerosis is a multi-system genetic disease in which there are tuber-like growths in the brain and other major organs. It is an autosomal dominant condition, although sporadic new mutations cause two thirds of cases, and is characterised by a triad of features: skin manifestations, intellectual disability and epilepsy. A classical case of Tuberous sclerosis with stroke due to vasculitis presented in this article. He had recurrent attack of epilepsy in the background of mental retardation and dermatologic manifestations.

Many patients in our setting present with features of Irritable Bowel Syndrome and among those wh... more Many patients in our setting present with features of Irritable Bowel Syndrome and among those who reports with chronic diarrhea may remain under evaluated. In the background of clinical condition like Bile acid diarrhea, we should review our diagnosis although confirmatory test is not readily available.

Background: Association between Cag A + H. pylori and gastric cancer was reported in several stud... more Background: Association between Cag A + H. pylori and gastric cancer was reported in several studies in different countries. If supported by large multicenter studies, this could form the basis for the development of new therapies directed at the mucous layer to eradicate H.pylori and thus reduce the risk of gastric cancer. Aims and Objectives: To find out the association of the Cag A+ H. pylori infection and gastric carcinoma. Materials and Method: This cross sectional comparative study was conducted in . Total number of forty confirmed cases with carcinoma stomach and another forty patients with apparently normal stomach i.e. control group were included according to inclusion and exclusion criteria. Then, Cag A status was ascertained in both case & control group by ELISA method. Result: 40 patients of case group [31 male, 9 female; mean age, 53.9 ± 10.8 years] and 40 patients of control group [25 male, 15 female; mean age, 50.7 ± 9.6 years] were similar in age and sex (p<0.05 each). Cag A+ H. pylori infection was 1.8 times higher (non-significant) in case group than that of control group [37 (92.5%) vs 35 (87.5%); OR=1.762 (95% of CI=0.392-7.929); p=0.456]. Conclusion: In conclusion, no significant difference between case & control in relation to Cag A status was found. Hypothesis of this study is not proved. There are several factors other than Cag A positivity in H.pylori infection in the causation of gastric carcinoma. Future research should be directed to find out the association of these hidden agents and gastric cancer.

Marfan’s syndrome is the commonest inherited degenerative connective tissue multi system disorder... more Marfan’s syndrome is the commonest inherited degenerative connective tissue multi system disorder of extracellular matrix that affects the musculoskeletal, cardiac, ocular,integumentary, respiratory and nervous system. A classical case of Marfan’s syndrome is presented in this article. She had cardiac, skeletal and ophthalmologic features.