Muhammad Sirajuddin - Academia.edu (original) (raw)
Papers by Muhammad Sirajuddin
Russian Journal of General Chemistry, 2017
Journal of the chemical society of pakistan
Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer,... more Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (1H and 13C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L22SnMe2 was found with maximum antibacterial activity among the screened compounds. Compounds L12SnMe2 and L12SnPh2 were found with remarkable antifungal activity. Similarly L1, L12SnBu2, L2 and L22SnMe3 were remarked with good antioxidant activity.
Iffat Aziz, Muhammad Sirajuddin*, Muhammad Haleem Khan, Shafqat Nadeem, Syed Ahmad Tirmizi**, Raf... more Iffat Aziz, Muhammad Sirajuddin*, Muhammad Haleem Khan, Shafqat Nadeem, Syed Ahmad Tirmizi**, Rafaqat Ali Khan Department of Chemistry, Quaid-i-Azam University 45320, Islamabad, Pakistan. Department of Chemistry, University of Science and Technology, Bannu, Pakistan. Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad. Department of Chemistry, University of Science and Technology, Abbottabad, 22060, Pakistan. m.siraj09@yahoo.com*, satirmizi_qau@yahooo.com**
Journal of the Chemical Society of Pakistan, 2016
Journal of the Iranian Chemical Society, 2021
Six new Zn(II) carboxylates derived from 2-(3-chlorophenyl) acetic acid, 2-(2-chlorophenyl) aceti... more Six new Zn(II) carboxylates derived from 2-(3-chlorophenyl) acetic acid, 2-(2-chlorophenyl) acetic acid and 2-(2-methoxy phenyl) acetic acid were synthesized and characterized by FTIR, multinuclear NMR ( 1 H and 13 C NMR) and single-crystal XRD. The geometry around the Zn atom in complexes 1 and 2 is distorted tetrahedral and distorted trigonal bipyramidal, respectively. The compounds were assessed for DNA interaction using UV–visible spectroscopy and viscosity measurements approving a partial intercalation mode of interaction. The interaction of compounds with CTAB was carried out by conductometric method showing a strong interaction with CTAB, which is noticeable from relatively higher CMC and negative Gibbs free energy of micellization. The IC 50 values of the synthesized compounds were highly efficient in contrast to the standard Glucantime. The activity represents a higher multitude interaction that might be a cause of enhanced antileishmanial activity. The results of cytotoxic...
Applied Organometallic Chemistry
Here we have presented the synthesis of three novel triorganotin(IV) complexes: trimethylstannyl ... more Here we have presented the synthesis of three novel triorganotin(IV) complexes: trimethylstannyl 4-(3-chloro-2-methylphenylamino)-4- oxobut-2-enoate (1); tributylstannyl 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoate (2) and triphenylstannyl 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoate (3). The ligand and its three complexes were spectroscopically characterized by NMR (1H and 13C) in solution and by FT-IR in solid state. Complexes 1 and 2 were further characterized by single crystal X-ray diffraction analysis. The X-ray crystallographic data reveal that complexes 1 and 2 both are structurally trialkytin analogs with distorted trigonal bipyramidal geometry. The geometry around tin atom is constituted by three alkyl groups (methyl in complex 1 and butyl in complex 2) occupying the equatorial positions and two oxygen atoms of 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoic acid ligand occupying the axial positions. The computational study was performed applying LANL2DZ (Los Alamos National Laboratory 2 Double-Zeta) functional with B3LYP (Lee, Yang and Parr ) level of theory to obtain the optimized geometry, spectroscopic analysis, frontier molecular orbitals as well as global and local reactivity. A good correlation was found between the experimental and computational results. The homogeneous catalytic performance of synthesized compounds was evaluated for the transesterification of corn oil with methanol into biodiesel. The obtained corn oil biodiesel (COB) was confirmed by FT-IR, 1H NMR and GC-MS. The catalytic results revealed that the complexes were active at optimized conditions and therefore can be potential candidates for the development of new catalytic system for biodiesel production.
Journal Chemical Society of Pakistan, 2013
ABSTRACT Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to syn... more ABSTRACT Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to synthesize biomacromolecules with antimicrobial properties. The covalent linkage of the antibiotic was performed by a radical process involving the residues in the side chains of gelatin able to undergo oxidative modifications. The conjugation of antibiotic moieties onto the protein structure was confirmed by FT-IR, UV-Vis, fluorescence, and calorimetric analyses. Biocompatibility tests were performed on human bone marrow mesenchymal stromal cells and the antibacterial properties of bioactive polymers were investigated by appropriate tests against Klebsiella pneumoniae and Escherichia coli. With regard to the tests conducted in the presence of E. coli, a minimum inhibitory concentration (MIC) ranging from 0.05 to 0.40 μg mL(-1) was recorded, while in the presence of K. pneumoniae this concentration varies from 0.10 to 1.60 μg mL(-1). In all the conjugates, the drug moieties retain their biological activity and the MIC values are lower than the resistance parameters of fluoroquinolon-type antibiotics versus Enterobacteriacae. The collected data suggest a broad range of applications, from biomedical to pharmaceutical and food science for all conjugates.
Alexandria Journal of Medicine, 2015
![Research paper thumbnail of 4-[(4-Chlorophenyl)carbamoyl]butanoic Acid](https://attachments.academia-assets.com/79452236/thumbnails/1.jpg)
](The X-ray crystal structure determination of the glutaric acid-amide derivative, 4-ClC6H4N(H)C(=O... more The X-ray crystal structure determination of the glutaric acid-amide derivative, 4-ClC6H4N(H)C(=O)(CH2)3C(=O)OH (1), is described. The backbone of the molecule adopts an extended, all-trans configuration but the terminal carboxylic acid and phenyl resides are twisted out of the plane through the bridging atoms, as seen in the torsion angles of O(carboxylic acid)–C(m)–C(m)–C(m) [13.9(5)°] and C(m)–N–C(p)–C(p) [47.1(4)°]; m = methylene and p = phenyl. The most striking feature of the molecular packing is the formation of supramolecular tapes mediated by carboxylic acid-O–H⋯O(carbonyl) and amide-N–H⋯O(amide) hydrogen bonding.
Journal of the chemical society of pakistan
The manuscript describes the binding of DNA as well as biological studies of some mixed ligand di... more The manuscript describes the binding of DNA as well as biological studies of some mixed ligand dithiocarbamate Palladium (II) complexes (1-5). The observed compounds are of general formulae [PdCl(DT)(PR3)]. The dithiocarbamate “DT” and “PR3” groups are varied among the studied complexes as DT = bis[(2-methoxyethyl) dithiocarbamate)] (1 and 2), dibutyl dithiocarbamate (4 and 5), bis[(2-ethyl) hexyl dithiocarbamate)] (3); PR3 = triphenyl phosphine (1), benzy diphenyl phosphine (2), diphenyl-tert-butyl phpsphine (3), diphenyl-p-tolyl phosphine (4) and diphenyl-2-methoxy phenyl phosphine (5). The synthesized complexes were screened for DNA binding study via (UV Visible spectrophotometry and Viscometery) and biological activities such as anti-bacterial and anti-fungal, Molinspiration calculations and antioxidant potencies stimulated by hydrogen peroxide in human blood lymphocytes. In case of drug DNA interaction, complexes showed some sort of interaction with DNA solution. Almost all the...
Journal of Molecular Structure
![Research paper thumbnail of Crystal structure of 4-[(3-methoxyphenyl)carbamoyl]butanoic acid, C12H15NO4](https://attachments.academia-assets.com/74661190/thumbnails/1.jpg)
](Zeitschrift für Kristallographie - New Crystal Structures
C12H15NO4, triclinic, P1̄ (no. 2), a = 5.0167(2) Å, b = 7.9264(5) Å, c = 15.2073(7) Å, α = 98.909... more C12H15NO4, triclinic, P1̄ (no. 2), a = 5.0167(2) Å, b = 7.9264(5) Å, c = 15.2073(7) Å, α = 98.909(4)°, β = 92.060(4)°, γ = 101.800(4)°, V = 583.36(5) Å3, Z = 2, Rgt(F) = 0.0403, wRref(F2) = 0.1179, T = 293(2) K.
![Research paper thumbnail of Crystal structure of 4-[(2-methoxyphenyl)carbamoyl]butanoic acid, C12H15NO4](https://attachments.academia-assets.com/74661189/thumbnails/1.jpg)
](Zeitschrift für Kristallographie - New Crystal Structures
C12H15NO4, triclinic, P1̄ (no. 2), a = 7.4325(3) Å, b = 7.5171(3) Å, c = 23.7377(9) Å, α = 87.780... more C12H15NO4, triclinic, P1̄ (no. 2), a = 7.4325(3) Å, b = 7.5171(3) Å, c = 23.7377(9) Å, α = 87.780(3)°, β = 89.105(3)°, γ = 61.299(4)°, V = 1162.42(9) Å3, Z = 4, Rgt(F) = 0.0566, wRref(F2) = 0.1652, T = 100(2) K.
![Research paper thumbnail of Crystal structure of 4-[(3,5-dichlorophenyl)carbamoyl]butanoic acid, C11H11Cl2NO3](https://attachments.academia-assets.com/74661191/thumbnails/1.jpg)
](Zeitschrift für Kristallographie - New Crystal Structures
C11H11Cl2NO3, monoclinic, P21/c (no. 14), a = 17.2336(3) Å, b = 4.9604(1) Å, c = 14.3696(3) Å, β ... more C11H11Cl2NO3, monoclinic, P21/c (no. 14), a = 17.2336(3) Å, b = 4.9604(1) Å, c = 14.3696(3) Å, β = 100.970(2)°, V = 1205.95(4) Å3, Z = 4, Rgt(F) = 0.0313, wRref(F2) = 0.0848, T = 293(2) K.
![Research paper thumbnail of Crystal structure of 4-[(4-methoxy-2-nitrophenyl)carbamoyl]butanoic acid, C12H14N2O6](https://attachments.academia-assets.com/74661188/thumbnails/1.jpg)
](Zeitschrift für Kristallographie - New Crystal Structures
C12H14N2O6, triclinic, P1̄ (no. 2), a = 4.8835(4) Å, b = 9.2111(7) Å, c = 14.6655(7) Å, α = 76.13... more C12H14N2O6, triclinic, P1̄ (no. 2), a = 4.8835(4) Å, b = 9.2111(7) Å, c = 14.6655(7) Å, α = 76.135(5)°, β = 82.693(6)°, γ = 87.379(7)°, V = 635.19(8) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1297, T = 293(1) K.
Journal of Coordination Chemistry
Journal of Biomolecular Structure and Dynamics
Journal of Molecular Structure
Journal of Alloys and Compounds
Russian Journal of General Chemistry, 2017
Journal of the chemical society of pakistan
Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer,... more Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents. Cis-platin (cytotoxic agent) has diverted attention of chemists towards organotin complexes with marked pharmacological activities. In present work aniline derivatives of Betulinic acid were synthesized followed by the synthesis of diorganotin and triorganotin metal complexes. These complexes were characterized by FT-IR and multinuclear NMR (1H and 13C) spectroscopy. The ligands and their organotin(IV) complexes were screened for antibacterial, antifungal and antioxidant activities. Compound L22SnMe2 was found with maximum antibacterial activity among the screened compounds. Compounds L12SnMe2 and L12SnPh2 were found with remarkable antifungal activity. Similarly L1, L12SnBu2, L2 and L22SnMe3 were remarked with good antioxidant activity.
Iffat Aziz, Muhammad Sirajuddin*, Muhammad Haleem Khan, Shafqat Nadeem, Syed Ahmad Tirmizi**, Raf... more Iffat Aziz, Muhammad Sirajuddin*, Muhammad Haleem Khan, Shafqat Nadeem, Syed Ahmad Tirmizi**, Rafaqat Ali Khan Department of Chemistry, Quaid-i-Azam University 45320, Islamabad, Pakistan. Department of Chemistry, University of Science and Technology, Bannu, Pakistan. Department of Chemistry, University of Azad Jammu and Kashmir, Muzaffarabad. Department of Chemistry, University of Science and Technology, Abbottabad, 22060, Pakistan. m.siraj09@yahoo.com*, satirmizi_qau@yahooo.com**
Journal of the Chemical Society of Pakistan, 2016
Journal of the Iranian Chemical Society, 2021
Six new Zn(II) carboxylates derived from 2-(3-chlorophenyl) acetic acid, 2-(2-chlorophenyl) aceti... more Six new Zn(II) carboxylates derived from 2-(3-chlorophenyl) acetic acid, 2-(2-chlorophenyl) acetic acid and 2-(2-methoxy phenyl) acetic acid were synthesized and characterized by FTIR, multinuclear NMR ( 1 H and 13 C NMR) and single-crystal XRD. The geometry around the Zn atom in complexes 1 and 2 is distorted tetrahedral and distorted trigonal bipyramidal, respectively. The compounds were assessed for DNA interaction using UV–visible spectroscopy and viscosity measurements approving a partial intercalation mode of interaction. The interaction of compounds with CTAB was carried out by conductometric method showing a strong interaction with CTAB, which is noticeable from relatively higher CMC and negative Gibbs free energy of micellization. The IC 50 values of the synthesized compounds were highly efficient in contrast to the standard Glucantime. The activity represents a higher multitude interaction that might be a cause of enhanced antileishmanial activity. The results of cytotoxic...
Applied Organometallic Chemistry
Here we have presented the synthesis of three novel triorganotin(IV) complexes: trimethylstannyl ... more Here we have presented the synthesis of three novel triorganotin(IV) complexes: trimethylstannyl 4-(3-chloro-2-methylphenylamino)-4- oxobut-2-enoate (1); tributylstannyl 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoate (2) and triphenylstannyl 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoate (3). The ligand and its three complexes were spectroscopically characterized by NMR (1H and 13C) in solution and by FT-IR in solid state. Complexes 1 and 2 were further characterized by single crystal X-ray diffraction analysis. The X-ray crystallographic data reveal that complexes 1 and 2 both are structurally trialkytin analogs with distorted trigonal bipyramidal geometry. The geometry around tin atom is constituted by three alkyl groups (methyl in complex 1 and butyl in complex 2) occupying the equatorial positions and two oxygen atoms of 4-(3-chloro-2-methylphenylamino)-4-oxobut-2-enoic acid ligand occupying the axial positions. The computational study was performed applying LANL2DZ (Los Alamos National Laboratory 2 Double-Zeta) functional with B3LYP (Lee, Yang and Parr ) level of theory to obtain the optimized geometry, spectroscopic analysis, frontier molecular orbitals as well as global and local reactivity. A good correlation was found between the experimental and computational results. The homogeneous catalytic performance of synthesized compounds was evaluated for the transesterification of corn oil with methanol into biodiesel. The obtained corn oil biodiesel (COB) was confirmed by FT-IR, 1H NMR and GC-MS. The catalytic results revealed that the complexes were active at optimized conditions and therefore can be potential candidates for the development of new catalytic system for biodiesel production.
Journal Chemical Society of Pakistan, 2013
ABSTRACT Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to syn... more ABSTRACT Different fluoroquinolon-type antibiotics were conjugated to gelatin with the aim to synthesize biomacromolecules with antimicrobial properties. The covalent linkage of the antibiotic was performed by a radical process involving the residues in the side chains of gelatin able to undergo oxidative modifications. The conjugation of antibiotic moieties onto the protein structure was confirmed by FT-IR, UV-Vis, fluorescence, and calorimetric analyses. Biocompatibility tests were performed on human bone marrow mesenchymal stromal cells and the antibacterial properties of bioactive polymers were investigated by appropriate tests against Klebsiella pneumoniae and Escherichia coli. With regard to the tests conducted in the presence of E. coli, a minimum inhibitory concentration (MIC) ranging from 0.05 to 0.40 μg mL(-1) was recorded, while in the presence of K. pneumoniae this concentration varies from 0.10 to 1.60 μg mL(-1). In all the conjugates, the drug moieties retain their biological activity and the MIC values are lower than the resistance parameters of fluoroquinolon-type antibiotics versus Enterobacteriacae. The collected data suggest a broad range of applications, from biomedical to pharmaceutical and food science for all conjugates.
Alexandria Journal of Medicine, 2015
The X-ray crystal structure determination of the glutaric acid-amide derivative, 4-ClC6H4N(H)C(=O... more The X-ray crystal structure determination of the glutaric acid-amide derivative, 4-ClC6H4N(H)C(=O)(CH2)3C(=O)OH (1), is described. The backbone of the molecule adopts an extended, all-trans configuration but the terminal carboxylic acid and phenyl resides are twisted out of the plane through the bridging atoms, as seen in the torsion angles of O(carboxylic acid)–C(m)–C(m)–C(m) [13.9(5)°] and C(m)–N–C(p)–C(p) [47.1(4)°]; m = methylene and p = phenyl. The most striking feature of the molecular packing is the formation of supramolecular tapes mediated by carboxylic acid-O–H⋯O(carbonyl) and amide-N–H⋯O(amide) hydrogen bonding.
Journal of the chemical society of pakistan
The manuscript describes the binding of DNA as well as biological studies of some mixed ligand di... more The manuscript describes the binding of DNA as well as biological studies of some mixed ligand dithiocarbamate Palladium (II) complexes (1-5). The observed compounds are of general formulae [PdCl(DT)(PR3)]. The dithiocarbamate “DT” and “PR3” groups are varied among the studied complexes as DT = bis[(2-methoxyethyl) dithiocarbamate)] (1 and 2), dibutyl dithiocarbamate (4 and 5), bis[(2-ethyl) hexyl dithiocarbamate)] (3); PR3 = triphenyl phosphine (1), benzy diphenyl phosphine (2), diphenyl-tert-butyl phpsphine (3), diphenyl-p-tolyl phosphine (4) and diphenyl-2-methoxy phenyl phosphine (5). The synthesized complexes were screened for DNA binding study via (UV Visible spectrophotometry and Viscometery) and biological activities such as anti-bacterial and anti-fungal, Molinspiration calculations and antioxidant potencies stimulated by hydrogen peroxide in human blood lymphocytes. In case of drug DNA interaction, complexes showed some sort of interaction with DNA solution. Almost all the...
Journal of Molecular Structure
Zeitschrift für Kristallographie - New Crystal Structures
C12H15NO4, triclinic, P1̄ (no. 2), a = 5.0167(2) Å, b = 7.9264(5) Å, c = 15.2073(7) Å, α = 98.909... more C12H15NO4, triclinic, P1̄ (no. 2), a = 5.0167(2) Å, b = 7.9264(5) Å, c = 15.2073(7) Å, α = 98.909(4)°, β = 92.060(4)°, γ = 101.800(4)°, V = 583.36(5) Å3, Z = 2, Rgt(F) = 0.0403, wRref(F2) = 0.1179, T = 293(2) K.
Zeitschrift für Kristallographie - New Crystal Structures
C12H15NO4, triclinic, P1̄ (no. 2), a = 7.4325(3) Å, b = 7.5171(3) Å, c = 23.7377(9) Å, α = 87.780... more C12H15NO4, triclinic, P1̄ (no. 2), a = 7.4325(3) Å, b = 7.5171(3) Å, c = 23.7377(9) Å, α = 87.780(3)°, β = 89.105(3)°, γ = 61.299(4)°, V = 1162.42(9) Å3, Z = 4, Rgt(F) = 0.0566, wRref(F2) = 0.1652, T = 100(2) K.
Zeitschrift für Kristallographie - New Crystal Structures
C11H11Cl2NO3, monoclinic, P21/c (no. 14), a = 17.2336(3) Å, b = 4.9604(1) Å, c = 14.3696(3) Å, β ... more C11H11Cl2NO3, monoclinic, P21/c (no. 14), a = 17.2336(3) Å, b = 4.9604(1) Å, c = 14.3696(3) Å, β = 100.970(2)°, V = 1205.95(4) Å3, Z = 4, Rgt(F) = 0.0313, wRref(F2) = 0.0848, T = 293(2) K.
Zeitschrift für Kristallographie - New Crystal Structures
C12H14N2O6, triclinic, P1̄ (no. 2), a = 4.8835(4) Å, b = 9.2111(7) Å, c = 14.6655(7) Å, α = 76.13... more C12H14N2O6, triclinic, P1̄ (no. 2), a = 4.8835(4) Å, b = 9.2111(7) Å, c = 14.6655(7) Å, α = 76.135(5)°, β = 82.693(6)°, γ = 87.379(7)°, V = 635.19(8) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1297, T = 293(1) K.
Journal of Coordination Chemistry
Journal of Biomolecular Structure and Dynamics
Journal of Molecular Structure
Journal of Alloys and Compounds