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Papers by Muhammad Wasim khan

Research paper thumbnail of Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Materials Advances, 2022

Cancer cases have reached an all-time high in the current era.

Research paper thumbnail of Progress in brain targeting drug delivery system by nasal route

Journal of Controlled Release, 2017

The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the br... more The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route. Novel DDSs such as nanoparticles (NPs), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (CNS). Complex geometry of the nasal cavity presented a big challenge to effective delivery of drugs beyond the nasal valve. Recently, pharmaceutical fir ms utilized latest and emerging nasal drug delivery technologies to overcome these barriers. This review aims to describe the latest development of brain targeted DDSs via nasal administration.

Research paper thumbnail of Engineering N-reduced graphene oxide wrapped Co3O4@f-MWCNT hybrid for enhance performance dye-sensitized solar cells

Journal of Electroanalytical Chemistry, 2019

Platinum-free and novel hybrid counter electrode is an important part of dye-sensitized solar cel... more Platinum-free and novel hybrid counter electrode is an important part of dye-sensitized solar cells (DSSCs). More and more researches reported that transitional metal oxide nanoparticles can be used as CEs in DSSCs. However, they are ready to be corroded by electrolyte, leading to a worse stability in catalytic activities for triiodide reduction in the cyclic voltammetry (CV) test. Multiwall carbon nanotubes (MWCNTs) have tangled network, exceptional specific surface area and unique hollow composition, can be higher for use as a CE material. The electrochemical performance analysis indicates that the Co3O4 nano flakes and functionalized multiwall carbon nanotubes (f-MWCNTs), wrapped with N-doped reduced graphene oxide (Co3O4@f-MWCNTs@N-RGO) electrode has lower charge transfer resistance (Rct) on the electrolyte/electrode interface and higher catalytic ability than bare Co3O4 nano flakes. Power conversion efficiency (PCE) of the prepared hybrid have been achieved up to 8.42 %, in contrast to the platinum-based counter electrode (PCE = 7.81 %) used in DSSCs. Besides, Co3O4@f-MWCNTs with N-RGO hybrid material shows strong catalytic activities for triiodide reduction, superior to Co3O4 nano flakes in the CV test.

Research paper thumbnail of Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Materials Advances, 2022

Cancer cases have reached an all-time high in the current era.

Research paper thumbnail of Progress in brain targeting drug delivery system by nasal route

Journal of Controlled Release, 2017

The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the br... more The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route. Novel DDSs such as nanoparticles (NPs), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (CNS). Complex geometry of the nasal cavity presented a big challenge to effective delivery of drugs beyond the nasal valve. Recently, pharmaceutical fir ms utilized latest and emerging nasal drug delivery technologies to overcome these barriers. This review aims to describe the latest development of brain targeted DDSs via nasal administration.

Research paper thumbnail of Engineering N-reduced graphene oxide wrapped Co3O4@f-MWCNT hybrid for enhance performance dye-sensitized solar cells

Journal of Electroanalytical Chemistry, 2019

Platinum-free and novel hybrid counter electrode is an important part of dye-sensitized solar cel... more Platinum-free and novel hybrid counter electrode is an important part of dye-sensitized solar cells (DSSCs). More and more researches reported that transitional metal oxide nanoparticles can be used as CEs in DSSCs. However, they are ready to be corroded by electrolyte, leading to a worse stability in catalytic activities for triiodide reduction in the cyclic voltammetry (CV) test. Multiwall carbon nanotubes (MWCNTs) have tangled network, exceptional specific surface area and unique hollow composition, can be higher for use as a CE material. The electrochemical performance analysis indicates that the Co3O4 nano flakes and functionalized multiwall carbon nanotubes (f-MWCNTs), wrapped with N-doped reduced graphene oxide (Co3O4@f-MWCNTs@N-RGO) electrode has lower charge transfer resistance (Rct) on the electrolyte/electrode interface and higher catalytic ability than bare Co3O4 nano flakes. Power conversion efficiency (PCE) of the prepared hybrid have been achieved up to 8.42 %, in contrast to the platinum-based counter electrode (PCE = 7.81 %) used in DSSCs. Besides, Co3O4@f-MWCNTs with N-RGO hybrid material shows strong catalytic activities for triiodide reduction, superior to Co3O4 nano flakes in the CV test.

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