Muhammet Satilmisoglu - Academia.edu (original) (raw)

Papers by Muhammet Satilmisoglu

Research paper thumbnail of Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease

Clinical Chemical Laboratory Medicine, 2008

Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetr... more Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), as well as homocysteine and cysteine thiols, in a cohort of subjects affected by retinal vein occlusion (RVO) disease. Methods: Capillary electrophoresis analysis was performed in both RVO subjects (ns54) and in a control group (ns32). Results: No differences were found between controls and patients; however, after categorisation for RVO type, central RVO (CRVO) patients showed higher levels of ADMA (0.710"0.139 mmol/L) than controls (0.635"0.117 mmol/L) and branch RVO patients (0.642"0.096 mmol/L). Moreover, cysteine plasma levels were also significantly higher in CRVO patients than in controls (265.8"46.9 vs. 226.7"51.9 mmol/L, p-0.01), while homocysteine plasma concentration was more or less identical in all groups. Conclusions: We hypothesise that the elevated levels of cysteine in CRVO patients may post-translationally inhibit dimethylarginine dimethylaminohydrolase enzyme activity, as already described for homocysteine, thus contributing to the accumulation of ADMA in this patient group.

Research paper thumbnail of Prognostic value of CHA2DS2-VASc score in patients with 'non-valvular atrial fibrillation' and valvular heart disease: the Loire Valley Atrial Fibrillation Project

European heart journal, Jan 20, 2015

The CHA2DS2VASc score is a clinical risk stratification tool which estimates the risk of stroke a... more The CHA2DS2VASc score is a clinical risk stratification tool which estimates the risk of stroke and thromboembolism in non-valvular atrial fibrillation (AF). We aimed to establish the value of this score for risk evaluation in patients with non-valvular AF and valvular heart disease. Among 8053 patients with non-valvular AF (ESC guidelines definition), patients were categorized into Group 1 (no valve disease, n = 6851; 85%) and Group 2 (valve disease with neither rheumatic mitral stenosis nor valve prothesis, n = 1202; 15%). After follow-up of 868 ± 1043 days, 627 stroke/ thromboembolic (TE) events were recorded. Group 2 was significantly older, had a higher CHA2DS2VASc score and had a higher risk of thromboembolic events [hazard ratio (HR) 1.39; 95% CI 1.14-1.69, P = 0.001] compared with Group 1. Severe valve disease was not associated with worse prognosis for stroke/TE events. In the two groups, stroke/TE risk increased with a higher CHA2DS2VASc score. Factors independently associ...

Research paper thumbnail of Hipertrofik kardiyomiyopatili hastalarda serum ürik asit seviyesi ile öngörülen beş yıllık ani kardiyak ölüm risk skoru arasındaki ilişkinin değerlendirilmesi

Research paper thumbnail of Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Dicle Tıp Dergisi, 2018

Vitamin-D status is very important for optimal function of human body especially cardiovascular s... more Vitamin-D status is very important for optimal function of human body especially cardiovascular system. The aim of this study was to investigate the long term prognostic value of admission vitamin D level in acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Methods: One hundred fifty seven consecutive patients, who were admitted to a training and research hospital with a diagnosis of STEMI and underwent PPCI, were recruited in this prospective study. The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease (CAD) was assessed with calculation of the SYNTAX score. Results: There were significant negative correlations between Vitamin-D level and SYNTAX score, serum glucose, and gender, but a positive correlation with hemoglobin level. Cardiovascular mortality was found to be significantly higher in the low vitamin-D group as compared to the high group (p<0.001). In multivariate analysis, low vitamin-D level was found as a significant independent predictor of long term cardiovascular mortality after adjusting for other risk factors. Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI. Primer perkutan girişim uygulanan akut STEMI hastalarda başvuru D vitamini düzeyinin uzun dönem prognostik değeri Öz Amaç: Vitamin-D, insan vücudunda özellikle kardiyovasküler sistemin işlevi için çok önemlidir. Bu çalışmanın amacı, primer perkütan koroner girişim (PPCI) uygulanan akut ST-segment yükselmeli miyokard infarktüsünde (STEMI), hastane başvurusu sırasındaki D vitamini düzeyinin uzun dönem prognostik değerini araştırmaktı. Yöntemler: Bu prospektif çalışmada, eğitim ve araştırma hastanesine STEMI tanısı ile başvuran ve PPCI uygulanan ardışık 157 hasta alındı. Çalışma hastaları başvuru vitamin-D düzeylerine göre 2 gruba ayrıldı: Yüksek vitamin-D grubu (n = 80) ve düşük vitamin-D grubu (n = 77). Koroner arter hastalığının şiddeti SYNTAX skoru ile hesaplandı. Bulgular: Vitamin-D düzeyi ile SYNTAX skoru, serum glikozu ve cinsiyet arasında anlamlı negatif korelasyon vardı, fakat hemoglobin düzeyi ile pozitif korelasyon vardı. Kardiyovasküler mortalite, düşük vitamin-D grubunda, yüksek gruba göre anlamlı olarak daha yüksek bulundu (p <0.001). Çok değişkenli analizde, düşük vitamin-D düzeyinin, diğer risk faktörlerini ayarladıktan sonra uzun vadede kardiyovasküler mortalitenin anlamlı bağımsız bir göstergesi olduğu bulunmuştur. Sonuç: Düşük başvuru vitamin D düzeyinin koroner arter hastalığı şiddeti ile ilişkili olduğunu gösterdik. Vitamin-D eksikliği, PPCI uygulanan akut STEMI'de uzun süreli kardiyovasküler mortalite için bağımsız bir belirleyicidir.

Research paper thumbnail of Evaluation of the association between serum uric acid level andthe predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, Mar 1, 2018

The aim of this study was to determine the relationship between serum uric acid (UA) level and th... more The aim of this study was to determine the relationship between serum uric acid (UA) level and the predicted risk score for sudden cardiac death in 5 years (the HCM Risk-SCD), galectin-3 level, and positive fragmented QRS (fQRS) on electrocardiography (ECG) in patients with hypertrophic cardiomyopathy (HCM). This was a prospective, observational study. In all, 115 consecutive patients (age >17 years) with HCM and 80 healthy participants were included in the study. The HCM Risk-SCD score (%), galectin-3 level, and fQRS on ECG were evaluated in all patients. The serum UA, galectin-3 level, UA/Creatinine ratio, incidence of ventricular tachycardia (VT) and syncope, and some echocardiographic parameters were significantly higher in the patient group than in the control group (all p<0.05). The UA value was significantly higher in patients with a high score on the HCM Risk-SCD, a positive fQRS, a high galectin-3 level, VT incidence, and need for implantable cardioverter defibrillato...

Research paper thumbnail of Association Between New Platelet Indices And Calcific Aortic Stenosis: Plateletcrit And Platelet to Lymphocyte Ratio

Van Medical Journal, 2016

Objective: Calcific aortic stenosis (AS) is the leading cause of death from valvular heart diseas... more Objective: Calcific aortic stenosis (AS) is the leading cause of death from valvular heart disease in worldwide. We aimed to evaluate the relationship between plateletcrit (PCT), platelet to lymphocyte ratio (PLR) and presence and severity of the calcific AS in the present study. Materials and Methods: A total of 98 consecutive patients diagnosed with calcific AS and 30 healthy controls were included in this retrospective study. Patients with calcific AS were divided into three groups according to severity of disease as follows: mild AS (n=35), moderate AS (n=30) and severe AS (n=33). Results: PCT and PLR were demonstrated to be significantly higher in the AS. Moreover, PCT and PLR were significantly highest in the severe AS group than in the mild and moderate AS groups. Correlation analysis indicated positive significant relationships between the PCT and maximal and mean transaortic gradients, and maximum jet velocities; but negative association with AVA. The same relations were obtained between PLR and echocardiographic parameters of severity of AS. Conclusion: PCT and PLR, which reflect elevated inflammatory status and platelet activation and aggregation, are useful, cheap, easily available and simply calculated markers that have an ability to improve risk stratification of patients with calcific AS for treatment strategies.

Research paper thumbnail of Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction

Therapeutics and Clinical Risk Management, 2017

Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary E... more Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods: A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results: Median D-dimer levels were 349.5 (48.0-7,210.0) ng/mL, the average TIMI score was 3.2±1.2 and the GRACE score was 90.4±27.6 with high GRACE scores (.118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay (r=0.215, P=0.01) and TIMI scores (r=0.504, P=0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio =18.465, 95% confidence interval: 1.059-322.084, P=0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion: Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients.

Research paper thumbnail of The Predictive Value of Admission Fragmented QRS Complex for In-Hospital Cardiovascular Mortality of Patients with Type 1 Acute Aortic Dissection

Annals of Noninvasive Electrocardiology, 2014

Background: Fragmented QRS (fQRS) arises from impaired ventricular depolarization due to heteroge... more Background: Fragmented QRS (fQRS) arises from impaired ventricular depolarization due to heterogeneous electrical activation of ischemic and/or infarcted ventricular myocardium. The shortand long-term prognostic values of fQRS have been reported for myocardial infarction, heart failure, fatal cardiac arrhythmias, and sudden cardiac death. The aim of this study was to investigate the predictive value of admission fQRS complex for in-hospital cardiovascular mortality of patients with type 1 acute aortic dissection (AAD). Methods: In this retrospective study, 203 consecutive patients with type 1 AAD who had been admitted to either of two large-volume tertiary hospitals between December 2008 and October 2013 were included. The patients were divided into two groups according to the presence or absence of the fQRS complex on admission. Results: In-hospital cardiovascular mortality (P < 0.001), major adverse cardiovascular events (P < 0.001), acute renal failure (P = 0.022), multiorgan dysfunction (P < 0.001), and acute decompensated heart failure (P < 0.001) were observed to be significantly more frequent in the fQRS-positive group than in the fQRS-negative group. fQRS (odds ratio [95% confidence interval]: 4.184 [1.927-9.082], P < 0.001), operation duration (4.184 [1.927-9.082], P = 0.001), and Killip class IV (3.900 [1.699-8.955], P = 0.001) were found to be significant independent predictors of in-hospital cardiovascular mortality after adjustment of other risk factors in the multivariate analysis. Conclusions: fQRS is a simple, inexpensive, and readily available electrocardiographic entity that provides an additional risk stratification level beyond that provided by conventional risk parameters in predicting in-hospital cardiovascular mortality in type 1 AAD. Ann Noninvasive Electrocardiol 2015;20(5):454-463 fragmented QRS; acute aortic dissection; cardiovascular mortality; electrocardiography Acute aortic dissection (AAD) still remains one of the most common causes of cardiovascular mortality and morbidity in developing countries, despite modern advances in diagnostic techniques and new approaches to treatment.

Research paper thumbnail of Assessment of the relationship between a narrow fragmented QRS complex and coronary slow flow

Cardiology journal, Jan 15, 2015

The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to t... more The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. This study included 165 consecutive patients (112 CSF,53 controls) who underwent first-time diagnostic conventional coronary angiography for suspected CAD. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Forty four patients were in the fQRS group (mean age, 52.97±3.13 years). There was no difference between the 2 groups w...

Research paper thumbnail of Comparison of Edwards Sapien XT versus Lotus valve devices in terms of electrophysiological study parameters in patients undergoing TAVI

Pacing and Clinical Electrophysiology, 2016

The purpose of this study is to assess the electrocardiographic and electrophysiological paramete... more The purpose of this study is to assess the electrocardiographic and electrophysiological parameters of conduction abnormalities in patients undergoing trans-catheter aortic valve implantation (TAVI) due to severe aortic valve stenosis. The study included 55 patients who underwent TAVI using either the Boston Scientific Lotus (n:25) or Edwards Sapien XT (n:30) prostheses. An electrophysiological study (EPS) was performed in the catheterization room immediately before the initial balloon valvuloplasty and immediately after prosthesis implantation. QRS duration and His bundle to ventricle (HV)intervals, which were similar between the 2 groups before the procedure, were found to be significantly higher in the Lotus valve group post-procedure. Permanent pacemakers (PPMs) were required more frequently in the Lotus group than in the Sapien XT group at discharge (24.0% vs 6.7%, p = 0.07). With the exception of a higher prevalence of paravalvular leak (PVL) (p&amp;amp;amp;amp;amp;amp;lt;0.001) in patients undergoing Sapien XT implantation, other clinical outcomes were similar between the 2 groups. Multiple regression analysis revealed that baseline atrioventricular (AV) conduction disorders and HV intervals after the procedure were independently associated with PPM implantation after TAVI. In this first study comparing the findings of electrophysiologic study (EPS) and electrocardiography (ECG) the impact of the Lotus valve on AV conduction systems was greater than that of the Sapien XT. However, the need for PPM was higher in the Lotus valve than in the Sapien XT. PPM requirement is related to valve design; it may decrease with reduced frame height and metal burden in novel valve systems. This article is protected by copyright. All rights reserved.

Research paper thumbnail of OP-030 Prognostic Value of CHA2DS2-VASc Score in Patients with ST-Elevation Myocardial Infarction Underwent Primary Percutaneous Coronary Intervention

The American Journal of Cardiology, 2016

Research paper thumbnail of Impact of the total pericardial closure using bilateral trap door incision and pericardial cavity intervention on outcomes following coronary artery bypass grafting: a randomized, controlled, parallel-group prospective study

Interactive CardioVascular and Thoracic Surgery, 2015

Research paper thumbnail of Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Cardiology Journal, 2013

The beneficial effects of the transcatheter aortic valve implantation (TAVI) on echocardiographic... more The beneficial effects of the transcatheter aortic valve implantation (TAVI) on echocardiographic parameters including left atrial (LA) and left ventricular (LV) functions were described by previous studies. The aim of this study was to analyze the effects of TAVI on left atrial appendage (LAA) function assessed by transthoracic and transesophageal echocardiography. Fifty-five patients with severe symptomatic AS were included in this prospective study. LAA early and late emptying velocities, LAA filling velocity, peak early diastolic (EM), late diastolic (AM), and systolic (SM) velocities were measured with Pulsed Wave (PW) Doppler and Doppler tissue imaging (DTI), and E/Em ratio was calculated before and 7.1±2.8 days after TAVI. A subgroup analysis was done in accordance with the left ventricular ejection fraction (LVEF) of the patients and the severity of their LV diastolic dysfunction. Although the post-procedure peaks and mean gradients of the patients decreased significantly, the LVEF increased significantly who had low LVEF before the procedure. The post-procedure E/Em ratio decreased significantly (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). The post-procedural LAA mean filling velocity and EM velocity were significantly higher than the pre-procedural filling velocity (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, p=0.002, respectively). In the subgroup analysis, the post-procedural LAA filling velocity, early and late LAA emptying velocities, in addition to the mean velocity of the EM, AM, and SM were significantly higher than before the procedure in patients with LVEF of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;50% and E/Em ratios of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;15. LAA function improved soon after the TAVI procedure, especially in patients with low LVEF and marked LV diastolic dysfunction.

Research paper thumbnail of CARDIAC SURGERY The effects of posterior pericardiotomy on pericardial effusion, tamponade, and atrial fibrillation after coronary artery surgery

Polish Journal of Cardio-Thoracic Surgery, 2014

Pericardial effusion and atrial fibrillation occur commonly after coronary artery surgery. A pros... more Pericardial effusion and atrial fibrillation occur commonly after coronary artery surgery. A prospective randomized clinical trial was conducted to evaluate the effects of posterior pericardiotomy on the occurrence of pericardial effusion, tamponade, and atrial fibrillation. The study group consisted of 96 patients (77 male and 19 female) at a mean age of 58.1 ± 9.8 years. The patients were randomly assigned to one of three study groups: patients undergoing posterior pericardiotomy (group I, n = 30), controls (group II, n = 33), and patients with additional posterior pericardial drainage tubes (28 mm) who did not undergo posterior pericardiotomy (group III, n = 33). Postoperative hospitalization (p = 0.03; 11.56 ± 10.64) and reoperation due to tamponade (p = 0.019; 12.1%) were significantly higher in group II. Extensive pericardial effusions were detected in one patient on the first postoperative day (group II, n = 1), in one patient on the fifth postoperative day (group III, n = 1), and in one patient on the 30(th) day after the operation (group III, n = 1). Pericardial effusion exhibited regression in group I on postoperative day 30 (p = 0.028). A higher rate of postoperative atrial fibrillation was noted in group I, but no significant differences were found between the groups with regard to postoperative atrial fibrillation. Patients who did not undergo posterior pericardiotomy or did not receive posterior chest tubes exhibited residual pericardial effusion, required longer hospitalization, and had to be reoperated due to tamponade. Both posterior pericardiotomy and the use of posterior tubes are effective in the early postoperative period.

Research paper thumbnail of The Predictive Value of Admission Fragmented QRS Complex for In-Hospital Cardiovascular Mortality of Patients with Type 1 Acute Aortic Dissection

Annals of Noninvasive Electrocardiology, 2014

Research paper thumbnail of Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Cardiology Journal, 2014

Background: Isovolumic acceleration (IVA) is a new tissue Doppler parameter in the assessment of ... more Background: Isovolumic acceleration (IVA) is a new tissue Doppler parameter in the assessment of systolic function of both left and right ventricles. It remains unaffected with the changes in pre-and after-load within the physiological range. The aim of our study was to assess the effect of mitral stenosis degree, which is determined by echocardiography, on the left ventricular (LV) function using IVA. Methods: A total number of 62 patients with mitral stenosis (MS) and 32 healthy controls were examined. The severity of MS (mild, moderate, and severe) was determined on the basis of mitral valve area (MVA) and the mean diastolic mitral gradient findings. The peak myocardial velocities during isovolumic contraction, systole, early diastole and late diastole were measured by using tissue Doppler imaging (TDI). Results: All TDI-derived global LV basal wall systolic (peak myocardial isovolumic contraction velocity, peak myocardial systolic velocity and IVA), and diastolic velocities (peak early and late diastolic velocities) were significantly decreased in the patients with MS, compared to the healthy patients (p < 0.001, for all). However, IVA was not different when the degree of MS was evaluated (p = 0.114). In addition, IVA was not correlated with the MVA (r = 0.185, p = 0.150). Conclusions: Left ventricular function is impaired in patients with MS regardless of the severity of the disease. (Cardiol J 2014; 21, 4: 442-448)

Research paper thumbnail of Assessment of the relationship between a narrow fragmented QRS complex and coronary slow flow

Cardiology journal, Jan 15, 2015

The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to t... more The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. This study included 165 consecutive patients (112 CSF,53 controls) who underwent first-time diagnostic conventional coronary angiography for suspected CAD. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Forty four patients were in the fQRS group (mean age, 52.97±3.13 years). There was no difference between the 2 groups w...

Research paper thumbnail of Increased plasma asymmetric dimethylarginine (ADMA) levels in retinal venous occlusive disease

Clinical Chemical Laboratory Medicine, 2008

Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetr... more Background: We investigated the levels of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine (ADMA), as well as homocysteine and cysteine thiols, in a cohort of subjects affected by retinal vein occlusion (RVO) disease. Methods: Capillary electrophoresis analysis was performed in both RVO subjects (ns54) and in a control group (ns32). Results: No differences were found between controls and patients; however, after categorisation for RVO type, central RVO (CRVO) patients showed higher levels of ADMA (0.710"0.139 mmol/L) than controls (0.635"0.117 mmol/L) and branch RVO patients (0.642"0.096 mmol/L). Moreover, cysteine plasma levels were also significantly higher in CRVO patients than in controls (265.8"46.9 vs. 226.7"51.9 mmol/L, p-0.01), while homocysteine plasma concentration was more or less identical in all groups. Conclusions: We hypothesise that the elevated levels of cysteine in CRVO patients may post-translationally inhibit dimethylarginine dimethylaminohydrolase enzyme activity, as already described for homocysteine, thus contributing to the accumulation of ADMA in this patient group.

Research paper thumbnail of Prognostic value of CHA2DS2-VASc score in patients with 'non-valvular atrial fibrillation' and valvular heart disease: the Loire Valley Atrial Fibrillation Project

European heart journal, Jan 20, 2015

The CHA2DS2VASc score is a clinical risk stratification tool which estimates the risk of stroke a... more The CHA2DS2VASc score is a clinical risk stratification tool which estimates the risk of stroke and thromboembolism in non-valvular atrial fibrillation (AF). We aimed to establish the value of this score for risk evaluation in patients with non-valvular AF and valvular heart disease. Among 8053 patients with non-valvular AF (ESC guidelines definition), patients were categorized into Group 1 (no valve disease, n = 6851; 85%) and Group 2 (valve disease with neither rheumatic mitral stenosis nor valve prothesis, n = 1202; 15%). After follow-up of 868 ± 1043 days, 627 stroke/ thromboembolic (TE) events were recorded. Group 2 was significantly older, had a higher CHA2DS2VASc score and had a higher risk of thromboembolic events [hazard ratio (HR) 1.39; 95% CI 1.14-1.69, P = 0.001] compared with Group 1. Severe valve disease was not associated with worse prognosis for stroke/TE events. In the two groups, stroke/TE risk increased with a higher CHA2DS2VASc score. Factors independently associ...

Research paper thumbnail of Hipertrofik kardiyomiyopatili hastalarda serum ürik asit seviyesi ile öngörülen beş yıllık ani kardiyak ölüm risk skoru arasındaki ilişkinin değerlendirilmesi

Research paper thumbnail of Assessment of long term prognostic value of admission vitamin D level in patients with acute STEMI undergoing primary percutaneous coronary intervention

Dicle Tıp Dergisi, 2018

Vitamin-D status is very important for optimal function of human body especially cardiovascular s... more Vitamin-D status is very important for optimal function of human body especially cardiovascular system. The aim of this study was to investigate the long term prognostic value of admission vitamin D level in acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). Methods: One hundred fifty seven consecutive patients, who were admitted to a training and research hospital with a diagnosis of STEMI and underwent PPCI, were recruited in this prospective study. The study patients were divided into 2 groups according to their vitamin-D levels as follows: High vitamin-D group (n=80) and Low vitamin-D group (n=77). The severity of coronary artery disease (CAD) was assessed with calculation of the SYNTAX score. Results: There were significant negative correlations between Vitamin-D level and SYNTAX score, serum glucose, and gender, but a positive correlation with hemoglobin level. Cardiovascular mortality was found to be significantly higher in the low vitamin-D group as compared to the high group (p<0.001). In multivariate analysis, low vitamin-D level was found as a significant independent predictor of long term cardiovascular mortality after adjusting for other risk factors. Conclusion: We demonstrated that low admission vitamin-D is related to severity of CAD. Vitamin-D deficiency is an independent predictor for long term cardiovascular mortality in acute STEMI undergoing PPCI. Primer perkutan girişim uygulanan akut STEMI hastalarda başvuru D vitamini düzeyinin uzun dönem prognostik değeri Öz Amaç: Vitamin-D, insan vücudunda özellikle kardiyovasküler sistemin işlevi için çok önemlidir. Bu çalışmanın amacı, primer perkütan koroner girişim (PPCI) uygulanan akut ST-segment yükselmeli miyokard infarktüsünde (STEMI), hastane başvurusu sırasındaki D vitamini düzeyinin uzun dönem prognostik değerini araştırmaktı. Yöntemler: Bu prospektif çalışmada, eğitim ve araştırma hastanesine STEMI tanısı ile başvuran ve PPCI uygulanan ardışık 157 hasta alındı. Çalışma hastaları başvuru vitamin-D düzeylerine göre 2 gruba ayrıldı: Yüksek vitamin-D grubu (n = 80) ve düşük vitamin-D grubu (n = 77). Koroner arter hastalığının şiddeti SYNTAX skoru ile hesaplandı. Bulgular: Vitamin-D düzeyi ile SYNTAX skoru, serum glikozu ve cinsiyet arasında anlamlı negatif korelasyon vardı, fakat hemoglobin düzeyi ile pozitif korelasyon vardı. Kardiyovasküler mortalite, düşük vitamin-D grubunda, yüksek gruba göre anlamlı olarak daha yüksek bulundu (p <0.001). Çok değişkenli analizde, düşük vitamin-D düzeyinin, diğer risk faktörlerini ayarladıktan sonra uzun vadede kardiyovasküler mortalitenin anlamlı bağımsız bir göstergesi olduğu bulunmuştur. Sonuç: Düşük başvuru vitamin D düzeyinin koroner arter hastalığı şiddeti ile ilişkili olduğunu gösterdik. Vitamin-D eksikliği, PPCI uygulanan akut STEMI'de uzun süreli kardiyovasküler mortalite için bağımsız bir belirleyicidir.

Research paper thumbnail of Evaluation of the association between serum uric acid level andthe predicted risk score of sudden cardiac death in five years in patients with hypertrophic cardiomyopathy

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, Mar 1, 2018

The aim of this study was to determine the relationship between serum uric acid (UA) level and th... more The aim of this study was to determine the relationship between serum uric acid (UA) level and the predicted risk score for sudden cardiac death in 5 years (the HCM Risk-SCD), galectin-3 level, and positive fragmented QRS (fQRS) on electrocardiography (ECG) in patients with hypertrophic cardiomyopathy (HCM). This was a prospective, observational study. In all, 115 consecutive patients (age >17 years) with HCM and 80 healthy participants were included in the study. The HCM Risk-SCD score (%), galectin-3 level, and fQRS on ECG were evaluated in all patients. The serum UA, galectin-3 level, UA/Creatinine ratio, incidence of ventricular tachycardia (VT) and syncope, and some echocardiographic parameters were significantly higher in the patient group than in the control group (all p<0.05). The UA value was significantly higher in patients with a high score on the HCM Risk-SCD, a positive fQRS, a high galectin-3 level, VT incidence, and need for implantable cardioverter defibrillato...

Research paper thumbnail of Association Between New Platelet Indices And Calcific Aortic Stenosis: Plateletcrit And Platelet to Lymphocyte Ratio

Van Medical Journal, 2016

Objective: Calcific aortic stenosis (AS) is the leading cause of death from valvular heart diseas... more Objective: Calcific aortic stenosis (AS) is the leading cause of death from valvular heart disease in worldwide. We aimed to evaluate the relationship between plateletcrit (PCT), platelet to lymphocyte ratio (PLR) and presence and severity of the calcific AS in the present study. Materials and Methods: A total of 98 consecutive patients diagnosed with calcific AS and 30 healthy controls were included in this retrospective study. Patients with calcific AS were divided into three groups according to severity of disease as follows: mild AS (n=35), moderate AS (n=30) and severe AS (n=33). Results: PCT and PLR were demonstrated to be significantly higher in the AS. Moreover, PCT and PLR were significantly highest in the severe AS group than in the mild and moderate AS groups. Correlation analysis indicated positive significant relationships between the PCT and maximal and mean transaortic gradients, and maximum jet velocities; but negative association with AVA. The same relations were obtained between PLR and echocardiographic parameters of severity of AS. Conclusion: PCT and PLR, which reflect elevated inflammatory status and platelet activation and aggregation, are useful, cheap, easily available and simply calculated markers that have an ability to improve risk stratification of patients with calcific AS for treatment strategies.

Research paper thumbnail of Predictive values of D-dimer assay, GRACE scores and TIMI scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction

Therapeutics and Clinical Risk Management, 2017

Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary E... more Purpose: To determine the predictive values of D-dimer assay, Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) risk scores for adverse outcome in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods: A total of 234 patients (mean age: 57.2±11.7 years, 75.2% were males) hospitalized with NSTEMI were included. Data on D-dimer assay, GRACE and TIMI risk scores were recorded. Logistic regression analysis was conducted to determine the risk factors predicting increased mortality. Results: Median D-dimer levels were 349.5 (48.0-7,210.0) ng/mL, the average TIMI score was 3.2±1.2 and the GRACE score was 90.4±27.6 with high GRACE scores (.118) in 17.5% of patients. The GRACE score was correlated positively with both the D-dimer assay (r=0.215, P=0.01) and TIMI scores (r=0.504, P=0.000). Multivariate logistic regression analysis revealed that higher creatinine levels (odds ratio =18.465, 95% confidence interval: 1.059-322.084, P=0.046) constituted the only significant predictor of increased mortality risk with no predictive values for age, D-dimer assay, ejection fraction, glucose, hemoglobin A1c, sodium, albumin or total cholesterol levels for mortality. Conclusion: Serum creatinine levels constituted the sole independent determinant of mortality risk, with no significant values for D-dimer assay, GRACE or TIMI scores for predicting the risk of mortality in NSTEMI patients.

Research paper thumbnail of The Predictive Value of Admission Fragmented QRS Complex for In-Hospital Cardiovascular Mortality of Patients with Type 1 Acute Aortic Dissection

Annals of Noninvasive Electrocardiology, 2014

Background: Fragmented QRS (fQRS) arises from impaired ventricular depolarization due to heteroge... more Background: Fragmented QRS (fQRS) arises from impaired ventricular depolarization due to heterogeneous electrical activation of ischemic and/or infarcted ventricular myocardium. The shortand long-term prognostic values of fQRS have been reported for myocardial infarction, heart failure, fatal cardiac arrhythmias, and sudden cardiac death. The aim of this study was to investigate the predictive value of admission fQRS complex for in-hospital cardiovascular mortality of patients with type 1 acute aortic dissection (AAD). Methods: In this retrospective study, 203 consecutive patients with type 1 AAD who had been admitted to either of two large-volume tertiary hospitals between December 2008 and October 2013 were included. The patients were divided into two groups according to the presence or absence of the fQRS complex on admission. Results: In-hospital cardiovascular mortality (P < 0.001), major adverse cardiovascular events (P < 0.001), acute renal failure (P = 0.022), multiorgan dysfunction (P < 0.001), and acute decompensated heart failure (P < 0.001) were observed to be significantly more frequent in the fQRS-positive group than in the fQRS-negative group. fQRS (odds ratio [95% confidence interval]: 4.184 [1.927-9.082], P < 0.001), operation duration (4.184 [1.927-9.082], P = 0.001), and Killip class IV (3.900 [1.699-8.955], P = 0.001) were found to be significant independent predictors of in-hospital cardiovascular mortality after adjustment of other risk factors in the multivariate analysis. Conclusions: fQRS is a simple, inexpensive, and readily available electrocardiographic entity that provides an additional risk stratification level beyond that provided by conventional risk parameters in predicting in-hospital cardiovascular mortality in type 1 AAD. Ann Noninvasive Electrocardiol 2015;20(5):454-463 fragmented QRS; acute aortic dissection; cardiovascular mortality; electrocardiography Acute aortic dissection (AAD) still remains one of the most common causes of cardiovascular mortality and morbidity in developing countries, despite modern advances in diagnostic techniques and new approaches to treatment.

Research paper thumbnail of Assessment of the relationship between a narrow fragmented QRS complex and coronary slow flow

Cardiology journal, Jan 15, 2015

The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to t... more The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. This study included 165 consecutive patients (112 CSF,53 controls) who underwent first-time diagnostic conventional coronary angiography for suspected CAD. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Forty four patients were in the fQRS group (mean age, 52.97±3.13 years). There was no difference between the 2 groups w...

Research paper thumbnail of Comparison of Edwards Sapien XT versus Lotus valve devices in terms of electrophysiological study parameters in patients undergoing TAVI

Pacing and Clinical Electrophysiology, 2016

The purpose of this study is to assess the electrocardiographic and electrophysiological paramete... more The purpose of this study is to assess the electrocardiographic and electrophysiological parameters of conduction abnormalities in patients undergoing trans-catheter aortic valve implantation (TAVI) due to severe aortic valve stenosis. The study included 55 patients who underwent TAVI using either the Boston Scientific Lotus (n:25) or Edwards Sapien XT (n:30) prostheses. An electrophysiological study (EPS) was performed in the catheterization room immediately before the initial balloon valvuloplasty and immediately after prosthesis implantation. QRS duration and His bundle to ventricle (HV)intervals, which were similar between the 2 groups before the procedure, were found to be significantly higher in the Lotus valve group post-procedure. Permanent pacemakers (PPMs) were required more frequently in the Lotus group than in the Sapien XT group at discharge (24.0% vs 6.7%, p = 0.07). With the exception of a higher prevalence of paravalvular leak (PVL) (p&amp;amp;amp;amp;amp;amp;lt;0.001) in patients undergoing Sapien XT implantation, other clinical outcomes were similar between the 2 groups. Multiple regression analysis revealed that baseline atrioventricular (AV) conduction disorders and HV intervals after the procedure were independently associated with PPM implantation after TAVI. In this first study comparing the findings of electrophysiologic study (EPS) and electrocardiography (ECG) the impact of the Lotus valve on AV conduction systems was greater than that of the Sapien XT. However, the need for PPM was higher in the Lotus valve than in the Sapien XT. PPM requirement is related to valve design; it may decrease with reduced frame height and metal burden in novel valve systems. This article is protected by copyright. All rights reserved.

Research paper thumbnail of OP-030 Prognostic Value of CHA2DS2-VASc Score in Patients with ST-Elevation Myocardial Infarction Underwent Primary Percutaneous Coronary Intervention

The American Journal of Cardiology, 2016

Research paper thumbnail of Impact of the total pericardial closure using bilateral trap door incision and pericardial cavity intervention on outcomes following coronary artery bypass grafting: a randomized, controlled, parallel-group prospective study

Interactive CardioVascular and Thoracic Surgery, 2015

Research paper thumbnail of Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Cardiology Journal, 2013

The beneficial effects of the transcatheter aortic valve implantation (TAVI) on echocardiographic... more The beneficial effects of the transcatheter aortic valve implantation (TAVI) on echocardiographic parameters including left atrial (LA) and left ventricular (LV) functions were described by previous studies. The aim of this study was to analyze the effects of TAVI on left atrial appendage (LAA) function assessed by transthoracic and transesophageal echocardiography. Fifty-five patients with severe symptomatic AS were included in this prospective study. LAA early and late emptying velocities, LAA filling velocity, peak early diastolic (EM), late diastolic (AM), and systolic (SM) velocities were measured with Pulsed Wave (PW) Doppler and Doppler tissue imaging (DTI), and E/Em ratio was calculated before and 7.1±2.8 days after TAVI. A subgroup analysis was done in accordance with the left ventricular ejection fraction (LVEF) of the patients and the severity of their LV diastolic dysfunction. Although the post-procedure peaks and mean gradients of the patients decreased significantly, the LVEF increased significantly who had low LVEF before the procedure. The post-procedure E/Em ratio decreased significantly (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001). The post-procedural LAA mean filling velocity and EM velocity were significantly higher than the pre-procedural filling velocity (p&amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;0.001, p=0.002, respectively). In the subgroup analysis, the post-procedural LAA filling velocity, early and late LAA emptying velocities, in addition to the mean velocity of the EM, AM, and SM were significantly higher than before the procedure in patients with LVEF of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt;50% and E/Em ratios of &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;gt;15. LAA function improved soon after the TAVI procedure, especially in patients with low LVEF and marked LV diastolic dysfunction.

Research paper thumbnail of CARDIAC SURGERY The effects of posterior pericardiotomy on pericardial effusion, tamponade, and atrial fibrillation after coronary artery surgery

Polish Journal of Cardio-Thoracic Surgery, 2014

Pericardial effusion and atrial fibrillation occur commonly after coronary artery surgery. A pros... more Pericardial effusion and atrial fibrillation occur commonly after coronary artery surgery. A prospective randomized clinical trial was conducted to evaluate the effects of posterior pericardiotomy on the occurrence of pericardial effusion, tamponade, and atrial fibrillation. The study group consisted of 96 patients (77 male and 19 female) at a mean age of 58.1 ± 9.8 years. The patients were randomly assigned to one of three study groups: patients undergoing posterior pericardiotomy (group I, n = 30), controls (group II, n = 33), and patients with additional posterior pericardial drainage tubes (28 mm) who did not undergo posterior pericardiotomy (group III, n = 33). Postoperative hospitalization (p = 0.03; 11.56 ± 10.64) and reoperation due to tamponade (p = 0.019; 12.1%) were significantly higher in group II. Extensive pericardial effusions were detected in one patient on the first postoperative day (group II, n = 1), in one patient on the fifth postoperative day (group III, n = 1), and in one patient on the 30(th) day after the operation (group III, n = 1). Pericardial effusion exhibited regression in group I on postoperative day 30 (p = 0.028). A higher rate of postoperative atrial fibrillation was noted in group I, but no significant differences were found between the groups with regard to postoperative atrial fibrillation. Patients who did not undergo posterior pericardiotomy or did not receive posterior chest tubes exhibited residual pericardial effusion, required longer hospitalization, and had to be reoperated due to tamponade. Both posterior pericardiotomy and the use of posterior tubes are effective in the early postoperative period.

Research paper thumbnail of The Predictive Value of Admission Fragmented QRS Complex for In-Hospital Cardiovascular Mortality of Patients with Type 1 Acute Aortic Dissection

Annals of Noninvasive Electrocardiology, 2014

Research paper thumbnail of Evaluation of the effect of mitral stenosis severity on the left ventricular systolic function using isovolumic myocardial acceleration

Cardiology Journal, 2014

Background: Isovolumic acceleration (IVA) is a new tissue Doppler parameter in the assessment of ... more Background: Isovolumic acceleration (IVA) is a new tissue Doppler parameter in the assessment of systolic function of both left and right ventricles. It remains unaffected with the changes in pre-and after-load within the physiological range. The aim of our study was to assess the effect of mitral stenosis degree, which is determined by echocardiography, on the left ventricular (LV) function using IVA. Methods: A total number of 62 patients with mitral stenosis (MS) and 32 healthy controls were examined. The severity of MS (mild, moderate, and severe) was determined on the basis of mitral valve area (MVA) and the mean diastolic mitral gradient findings. The peak myocardial velocities during isovolumic contraction, systole, early diastole and late diastole were measured by using tissue Doppler imaging (TDI). Results: All TDI-derived global LV basal wall systolic (peak myocardial isovolumic contraction velocity, peak myocardial systolic velocity and IVA), and diastolic velocities (peak early and late diastolic velocities) were significantly decreased in the patients with MS, compared to the healthy patients (p < 0.001, for all). However, IVA was not different when the degree of MS was evaluated (p = 0.114). In addition, IVA was not correlated with the MVA (r = 0.185, p = 0.150). Conclusions: Left ventricular function is impaired in patients with MS regardless of the severity of the disease. (Cardiol J 2014; 21, 4: 442-448)

Research paper thumbnail of Assessment of the relationship between a narrow fragmented QRS complex and coronary slow flow

Cardiology journal, Jan 15, 2015

The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to t... more The coronary slow flow (CSF) phenomenon is a delayed antegrade progression of contrast agent to the distal branch of a coronary artery in the absence of obstructive coronary artery disease (CAD). A narrow fragmented QRS (fQRS) has been reported as a significant predictor of sudden cardiac death in patients with idiopathic dilated cardiomyopathy. The present study aimed to investigate the relationship between a narrow fQRS on the admission electrocardiogram (ECG) and CSF on coronary angiography. This study included 165 consecutive patients (112 CSF,53 controls) who underwent first-time diagnostic conventional coronary angiography for suspected CAD. Coronary flow was quantified by thrombolysis in myocardial infarction (TIMI) frame count (TFC). The patients were divided into two groups according to the presence or absence of a narrow fQRS complex on the admission ECG. Forty four patients were in the fQRS group (mean age, 52.97±3.13 years). There was no difference between the 2 groups w...