Mukesh Jadeja - Academia.edu (original) (raw)

Papers by Mukesh Jadeja

Research paper thumbnail of A Novel Approach for the Treatment of Hypertension: Gastroretentive Microballoons of Atenolol

International journal of pharmaceutical sciences and drug research, Mar 30, 2023

Research paper thumbnail of Development and optimization of Ropinirole loaded self-nanoemulsifying tablets

Future Journal of Pharmaceutical Sciences

Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Dru... more Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral bioavailability and reduces plasma drug concentration and an overall reduction in therapeutic effects. Avoiding hepatic first-pass metabolism by increasing lymphatic uptake is the goal of the creation of the Ropinirole Self-NanoEmulsifying System. The solvent system for the liquid Self-NanoEmulsifying Drug Delivery System (SNEDDS) was optimized using Box-Behnken Design, where the concentration of oil(X1), surfactant (X2), and co-surfactant(X3) were taken as independent variables. The formulated liquid SNEDDS were then converted into solid SNEDDS by the adsorption method for improving patient compliance. Results The obtained mean droplet size of the formulated SNEDDS was 96.71 nm, and the rate of emulsification was 22 s. Liquid SNEDDS was converted...

Research paper thumbnail of Development and Evaluation of Rizatriptan Benzoate-loaded Nanostructured Lipid Carriers for the Treatment of Migraine

Research Square (Research Square), Aug 1, 2022

The aim is to develop and evaluate rizatriptan benzoate (RB) loaded nanostructured lipid carriers... more The aim is to develop and evaluate rizatriptan benzoate (RB) loaded nanostructured lipid carriers (NLCs) that might improve oral bioavailability. NLC was prepared using High-Speed Homogenization (HSH) coupled with the ultrasonication method. Process parameters were selected on basis of the trial-and-error method which is time for homogenization, speed of homogenization, and time for sonication. Using a Design expert, 3 2 Full Factorial design was prepared using solid lipid to liquid lipid ratio and concentration of surfactant as independent variables. RB-NLC was evaluated on basis of particle size, %Entrapment E ciency (EE), Zeta potential, Transmission electron microscopy (TEM), In-Vitro permeation study, and Ex-vivo permeation study. Confocal Laser Scanning Microscopy was performed to study the uptake of RB-NLC through M-Cells, and Peyer's Patches. RB-NLC dispersion was converted into freeowing lyophilized powder using cryoprotectant which is trehalose and in vitro permeation study was performed. Among all the batches of RB-NLC, the Optimized batch was evaluated. The optimized formulation showed a particle size of 412.8 ± 1.15nm with 0.261 PDI and − 36.6mV zeta potential. It showed 84.26 ± 1.03% EE. TEM image showed a spherical shape and smooth surface area. In-Vitro and Ex-vivo studies showed 97.21 ± 0.36%CDR up to 22 hours & 61.02 ± 1.25%CDR up to 6 hours. Lyophilized powder showed 96.37 ± 0.36%CDR up to 22 hours. Based on the data we can conclude that RB-NLC increases the permeation and it may increase its Bioavailability (BA). Lyophilized powder of RB-NLC showed a sustained release pattern and it may reduce the dosing frequency of the drug.

Research paper thumbnail of Development and evaluation of ultradeformable vesicles loaded transdermal film of boswellic acid

Future Journal of Pharmaceutical Sciences

Background Boswellic acid (BA), a phytoconstituent obtained from Boswellia serrata, suffers from ... more Background Boswellic acid (BA), a phytoconstituent obtained from Boswellia serrata, suffers from several limitations after oral administration such as poor systemic absorption, high first-pass metabolism and high frequency of dose requirement, which creates a need to develop an alternative route for drug administration via novel drug delivery formulation. The present research work aims at developing ultradeformable vesicular carriers (transferosomes) for transdermal delivery of boswellic acid to effectively deliver the drug into deeper layers of the skin reaching the target site and thus improving its systemic bioavailability. Ultradeformable vesicles were prepared by thin-film hydration technique, and the formulation was optimized using 32 full factorial design where the amount of lecithin (mg) and concentration of surfactant (%) were considered as independent variables. The formulated boswellic acid-loaded vesicles were incorporated into transdermal film via solvent evaporation te...

Research paper thumbnail of Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization

Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 2012

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dis... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.

Research paper thumbnail of In Vitro Dissolution Enhancement of Ondansetron by Solid Dispersion in Superdisintegrants

Dissolution Technologies, 2013

Ondansetron hydrochloride (OSH) is a highly selective and potent antagonist of 5-hydroxytryptamin... more Ondansetron hydrochloride (OSH) is a highly selective and potent antagonist of 5-hydroxytryptamine at 5HT 3 receptors in the gastrointestinal tract where it blocks both sites of serotonin induced nausea and vomiting. Physical mixtures and solid dispersions of the drug using superdisintegrants as carriers were prepared by a solvent method at different drug-carrier (w/w) ratios and evaluated with an objective of enhancing the dissolution rate of OSH from solid dispersion. Equilibrium solubility studies were performed for drug-carrier interactions in solution, and Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD), and differential scanning calorimetry (DSC) studies were carried out to characterize the solid dispersions. FTIR spectra reveal no chemical interaction between the drug and superdisintegrants. XRD and DSC data indicate OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. A marked enhancement in the dissolution of OSH was observed with all the superdisintegrants.

Research paper thumbnail of A Novel Approach for the Treatment of Hypertension: Gastroretentive Microballoons of Atenolol

International journal of pharmaceutical sciences and drug research, Mar 30, 2023

Research paper thumbnail of Development and optimization of Ropinirole loaded self-nanoemulsifying tablets

Future Journal of Pharmaceutical Sciences

Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Dru... more Background The present research work aims to develop a Ropinirole-loaded self-Nanoemulsifying Drug Delivery system. Ropinirole has limited oral bioavailability due to substantial first-pass metabolism, which ultimately results in poor oral bioavailability and reduces plasma drug concentration and an overall reduction in therapeutic effects. Avoiding hepatic first-pass metabolism by increasing lymphatic uptake is the goal of the creation of the Ropinirole Self-NanoEmulsifying System. The solvent system for the liquid Self-NanoEmulsifying Drug Delivery System (SNEDDS) was optimized using Box-Behnken Design, where the concentration of oil(X1), surfactant (X2), and co-surfactant(X3) were taken as independent variables. The formulated liquid SNEDDS were then converted into solid SNEDDS by the adsorption method for improving patient compliance. Results The obtained mean droplet size of the formulated SNEDDS was 96.71 nm, and the rate of emulsification was 22 s. Liquid SNEDDS was converted...

Research paper thumbnail of Development and Evaluation of Rizatriptan Benzoate-loaded Nanostructured Lipid Carriers for the Treatment of Migraine

Research Square (Research Square), Aug 1, 2022

The aim is to develop and evaluate rizatriptan benzoate (RB) loaded nanostructured lipid carriers... more The aim is to develop and evaluate rizatriptan benzoate (RB) loaded nanostructured lipid carriers (NLCs) that might improve oral bioavailability. NLC was prepared using High-Speed Homogenization (HSH) coupled with the ultrasonication method. Process parameters were selected on basis of the trial-and-error method which is time for homogenization, speed of homogenization, and time for sonication. Using a Design expert, 3 2 Full Factorial design was prepared using solid lipid to liquid lipid ratio and concentration of surfactant as independent variables. RB-NLC was evaluated on basis of particle size, %Entrapment E ciency (EE), Zeta potential, Transmission electron microscopy (TEM), In-Vitro permeation study, and Ex-vivo permeation study. Confocal Laser Scanning Microscopy was performed to study the uptake of RB-NLC through M-Cells, and Peyer's Patches. RB-NLC dispersion was converted into freeowing lyophilized powder using cryoprotectant which is trehalose and in vitro permeation study was performed. Among all the batches of RB-NLC, the Optimized batch was evaluated. The optimized formulation showed a particle size of 412.8 ± 1.15nm with 0.261 PDI and − 36.6mV zeta potential. It showed 84.26 ± 1.03% EE. TEM image showed a spherical shape and smooth surface area. In-Vitro and Ex-vivo studies showed 97.21 ± 0.36%CDR up to 22 hours & 61.02 ± 1.25%CDR up to 6 hours. Lyophilized powder showed 96.37 ± 0.36%CDR up to 22 hours. Based on the data we can conclude that RB-NLC increases the permeation and it may increase its Bioavailability (BA). Lyophilized powder of RB-NLC showed a sustained release pattern and it may reduce the dosing frequency of the drug.

Research paper thumbnail of Development and evaluation of ultradeformable vesicles loaded transdermal film of boswellic acid

Future Journal of Pharmaceutical Sciences

Background Boswellic acid (BA), a phytoconstituent obtained from Boswellia serrata, suffers from ... more Background Boswellic acid (BA), a phytoconstituent obtained from Boswellia serrata, suffers from several limitations after oral administration such as poor systemic absorption, high first-pass metabolism and high frequency of dose requirement, which creates a need to develop an alternative route for drug administration via novel drug delivery formulation. The present research work aims at developing ultradeformable vesicular carriers (transferosomes) for transdermal delivery of boswellic acid to effectively deliver the drug into deeper layers of the skin reaching the target site and thus improving its systemic bioavailability. Ultradeformable vesicles were prepared by thin-film hydration technique, and the formulation was optimized using 32 full factorial design where the amount of lecithin (mg) and concentration of surfactant (%) were considered as independent variables. The formulated boswellic acid-loaded vesicles were incorporated into transdermal film via solvent evaporation te...

Research paper thumbnail of Development of Fast Dissolving Tablets Containing Ondansetron via Camphor Sublimation and its Characterization

Research & Reviews: Journal of Pharmacy and Pharmaceutical Sciences, 2012

Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dis... more Ondansetron Hydrochloride (OSH) is a sparingly water-soluble drug. In this investigation fast dissolving tablets (FDTs) of ondansetron were prepared using different superdisintegrants by sublimation method. FDTs were evaluated for physicochemical properties and in vitro dissolution. The wetting time (10.5s) of formulation batch containing crospovidone (F2) was least and tablets showed fastest disintegration (3.2s). The drug release from FDTs containing superdisintegrants was more as compared to FDTs without superdisintegrant and it was found to be highest (98% drug release after 30 min) with formulation batch containing crospovidone (F2) so it can be concluded as promising formulation.

Research paper thumbnail of In Vitro Dissolution Enhancement of Ondansetron by Solid Dispersion in Superdisintegrants

Dissolution Technologies, 2013

Ondansetron hydrochloride (OSH) is a highly selective and potent antagonist of 5-hydroxytryptamin... more Ondansetron hydrochloride (OSH) is a highly selective and potent antagonist of 5-hydroxytryptamine at 5HT 3 receptors in the gastrointestinal tract where it blocks both sites of serotonin induced nausea and vomiting. Physical mixtures and solid dispersions of the drug using superdisintegrants as carriers were prepared by a solvent method at different drug-carrier (w/w) ratios and evaluated with an objective of enhancing the dissolution rate of OSH from solid dispersion. Equilibrium solubility studies were performed for drug-carrier interactions in solution, and Fourier transform infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD), and differential scanning calorimetry (DSC) studies were carried out to characterize the solid dispersions. FTIR spectra reveal no chemical interaction between the drug and superdisintegrants. XRD and DSC data indicate OSH was in the amorphous form, which explains the better dissolution rate of the drug from its solid dispersions. A marked enhancement in the dissolution of OSH was observed with all the superdisintegrants.