Murat Sarıcı - Academia.edu (original) (raw)

Papers by Murat Sarıcı

Research paper thumbnail of Conjunctival leiomyosarcoma in a patient with xeroderma pigmentosum: 5-year follow-up without recurrence

Arquivos Brasileiros de Oftalmologia

Research paper thumbnail of Retinal Vascular Patterns and Capillary Plexus Reflectivity of Intraocular Tumors; an Optical Coherence Tomography Angiography Study

Research paper thumbnail of Episcleral iodine-125 radioactive plaque brachytherapy as a salvage treatment for retinoblastoma in the era of intraarterial chemotherapy

The Turkish Journal of Pediatrics

Background. Retinoblastoma shows high rates of recurrence after initial chemotherapy (systemic or... more Background. Retinoblastoma shows high rates of recurrence after initial chemotherapy (systemic or intraarterial). Our aim was to evaluate the effectiveness of iodine-125 radioactive plaque brachytherapy as a salvage treatment with globe-preserving attributes after initial chemotherapy in patients with intraocular retinoblastoma. Methods. The effect of brachytherapy was investigated retrospectively in 17 eyes of 17 patients who were followed up due to retinoblastoma between May 2012 and June 2018 and who received iodine-125 radioactive plaque brachytherapy as a salvage treatment after systemic or intra-arterial chemotherapy. The regression, ocular toxicity, and enucleation rates were evaluated at the end of the follow-up period. Results. The tumor locations were post equator, macular, anterior to the equator, and peripapillary in 5, 3, 7, and 2 patients, respectively. Regression was initially and rapidly observed in 17 of the 17 eyes that underwent brachytherapy. Enucleation was performed in 5 (29.42%) of these patients due to recurrence with diffuse tumor involvement, and 4 of the tumors were located anterior to the equator. In 12 (70.58%) patients, the eyes were protected from enucleation following local brachytherapy. Conclusions. Radioactive plaque brachytherapy can be applied as an effective salvage therapy with successful results in retinoblastoma patients who have received initial systemic or intra-arterial chemotherapy. Post equator-located solitary tumors have the highest success rate.

Research paper thumbnail of Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy

International Ophthalmology, 2017

Purpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucle... more Purpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucleated for retinoblastoma and to analyze the association between growth pattern, rosetta formation, tumor thickness, presence of necrosis, calcification, neovascularization, rate of mitosis, and high-risk histopathologic factors. Methods Pathology reports of 59 eyes who had received enucleation for retinoblastoma were reviewed retrospectively. The histopathologic data included presence of choroidal invasion, optic nerve invasion, scleral extension, tumor thickness, presence of necrosis, calcification, neovascularization, rosetta formation and lymphocyte infiltration, rate of mitosis, and growth pattern. Results This study included 59 eyes from 30 (50.8%) male and 29 (49.2%) female patients. The mean age was 22.87 ± 18.99 months. There were 30 (50.8%) eyes with choroidal invasion, 30 (50.8%) eyes with optic nerve invasion, and 5 (8.5%) eyes with scleral invasion. Endophytic growth pattern was seen in 27 (45.8%) eyes, exophytic growth pattern was seen in 2 (3.4%) eyes, and combined growth pattern was seen in 30 (50.8%) eyes. Exophytic growth pattern was found statistically related to choroidal invasion (p = 0.00). Although tumor with greater thickness tended to have more choroidal invasion (p = 0.02), there was no relation between tumor thickness and optic nerve invasion (p = 0.09). Conclusions Incidences of choroidal and optic nerve invasion showed similarity with other developing countries. Because of higher incidence of high-risk

Research paper thumbnail of Evaulation of Incidence and Risk Factors for Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection

Türk Oftalmoloji Dergisi, 2015

Makula ödemi tedavisinde kullanılan intravitreal triamsinolon asetonidin göz içi basıncı (GİB) üz... more Makula ödemi tedavisinde kullanılan intravitreal triamsinolon asetonidin göz içi basıncı (GİB) üzerine etkisini ve GİB artışı açısından risk faktörlerini araştırmaktır. Ge reç ve Yön tem: Bu retrospektif çalışmada 56'sı (%65,8) diyabetik retinopati, 7'si (%8,2) santral retinal ven ve 22'si (%25,8) retinal ven dal tıkanıklığı ilişkili makula ödemi nedeniyle 4 mg intravitreal triamsinolon uygulanan 85 hastanın 93 gözü değerlendirildi. Hastalar enjeksiyon sonrası GİB değişimleri, GİB artışı ile yaş, cinsiyet, lens durumu, makula ödem etiyolojisi ve başlangıç GİB değeri arasındaki ilişki açısından incelendi. Bulgular: Otuz dokuzu kadın 46'sı erkek olan hastaların yaş ortalaması 61,58±9,5 yıl idi. İzlem boyunca 30 gözde (%32,2) ortalama 7,5 haftada 24 mmHg'nin üzerine çıkan GİB artışı görüldü. GİB artışı görülen hastaların tamamı topikal antiglokomatöz ilaç ile kontrol altına alınabildi. Ven tıkanıklığı olan 29 gözün 15'inde (%51,7), diyabetik makula ödemi olan 64 gözün 15'inde (%23,3) GİB artışı görüldü (p=0,01). Fakik 73 gözün 26'sında (%35,6), psödofakik 20 gözün 4'ünde (%20) GİB 24 mmHg'nin üzerinde ölçüldü (p=0,16). GİB artışı ile cinsiyet arasında anlamlı ilişki bulunmadı (p=0,33). GİB'de artış saptanan gözlerin enjeksiyon öncesi GİB ortalamaları 16,47±2,8 mmHg iken, artış saptanmayanlarınki 14,78±2,4 mmHg idi. GİB artışı gelişimi ile başlangıç GİB değeri arasında anlamlı ilişki vardı (p=0,01). Sonuç: GİB artışı intravitreal triamsinolon enjeksiyonu sonrasında sık görülen bir yan etkidir fakat çoğunlukla topikal tedavi ile kontrol altına alınabilmektedir. Özellikle başlangıç GİB>15 mmHg olan ve ven oklüzyonu nedeniyle enjeksiyon uygulanan hastalar GİB artışı açısından daha fazla risk taşımaktadır. (Turk J Ophthalmol 2015; 45: 86-91) Anah tar Ke li me ler: Glokom, intravitreal steroid enjeksiyonu, intraoküler basınç, risk faktörleri Objectives: To investigate the effect of intravitreal triamcinolone acetonide (IVTA) used for the macular edema on intraocular pressure (IOP) and to determine the risk factors for IOP elevation. Ma te ri als and Met hods: This retrospective study included 93 eyes of 85 patients who had 4 mg intravitreal triamcinolone injection. Of the 85 patients, 56 (65.8%) had diabetic macular edema, 22 (25.8%) had branch retinal, and 7 (8.2%) had central retinal vein occlusion. IOP changes after injection as well as the relation between IOP elevation and age, sex, lens status, etiology of macular edema, baseline IOP were evaluated. Re sults: Fourty-six male and 39 female patients with mean age 61.58±9.5 years were evaluated. IOP was recorded to be >24 mmHg in 30 eyes (32.2%) at follow-up visit after an average of 7.5 weeks. Normalization of IOP with medication was achieved in all IOP elevated eyes. Fifteen of 29 eyes (51.7%) with vein occlusion and 15 of 64 eyes (23.3%) with diabetic macula edema had IOP elevation (p=0.01). Twenty-six of 73 phakic (35.6%) and 4 of 20 pseudophakic eyes (20%) had IOP >24 mmHg (p=0.16). There was no association between IOP elevation and sex (p=0.33). Baseline IOP was 16.47±2.8 mmHg in eyes which had elevated IOP and 14.78±2.4 mmHg in the remaining. There was significant relation between IOP elevation and baseline IOP level (p=0.01). Conclusion: Elevated IOP is common side effect after IVTA, but normalization is usually achieved by topical medication. Patients with baseline IOP ≥15 mmHg and vein occlusion have higher risk for IOP elevation.

Research paper thumbnail of Tenon advancement and duplication technique to prevent postoperative Ahmed valve tube exposure in patients with refractory glaucoma

Japanese Journal of Ophthalmology, 2013

Purpose To present and compare the long-term results of Dr. Tamcelik's previously described techn... more Purpose To present and compare the long-term results of Dr. Tamcelik's previously described technique of Tenon advancement and duplication with the conventional Ahmed glaucoma valve (AGV) implantation technique in patients with refractory glaucoma. Methods This study was a multicenter, retrospective case series that included 303 eyes of 276 patients with refractory glaucoma who underwent glaucoma valve implantation surgery. The patients were divided into three groups according to the surgical technique applied and the outcomes compared. In group 1, 96 eyes of 86 patients underwent AGV implant surgery without patch graft; in group 2, 78 eyes of 72 patients underwent AGV implant surgery with donor scleral patch; in group 3, 129 eyes of 118 patients underwent Ahmed valve implant surgery with ''combined short scleral tunnel with Tenon advancement and duplication technique''. The endpoint assessed was tube exposure through the conjunctiva. Results In group 1, conjunctival tube exposure was seen in 11 eyes (12.9 %) after a mean 9.2 ± 3.7 years of follow-up. In group 2, conjunctival tube exposure was seen in six eyes (2.2 %) after a mean 8.9 ± 3.3 years of follow-up. In group 3, there was no conjunctival exposure after a mean 7.8 ± 2.8 years of follow-up. The difference between the groups was statistically significant. (P = 0.0001, Chi-square test). Conclusion This novel surgical technique combining a short scleral tunnel with Tenon advancement and duplication was found to be effective and safe to prevent conjunctival tube exposure after AGV implantation surgery in patients with refractory glaucoma. Keywords Tube exposure Á Ahmed glaucoma valve Á Glaucoma Á Glaucoma drainage implant Á Tenon advancement and duplication technique

Research paper thumbnail of Conjunctival leiomyosarcoma in a patient with xeroderma pigmentosum: 5-year follow-up without recurrence

Arquivos Brasileiros de Oftalmologia

Research paper thumbnail of Retinal Vascular Patterns and Capillary Plexus Reflectivity of Intraocular Tumors; an Optical Coherence Tomography Angiography Study

Research paper thumbnail of Episcleral iodine-125 radioactive plaque brachytherapy as a salvage treatment for retinoblastoma in the era of intraarterial chemotherapy

The Turkish Journal of Pediatrics

Background. Retinoblastoma shows high rates of recurrence after initial chemotherapy (systemic or... more Background. Retinoblastoma shows high rates of recurrence after initial chemotherapy (systemic or intraarterial). Our aim was to evaluate the effectiveness of iodine-125 radioactive plaque brachytherapy as a salvage treatment with globe-preserving attributes after initial chemotherapy in patients with intraocular retinoblastoma. Methods. The effect of brachytherapy was investigated retrospectively in 17 eyes of 17 patients who were followed up due to retinoblastoma between May 2012 and June 2018 and who received iodine-125 radioactive plaque brachytherapy as a salvage treatment after systemic or intra-arterial chemotherapy. The regression, ocular toxicity, and enucleation rates were evaluated at the end of the follow-up period. Results. The tumor locations were post equator, macular, anterior to the equator, and peripapillary in 5, 3, 7, and 2 patients, respectively. Regression was initially and rapidly observed in 17 of the 17 eyes that underwent brachytherapy. Enucleation was performed in 5 (29.42%) of these patients due to recurrence with diffuse tumor involvement, and 4 of the tumors were located anterior to the equator. In 12 (70.58%) patients, the eyes were protected from enucleation following local brachytherapy. Conclusions. Radioactive plaque brachytherapy can be applied as an effective salvage therapy with successful results in retinoblastoma patients who have received initial systemic or intra-arterial chemotherapy. Post equator-located solitary tumors have the highest success rate.

Research paper thumbnail of Evaluation of high-risk features of primary enucleation of patients with retinoblastoma in a tertiary center of a developing country in the era of intra-arterial chemotherapy

International Ophthalmology, 2017

Purpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucle... more Purpose To evaluate the frequency of high-risk histopathologic factors in Turkish children enucleated for retinoblastoma and to analyze the association between growth pattern, rosetta formation, tumor thickness, presence of necrosis, calcification, neovascularization, rate of mitosis, and high-risk histopathologic factors. Methods Pathology reports of 59 eyes who had received enucleation for retinoblastoma were reviewed retrospectively. The histopathologic data included presence of choroidal invasion, optic nerve invasion, scleral extension, tumor thickness, presence of necrosis, calcification, neovascularization, rosetta formation and lymphocyte infiltration, rate of mitosis, and growth pattern. Results This study included 59 eyes from 30 (50.8%) male and 29 (49.2%) female patients. The mean age was 22.87 ± 18.99 months. There were 30 (50.8%) eyes with choroidal invasion, 30 (50.8%) eyes with optic nerve invasion, and 5 (8.5%) eyes with scleral invasion. Endophytic growth pattern was seen in 27 (45.8%) eyes, exophytic growth pattern was seen in 2 (3.4%) eyes, and combined growth pattern was seen in 30 (50.8%) eyes. Exophytic growth pattern was found statistically related to choroidal invasion (p = 0.00). Although tumor with greater thickness tended to have more choroidal invasion (p = 0.02), there was no relation between tumor thickness and optic nerve invasion (p = 0.09). Conclusions Incidences of choroidal and optic nerve invasion showed similarity with other developing countries. Because of higher incidence of high-risk

Research paper thumbnail of Evaulation of Incidence and Risk Factors for Intraocular Pressure Elevation After Intravitreal Triamcinolone Acetonide Injection

Türk Oftalmoloji Dergisi, 2015

Makula ödemi tedavisinde kullanılan intravitreal triamsinolon asetonidin göz içi basıncı (GİB) üz... more Makula ödemi tedavisinde kullanılan intravitreal triamsinolon asetonidin göz içi basıncı (GİB) üzerine etkisini ve GİB artışı açısından risk faktörlerini araştırmaktır. Ge reç ve Yön tem: Bu retrospektif çalışmada 56'sı (%65,8) diyabetik retinopati, 7'si (%8,2) santral retinal ven ve 22'si (%25,8) retinal ven dal tıkanıklığı ilişkili makula ödemi nedeniyle 4 mg intravitreal triamsinolon uygulanan 85 hastanın 93 gözü değerlendirildi. Hastalar enjeksiyon sonrası GİB değişimleri, GİB artışı ile yaş, cinsiyet, lens durumu, makula ödem etiyolojisi ve başlangıç GİB değeri arasındaki ilişki açısından incelendi. Bulgular: Otuz dokuzu kadın 46'sı erkek olan hastaların yaş ortalaması 61,58±9,5 yıl idi. İzlem boyunca 30 gözde (%32,2) ortalama 7,5 haftada 24 mmHg'nin üzerine çıkan GİB artışı görüldü. GİB artışı görülen hastaların tamamı topikal antiglokomatöz ilaç ile kontrol altına alınabildi. Ven tıkanıklığı olan 29 gözün 15'inde (%51,7), diyabetik makula ödemi olan 64 gözün 15'inde (%23,3) GİB artışı görüldü (p=0,01). Fakik 73 gözün 26'sında (%35,6), psödofakik 20 gözün 4'ünde (%20) GİB 24 mmHg'nin üzerinde ölçüldü (p=0,16). GİB artışı ile cinsiyet arasında anlamlı ilişki bulunmadı (p=0,33). GİB'de artış saptanan gözlerin enjeksiyon öncesi GİB ortalamaları 16,47±2,8 mmHg iken, artış saptanmayanlarınki 14,78±2,4 mmHg idi. GİB artışı gelişimi ile başlangıç GİB değeri arasında anlamlı ilişki vardı (p=0,01). Sonuç: GİB artışı intravitreal triamsinolon enjeksiyonu sonrasında sık görülen bir yan etkidir fakat çoğunlukla topikal tedavi ile kontrol altına alınabilmektedir. Özellikle başlangıç GİB>15 mmHg olan ve ven oklüzyonu nedeniyle enjeksiyon uygulanan hastalar GİB artışı açısından daha fazla risk taşımaktadır. (Turk J Ophthalmol 2015; 45: 86-91) Anah tar Ke li me ler: Glokom, intravitreal steroid enjeksiyonu, intraoküler basınç, risk faktörleri Objectives: To investigate the effect of intravitreal triamcinolone acetonide (IVTA) used for the macular edema on intraocular pressure (IOP) and to determine the risk factors for IOP elevation. Ma te ri als and Met hods: This retrospective study included 93 eyes of 85 patients who had 4 mg intravitreal triamcinolone injection. Of the 85 patients, 56 (65.8%) had diabetic macular edema, 22 (25.8%) had branch retinal, and 7 (8.2%) had central retinal vein occlusion. IOP changes after injection as well as the relation between IOP elevation and age, sex, lens status, etiology of macular edema, baseline IOP were evaluated. Re sults: Fourty-six male and 39 female patients with mean age 61.58±9.5 years were evaluated. IOP was recorded to be >24 mmHg in 30 eyes (32.2%) at follow-up visit after an average of 7.5 weeks. Normalization of IOP with medication was achieved in all IOP elevated eyes. Fifteen of 29 eyes (51.7%) with vein occlusion and 15 of 64 eyes (23.3%) with diabetic macula edema had IOP elevation (p=0.01). Twenty-six of 73 phakic (35.6%) and 4 of 20 pseudophakic eyes (20%) had IOP >24 mmHg (p=0.16). There was no association between IOP elevation and sex (p=0.33). Baseline IOP was 16.47±2.8 mmHg in eyes which had elevated IOP and 14.78±2.4 mmHg in the remaining. There was significant relation between IOP elevation and baseline IOP level (p=0.01). Conclusion: Elevated IOP is common side effect after IVTA, but normalization is usually achieved by topical medication. Patients with baseline IOP ≥15 mmHg and vein occlusion have higher risk for IOP elevation.

Research paper thumbnail of Tenon advancement and duplication technique to prevent postoperative Ahmed valve tube exposure in patients with refractory glaucoma

Japanese Journal of Ophthalmology, 2013

Purpose To present and compare the long-term results of Dr. Tamcelik's previously described techn... more Purpose To present and compare the long-term results of Dr. Tamcelik's previously described technique of Tenon advancement and duplication with the conventional Ahmed glaucoma valve (AGV) implantation technique in patients with refractory glaucoma. Methods This study was a multicenter, retrospective case series that included 303 eyes of 276 patients with refractory glaucoma who underwent glaucoma valve implantation surgery. The patients were divided into three groups according to the surgical technique applied and the outcomes compared. In group 1, 96 eyes of 86 patients underwent AGV implant surgery without patch graft; in group 2, 78 eyes of 72 patients underwent AGV implant surgery with donor scleral patch; in group 3, 129 eyes of 118 patients underwent Ahmed valve implant surgery with ''combined short scleral tunnel with Tenon advancement and duplication technique''. The endpoint assessed was tube exposure through the conjunctiva. Results In group 1, conjunctival tube exposure was seen in 11 eyes (12.9 %) after a mean 9.2 ± 3.7 years of follow-up. In group 2, conjunctival tube exposure was seen in six eyes (2.2 %) after a mean 8.9 ± 3.3 years of follow-up. In group 3, there was no conjunctival exposure after a mean 7.8 ± 2.8 years of follow-up. The difference between the groups was statistically significant. (P = 0.0001, Chi-square test). Conclusion This novel surgical technique combining a short scleral tunnel with Tenon advancement and duplication was found to be effective and safe to prevent conjunctival tube exposure after AGV implantation surgery in patients with refractory glaucoma. Keywords Tube exposure Á Ahmed glaucoma valve Á Glaucoma Á Glaucoma drainage implant Á Tenon advancement and duplication technique