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Papers by Murat Tosun
Journal of Drugs in Dermatology Jdd, Oct 1, 2010
Wound healing is a complex process, and the role of retinoids in wounds is confusing and controve... more Wound healing is a complex process, and the role of retinoids in wounds is confusing and controversial. In this study, the authors aimed to evaluate the role of oral isotretinoin on mast cells, collagen production and remodeling in the wound healing process. In the first group 2 mg/kg/day isotretinoin dissolved in sunflower oil were administrated for 28 days. In the second group, only sunflower oil was administered. At the end of first week, four incisions were made on rats' back. In the seventh (group 1a and 2a), fourteenth (group 1b and 2b) and twenty-first (group 1c and 2c) days, the skin biopsies were taken from around of the incision areas from both groups. The authors revealed that isotretinoin administration permanently accelerates mast cell accumulation parallel to days in the wound area. The histological features of wound healing in isotretinoin administered rats were faster and better than the group 2.
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
ABSTRACT Ebselen is a organoselenium compound which has strong antioxidant and anti-inflammatory ... more ABSTRACT Ebselen is a organoselenium compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of ebselen pretreatment in rats with experimental sciatic nerve ischemia-reperfusion (I/R) injury. Adult male Spraque-Dawley rats were divided into four groups (N = 7 in each group). Before sciatic nerve I/R was induced, ebselen was injected intraperitoneally at doses of 15 and 30 mg/kg. After 2 h ischemia and 3 h reperfusion period, sciatic nerve tissues were excised. Tissue levels of malondialdehyde (MDA) and nitric oxide (NO), and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured. Sciatic nerve tissues were also examined histopathologically. The 15 mg/kg ebselen reduced sciatic nerve damage and apoptosis (P < 0.01), MDA, NO levels, and inducible nitric oxide synthase (iNOS) positive cells (P < 0.01, P < 0.05, respectively) and increased SOD, GPx, and CAT activities (P <...
Journal of Surgical Research, 2014
Journal of Surgical Research, 2015
Journal of Laparoendoscopic & Advanced Surgical Techniques, 2008
Journal of Drugs in Dermatology Jdd, Oct 1, 2010
Wound healing is a complex process, and the role of retinoids in wounds is confusing and controve... more Wound healing is a complex process, and the role of retinoids in wounds is confusing and controversial. In this study, the authors aimed to evaluate the role of oral isotretinoin on mast cells, collagen production and remodeling in the wound healing process. In the first group 2 mg/kg/day isotretinoin dissolved in sunflower oil were administrated for 28 days. In the second group, only sunflower oil was administered. At the end of first week, four incisions were made on rats' back. In the seventh (group 1a and 2a), fourteenth (group 1b and 2b) and twenty-first (group 1c and 2c) days, the skin biopsies were taken from around of the incision areas from both groups. The authors revealed that isotretinoin administration permanently accelerates mast cell accumulation parallel to days in the wound area. The histological features of wound healing in isotretinoin administered rats were faster and better than the group 2.
Bosnian journal of basic medical sciences / Udruzenje basicnih mediciniskih znanosti = Association of Basic Medical Sciences
ABSTRACT Ebselen is a organoselenium compound which has strong antioxidant and anti-inflammatory ... more ABSTRACT Ebselen is a organoselenium compound which has strong antioxidant and anti-inflammatory effects. We investigated the neuroprotective role of ebselen pretreatment in rats with experimental sciatic nerve ischemia-reperfusion (I/R) injury. Adult male Spraque-Dawley rats were divided into four groups (N = 7 in each group). Before sciatic nerve I/R was induced, ebselen was injected intraperitoneally at doses of 15 and 30 mg/kg. After 2 h ischemia and 3 h reperfusion period, sciatic nerve tissues were excised. Tissue levels of malondialdehyde (MDA) and nitric oxide (NO), and activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were measured. Sciatic nerve tissues were also examined histopathologically. The 15 mg/kg ebselen reduced sciatic nerve damage and apoptosis (P < 0.01), MDA, NO levels, and inducible nitric oxide synthase (iNOS) positive cells (P < 0.01, P < 0.05, respectively) and increased SOD, GPx, and CAT activities (P <...
Journal of Surgical Research, 2014
Journal of Surgical Research, 2015
Journal of Laparoendoscopic & Advanced Surgical Techniques, 2008