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Papers by Muskaan Chhabra

Research paper thumbnail of Multidrug Regimen for Prevention of Mother-to-child Transmission in Human Immunodeficiency Virus-positive Mothers in India—From Prevention toward Elimination

Journal of SAFOG, 2019

Objectives: To study the incidence, demographics, and course till delivery of HIV positive women ... more Objectives: To study the incidence, demographics, and course till delivery of HIV positive women on multidrug regimen for prevention of mother-to-child transmission (PMTCT). To study the efficacy of this regimen, neonatal outcome and human immunodeficiency virus (HIV) status in infants of these women to detect transmission.

Research paper thumbnail of Solid pseudopapillary epithelial neoplasm of pancreas in pregnancy: Case Report of a Rare Co-Occurrence

journal of medical science and clinical research, 2017

Background: Solid pseudopapillary epithelial neoplasm of pancreas (SPEN) also known as papillary ... more Background: Solid pseudopapillary epithelial neoplasm of pancreas (SPEN) also known as papillary epithelial neoplasm and cystic-solid papillary carcinoma of the pancreas is an uncommon neoplasm of exocrine pancreas. It predominantly occurs in young women in their twenties and thirties and accounts for 1-2% of all pancreatic tumors. It is a peculiar tumor for having low grade malignant potential and an excellent prognosis. Most patients are asymptomatic at diagnosis and may present with gradually enlarging abdominal mass or vague abdominal pain. The diagnosis is usually done by imaging (CECT, MRI) and histopathology. Here we report a case of 22 years old pregnant woman who was referred to our hospital with a history of gradually increasing abdominal lump and vague abdominal pain since 1 year. She was diagnosed with SPN by imaging and histopathology. Case Report: A 22 years old female with full term gestation was referred to us in view of gradually increasing abdominal mass and history of vague abdominal pain since 1 year. At 12 weeks of gestation she was investigated at her native place and was diagnosed with a mass in left renal fossa. In our hospital she delivered male child at full term by normal vaginal delivery. In postnatal period CECT was done which showed a lobulated lesion with internal calcification in left anterior para-renal space. A USG guided trucut biopsy confirmed the diagnosis of pseudopapillary epithelial neoplasm of pancreas. Distal pancreaticosplenectomy with left radical nephrectomy and left hemicolectomy was done. At the time of discharge patient was advised regular follow up. We are reporting this case because SPN are uncommon tumors and their co-occurrence with pregnancy is even rarer. Conclusion: SPENs are rare but curable neoplasm of exocrine pancreas affecting young females in their 2nd or 3rd decade. The diagnosis is sometimes difficult because of a wide differential diagnosis however once diagnosed it has an excellent prognosis because of its low malignant potential. Presence of gradually increasing, well defined, cystic pancreatic mass in young females should raise the suspicion of SPN.

Research paper thumbnail of Does Number Matter: A Case Series of Gestational Trophoblastic Disease with Coexistent Live Pregnancies Post-multiple Embryo Transfer after In vitro Fertilization–intracytoplasmic Sperm Injection

International Journal of Infertility & Fetal Medicine

Aim and objective: We present three cases of multiple pregnancies associated with hydatidiform mo... more Aim and objective: We present three cases of multiple pregnancies associated with hydatidiform mole occurring after in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI). Background: The phenomenon of molar pregnancy coexisting with higher-order pregnancies after IVF-ICSI is extremely rare as assisted reproduction techniques allow us to directly assess gametes and ICSI curtails any chances of dispermic fertilization. Case description: Three cases are discussed each of which was managed differently according to gestational age and parity of the patient. Individualization of management along with strict follow-up is necessary in such cases. Conclusion: A high index of suspicion must be kept for the possibility of coexistent molar pregnancy, especially in multiple conceptions occurring after IVF-ICSI. Even though rare, if diagnosed early, appropriate management can help avoid catastrophic complications and preserve future fertility. Clinical significance: No clear guidelines exist at present regarding the management of molar pregnancies coexisting with IVF-ICSI conceptions and many factors unique to these pregnancies need to be addressed. The possibility of severe complications like massive bleeding may necessitate the termination of a precious pregnancy. The high possibility of gestational trophoblastic neoplasia and the need for long-term follow-up may delay further cycles and deny the couple a chance at their own genetic baby. Mole can recur in subsequent pregnancies and this also requires detailed patient counseling with an option for use of preimplantation genetic diagnosis techniques.

Research paper thumbnail of Successful live birth after heterotopic ruptured cornual pregnancy with twin intrauterine gestation in an in vitro fertilization conception

International journal of reproduction, contraception, obstetrics and gynecology, 2019

Heterotopic pregnancy is defined as coexistence of intrauterine with extrauterine gestation. A na... more Heterotopic pregnancy is defined as coexistence of intrauterine with extrauterine gestation. A naturally occurring heterotopic pregnancy is a rarity with incidence being as low as 1 in 30,000. But with the advent of assisted reproductive techniques, the scenario has radically changed. With the increased availability of In vitro fertilization techniques, heterotopic pregnancies are more commonly encountered today and the incidence of these in IVF pregnancies shoots up to 1 in 100 to 1 in 500. However, the management protocols of such pregnancies may vary greatly depending upon the location of the intrauterine pregnancy, hemodynamic stability of the patient and the gestation of the pregnancy. We present a case report detailing one such patient where a heterotropic cornual pregnancy was seen along with an intrauterine twin pregnancy and was successfully managed. ABSTRACT

Research paper thumbnail of Neurofibromatosis and its varied manifestations in pregnancy: A case report

Research paper thumbnail of Live second trimester intrauterine pregnancy with invasive mole: a rare case report

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Gestational trophoblastic disease or gestational trophoblastic neoplasia is a collective term use... more Gestational trophoblastic disease or gestational trophoblastic neoplasia is a collective term used to describe hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumours. Since any molar pregnancy has the potential to develop into invasive mole these patients should be carefully monitored for development of malignant disease. Here we are reporting a case of invasive molar pregnancy with a single live fetus of 17 weeks gestational age. A 24 years old woman, G3P2L2 with a history of amenorrhea since approximately 5 months presented with profuse per vaginal bleeding. Ultrasound showed presence of live fetus of approximate gestational age of 17 weeks. Along with the fetus there was also presence of cystic areas with no vascularity s/o Hydatiform mole. In view of continued bleeding and severe anemia pregnancy was terminated and fetus along with vesicular tissue was expelled. On follow up Beta hcg titers showed increasing trend over the next week. Repeat USG ...

Research paper thumbnail of Multidrug Regimen for Prevention of Mother-to-child Transmission in Human Immunodeficiency Virus-positive Mothers in India—From Prevention toward Elimination

Journal of SAFOG, 2019

Objectives: To study the incidence, demographics, and course till delivery of HIV positive women ... more Objectives: To study the incidence, demographics, and course till delivery of HIV positive women on multidrug regimen for prevention of mother-to-child transmission (PMTCT). To study the efficacy of this regimen, neonatal outcome and human immunodeficiency virus (HIV) status in infants of these women to detect transmission.

Research paper thumbnail of Solid pseudopapillary epithelial neoplasm of pancreas in pregnancy: Case Report of a Rare Co-Occurrence

journal of medical science and clinical research, 2017

Background: Solid pseudopapillary epithelial neoplasm of pancreas (SPEN) also known as papillary ... more Background: Solid pseudopapillary epithelial neoplasm of pancreas (SPEN) also known as papillary epithelial neoplasm and cystic-solid papillary carcinoma of the pancreas is an uncommon neoplasm of exocrine pancreas. It predominantly occurs in young women in their twenties and thirties and accounts for 1-2% of all pancreatic tumors. It is a peculiar tumor for having low grade malignant potential and an excellent prognosis. Most patients are asymptomatic at diagnosis and may present with gradually enlarging abdominal mass or vague abdominal pain. The diagnosis is usually done by imaging (CECT, MRI) and histopathology. Here we report a case of 22 years old pregnant woman who was referred to our hospital with a history of gradually increasing abdominal lump and vague abdominal pain since 1 year. She was diagnosed with SPN by imaging and histopathology. Case Report: A 22 years old female with full term gestation was referred to us in view of gradually increasing abdominal mass and history of vague abdominal pain since 1 year. At 12 weeks of gestation she was investigated at her native place and was diagnosed with a mass in left renal fossa. In our hospital she delivered male child at full term by normal vaginal delivery. In postnatal period CECT was done which showed a lobulated lesion with internal calcification in left anterior para-renal space. A USG guided trucut biopsy confirmed the diagnosis of pseudopapillary epithelial neoplasm of pancreas. Distal pancreaticosplenectomy with left radical nephrectomy and left hemicolectomy was done. At the time of discharge patient was advised regular follow up. We are reporting this case because SPN are uncommon tumors and their co-occurrence with pregnancy is even rarer. Conclusion: SPENs are rare but curable neoplasm of exocrine pancreas affecting young females in their 2nd or 3rd decade. The diagnosis is sometimes difficult because of a wide differential diagnosis however once diagnosed it has an excellent prognosis because of its low malignant potential. Presence of gradually increasing, well defined, cystic pancreatic mass in young females should raise the suspicion of SPN.

Research paper thumbnail of Does Number Matter: A Case Series of Gestational Trophoblastic Disease with Coexistent Live Pregnancies Post-multiple Embryo Transfer after In vitro Fertilization–intracytoplasmic Sperm Injection

International Journal of Infertility & Fetal Medicine

Aim and objective: We present three cases of multiple pregnancies associated with hydatidiform mo... more Aim and objective: We present three cases of multiple pregnancies associated with hydatidiform mole occurring after in vitro fertilization (IVF)-intracytoplasmic sperm injection (ICSI). Background: The phenomenon of molar pregnancy coexisting with higher-order pregnancies after IVF-ICSI is extremely rare as assisted reproduction techniques allow us to directly assess gametes and ICSI curtails any chances of dispermic fertilization. Case description: Three cases are discussed each of which was managed differently according to gestational age and parity of the patient. Individualization of management along with strict follow-up is necessary in such cases. Conclusion: A high index of suspicion must be kept for the possibility of coexistent molar pregnancy, especially in multiple conceptions occurring after IVF-ICSI. Even though rare, if diagnosed early, appropriate management can help avoid catastrophic complications and preserve future fertility. Clinical significance: No clear guidelines exist at present regarding the management of molar pregnancies coexisting with IVF-ICSI conceptions and many factors unique to these pregnancies need to be addressed. The possibility of severe complications like massive bleeding may necessitate the termination of a precious pregnancy. The high possibility of gestational trophoblastic neoplasia and the need for long-term follow-up may delay further cycles and deny the couple a chance at their own genetic baby. Mole can recur in subsequent pregnancies and this also requires detailed patient counseling with an option for use of preimplantation genetic diagnosis techniques.

Research paper thumbnail of Successful live birth after heterotopic ruptured cornual pregnancy with twin intrauterine gestation in an in vitro fertilization conception

International journal of reproduction, contraception, obstetrics and gynecology, 2019

Heterotopic pregnancy is defined as coexistence of intrauterine with extrauterine gestation. A na... more Heterotopic pregnancy is defined as coexistence of intrauterine with extrauterine gestation. A naturally occurring heterotopic pregnancy is a rarity with incidence being as low as 1 in 30,000. But with the advent of assisted reproductive techniques, the scenario has radically changed. With the increased availability of In vitro fertilization techniques, heterotopic pregnancies are more commonly encountered today and the incidence of these in IVF pregnancies shoots up to 1 in 100 to 1 in 500. However, the management protocols of such pregnancies may vary greatly depending upon the location of the intrauterine pregnancy, hemodynamic stability of the patient and the gestation of the pregnancy. We present a case report detailing one such patient where a heterotropic cornual pregnancy was seen along with an intrauterine twin pregnancy and was successfully managed. ABSTRACT

Research paper thumbnail of Neurofibromatosis and its varied manifestations in pregnancy: A case report

Research paper thumbnail of Live second trimester intrauterine pregnancy with invasive mole: a rare case report

International Journal of Reproduction, Contraception, Obstetrics and Gynecology

Gestational trophoblastic disease or gestational trophoblastic neoplasia is a collective term use... more Gestational trophoblastic disease or gestational trophoblastic neoplasia is a collective term used to describe hydatiform mole, invasive mole, choriocarcinoma and placental site trophoblastic tumours. Since any molar pregnancy has the potential to develop into invasive mole these patients should be carefully monitored for development of malignant disease. Here we are reporting a case of invasive molar pregnancy with a single live fetus of 17 weeks gestational age. A 24 years old woman, G3P2L2 with a history of amenorrhea since approximately 5 months presented with profuse per vaginal bleeding. Ultrasound showed presence of live fetus of approximate gestational age of 17 weeks. Along with the fetus there was also presence of cystic areas with no vascularity s/o Hydatiform mole. In view of continued bleeding and severe anemia pregnancy was terminated and fetus along with vesicular tissue was expelled. On follow up Beta hcg titers showed increasing trend over the next week. Repeat USG ...