Mustafa M Abdulrasool - Academia.edu (original) (raw)

Mustafa M Abdulrasool

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Papers by Mustafa M Abdulrasool

Research paper thumbnail of Synthesis, Characterization and Evaluation of Biological Activity of New Heterocyclic Compounds Containing 1,2,4- Triazoleand 1,3,4-Thiadiazole Rings

In this study, a new Triazole derivative was synthesized by many cyclization reactions. Compound ... more In this study, a new Triazole derivative was synthesized by many cyclization reactions. Compound (1) was cyclized by the reaction of hydrazine hydrate with carbon disulfide. The compound (1) was reacted with chloroethyl acetate in presence of alkali ethanol to give the ester (2). The compound was obtained from the reaction of compound (2) with hydrazine hydrate. The salt and were studied. The result showed that the compounds and possess high biological activity.

Research paper thumbnail of SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOLOGICAL ACTIVITY OF SOME HETEROCYCLIC COMPOUNDS CONTAINING 1,2,4- TRIAZOLE RING

In this study, a new triazole derivatives were synthesized by many cyclization reactions. The mal... more In this study, a new triazole derivatives were synthesized by many cyclization reactions. The malonichydrazide 1 was synthesized by the reaction of ethyl malonate with hydrazine hydrate . The compound1 was react with CS2 in asolution of alkali ethanol to give the salt2. The triazole3 was obtained from thecyclization of the salt2 with hydrazine hydrate derivative4 was prepared by the cyclization reaction of compound 3 with p-Bromophenacyl bromide, the compounds 7 and 8 were prepared according to the same procedures of the compound 3 and 4 using methyl benzoate instead of ethyl malonate. The biological activity of compounds 3,4,7 and 8 were studied against four types of bacteria two of them were gram negative (E.Coli and K.pneomonia ) and the others were gram positive (S. aureus and E. faecalis ). One type of fungi was used which was Candida albicans. The result showed that the mentioned above compounds possess high biological activity.

Research paper thumbnail of Synthesis, Characterization and Evaluation of Biological Activity of New Heterocyclic Compounds Containing 1,2,4- Triazoleand 1,3,4-Thiadiazole Rings

In this study, a new Triazole derivative was synthesized by many cyclization reactions. Compound ... more In this study, a new Triazole derivative was synthesized by many cyclization reactions. Compound (1) was cyclized by the reaction of hydrazine hydrate with carbon disulfide. The compound (1) was reacted with chloroethyl acetate in presence of alkali ethanol to give the ester (2). The compound was obtained from the reaction of compound (2) with hydrazine hydrate. The salt and were studied. The result showed that the compounds and possess high biological activity.

Research paper thumbnail of SYNTHESIS, CHARACTERIZATION AND EVALUATION OF BIOLOGICAL ACTIVITY OF SOME HETEROCYCLIC COMPOUNDS CONTAINING 1,2,4- TRIAZOLE RING

In this study, a new triazole derivatives were synthesized by many cyclization reactions. The mal... more In this study, a new triazole derivatives were synthesized by many cyclization reactions. The malonichydrazide 1 was synthesized by the reaction of ethyl malonate with hydrazine hydrate . The compound1 was react with CS2 in asolution of alkali ethanol to give the salt2. The triazole3 was obtained from thecyclization of the salt2 with hydrazine hydrate derivative4 was prepared by the cyclization reaction of compound 3 with p-Bromophenacyl bromide, the compounds 7 and 8 were prepared according to the same procedures of the compound 3 and 4 using methyl benzoate instead of ethyl malonate. The biological activity of compounds 3,4,7 and 8 were studied against four types of bacteria two of them were gram negative (E.Coli and K.pneomonia ) and the others were gram positive (S. aureus and E. faecalis ). One type of fungi was used which was Candida albicans. The result showed that the mentioned above compounds possess high biological activity.

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