Mustafa Aydın - Academia.edu (original) (raw)
Papers by Mustafa Aydın
Acta Biochimica Polonica, 2011
Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of ... more Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found i...
Clinical & Investigative Medicine, 2012
Purpose: The aim of this study is to investigate whether P wave dispersion (PWD), measured before... more Purpose: The aim of this study is to investigate whether P wave dispersion (PWD), measured before, during and after fibrinolytic therapy (FT,) is able to predict successful reperfusion and infarct related artery (IRA) patency in patients with acute anterior MI who received FT. Methods: Sixty-eight patients who presented with acute anterior MI were enrolled in the study. An electrocardiogram was performed before and at 30, 60, 90 and 120 minutes after the start of FT. PWD was defined as the difference between maximum and minimum P wave duration on standard 12-lead surface electrocardiogram. A multivariate logistic regression model was used to assess whether PWD was predictor of IRA patency and ST-segment resolution (STR) on electrocardiogram. Results: PWD120 was significantly lower in patients with STR on electrocardiogram (38 patients) compared with those without STR (30 patients) (44.8±11.5 vs. 52.9±10.3 ms; p < 0.001). PWD120 was found to be significantly lower in patients with...
Interventional Medicine and Applied Science, 2017
Background: Ghrelin has recently been reported to have beneficial effects on cardiac contractile ... more Background: Ghrelin has recently been reported to have beneficial effects on cardiac contractile functions and coronary blood flow. The main purpose of this study was to investigate the role of ghrelin in the pathogenesis of coronary slow flow (CSF) together with endothelial functions. Methods: Twenty-five patients having normal coronary arteries with CSF and 25 controls with normal coronary flow were included into the study. The quantitative measurement of coronary blood flow was performed for each coronary artery using the thrombolysis in myocardial infarction (TIMI) frame count (TFC) method. Ghrelin levels were measured using the enzyme-linked immunosorbent assay method from venous blood samples. Endothelial functions were evaluated from the brachial artery with the flow-mediated dilation (FMD) and nitrate-related dilation methods. Results: There was a significant difference in terms of mean TFC values between the control and CSF groups (p < 0.001 for all coronary arteries). The mean FMD percentage among patients with CSF was lower than that of the control group (5.9 ± 0.8 vs. 10.7% ± 1.1%; p < 0.001). A moderate negative correlation was observed between the FMD percentages and the TFCs. There was no relationship between the TFC and ghrelin levels. Conclusion: Plasma ghrelin levels seem to be uninfluential while impaired endothelial functions play an important role in the etiopathogenesis of CSF.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2016
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2005
The purpose of this prospective study was to determine the relationship between circadian blood p... more The purpose of this prospective study was to determine the relationship between circadian blood pressure and left ventricular diastolic function in essential hypertension. The study population included 25 patients aged 56 +/- 18 years with non-dipper hypertension and 25 age- and sex-matched patients with dipper hypertension. They underwent conventional Doppler echocardiography and color tissue Doppler from apical 4- and 2-chamber views. In non-dipper patients, diastolic left ventricular function was reduced significantly. The transmitral E wave decreased (0.55 +/- 0.2 vs 0.62 +/- 0.2 m/s, P < 0.05), the transmitral A wave increased (0.77 +/- 0.1 vs 0.70 +/- 0.1 m/s, P < 0.01), the transmitral E/A ratio decreased (0.78 +/- 0.1 vs 0.86 +/- 0.2, P < 0.05), and the transmitral E-wave deceleration time increased in non-dipper patients (211 +/- 44 vs 196 +/- 42 ms, P < 0.05). The isovolumic relaxation time increased (112 +/- 15 vs 105 +/- 14 m/s, P < 0.05). The mean left ve...
![Research paper thumbnail of [Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure]](https://attachments.academia-assets.com/107325759/thumbnails/1.jpg)
](Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2005
In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary ... more In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure. Twenty-four patients (mean age: 55+/-8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values. Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolo...
European heart journal cardiovascular Imaging, 2012
To investigate the atrial electromechanical delay (EMD) duration that is a non-invasive predictor... more To investigate the atrial electromechanical delay (EMD) duration that is a non-invasive predictor of atrial fibrillation (AF) in patients with Behcet's disease (BD). Thirty-eight Behcet's patients (24 females, 14 males; mean age: 43.6 ± 10.3 years) who were being followed in the dermatology or internal medicine department and 29 demographically matched controls (13 females, 16 males; mean: age 42.6 ± 11.1 years) were included in the study. The inclusion criteria were recurrent oral ulcerations and two of the following features: recurrent genital ulceration, eye lesions, skin lesions or positive pathergy skin test for Behcet's group. Using tissue Doppler imaging, atrial electromechanical coupling [time interval from the onset of P wave on surface electrocardiogram to the beginning of A wave interval with tissue Doppler echocardiography (PA)] were measured from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septum), and right ventricular tricuspid annul...
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2012
Lymphomatoid granulomatosis is a rare, diffuse, large B-cell lymphoma that is positive for Epstei... more Lymphomatoid granulomatosis is a rare, diffuse, large B-cell lymphoma that is positive for Epstein-Barr virus. A multiorgan process, it manifests itself chiefly in the lungs but can also affect the skin, nervous system, and kidneys. Cardiac involvement and pericardial effusion are very unusual. We report the case of a 62-year-old man with lymphomatoid granulomatosis involving the heart and lungs. Diagnosis was confirmed with wedge biopsy at pericardiotomy, and the patient was treated with cyclophosphamide, prednisolone, and vincristine. Although the patient was still symptomatic at 6-month follow-up, he was in partial remission with improved functional capacity.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2012
Case Reports in Cardiology, 2012
We report a case of hypertrophic cardiomyopathy due to systolic total narrowing of side branches ... more We report a case of hypertrophic cardiomyopathy due to systolic total narrowing of side branches of all major coronary arteries.
Kosuyolu Heart Journal, 2012
Introduction: The aim of this study was to evaluate the relationship between the extend and sever... more Introduction: The aim of this study was to evaluate the relationship between the extend and severity of coronary artery disease (CAD) determined by the Gensini score and complete blood count parameters (white blood cell, hemoglobin, platelet, mean platelet volume, lymphocyte, neutrophil). Patients and Methods: Ninety patients with CAD underwent coronary angiography (40 females, mean age 61 ± 1.2 years) were included in this study. Patients with acute coronary syndrome and prior cardiovascular disease excluded from the study. The association between the extent and severity of CAD, which were assessed by the Gensini score, and complete blood count parameters was analyzed by a correlation analysis. Results: Coronary angiography revealed, 6 (6.7%) patients had three, 16 (17.8%) patients had two, and 24 (26.7%) patients had single-vessel disease; 44 (48.9%) patients had non-critical stenosis. The mean Gensini score was 19.1 ± 2.1. We found a relationship between white blood cell and neutrophil counts and the Gensini score. There was no relationship between Gensini score and the mean platelet volume and other parameters. Conclusion: The present study supports the hypothesis that inflammation is one of the main component in the pathogenesis of CAD.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2010
We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometab... more We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometabolic risk profile and the control of blood pressure (BP) of adult hypertensive outpatients in 12 countries across Europe. A total of 218 hypertensive patients (139 females, 79 males; mean age 57.2±10.9 years) from Turkey were included in this pan-European survey. Blood pressure control (defined as BP <140/90 mmHg for nondiabetics and <130/80 mmHg for diabetics) and cardiometabolic risk factors such as diabetes mellitus, metabolic syndrome, obesity, sedentary lifestyle, and atherogenic dyslipidemia were evaluated in accordance with the 2003 ESH/ESC guidelines on management of hypertension. Control of BP was achieved in only 21.6% of the patients diagnosed with hypertension for a mean duration of 7.7±5.4 years. The mean systolic and diastolic BPs were 144±21 mmHg and 88±14 mmHg, respectively. The most frequent concomitant disease was type 2 diabetes mellitus (66 patients, 30.3%). Pat...
Mediators of Inflammation, 2009
Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumo... more Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF- and IL-6 in CAE patients.Methods. Plasma concentrations of TNF- and IL-6 were measured in 36 patients with CAE (28 males, mean age: years), and results were compared with age and sex-matched controls () without coronary artery ectasia. TNF- and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA).Results. Baseline characteristics of the two groups were similar. TNF- and IL-6 levels were significantly higher in CAE group than controls ( pg/mL versus pg/mL, , and versus , resp.).Conclusion. CAE patients showed increases in TNF- and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the in...
Mediators of Inflammation, 2010
Background. Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coro... more Background. Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coronary arteries. There are scarce data about the role of dendritic cells in CAE development. In this study we investigated the activation markers on the surface of monocyte-derived dendritic cells (mDCs) in coronary artery disease (CAD) patients with or without CAE.Method. The study consisted of 6 patients who had obstructive CAD with CAE, 6 CAD patients without CAE and 6 subjects with angiographically normal coronary arteries. mDCs were cultivated from peripheral blood monocytes. Surface activation markers were detected by flow cytometry.Results. CAD patients with CAE were detected to have significantly higher mean fluorescence intensities of CD11b, CD11c, CD54 , CD83, CD86 and MHC Class II molecules on mDCs in comparison to CAD patients without CAE and normal controls ( for all). A significant positive correlation was found between the number of vessels with CAE and the levels of CD11c, ...
Mediators of Inflammation, 2003
Inflammation is the most important mechanism of plaque disruption playing an essential role in ac... more Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1b, IL-2, IL-8 and tumor necrosis factor (TNF)-a in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1b, IL-2, IL-8 and TNF-a during the early stage of UAP. Methods and results: Thirty-seven patients with UAP (12 females and 25 males; mean age, 57.59/9.7 years) within 6 h of admission and 20 healthy volunteers (eight females and 12 males; mean age, 51.39/6.3 years) were included in the study. IL-1b, IL-2, IL-8 and TNF-a levels were measured using the enzyme-linked immunosorbent assay method. Patients with acute or chronic inflammation, renal failure or chronic heart failure were excluded from the study. The age, gender and risk factors of the study and control groups were similar. The levels of IL-1b, IL-8 and TNF-a were significantly increased (p B/0.0001, p B/0.001 and p B/0.016, respectively) in patients with UAP. There was no difference of IL-2 levels between the UAP group and controls. Conclusion: We detected high levels of IL-1b, IL-8 and TNF-a in patients with UAP during early phase. We suggest that proinflammatory cytokines (e.g. IL-1b, IL-8, TNF-a) may play an important role in the development of atherosclerosis and its complications.
Kidney and Blood Pressure Research, 2012
Background: We aimed here to investigate hydration status by echocardiography in end stage renal ... more Background: We aimed here to investigate hydration status by echocardiography in end stage renal disease (ESRD) patients. Methods: 25 ESRD patients [15 males; mean age: 54.0±16.6 years; 13 hemodialysis; 12 peritoneal dialysis] were considered eligible for this study. We also examined 29 healthy volunteers as a control group (17 males; mean age: 46.5±12.8 years). Body composition analysis using the bioimpedance spectroscopy technique was performed for volume overload diagnosis. The ratio of extracellular water (ECW) to height was used as volume indices. The aortic elastic parameters were calculated by echocardiography. A correlation analyses was performed between the ratio of ECW to height indicating the volume overload and the aortic elastic parameters e.g. Aortic strain (AS), Aortic distensibility (AD) and Aortic stiffness index (ASI). Results: The ratio of ECW to height that indicates volume overload in ESRD patients was considerably higher than that in the control group (10.25±1.98 L/m vs 8.66±1.22 L/m, p=0.001). There was a negative correlation between the ratio of ECW to height and AS and AD and a positive correlation between the ratio of ECW to height and ASI. Conclusion: Given the importance of the diagnosis and follow up of volume overload, the results show that aortic elasticity measurements, being easy to perform and replicate, can be used for this purpose.
Journal of the American College of Cardiology, 2013
Journal of the American College of Cardiology, 2013
International Heart Journal, 2011
Japanese Heart Journal, 2004
We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiogr... more We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiography revealed massive intracoronary thrombus, which completely occluded the distal part of the left circumflex coronary artery. The thrombotic segment and the rest of the coronary tree were free of atherosclerosis. The patient was treated with intravenous tirofiban, a glycoprotein IIb/IIIa inhibitor. A control angiography was performed one week later and showed total dissolution of the thrombus with tirofiban therapy.
Acta Biochimica Polonica, 2011
Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of ... more Prostate Specific Antigen (PSA), a member of kallikrein family, is a specific serine protease of prostatic tissue. In some case reports, changes in PSA levels after acute myocardial infarction (AMI) have been reported. In this study we evaluated variations in PSA levels post-AMI. Twenty-six male patients who had PSA levels within reference limits were included in the study. The diagnosis of AMI was confirmed by clinical findings, ECG (electrocardiogram) and cardiac marker studies. Serum total PSA (tPSA) and free PSA (fPSA) levels were measured at days 0 (day of admission), 1, 2 and 3 after AMI. PSA/albumin ratio was also calculated in order to evaluate the effect of dilution. A statistical analysis of the results of all patients revealed significant decrease in tPSA levels and tPSA/Albumin ratio at day 2 when compared to days 0 and 3, which showed a similar pattern. Changes of fPSA and fPSA/ Albumin ratio according to days were not found significant. In only four patients we found i...
Clinical & Investigative Medicine, 2012
Purpose: The aim of this study is to investigate whether P wave dispersion (PWD), measured before... more Purpose: The aim of this study is to investigate whether P wave dispersion (PWD), measured before, during and after fibrinolytic therapy (FT,) is able to predict successful reperfusion and infarct related artery (IRA) patency in patients with acute anterior MI who received FT. Methods: Sixty-eight patients who presented with acute anterior MI were enrolled in the study. An electrocardiogram was performed before and at 30, 60, 90 and 120 minutes after the start of FT. PWD was defined as the difference between maximum and minimum P wave duration on standard 12-lead surface electrocardiogram. A multivariate logistic regression model was used to assess whether PWD was predictor of IRA patency and ST-segment resolution (STR) on electrocardiogram. Results: PWD120 was significantly lower in patients with STR on electrocardiogram (38 patients) compared with those without STR (30 patients) (44.8±11.5 vs. 52.9±10.3 ms; p < 0.001). PWD120 was found to be significantly lower in patients with...
Interventional Medicine and Applied Science, 2017
Background: Ghrelin has recently been reported to have beneficial effects on cardiac contractile ... more Background: Ghrelin has recently been reported to have beneficial effects on cardiac contractile functions and coronary blood flow. The main purpose of this study was to investigate the role of ghrelin in the pathogenesis of coronary slow flow (CSF) together with endothelial functions. Methods: Twenty-five patients having normal coronary arteries with CSF and 25 controls with normal coronary flow were included into the study. The quantitative measurement of coronary blood flow was performed for each coronary artery using the thrombolysis in myocardial infarction (TIMI) frame count (TFC) method. Ghrelin levels were measured using the enzyme-linked immunosorbent assay method from venous blood samples. Endothelial functions were evaluated from the brachial artery with the flow-mediated dilation (FMD) and nitrate-related dilation methods. Results: There was a significant difference in terms of mean TFC values between the control and CSF groups (p < 0.001 for all coronary arteries). The mean FMD percentage among patients with CSF was lower than that of the control group (5.9 ± 0.8 vs. 10.7% ± 1.1%; p < 0.001). A moderate negative correlation was observed between the FMD percentages and the TFCs. There was no relationship between the TFC and ghrelin levels. Conclusion: Plasma ghrelin levels seem to be uninfluential while impaired endothelial functions play an important role in the etiopathogenesis of CSF.
Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2016
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2005
The purpose of this prospective study was to determine the relationship between circadian blood p... more The purpose of this prospective study was to determine the relationship between circadian blood pressure and left ventricular diastolic function in essential hypertension. The study population included 25 patients aged 56 +/- 18 years with non-dipper hypertension and 25 age- and sex-matched patients with dipper hypertension. They underwent conventional Doppler echocardiography and color tissue Doppler from apical 4- and 2-chamber views. In non-dipper patients, diastolic left ventricular function was reduced significantly. The transmitral E wave decreased (0.55 +/- 0.2 vs 0.62 +/- 0.2 m/s, P < 0.05), the transmitral A wave increased (0.77 +/- 0.1 vs 0.70 +/- 0.1 m/s, P < 0.01), the transmitral E/A ratio decreased (0.78 +/- 0.1 vs 0.86 +/- 0.2, P < 0.05), and the transmitral E-wave deceleration time increased in non-dipper patients (211 +/- 44 vs 196 +/- 42 ms, P < 0.05). The isovolumic relaxation time increased (112 +/- 15 vs 105 +/- 14 m/s, P < 0.05). The mean left ve...
Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2005
In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary ... more In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure. Twenty-four patients (mean age: 55+/-8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values. Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolo...
European heart journal cardiovascular Imaging, 2012
To investigate the atrial electromechanical delay (EMD) duration that is a non-invasive predictor... more To investigate the atrial electromechanical delay (EMD) duration that is a non-invasive predictor of atrial fibrillation (AF) in patients with Behcet's disease (BD). Thirty-eight Behcet's patients (24 females, 14 males; mean age: 43.6 ± 10.3 years) who were being followed in the dermatology or internal medicine department and 29 demographically matched controls (13 females, 16 males; mean: age 42.6 ± 11.1 years) were included in the study. The inclusion criteria were recurrent oral ulcerations and two of the following features: recurrent genital ulceration, eye lesions, skin lesions or positive pathergy skin test for Behcet's group. Using tissue Doppler imaging, atrial electromechanical coupling [time interval from the onset of P wave on surface electrocardiogram to the beginning of A wave interval with tissue Doppler echocardiography (PA)] were measured from the lateral mitral annulus (PA lateral), septal mitral annulus (PA septum), and right ventricular tricuspid annul...
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2012
Lymphomatoid granulomatosis is a rare, diffuse, large B-cell lymphoma that is positive for Epstei... more Lymphomatoid granulomatosis is a rare, diffuse, large B-cell lymphoma that is positive for Epstein-Barr virus. A multiorgan process, it manifests itself chiefly in the lungs but can also affect the skin, nervous system, and kidneys. Cardiac involvement and pericardial effusion are very unusual. We report the case of a 62-year-old man with lymphomatoid granulomatosis involving the heart and lungs. Diagnosis was confirmed with wedge biopsy at pericardiotomy, and the patient was treated with cyclophosphamide, prednisolone, and vincristine. Although the patient was still symptomatic at 6-month follow-up, he was in partial remission with improved functional capacity.
Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital, 2012
Case Reports in Cardiology, 2012
We report a case of hypertrophic cardiomyopathy due to systolic total narrowing of side branches ... more We report a case of hypertrophic cardiomyopathy due to systolic total narrowing of side branches of all major coronary arteries.
Kosuyolu Heart Journal, 2012
Introduction: The aim of this study was to evaluate the relationship between the extend and sever... more Introduction: The aim of this study was to evaluate the relationship between the extend and severity of coronary artery disease (CAD) determined by the Gensini score and complete blood count parameters (white blood cell, hemoglobin, platelet, mean platelet volume, lymphocyte, neutrophil). Patients and Methods: Ninety patients with CAD underwent coronary angiography (40 females, mean age 61 ± 1.2 years) were included in this study. Patients with acute coronary syndrome and prior cardiovascular disease excluded from the study. The association between the extent and severity of CAD, which were assessed by the Gensini score, and complete blood count parameters was analyzed by a correlation analysis. Results: Coronary angiography revealed, 6 (6.7%) patients had three, 16 (17.8%) patients had two, and 24 (26.7%) patients had single-vessel disease; 44 (48.9%) patients had non-critical stenosis. The mean Gensini score was 19.1 ± 2.1. We found a relationship between white blood cell and neutrophil counts and the Gensini score. There was no relationship between Gensini score and the mean platelet volume and other parameters. Conclusion: The present study supports the hypothesis that inflammation is one of the main component in the pathogenesis of CAD.
Türk Kardiyoloji Derneği arşivi : Türk Kardiyoloji Derneğinin yayın organıdır, 2010
We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometab... more We evaluated the results of the Turkish arm of the GOOD survey which investigated the cardiometabolic risk profile and the control of blood pressure (BP) of adult hypertensive outpatients in 12 countries across Europe. A total of 218 hypertensive patients (139 females, 79 males; mean age 57.2±10.9 years) from Turkey were included in this pan-European survey. Blood pressure control (defined as BP <140/90 mmHg for nondiabetics and <130/80 mmHg for diabetics) and cardiometabolic risk factors such as diabetes mellitus, metabolic syndrome, obesity, sedentary lifestyle, and atherogenic dyslipidemia were evaluated in accordance with the 2003 ESH/ESC guidelines on management of hypertension. Control of BP was achieved in only 21.6% of the patients diagnosed with hypertension for a mean duration of 7.7±5.4 years. The mean systolic and diastolic BPs were 144±21 mmHg and 88±14 mmHg, respectively. The most frequent concomitant disease was type 2 diabetes mellitus (66 patients, 30.3%). Pat...
Mediators of Inflammation, 2009
Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumo... more Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF- and IL-6 in CAE patients.Methods. Plasma concentrations of TNF- and IL-6 were measured in 36 patients with CAE (28 males, mean age: years), and results were compared with age and sex-matched controls () without coronary artery ectasia. TNF- and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA).Results. Baseline characteristics of the two groups were similar. TNF- and IL-6 levels were significantly higher in CAE group than controls ( pg/mL versus pg/mL, , and versus , resp.).Conclusion. CAE patients showed increases in TNF- and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the in...
Mediators of Inflammation, 2010
Background. Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coro... more Background. Coronary artery ectasia (CAE) is defined as localized or diffuse dilation of the coronary arteries. There are scarce data about the role of dendritic cells in CAE development. In this study we investigated the activation markers on the surface of monocyte-derived dendritic cells (mDCs) in coronary artery disease (CAD) patients with or without CAE.Method. The study consisted of 6 patients who had obstructive CAD with CAE, 6 CAD patients without CAE and 6 subjects with angiographically normal coronary arteries. mDCs were cultivated from peripheral blood monocytes. Surface activation markers were detected by flow cytometry.Results. CAD patients with CAE were detected to have significantly higher mean fluorescence intensities of CD11b, CD11c, CD54 , CD83, CD86 and MHC Class II molecules on mDCs in comparison to CAD patients without CAE and normal controls ( for all). A significant positive correlation was found between the number of vessels with CAE and the levels of CD11c, ...
Mediators of Inflammation, 2003
Inflammation is the most important mechanism of plaque disruption playing an essential role in ac... more Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1b, IL-2, IL-8 and tumor necrosis factor (TNF)-a in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1b, IL-2, IL-8 and TNF-a during the early stage of UAP. Methods and results: Thirty-seven patients with UAP (12 females and 25 males; mean age, 57.59/9.7 years) within 6 h of admission and 20 healthy volunteers (eight females and 12 males; mean age, 51.39/6.3 years) were included in the study. IL-1b, IL-2, IL-8 and TNF-a levels were measured using the enzyme-linked immunosorbent assay method. Patients with acute or chronic inflammation, renal failure or chronic heart failure were excluded from the study. The age, gender and risk factors of the study and control groups were similar. The levels of IL-1b, IL-8 and TNF-a were significantly increased (p B/0.0001, p B/0.001 and p B/0.016, respectively) in patients with UAP. There was no difference of IL-2 levels between the UAP group and controls. Conclusion: We detected high levels of IL-1b, IL-8 and TNF-a in patients with UAP during early phase. We suggest that proinflammatory cytokines (e.g. IL-1b, IL-8, TNF-a) may play an important role in the development of atherosclerosis and its complications.
Kidney and Blood Pressure Research, 2012
Background: We aimed here to investigate hydration status by echocardiography in end stage renal ... more Background: We aimed here to investigate hydration status by echocardiography in end stage renal disease (ESRD) patients. Methods: 25 ESRD patients [15 males; mean age: 54.0±16.6 years; 13 hemodialysis; 12 peritoneal dialysis] were considered eligible for this study. We also examined 29 healthy volunteers as a control group (17 males; mean age: 46.5±12.8 years). Body composition analysis using the bioimpedance spectroscopy technique was performed for volume overload diagnosis. The ratio of extracellular water (ECW) to height was used as volume indices. The aortic elastic parameters were calculated by echocardiography. A correlation analyses was performed between the ratio of ECW to height indicating the volume overload and the aortic elastic parameters e.g. Aortic strain (AS), Aortic distensibility (AD) and Aortic stiffness index (ASI). Results: The ratio of ECW to height that indicates volume overload in ESRD patients was considerably higher than that in the control group (10.25±1.98 L/m vs 8.66±1.22 L/m, p=0.001). There was a negative correlation between the ratio of ECW to height and AS and AD and a positive correlation between the ratio of ECW to height and ASI. Conclusion: Given the importance of the diagnosis and follow up of volume overload, the results show that aortic elasticity measurements, being easy to perform and replicate, can be used for this purpose.
Journal of the American College of Cardiology, 2013
Journal of the American College of Cardiology, 2013
International Heart Journal, 2011
Japanese Heart Journal, 2004
We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiogr... more We report a 64-year-old Turkish man who presented with unstable angina pectoris. Coronary angiography revealed massive intracoronary thrombus, which completely occluded the distal part of the left circumflex coronary artery. The thrombotic segment and the rest of the coronary tree were free of atherosclerosis. The patient was treated with intravenous tirofiban, a glycoprotein IIb/IIIa inhibitor. A control angiography was performed one week later and showed total dissolution of the thrombus with tirofiban therapy.