Mustafa Balcı - Academia.edu (original) (raw)

Papers by Mustafa Balcı

Research paper thumbnail of Clinical Features, Serum Interleukin6, and Interferon-γ Levels of 34 Turkish Patients With Hepatoportal Sclerosis

Digestive Diseases and Sciences, 2007

Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clini... more Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clinical profile. The aim of the study was to summarize the clinical features of Turkish patients with HPS and to measure the serum levels of interleukin (IL)-6 and interferon (IFN)-γ to determine the T helper cell profile in the pathogenesis. The study was conducted on 34 HPS patients (17 men, 17 women; mean age at diagnosis, 27±10 years) and 15 healthy controls. The clinical features of HPS patients including demographics, clinical history, laboratory, and ultrasonography findings were summarized. Serum IL-6 and IFN-γ levels were measured by using commercially available enzyme-linked immunosorbent assay kits. Gastrointestinal bleeding was the most common dominant presenting symptom. Majority of the patients had preserved liver function tests. Serum triglyceride levels were decreased in 30%. Abdominal ultrasonography revealed well-demarcated bands of increased echogenicity surrounding the portal vein wall and sudden narrowing of the intrahepatic second-degree portal vein branches in all cases. Spontaneous shunts and/or collaterals were seen in 13 cases (37%). Extrahepatic portal vein thrombosis were seen in 7 (20%) patients after at least 5 years of disease duration. Serum levels of both IL-6 (median, 3.2 pg/mL) and IFN-γ (median, 7.8 pg/mL) were significantly higher in HPS patients compared with the control group (median, 1 pg/mL). HPS has variable clinical profile in different geographic areas of the world. Both Th1 and 2 cells may have a role in the regulation of immune response and pathogenesis of the disease.

Research paper thumbnail of Taux d'interféron gamma au cours de la maladie périodique

Revue Du Rhumatisme, 2005

Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de f... more Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de fièvre familiale méditerranéenne (maladie périodique).Méthodes. – Les taux plasmatiques d'IFN-γ ont été mesurés chez 29 patients atteints de maladie périodique en dehors de période de crise (âge moyen : 32 ans ; extrêmes : 17–48; hommes/femmes 10/19), 18 patients en période de crise aiguë (âge moyen : 32 ans ; extrêmes : 19–50; hommes/femmes : 8/10), et 19 volontaires sains (âge moyen 32 ± 1,5, extrêmes : 23–42 ; hommes/femmes : 11/8). Les taux d'IFN-γ étaient aussi comparés entre patients traités ou non par de la colchicine.Résultats. – Les taux plasmatiques d' IFN-γ étaient significativement plus élevés chez les patients atteints de maladie périodique, en période de crise ou non, comparés aux témoins (p < 0,05). De plus, les taux plasmatiques d'IFN-γ étaient plus élevés chez les patients en crise aiguë que chez les patients pris en dehors des crises (p < 0,05). Les taux plasmatiques d'IFN-γ étaient comparables entre les groupes traités avec de la colchicine et les groupes non traités.Conclusion. – Nos résultats suggèrent que l'IFN-γ joue un rôle dans le processus inflammatoire au cours de la maladie périodique.Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Materials and methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10:19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8:10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11:8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.

Research paper thumbnail of Interferon-gamma levels in familial Mediterranean fever

Joint Bone Spine, 2005

Methods. -Plasma levels of IFN-c were assayed in 29 FMF patients in attack-free period (mean age:... more Methods. -Plasma levels of IFN-c were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 ± 1.50, min-max: 23-42; male/female: 11/8). IFN-c levels were also compared among colchicine treated and untreated groups.

Research paper thumbnail of Clinical Features, Serum Interleukin6, and Interferon-γ Levels of 34 Turkish Patients With Hepatoportal Sclerosis

Digestive Diseases and Sciences, 2007

Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clini... more Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clinical profile. The aim of the study was to summarize the clinical features of Turkish patients with HPS and to measure the serum levels of interleukin (IL)-6 and interferon (IFN)-γ to determine the T helper cell profile in the pathogenesis. The study was conducted on 34 HPS patients (17 men, 17 women; mean age at diagnosis, 27±10 years) and 15 healthy controls. The clinical features of HPS patients including demographics, clinical history, laboratory, and ultrasonography findings were summarized. Serum IL-6 and IFN-γ levels were measured by using commercially available enzyme-linked immunosorbent assay kits. Gastrointestinal bleeding was the most common dominant presenting symptom. Majority of the patients had preserved liver function tests. Serum triglyceride levels were decreased in 30%. Abdominal ultrasonography revealed well-demarcated bands of increased echogenicity surrounding the portal vein wall and sudden narrowing of the intrahepatic second-degree portal vein branches in all cases. Spontaneous shunts and/or collaterals were seen in 13 cases (37%). Extrahepatic portal vein thrombosis were seen in 7 (20%) patients after at least 5 years of disease duration. Serum levels of both IL-6 (median, 3.2 pg/mL) and IFN-γ (median, 7.8 pg/mL) were significantly higher in HPS patients compared with the control group (median, 1 pg/mL). HPS has variable clinical profile in different geographic areas of the world. Both Th1 and 2 cells may have a role in the regulation of immune response and pathogenesis of the disease.

Research paper thumbnail of Taux d'interféron gamma au cours de la maladie périodique

Revue Du Rhumatisme, 2005

Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de f... more Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de fièvre familiale méditerranéenne (maladie périodique).Méthodes. – Les taux plasmatiques d'IFN-γ ont été mesurés chez 29 patients atteints de maladie périodique en dehors de période de crise (âge moyen : 32 ans ; extrêmes : 17–48; hommes/femmes 10/19), 18 patients en période de crise aiguë (âge moyen : 32 ans ; extrêmes : 19–50; hommes/femmes : 8/10), et 19 volontaires sains (âge moyen 32 ± 1,5, extrêmes : 23–42 ; hommes/femmes : 11/8). Les taux d'IFN-γ étaient aussi comparés entre patients traités ou non par de la colchicine.Résultats. – Les taux plasmatiques d' IFN-γ étaient significativement plus élevés chez les patients atteints de maladie périodique, en période de crise ou non, comparés aux témoins (p < 0,05). De plus, les taux plasmatiques d'IFN-γ étaient plus élevés chez les patients en crise aiguë que chez les patients pris en dehors des crises (p < 0,05). Les taux plasmatiques d'IFN-γ étaient comparables entre les groupes traités avec de la colchicine et les groupes non traités.Conclusion. – Nos résultats suggèrent que l'IFN-γ joue un rôle dans le processus inflammatoire au cours de la maladie périodique.Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Materials and methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10:19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8:10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11:8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.

Research paper thumbnail of Interferon-gamma levels in familial Mediterranean fever

Joint Bone Spine, 2005

Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial M... more Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11/8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.

Research paper thumbnail of Clinical Features, Serum Interleukin6, and Interferon-γ Levels of 34 Turkish Patients With Hepatoportal Sclerosis

Digestive Diseases and Sciences, 2007

Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clini... more Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clinical profile. The aim of the study was to summarize the clinical features of Turkish patients with HPS and to measure the serum levels of interleukin (IL)-6 and interferon (IFN)-γ to determine the T helper cell profile in the pathogenesis. The study was conducted on 34 HPS patients (17 men, 17 women; mean age at diagnosis, 27±10 years) and 15 healthy controls. The clinical features of HPS patients including demographics, clinical history, laboratory, and ultrasonography findings were summarized. Serum IL-6 and IFN-γ levels were measured by using commercially available enzyme-linked immunosorbent assay kits. Gastrointestinal bleeding was the most common dominant presenting symptom. Majority of the patients had preserved liver function tests. Serum triglyceride levels were decreased in 30%. Abdominal ultrasonography revealed well-demarcated bands of increased echogenicity surrounding the portal vein wall and sudden narrowing of the intrahepatic second-degree portal vein branches in all cases. Spontaneous shunts and/or collaterals were seen in 13 cases (37%). Extrahepatic portal vein thrombosis were seen in 7 (20%) patients after at least 5 years of disease duration. Serum levels of both IL-6 (median, 3.2 pg/mL) and IFN-γ (median, 7.8 pg/mL) were significantly higher in HPS patients compared with the control group (median, 1 pg/mL). HPS has variable clinical profile in different geographic areas of the world. Both Th1 and 2 cells may have a role in the regulation of immune response and pathogenesis of the disease.

Research paper thumbnail of Taux d'interféron gamma au cours de la maladie périodique

Revue Du Rhumatisme, 2005

Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de f... more Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de fièvre familiale méditerranéenne (maladie périodique).Méthodes. – Les taux plasmatiques d'IFN-γ ont été mesurés chez 29 patients atteints de maladie périodique en dehors de période de crise (âge moyen : 32 ans ; extrêmes : 17–48; hommes/femmes 10/19), 18 patients en période de crise aiguë (âge moyen : 32 ans ; extrêmes : 19–50; hommes/femmes : 8/10), et 19 volontaires sains (âge moyen 32 ± 1,5, extrêmes : 23–42 ; hommes/femmes : 11/8). Les taux d'IFN-γ étaient aussi comparés entre patients traités ou non par de la colchicine.Résultats. – Les taux plasmatiques d' IFN-γ étaient significativement plus élevés chez les patients atteints de maladie périodique, en période de crise ou non, comparés aux témoins (p < 0,05). De plus, les taux plasmatiques d'IFN-γ étaient plus élevés chez les patients en crise aiguë que chez les patients pris en dehors des crises (p < 0,05). Les taux plasmatiques d'IFN-γ étaient comparables entre les groupes traités avec de la colchicine et les groupes non traités.Conclusion. – Nos résultats suggèrent que l'IFN-γ joue un rôle dans le processus inflammatoire au cours de la maladie périodique.Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Materials and methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10:19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8:10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11:8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.

Research paper thumbnail of Interferon-gamma levels in familial Mediterranean fever

Joint Bone Spine, 2005

Methods. -Plasma levels of IFN-c were assayed in 29 FMF patients in attack-free period (mean age:... more Methods. -Plasma levels of IFN-c were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 ± 1.50, min-max: 23-42; male/female: 11/8). IFN-c levels were also compared among colchicine treated and untreated groups.

Research paper thumbnail of Clinical Features, Serum Interleukin6, and Interferon-γ Levels of 34 Turkish Patients With Hepatoportal Sclerosis

Digestive Diseases and Sciences, 2007

Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clini... more Hepatoportal sclerosis (HPS) is a clinical disorder of obscure pathogenesis with a variable clinical profile. The aim of the study was to summarize the clinical features of Turkish patients with HPS and to measure the serum levels of interleukin (IL)-6 and interferon (IFN)-γ to determine the T helper cell profile in the pathogenesis. The study was conducted on 34 HPS patients (17 men, 17 women; mean age at diagnosis, 27±10 years) and 15 healthy controls. The clinical features of HPS patients including demographics, clinical history, laboratory, and ultrasonography findings were summarized. Serum IL-6 and IFN-γ levels were measured by using commercially available enzyme-linked immunosorbent assay kits. Gastrointestinal bleeding was the most common dominant presenting symptom. Majority of the patients had preserved liver function tests. Serum triglyceride levels were decreased in 30%. Abdominal ultrasonography revealed well-demarcated bands of increased echogenicity surrounding the portal vein wall and sudden narrowing of the intrahepatic second-degree portal vein branches in all cases. Spontaneous shunts and/or collaterals were seen in 13 cases (37%). Extrahepatic portal vein thrombosis were seen in 7 (20%) patients after at least 5 years of disease duration. Serum levels of both IL-6 (median, 3.2 pg/mL) and IFN-γ (median, 7.8 pg/mL) were significantly higher in HPS patients compared with the control group (median, 1 pg/mL). HPS has variable clinical profile in different geographic areas of the world. Both Th1 and 2 cells may have a role in the regulation of immune response and pathogenesis of the disease.

Research paper thumbnail of Taux d'interféron gamma au cours de la maladie périodique

Revue Du Rhumatisme, 2005

Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de f... more Objectifs. – Évaluer les taux d'interféron gamma (IFN-γ) endogène chez les patients atteints de fièvre familiale méditerranéenne (maladie périodique).Méthodes. – Les taux plasmatiques d'IFN-γ ont été mesurés chez 29 patients atteints de maladie périodique en dehors de période de crise (âge moyen : 32 ans ; extrêmes : 17–48; hommes/femmes 10/19), 18 patients en période de crise aiguë (âge moyen : 32 ans ; extrêmes : 19–50; hommes/femmes : 8/10), et 19 volontaires sains (âge moyen 32 ± 1,5, extrêmes : 23–42 ; hommes/femmes : 11/8). Les taux d'IFN-γ étaient aussi comparés entre patients traités ou non par de la colchicine.Résultats. – Les taux plasmatiques d' IFN-γ étaient significativement plus élevés chez les patients atteints de maladie périodique, en période de crise ou non, comparés aux témoins (p < 0,05). De plus, les taux plasmatiques d'IFN-γ étaient plus élevés chez les patients en crise aiguë que chez les patients pris en dehors des crises (p < 0,05). Les taux plasmatiques d'IFN-γ étaient comparables entre les groupes traités avec de la colchicine et les groupes non traités.Conclusion. – Nos résultats suggèrent que l'IFN-γ joue un rôle dans le processus inflammatoire au cours de la maladie périodique.Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Materials and methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10:19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8:10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11:8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.

Research paper thumbnail of Interferon-gamma levels in familial Mediterranean fever

Joint Bone Spine, 2005

Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial M... more Aims. – To evaluate the levels of endogenous interferon-gamma (IFN-γ) in patients with familial Mediterranean fever (FMF).Methods. – Plasma levels of IFN-γ were assayed in 29 FMF patients in attack-free period (mean age: 32, min–max: 17–48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min–max: 19–50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 ± 1.50, min–max: 23–42; male/female: 11/8). IFN-γ levels were also compared among colchicine treated and untreated groups.Results. – Median plasma IFN-γ levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-γ levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-γ were comparable in colchicine treated and untreated groups.Conclusion. – Our results suggest that IFN-γ may contribute to the inflammatory cascade of FMF.