Mustafa Senocak - Academia.edu (original) (raw)
Papers by Mustafa Senocak
Tuberculin Skin Test in Children, 2013
Back ground: Elongated styloid (ES) (also known as Eagle’s syndrome) is a rare condition causing ... more Back ground: Elongated styloid (ES) (also known as Eagle’s syndrome) is a rare condition causing pain and various symptoms in the maxillofacial region. Purpose: In our study we aimed to evaluate the length of the styloid process in the Turkish population and to assess the correlation between this length and clinical symptoms. Method: We measured the length of Styloid process (SP) on the randomly chosen Cone beam computerized tomographies (CBCT) of 530 patients. Arithmetic mean and Standard deviation as well as Ranges, medians and 95.percentile values were used for descriptive statistics. Regression models were evaluated for the relationships between age and SP length, student-t test was used to compare means. Results: Statistically significant differences have not been found between genders in SP lengths and ages. None of the results are powerful enough for a clinically meaningful relationship (R 2 > 0.1). Conclusion: Although many researchers worked on this subject so far but it still needs more investigation
Rhinology, 2004
Primary headaches or other chronic headaches can be triggered by sinonasal pathologies, or variat... more Primary headaches or other chronic headaches can be triggered by sinonasal pathologies, or variations within the sinonasal tract. Establishing a cause and effect relationship between certain sinonasal conditions and chronic headaches can justify sinonasal surgery for the relief of headaches and provide considerable relief to a subgroup of patients with chronic headaches resistant to medical treatment. A prospective study on 204 patients undergoing sinonasal surgery for an apperent symptomatic sinonasal pathology was conducted to determine the incidence and types of headaches in sinonasal patients preoperatively, the presence of potential sinonasal triggering mechanisms, and postoperative headache relief when such triggers are removed. The relationship between potential triggers and postoperative relief is analysed to determine a possible link. Headache was a major complaint in 50% of these patients and the overall incidence of primary type headaches was 25.5% (52 of 204 patients). P...
Saudi medical journal, 2006
OBJECTIVE To find out the prevalence of natural menopause among Turkish women according to age an... more OBJECTIVE To find out the prevalence of natural menopause among Turkish women according to age and certain demographic variables in a specific rural area. METHODS This cross sectional study was carried out in Silivri district of Istanbul, Turkey between January and May 2000. Included in the study were 845 women between the ages of 30-60 years, not undergoing any hormonal replacement, living in the villages of Silivri district, Istanbul, Turkey. The participants were asked for their ages, level of education, number of pregnancies, age at menarche, presence of menstruation, age at the onset of menopause, physical activity outside home and the use of oral contraceptives. Females declaring at least one year of amenorrhea were accepted as being in menopause. RESULTS The median age for menopause was 47 years. Of the total 845 participants, 326 women were found to be in natural menopause. The prevalence of menopause was estimated as 8.6% for females younger than 40 years, 31.8% for females...
![Research paper thumbnail of [Reliability and validity of the schedule for deficit syndrome in schizophrenia]](https://attachments.academia-assets.com/78416074/thumbnails/1.jpg)
](Turk psikiyatri dergisi = Turkish journal of psychiatry, 2006
OBJECTIVE The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic... more OBJECTIVE The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic patients as those with and without deficit syndrome. This schedule has been translated and adapted into the Turkish language in order to study its reliability and validity. METHOD 30 male schizophrenic patients were included in the study. The patients had been ill for a long period of time and the course was continuous. The patients were assessed by two different raters using the SDS as a means of testing its reliability. A third rater assessed the same group of patients using the BPRS to test the validity of the SDS. RESULTS The raters using the SDS demonstrated good inter-rater reliability for the categorization of patients with and without deficit syndrome, as well as for rating global severity (kappa: 0.88-0.93) and individual negative symptoms (kappa: 0.51-0.61). The schedule was also found to have a high validity for both categorization and measuring individual negative symptoms. ...
Psychiatry and Clinical Psychopharmacology
Indian Journal of Cancer
Background: Sexual dysfunction is an important side-effect after radiotherapy (RT) for prostate c... more Background: Sexual dysfunction is an important side-effect after radiotherapy (RT) for prostate cancer (PCa). The aim of this study was to compare sexual functions of PCa patients before and after intensity-modulated RT and to analyze their correlation with penile bulb (PB) doses and patient characteristics. Materials and Methods: Forty-two patients who underwent RT ± hormone therapy for PCa between 2010 and 2013 were analyzed. Sexual functions assessed by patient-reported questionnaire and physician reported scale before and 3 years after treatment. The effect of patients' age, prostate volume, testosterone levels, comorbidity, smoking status, tumor stage, RT technique, hormone therapy, and PB doses to sexual functions were investigated. Results:After 3 years of RT, 64.3% of all patients had a lower erectile score; and 75% of patients who were previously potent (n = 24) had become impotent after treatment. However sexual desire still remained in 75.8% of patients who had desire before treatment (n = 33). Statistical analysis showed that two parameters were correlated with postradiotherapy impotency outcome; PB mean radiation dose (P = 0.033) and testosterone levels (P = 0.032). Conclusions: RT, despite modern techniques, affects the sexual function of PCa patients in varying degrees. Reducing radiation doses to penile structures may play a role in preventing erectile dysfunction.
Eurasian Journal of Medical Investigation
T he reference intervals, which play an important role in diagnostics, first observed when the la... more T he reference intervals, which play an important role in diagnostics, first observed when the laboratory tests were improved in 1965. [1] They were first used by the clinicians at the end of 1990s. As a result of that the importance of the reference intervals increased after 2000, plenty of authors stressed the importance of the careful choice of reference individuals [1, 2] of authors stressed the importance of the careful choice of reference individuals. [5, 22] Beside this, other medical decisions are important and laboratory tests provide essential information for the medical decision process. But when several serial test results for one person are available, there is another interesting approach for the interpretation of laboratory results. These laboratory results vary person to person. [3] It is an important fact that the population-based reference intervals (PBRI) for the use in medical decision process. However, PBRI may reflect Objectives: The aim of this study was to examine the reference change value defined as a normal difference in serial test results to investigate clinically significant changes in a given proportion of all healthy persons. Methods: In all, 18 volunteers were included in a cross-sectional and methodological study. The participants provided 5-mL blood samples twice a day, before and after having breakfast, 3 times in 15-day periods. The levels of glycose and insulin were evaluated biochemically and with a hormone auto-analyzer. Biological variation, the reference change value, and the individual index were calculated. Results: The mean participant age±SD was 40.1±7.81 years, and the median age was 41.0 years (min: 27, max: 55 years). Twelve (66.67%) were female and 6 (33.33%) were male. While fasting blood sugar (FBS) was influenced by both time and individual characteristics (p=0.030 and 0.006, respectively), fasting insulin resistance (FIR) changed over time, but was not influenced by individual characteristics, according to the LOG10 base (p=0.796 and p=0.015, respectively). The level 1 FBS intra-individual variation was 7.62 and the inter-individual variation was 7.69. For level 2, the intra-individual variation was 7.71 and the inter-individual variation was 7.65. The intra-individual variation < the inter-individual variation for FIR in both level 1 (15.50<18.44) and level 2 (15.69<18.37). Conclusion: Measurements of glucose and insulin levels should be examined using the analytic variation values of the device. This study demonstrates the importance of analytical variation, intra-and inter-individual variation, the index of individuality, and reference change value.
Turkish thoracic journal, 2017
There is no validated questionnaire in Turkish to assess asthma knowledge. In this study, we aime... more There is no validated questionnaire in Turkish to assess asthma knowledge. In this study, we aimed to evaluate the reliability and validity of the Turkish version of the Asthma Self-Management Knowledge Questionnaire (AKQ) among asthmatic adults. The AKQ was translated into Turkish by two medical-text translators, followed by back translation and final review by two clinicians with experience in asthma management. The Turkish Asthma Self-Management Questionnaire was then applied to 202 adult asthma patients, and additional demographic and clinical features of the patients were collected for analysis. The internal reliability of the 24-item AKQ was not high (Cronbach's alpha=0.55). Tukey's test of additivity was significant (p<0.001). This result revealed that all questions are consistent and measure the same concepts. Factor analysis demonstrated a probable structure of 10 factors that together explained 63.7% of total variance in results. Intra-class reliability of the A...
Turk Kardiyoloji Dernegi Arsivi Turk Kardiyoloji Derneginin Yayin Organidir, 2009
Objectives: We evaluated the impact of diabetes mellitus (DM) and/or coronary artery disease (CAD... more Objectives: We evaluated the impact of diabetes mellitus (DM) and/or coronary artery disease (CAD) on cardiovascular endpoints in a cohort of hypertensive patients. Study design: The Vascular Risk Study is a cross-sectional, multicenter, observational study conducted among 5,600 patients from various regions of Turkey. This analysis included 2,664 patients (1,643 women, 1,021 men; mean age 65.3 years; range 55-99 years) whose follow-up data were adequate among a population of 4,506 hypertensive subjects. Cardiovascular primary and secondary endpoints at the end of a five-year follow-up were assessed in patients who had hypertension alone, and in those having DM and/or CAD. Information on the cause of death was obtained from the relatives of the patients by follow-up phone calls. Results: There were 1,171 patients (44%) with isolated hypertension, 631 (23.7%) with DM, 530 (19.9%) with CAD, and 332 (12.5%) with both DM and CAD. The presence of either DM or CAD was associated with significant increases in the incidences of all endpoints. The occurrences of primary and secondary endpoints, cardiovascular death, and all death were similar in hypertensive patients who had DM without CAD and in patients who had CAD without DM. In survival analysis, the incidence of cardiovascular death was lowest (5.7%) in hypertensive patients without DM and CAD, and highest (18.4%) in hypertensive patients with DM and CAD. The cumulative survival rates were similar in hypertensive patients with either DM or CAD alone (p>0.05). Conclusion: This study demonstrated that the level of cardiovascular risk associated with DM was equal to the risk associated with CAD in hypertensive patients and that the coexistence of DM and CAD in these patients increases the risk geometrically.
![Research paper thumbnail of [Reliability and validity of the schedule for deficit syndrome in schizophrenia]](https://attachments.academia-assets.com/70219955/thumbnails/1.jpg)
](Turk Psikiyatri Dergisi Turkish Journal of Psychiatry, Feb 1, 2006
Objective: The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophreni... more Objective: The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic patients as those with and without deficit syndrome. This schedule has been translated and adapted into the Turkish language in order to study its reliability and validity. Method: 30 male schizophrenic patients were included in the study. The patients had been ill for a long period of time and the course was continuous. The patients were assessed by two different raters using the SDS as a means of testing its reliability. A third rater assessed the same group of patients using the BPRS to test the validity of the SDS. Results: The raters using the SDS demonstrated good interrater reliability for the categorization of patients with and without deficit syndrome, as well as for rating global severity (kappa: 0.88-0.93) and individual negative symptoms (kappa: 0.51-0.61). The schedule was also found to have a high validity for both categorization and measuring individual negative symptoms. (U: 60.0, P: 0.03). Conclusion: The results demonstrated that the Turkish version of the SDS would be a reliable and valid instrument that could be used in the study of schizophrenia.
Otolaryngology and Head and Neck Surgery, Dec 31, 2005
Determine the efficacy of computerized tomography (CT) in detecting the intranasal distribution o... more Determine the efficacy of computerized tomography (CT) in detecting the intranasal distribution of sprayed radio-enhanced particles and the effects of topical decongestion on particle distribution. Sinonasal distribution of a radio-enhanced spray solution was studied using CT imaging in 14 adults with no sinonasal symptoms. One nostril was sprayed with oximetazoline 5 minutes prior to particle application. Serial CT imaging of the sinonasal cavity in approximately 11 minutes was carried out to detect particle distribution into the nasal vestibule, turbinate surfaces, middle meatus and osteomeatal complex area, and the nasopharynx. Particle detection within the nasal vestibule was possible in all cases while distribution into the anterior nasal chamber was visible in 22 cases. Particles could be detected on the inferior turbinate in 7 nasal cavities (25%) and in only 2 cases on the middle turbinate (7.5%). Particles were detected in the middle meatus in 1 case and in no instances in the osteomeatal complex area. Oximetazoline application reduced the amount of particle deposition on the inferior turbinate but did not enhance distribution on the middle turbinate or into the middle meatus. Detection of radio-enhanced sprayed particles within the sinonasal cavity using CT imaging can be a reliable method to study the principles of intranasal particle distribution. Our study failed to show particle distribution into OMC, or any positive effects of nasal decongestion on particle distribution.
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 2015
To evaluate the impact of caseload volume on the outcomes of open and laparoscopic surgery for co... more To evaluate the impact of caseload volume on the outcomes of open and laparoscopic surgery for colorectal cancer. Between April 1999 and January 2011, patients who underwent open or laparoscopic resection for colorectal adenocarcinoma with curative intent were identified. There were 2 groups of surgeons, whose primary practice is gastrointestinal surgery (n=5, group A) and general surgery (n=14, group B). Histopathologic and oncologic outcomes, as well as survival data were evaluated. A total of 815 patients fulfilled the study criteria and 356 (group A: 120, group B: 236) patients who had &amp;amp;amp;amp;amp;gt;2 years&amp;amp;amp;amp;amp;#39; follow-up data were included. Colorectal procedures constituted 33% and 19% of all the operations in A and B groups, respectively (P&amp;amp;amp;amp;amp;lt;0.0001). Among the colorectal cases, rates of laparoscopic surgery were 37% and 20% in the group A and B, respectively (P&amp;amp;amp;amp;amp;lt;0.0001). Practice pattern was independently associated with better overall survival and was favoring the group A (P=0.02). Increased caseload volume improves oncologic outcomes in patients undergoing colorectal resection for nonmetastatic cancer.
British Journal of Medicine and Medical Research, 2016
Saudi medical journal, 2006
To find out the prevalence of natural menopause among Turkish women according to age and certain ... more To find out the prevalence of natural menopause among Turkish women according to age and certain demographic variables in a specific rural area. This cross sectional study was carried out in Silivri district of Istanbul, Turkey between January and May 2000. Included in the study were 845 women between the ages of 30-60 years, not undergoing any hormonal replacement, living in the villages of Silivri district, Istanbul, Turkey. The participants were asked for their ages, level of education, number of pregnancies, age at menarche, presence of menstruation, age at the onset of menopause, physical activity outside home and the use of oral contraceptives. Females declaring at least one year of amenorrhea were accepted as being in menopause. The median age for menopause was 47 years. Of the total 845 participants, 326 women were found to be in natural menopause. The prevalence of menopause was estimated as 8.6% for females younger than 40 years, 31.8% for females between the ages 40-45 ye...
Nuclear medicine communications, 2015
Single-photon emission computed tomography (SPECT) myocardial perfusion imaging is an accepted me... more Single-photon emission computed tomography (SPECT) myocardial perfusion imaging is an accepted method for reflecting the pathophysiological significance of lesions detected by coronary angiography. However, it has an inherent drawback in terms of false-positive perfusion defects for the inferior myocardial wall. To overcome this problem, different acquisition techniques have been proposed, including the computed tomographic-based attenuation correction method. In this respect, a new imaging technique, left supine lateral position SPECT myocardial perfusion imaging with technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI), has been proposed to eliminate this problem and its value has been investigated in this report. Sixty-two patients were prospectively and randomly enrolled in this study. They underwent Tc-99m MIBI SPECT in the supine, prone, left lateral, and sitting positions after an adequate stress test on the same day.The presence and extent of defects on stress images were ...
Amer J Clin Pathol, 2001
Among the cutaneous manifestations, nodular lesions are rather common in Behçet syndrome. The his... more Among the cutaneous manifestations, nodular lesions are rather common in Behçet syndrome. The histologic nature of these lesions has been a matter of controversy. To establish their distinguishing features, biopsy specimens from nodular lesions of 24 patients with Behçet syndrome, 25 with nodular vasculitis (NV), and 20 with erythema nodosum (EN) were compared. Statistical analysis revealed insignificant differences between most of the histologic features of Behçet syndrome and NV. However, neutrophil-predominating infiltrate in the subcutis was more common in Behçet syndrome, while necrosis and granuloma formation were encountered more frequently in NV. The differences between Behçet syndrome and EN were more significant. Septal panniculitis, lymphocytepredominating infiltrate, absence of many vascular changes as well as vasculitis, and necrosis were features in favor of EN. Nodular lesions of Behçet syndrome are mainly neutrophilic vascular reactions with histologic features similar to NV but significantly differing from EN associated with other systemic diseases.
Surgery Today, Apr 1, 2003
Splenectomy is sometimes performed simultaneously with curative gastrectomy for gastric carcinoma... more Splenectomy is sometimes performed simultaneously with curative gastrectomy for gastric carcinoma, especially when the tumor originates in the proximal one-third of the stomach or corpus, or when it invades the entire stomach, in an effort to remove metastatic lymph nodes at the splenic hilus and improve survival. However, splenectomy is not an innocent procedure and may cause increased morbidity and even mortality. Moreover, the long-term effect of splenectomy on survival is still controversial. The purpose of this study was to investigate the effect of simultaneous splenectomy on survival in patients with proximal tumors undergoing curative gastrectomy for gastric cancer. The effect of splenectomy on the 5-year survival of 61 patients with proximal gastric cancer (located in the cardia or the corpus) who underwent curative gastrectomy in our hospital between 1989 and 1993 was investigated retrospectively. Of these 61 patients, 38 (62.3%) underwent splenectomy and 23 (37.7%) did not. The relationship between the clinicohistopathological parameters and 5-year survival was retrospectively analyzed. No significant differences were found in bivariate analysis between the survival of patients who underwent curative gastrectomy with and those who underwent curative gastrectomy without splenectomy ( P = 0.984). Multivariate regression analysis indicated that only histological grade ( P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.003) and lymph node metastasis ( P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) were independent prognostic factors with or without splenectomy. Splenectomy itself was not an independent prognostic factor ( P = 0.528). The findings of this retrospective study showed that simultaneous splenectomy had no effect on the survival of patients who underwent curative gastrectomy for gastric carcinoma. Thus, splenectomy may only be appropriate for patients with direct invasion of the spleen.
Tuberculin Skin Test in Children, 2013
Back ground: Elongated styloid (ES) (also known as Eagle’s syndrome) is a rare condition causing ... more Back ground: Elongated styloid (ES) (also known as Eagle’s syndrome) is a rare condition causing pain and various symptoms in the maxillofacial region. Purpose: In our study we aimed to evaluate the length of the styloid process in the Turkish population and to assess the correlation between this length and clinical symptoms. Method: We measured the length of Styloid process (SP) on the randomly chosen Cone beam computerized tomographies (CBCT) of 530 patients. Arithmetic mean and Standard deviation as well as Ranges, medians and 95.percentile values were used for descriptive statistics. Regression models were evaluated for the relationships between age and SP length, student-t test was used to compare means. Results: Statistically significant differences have not been found between genders in SP lengths and ages. None of the results are powerful enough for a clinically meaningful relationship (R 2 > 0.1). Conclusion: Although many researchers worked on this subject so far but it still needs more investigation
Rhinology, 2004
Primary headaches or other chronic headaches can be triggered by sinonasal pathologies, or variat... more Primary headaches or other chronic headaches can be triggered by sinonasal pathologies, or variations within the sinonasal tract. Establishing a cause and effect relationship between certain sinonasal conditions and chronic headaches can justify sinonasal surgery for the relief of headaches and provide considerable relief to a subgroup of patients with chronic headaches resistant to medical treatment. A prospective study on 204 patients undergoing sinonasal surgery for an apperent symptomatic sinonasal pathology was conducted to determine the incidence and types of headaches in sinonasal patients preoperatively, the presence of potential sinonasal triggering mechanisms, and postoperative headache relief when such triggers are removed. The relationship between potential triggers and postoperative relief is analysed to determine a possible link. Headache was a major complaint in 50% of these patients and the overall incidence of primary type headaches was 25.5% (52 of 204 patients). P...
Saudi medical journal, 2006
OBJECTIVE To find out the prevalence of natural menopause among Turkish women according to age an... more OBJECTIVE To find out the prevalence of natural menopause among Turkish women according to age and certain demographic variables in a specific rural area. METHODS This cross sectional study was carried out in Silivri district of Istanbul, Turkey between January and May 2000. Included in the study were 845 women between the ages of 30-60 years, not undergoing any hormonal replacement, living in the villages of Silivri district, Istanbul, Turkey. The participants were asked for their ages, level of education, number of pregnancies, age at menarche, presence of menstruation, age at the onset of menopause, physical activity outside home and the use of oral contraceptives. Females declaring at least one year of amenorrhea were accepted as being in menopause. RESULTS The median age for menopause was 47 years. Of the total 845 participants, 326 women were found to be in natural menopause. The prevalence of menopause was estimated as 8.6% for females younger than 40 years, 31.8% for females...
Turk psikiyatri dergisi = Turkish journal of psychiatry, 2006
OBJECTIVE The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic... more OBJECTIVE The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic patients as those with and without deficit syndrome. This schedule has been translated and adapted into the Turkish language in order to study its reliability and validity. METHOD 30 male schizophrenic patients were included in the study. The patients had been ill for a long period of time and the course was continuous. The patients were assessed by two different raters using the SDS as a means of testing its reliability. A third rater assessed the same group of patients using the BPRS to test the validity of the SDS. RESULTS The raters using the SDS demonstrated good inter-rater reliability for the categorization of patients with and without deficit syndrome, as well as for rating global severity (kappa: 0.88-0.93) and individual negative symptoms (kappa: 0.51-0.61). The schedule was also found to have a high validity for both categorization and measuring individual negative symptoms. ...
Psychiatry and Clinical Psychopharmacology
Indian Journal of Cancer
Background: Sexual dysfunction is an important side-effect after radiotherapy (RT) for prostate c... more Background: Sexual dysfunction is an important side-effect after radiotherapy (RT) for prostate cancer (PCa). The aim of this study was to compare sexual functions of PCa patients before and after intensity-modulated RT and to analyze their correlation with penile bulb (PB) doses and patient characteristics. Materials and Methods: Forty-two patients who underwent RT ± hormone therapy for PCa between 2010 and 2013 were analyzed. Sexual functions assessed by patient-reported questionnaire and physician reported scale before and 3 years after treatment. The effect of patients' age, prostate volume, testosterone levels, comorbidity, smoking status, tumor stage, RT technique, hormone therapy, and PB doses to sexual functions were investigated. Results:After 3 years of RT, 64.3% of all patients had a lower erectile score; and 75% of patients who were previously potent (n = 24) had become impotent after treatment. However sexual desire still remained in 75.8% of patients who had desire before treatment (n = 33). Statistical analysis showed that two parameters were correlated with postradiotherapy impotency outcome; PB mean radiation dose (P = 0.033) and testosterone levels (P = 0.032). Conclusions: RT, despite modern techniques, affects the sexual function of PCa patients in varying degrees. Reducing radiation doses to penile structures may play a role in preventing erectile dysfunction.
Eurasian Journal of Medical Investigation
T he reference intervals, which play an important role in diagnostics, first observed when the la... more T he reference intervals, which play an important role in diagnostics, first observed when the laboratory tests were improved in 1965. [1] They were first used by the clinicians at the end of 1990s. As a result of that the importance of the reference intervals increased after 2000, plenty of authors stressed the importance of the careful choice of reference individuals [1, 2] of authors stressed the importance of the careful choice of reference individuals. [5, 22] Beside this, other medical decisions are important and laboratory tests provide essential information for the medical decision process. But when several serial test results for one person are available, there is another interesting approach for the interpretation of laboratory results. These laboratory results vary person to person. [3] It is an important fact that the population-based reference intervals (PBRI) for the use in medical decision process. However, PBRI may reflect Objectives: The aim of this study was to examine the reference change value defined as a normal difference in serial test results to investigate clinically significant changes in a given proportion of all healthy persons. Methods: In all, 18 volunteers were included in a cross-sectional and methodological study. The participants provided 5-mL blood samples twice a day, before and after having breakfast, 3 times in 15-day periods. The levels of glycose and insulin were evaluated biochemically and with a hormone auto-analyzer. Biological variation, the reference change value, and the individual index were calculated. Results: The mean participant age±SD was 40.1±7.81 years, and the median age was 41.0 years (min: 27, max: 55 years). Twelve (66.67%) were female and 6 (33.33%) were male. While fasting blood sugar (FBS) was influenced by both time and individual characteristics (p=0.030 and 0.006, respectively), fasting insulin resistance (FIR) changed over time, but was not influenced by individual characteristics, according to the LOG10 base (p=0.796 and p=0.015, respectively). The level 1 FBS intra-individual variation was 7.62 and the inter-individual variation was 7.69. For level 2, the intra-individual variation was 7.71 and the inter-individual variation was 7.65. The intra-individual variation < the inter-individual variation for FIR in both level 1 (15.50<18.44) and level 2 (15.69<18.37). Conclusion: Measurements of glucose and insulin levels should be examined using the analytic variation values of the device. This study demonstrates the importance of analytical variation, intra-and inter-individual variation, the index of individuality, and reference change value.
Turkish thoracic journal, 2017
There is no validated questionnaire in Turkish to assess asthma knowledge. In this study, we aime... more There is no validated questionnaire in Turkish to assess asthma knowledge. In this study, we aimed to evaluate the reliability and validity of the Turkish version of the Asthma Self-Management Knowledge Questionnaire (AKQ) among asthmatic adults. The AKQ was translated into Turkish by two medical-text translators, followed by back translation and final review by two clinicians with experience in asthma management. The Turkish Asthma Self-Management Questionnaire was then applied to 202 adult asthma patients, and additional demographic and clinical features of the patients were collected for analysis. The internal reliability of the 24-item AKQ was not high (Cronbach's alpha=0.55). Tukey's test of additivity was significant (p<0.001). This result revealed that all questions are consistent and measure the same concepts. Factor analysis demonstrated a probable structure of 10 factors that together explained 63.7% of total variance in results. Intra-class reliability of the A...
Turk Kardiyoloji Dernegi Arsivi Turk Kardiyoloji Derneginin Yayin Organidir, 2009
Objectives: We evaluated the impact of diabetes mellitus (DM) and/or coronary artery disease (CAD... more Objectives: We evaluated the impact of diabetes mellitus (DM) and/or coronary artery disease (CAD) on cardiovascular endpoints in a cohort of hypertensive patients. Study design: The Vascular Risk Study is a cross-sectional, multicenter, observational study conducted among 5,600 patients from various regions of Turkey. This analysis included 2,664 patients (1,643 women, 1,021 men; mean age 65.3 years; range 55-99 years) whose follow-up data were adequate among a population of 4,506 hypertensive subjects. Cardiovascular primary and secondary endpoints at the end of a five-year follow-up were assessed in patients who had hypertension alone, and in those having DM and/or CAD. Information on the cause of death was obtained from the relatives of the patients by follow-up phone calls. Results: There were 1,171 patients (44%) with isolated hypertension, 631 (23.7%) with DM, 530 (19.9%) with CAD, and 332 (12.5%) with both DM and CAD. The presence of either DM or CAD was associated with significant increases in the incidences of all endpoints. The occurrences of primary and secondary endpoints, cardiovascular death, and all death were similar in hypertensive patients who had DM without CAD and in patients who had CAD without DM. In survival analysis, the incidence of cardiovascular death was lowest (5.7%) in hypertensive patients without DM and CAD, and highest (18.4%) in hypertensive patients with DM and CAD. The cumulative survival rates were similar in hypertensive patients with either DM or CAD alone (p>0.05). Conclusion: This study demonstrated that the level of cardiovascular risk associated with DM was equal to the risk associated with CAD in hypertensive patients and that the coexistence of DM and CAD in these patients increases the risk geometrically.
Turk Psikiyatri Dergisi Turkish Journal of Psychiatry, Feb 1, 2006
Objective: The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophreni... more Objective: The Schedule for Deficit Syndrome (SDS) is an instrument for categorizing schizophrenic patients as those with and without deficit syndrome. This schedule has been translated and adapted into the Turkish language in order to study its reliability and validity. Method: 30 male schizophrenic patients were included in the study. The patients had been ill for a long period of time and the course was continuous. The patients were assessed by two different raters using the SDS as a means of testing its reliability. A third rater assessed the same group of patients using the BPRS to test the validity of the SDS. Results: The raters using the SDS demonstrated good interrater reliability for the categorization of patients with and without deficit syndrome, as well as for rating global severity (kappa: 0.88-0.93) and individual negative symptoms (kappa: 0.51-0.61). The schedule was also found to have a high validity for both categorization and measuring individual negative symptoms. (U: 60.0, P: 0.03). Conclusion: The results demonstrated that the Turkish version of the SDS would be a reliable and valid instrument that could be used in the study of schizophrenia.
Otolaryngology and Head and Neck Surgery, Dec 31, 2005
Determine the efficacy of computerized tomography (CT) in detecting the intranasal distribution o... more Determine the efficacy of computerized tomography (CT) in detecting the intranasal distribution of sprayed radio-enhanced particles and the effects of topical decongestion on particle distribution. Sinonasal distribution of a radio-enhanced spray solution was studied using CT imaging in 14 adults with no sinonasal symptoms. One nostril was sprayed with oximetazoline 5 minutes prior to particle application. Serial CT imaging of the sinonasal cavity in approximately 11 minutes was carried out to detect particle distribution into the nasal vestibule, turbinate surfaces, middle meatus and osteomeatal complex area, and the nasopharynx. Particle detection within the nasal vestibule was possible in all cases while distribution into the anterior nasal chamber was visible in 22 cases. Particles could be detected on the inferior turbinate in 7 nasal cavities (25%) and in only 2 cases on the middle turbinate (7.5%). Particles were detected in the middle meatus in 1 case and in no instances in the osteomeatal complex area. Oximetazoline application reduced the amount of particle deposition on the inferior turbinate but did not enhance distribution on the middle turbinate or into the middle meatus. Detection of radio-enhanced sprayed particles within the sinonasal cavity using CT imaging can be a reliable method to study the principles of intranasal particle distribution. Our study failed to show particle distribution into OMC, or any positive effects of nasal decongestion on particle distribution.
Surgical Laparoscopy, Endoscopy & Percutaneous Techniques, 2015
To evaluate the impact of caseload volume on the outcomes of open and laparoscopic surgery for co... more To evaluate the impact of caseload volume on the outcomes of open and laparoscopic surgery for colorectal cancer. Between April 1999 and January 2011, patients who underwent open or laparoscopic resection for colorectal adenocarcinoma with curative intent were identified. There were 2 groups of surgeons, whose primary practice is gastrointestinal surgery (n=5, group A) and general surgery (n=14, group B). Histopathologic and oncologic outcomes, as well as survival data were evaluated. A total of 815 patients fulfilled the study criteria and 356 (group A: 120, group B: 236) patients who had &amp;amp;amp;amp;amp;gt;2 years&amp;amp;amp;amp;amp;#39; follow-up data were included. Colorectal procedures constituted 33% and 19% of all the operations in A and B groups, respectively (P&amp;amp;amp;amp;amp;lt;0.0001). Among the colorectal cases, rates of laparoscopic surgery were 37% and 20% in the group A and B, respectively (P&amp;amp;amp;amp;amp;lt;0.0001). Practice pattern was independently associated with better overall survival and was favoring the group A (P=0.02). Increased caseload volume improves oncologic outcomes in patients undergoing colorectal resection for nonmetastatic cancer.
British Journal of Medicine and Medical Research, 2016
Saudi medical journal, 2006
To find out the prevalence of natural menopause among Turkish women according to age and certain ... more To find out the prevalence of natural menopause among Turkish women according to age and certain demographic variables in a specific rural area. This cross sectional study was carried out in Silivri district of Istanbul, Turkey between January and May 2000. Included in the study were 845 women between the ages of 30-60 years, not undergoing any hormonal replacement, living in the villages of Silivri district, Istanbul, Turkey. The participants were asked for their ages, level of education, number of pregnancies, age at menarche, presence of menstruation, age at the onset of menopause, physical activity outside home and the use of oral contraceptives. Females declaring at least one year of amenorrhea were accepted as being in menopause. The median age for menopause was 47 years. Of the total 845 participants, 326 women were found to be in natural menopause. The prevalence of menopause was estimated as 8.6% for females younger than 40 years, 31.8% for females between the ages 40-45 ye...
Nuclear medicine communications, 2015
Single-photon emission computed tomography (SPECT) myocardial perfusion imaging is an accepted me... more Single-photon emission computed tomography (SPECT) myocardial perfusion imaging is an accepted method for reflecting the pathophysiological significance of lesions detected by coronary angiography. However, it has an inherent drawback in terms of false-positive perfusion defects for the inferior myocardial wall. To overcome this problem, different acquisition techniques have been proposed, including the computed tomographic-based attenuation correction method. In this respect, a new imaging technique, left supine lateral position SPECT myocardial perfusion imaging with technetium-99m methoxyisobutylisonitrile (Tc-99m MIBI), has been proposed to eliminate this problem and its value has been investigated in this report. Sixty-two patients were prospectively and randomly enrolled in this study. They underwent Tc-99m MIBI SPECT in the supine, prone, left lateral, and sitting positions after an adequate stress test on the same day.The presence and extent of defects on stress images were ...
Amer J Clin Pathol, 2001
Among the cutaneous manifestations, nodular lesions are rather common in Behçet syndrome. The his... more Among the cutaneous manifestations, nodular lesions are rather common in Behçet syndrome. The histologic nature of these lesions has been a matter of controversy. To establish their distinguishing features, biopsy specimens from nodular lesions of 24 patients with Behçet syndrome, 25 with nodular vasculitis (NV), and 20 with erythema nodosum (EN) were compared. Statistical analysis revealed insignificant differences between most of the histologic features of Behçet syndrome and NV. However, neutrophil-predominating infiltrate in the subcutis was more common in Behçet syndrome, while necrosis and granuloma formation were encountered more frequently in NV. The differences between Behçet syndrome and EN were more significant. Septal panniculitis, lymphocytepredominating infiltrate, absence of many vascular changes as well as vasculitis, and necrosis were features in favor of EN. Nodular lesions of Behçet syndrome are mainly neutrophilic vascular reactions with histologic features similar to NV but significantly differing from EN associated with other systemic diseases.
Surgery Today, Apr 1, 2003
Splenectomy is sometimes performed simultaneously with curative gastrectomy for gastric carcinoma... more Splenectomy is sometimes performed simultaneously with curative gastrectomy for gastric carcinoma, especially when the tumor originates in the proximal one-third of the stomach or corpus, or when it invades the entire stomach, in an effort to remove metastatic lymph nodes at the splenic hilus and improve survival. However, splenectomy is not an innocent procedure and may cause increased morbidity and even mortality. Moreover, the long-term effect of splenectomy on survival is still controversial. The purpose of this study was to investigate the effect of simultaneous splenectomy on survival in patients with proximal tumors undergoing curative gastrectomy for gastric cancer. The effect of splenectomy on the 5-year survival of 61 patients with proximal gastric cancer (located in the cardia or the corpus) who underwent curative gastrectomy in our hospital between 1989 and 1993 was investigated retrospectively. Of these 61 patients, 38 (62.3%) underwent splenectomy and 23 (37.7%) did not. The relationship between the clinicohistopathological parameters and 5-year survival was retrospectively analyzed. No significant differences were found in bivariate analysis between the survival of patients who underwent curative gastrectomy with and those who underwent curative gastrectomy without splenectomy ( P = 0.984). Multivariate regression analysis indicated that only histological grade ( P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.003) and lymph node metastasis ( P &amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;amp;lt; 0.001) were independent prognostic factors with or without splenectomy. Splenectomy itself was not an independent prognostic factor ( P = 0.528). The findings of this retrospective study showed that simultaneous splenectomy had no effect on the survival of patients who underwent curative gastrectomy for gastric carcinoma. Thus, splenectomy may only be appropriate for patients with direct invasion of the spleen.