Mustafa Yenigun - Academia.edu (original) (raw)

Papers by Mustafa Yenigun

Clinical hemorheology and microcirculation, 2014

Smoking is considered to be one the of risk factors effecting atherosclerosis which is associated... more Smoking is considered to be one the of risk factors effecting atherosclerosis which is associated the physical forces, biological and chemical stimuli occuring in vessel wall. The aim of this study is analysis of the biomechanical (plasma viscosity) and biochemical effect (nitric oxide, NOx; asymmetric dimethylarginine, ADMA) of smoking on endothelial function. One hundred-twenty two individuals were divided into three groups according to their smoking status. Plasma viscosity was measured by Harkness Capillary Viscometer. Plasma NOx level was determined by enzymatic methods using commercial kits. ADMA concentration was determined by Elisa Plasma Assay and and physiologic spirometric and arterial gas parameters and pulmonary blood flow rate (PBFR) were measured. Viscosity variables of former smokers were significantly higher than those of non-smokers (p < 0.001). NOx levels were found to be statistically significantly higher when compared with current smokers and non-smokers (p &...

JPMA. The Journal of the Pakistan Medical Association, 2011

To determine whether alterations in pulmonary function takes place in subclinical hypothyroidism ... more To determine whether alterations in pulmonary function takes place in subclinical hypothyroidism by examining the diffusion lung capacity and muscle strength of such patients. This is a descriptive study conducted in 2009 at Haseki Training and Research Hospital, Istanbul, Turkey. Hundred and twenty-six patients with subclinical hypothyroidism and 58 age and sex matched individuals were recruited. Simple spirometry tests were performed, and pulmonary diffusion capacity (DLco) and muscle strength were measured. ScH patients showed a significant reduciton of the following pulmonary function tests (% predicted value) as compared with control subjects: FVC, FEV1, FEV1%, FEF25-75, FEF25-75%, DLco, DLco/VA, Pimax, Pimax% and Pemax%. These data indicate that pulmonary functions are effected in subclinical hypothyrodism. Therefore patients with or who are at high risk of having subclinical hypothyroidism, should be subjected to evaluation of pulmonary functions with simple spirometry.

Journal of nephrology

In alkaptonuria, the absence of homogentisic acid oxidase (HGO) results in the accumulation of ho... more In alkaptonuria, the absence of homogentisic acid oxidase (HGO) results in the accumulation of homogentisic acid (HGA) in the body. Associated renal failure is rare and usually occurs in the later stages of the disease. We report a 33-year-old male who presented, initially, with renal failure, but no past history of illness. He had pigmentation of sclerae and ear helices, intervertebral disk calcifications and mild mitral insufficiency. His disease was confirmed by HGA detection in the urine. As size and thickness of renal parenchyma seen on ultrasonography were normal, renal biopsy was performed and it showed glomerular sclerosis, diffuse tubular atrophy and interstitial fibrosis with inflammation. Wall thickening of small arteries and pigment deposits were identified in some kidney tissue elements. He progressed to end-stage renal disease despite supportive therapy.

Journal of Turkish Society of Obstetric and Gynecology, 2011

1 Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Istanbul, Turke... more 1 Department of Obstetrics and Gynecology, Haseki Training and Research Hospital, Istanbul, Turkey 2 Department of Biochemistry, Haseki Training and Research Hospital, Istanbul, Turkey 3 Department of Internal Medicine, Haseki Training and Research ...

American Journal of Case Reports, 2012

Sjögren syndrome (SS) is an autoimmune-lymphoproliferative disorder characterized by mononuclear ... more Sjögren syndrome (SS) is an autoimmune-lymphoproliferative disorder characterized by mononuclear cell infiltration of exocrine glands. Clinically, Sjögren syndrome (SS) has a wide spectrum, varying from autoimmune exocrinopathy to systemic involvement. There have been few cases reporting that primary SS developed with distal renal tubular acidosis clinically.

The Endocrinologist, 2010

Medical Science Monitor, 2013

This study was performed to evaluate neck circumference (NC) and metabolic syndrome (MS) paramete... more This study was performed to evaluate neck circumference (NC) and metabolic syndrome (MS) parameters in severe and non-severe (mild-moderate) obstructive sleep apnea syndrome (OSAS) patients according to apnea-hypopnea index (AHI). Material/Method:

Journal of Public Health, 2012

Aim Acute poisoning is one of the major topics in emergency medicine practices. Despite the recen... more Aim Acute poisoning is one of the major topics in emergency medicine practices. Despite the recent developments in toxicology, technological advances and changing lifestyles reveal new factors, and poisoning cases remain to be a problem. All poisonings should be considered serious and independent from their clinical presentation at the time of admission. Identifying the cause and prompt initiation of treatment is life-saving. Causes of poisoning vary between countries and different regions of the same country. In the present study, cases admitted to the Emergency Department of Internal Medicine at Haseki Training and Research Hospital were evaluated and causes of acute poisoning were investigated. Subject and methods Medical records of 675 cases of acute poisoning were retrospectively evaluated in the present study.

Journal of International Medical Research, 2013

Objective: To determine the prevalence of metabolic syndrome and its risk factors in various ethn... more Objective: To determine the prevalence of metabolic syndrome and its risk factors in various ethnic groups in Istanbul, Turkey. Methods: Study participants were aged !20 years. Risk factor components for metabolic syndrome were measured and its presence was determined in study participants. Results: The study included 254 Greeks, 273 West Thracians, 275 East Turkistanis and 304 Armenians. The prevalence of metabolic syndrome was significantly different between groups (Greeks, 19.3%; West Thracians, 24.9%; East Turkistanis, 15.3%; Armenians, 20.4%), and increased with age in all groups. Low levels of high-density lipoprotein cholesterol (HDL-C) were found mainly in Greeks (females, 64.5%; males, 61.6%) and West Thracians (females, 75.8%; males, 73.1%). Among East Turkistanis, HDL-C and triglyceride levels were significantly higher compared with the other ethnic groups. Hypertension was the most frequently encountered component of metabolic syndrome in East Turkistanis. Conclusions: The prevalence of metabolic syndrome varied between ethnic groups living in the same geographical location. In Turkey, metabolic syndrome is common. It is important to determine differences between ethnic groups, as this will assist in identifying those at higher risk of developing coronary heart disease.

Internal Medicine, 2009

Objective The current study was conducted to determine whether or not the lung is one of the targ... more Objective The current study was conducted to determine whether or not the lung is one of the target organs in the development of vascular complications in diabetic patients. We also investigated the relationship between pulmonary diffusing capacity and microalbuminuria.

… Journal of Medicine …, 2009

... Strategies for screening for Chronic Obstructive Pulmonary Disease. Respir Care. 48(12):1194-... more ... Strategies for screening for Chronic Obstructive Pulmonary Disease. Respir Care. 48(12):1194-1201. Giovanni V, Marzia P, Francesco P, Francesco DP, Sandra B, Laura C, Carlo G (2000). Prevalence of Airways Obstruction in a General Population. Chest. 117:339-345. ...

Journal of Diabetes, 2009

Background: The intima-media thickness (IMT) of the carotid artery is highly correlated with card... more Background: The intima-media thickness (IMT) of the carotid artery is highly correlated with cardiovascular events in Type 2 diabetes mellitus (T2DM). The aim of the present study was to undertake a cardiovascular risk assessment in a group of patients (n = 102) who had been followedup for 10 years. Methods: Framingham risk score (FRS), IMT, and various other clinical parameters were evaluated retrospectively using Student's t-test, regression analysis, and v 2 tests. Primary endpoints were defined as cardiovascular death, non-fatal myocardial infarction, angina, and ischemic stroke. Results: The IMT (1.09 ± 0.32 vs 0.89 ± 0.25; P < 0.001) and percentage coronary risk as determined by the FRS (24.33 ± 11.07 vs 16.54 ± 8.35; P = 0.001) were significantly higher in patients presenting with any of the primary endpoints compared with patients in whom no cardiovascular morbidity or mortality was recorded. Other factors that significantly predicted cardiovascular mortality and morbidity included diastolic blood pressure and urinary albumin excretion (UAE; P < 0.001). The likelihood of primary endpoints could be predicted by UAE >30 mg ⁄ day, carotid artery IMT ‡0.9 mm, and FRS ‡20 (odds ratios 8.800, 3.377, and 2.807, respectively). Conclusion: Although FRS predicts 10-year risk for cardiovascular mortality and morbidity in T2DM, we suggest that UAE and carotid artery IMT should also be considered in risk assessments.