N. Aşina - Academia.edu (original) (raw)
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Hydrogels are ideal drug carrier systems for wound healing in tissue engineering and regenerative... more Hydrogels are ideal drug carrier systems for wound healing in tissue engineering and regenerative medicine applications. Their 3D structure supports the cell binding and tissue forming while treating the extracellular matrix for regulating the cellular functions. Poly (ethylene glycol) dmethacrylate (PEGDMA) based hydrogels hold a prominent place in tissue engineering but their applications are limited due to the low porosity and low biodegradability. Carboxymethyl cellulose (CMC) combined with PEGDMA hydrogels aims to decrease the porosity and cell viability for tissue regeneration with better swelling and biocompatibility features. The hydrogels were prepared with different concentrations of PEGDMA, CMC and Irgacure (2959). Surface morphology, pore size profile, chemical bonds and swelling behavior were investigated by scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR), respectively. The results show that the use of CMC improves the porosity along with the swelling behavior. Swelling results are in the range of 90-99.4%.
Hydrogels are ideal drug carrier systems for wound healing in tissue engineering and regenerative... more Hydrogels are ideal drug carrier systems for wound healing in tissue engineering and regenerative medicine applications. Their 3D structure supports the cell binding and tissue forming while treating the extracellular matrix for regulating the cellular functions. Poly (ethylene glycol) dmethacrylate (PEGDMA) based hydrogels hold a prominent place in tissue engineering but their applications are limited due to the low porosity and low biodegradability. Carboxymethyl cellulose (CMC) combined with PEGDMA hydrogels aims to decrease the porosity and cell viability for tissue regeneration with better swelling and biocompatibility features. The hydrogels were prepared with different concentrations of PEGDMA, CMC and Irgacure (2959). Surface morphology, pore size profile, chemical bonds and swelling behavior were investigated by scanning electron microscope (SEM) and Fourier-transform infrared spectroscopy (FTIR), respectively. The results show that the use of CMC improves the porosity along with the swelling behavior. Swelling results are in the range of 90-99.4%.