N. Altanlar - Academia.edu (original) (raw)
Papers by N. Altanlar
CCDC 723964: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 285666: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 626234: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2020
Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles
Il Farmaco
A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepare... more A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.
[Microbiological quality control of lipsticks which are on the market in our country]
Mikrobiyoloji bülteni, 1989
In this study, microbiological quality control of lipsticks has been investigated. In 81 samples,... more In this study, microbiological quality control of lipsticks has been investigated. In 81 samples, we found that 34 of them (42%) had total aerobic plate count and 19 of them (23.5%) were found to consist mold and yeast which are not allowed by the cosmetic regulations. In none of the samples, pathogen microorganisms such as S. aureus, P. aeruginosa, E.coli, Salmonella and Shigella were detected. Indeed, after carefully examining of the microbiological content of these lipsticks, their biostatistical efficiency was also determined. In each counting procedure, for different bacteria, it was found that only one sample was effective at the 3rd and 14th day. The remaining 9 lipstick samples (90%) were kept under investigation until the end of the testing procedure on the 28th day.
Zeitschrift für Naturforschung C, 2011
There has been an increasing importance of drug-resistant pathogens in clinical microbiological a... more There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in vitro antimicrobial activities using the twofold serial dilution technique against Staphylococcus aureus, methicillin-resistant S. aureus, methicillinresistant S. aureus isolate, Escherichia coli, Bacillus subtilis, and Candida albicans. The minimum inhibitory concentration (MIC) of the test compounds and the reference standards sultamicillin, ampicillin, fl uconazole, and ciprofl oxacin was determined. All compounds possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Aromaticity and disubstitution of the phenyl ring with especially fl uorine and chlorine atoms were found to be signifi cant for the antimicrobial activity
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones
Bioorganic & Medicinal Chemistry, 2008
A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reactio... more A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
Reviewer List for the Year of 2004
fabad.org.tr
... Aydn, Erdem Baflaran, Nurflen Baykara, Tamer Bozkr, Asuman Caner, Biray Çalfl, Sema De¤im,... more ... Aydn, Erdem Baflaran, Nurflen Baykara, Tamer Bozkr, Asuman Caner, Biray Çalfl, Sema De¤im, Tuncer De¤im, Zelihagül Do¤ru, Bilgehan Dortunç, Betül Duydu, Yalçn Gö¤er, Nilgün Günden Gönül, Bilge Kr, Metin Kocabafl, Neslihan Aygün Özçelikay, Gülbin Özçelikay ...
DEGÍ § ÍK KLÍNlK ÖRNEKLERDEN IZÓLE EDÍLEN CANDIDA TÜRLERÍNÍN DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA § TIRILMASI
ANKEM …, 1999
... DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA§TIRILMASI* Nurten ALTANLAR/ Ali ERDEMOGLIP, Güro... more ... DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA§TIRILMASI* Nurten ALTANLAR/ Ali ERDEMOGLIP, Gürol EMEKDAÇ2, Ömer KOCABEYOGLU2, Ahmet ... maddelere duyaihlik farklihklan nedeniyle mantar hastahklarm-da tcdavide ba§anyi artirmak amaciyla tur tanisi ve ...
Ankara Universitesi Eczacilik Fakultesi Dergisi, 1999
Vaginal akıntı kaşıntı yakınmalarıyla Ankara'da çeşitli sağlık ocağına başvuran değişik yaş grupl... more Vaginal akıntı kaşıntı yakınmalarıyla Ankara'da çeşitli sağlık ocağına başvuran değişik yaş gruplarından 354 hastanın vajinal sürüntü örnekleri fungal enfeksiyon varlığı bakımından incelenmeye alınmıştır. Vaginal numuneler Sabouraud Dextrose Agar (SDA) ve kanlı agara inoküle edilmiş ayrıca boyasız ve Gram ile boyanarak taze preparat incelenmiştir. Direkt preparat ve vajinal kültürler sonucunda numunelerin 78'inde (%22.30) maya varlığı belirlenmiştir. İzole edilen mayalar klasik tiplendirme yöntemleri ve ticari Fungichrom test kiti ile tiplendirilmiştir. Klasik yöntemler ile ticari kit sonuçlarının uyumlu olduğu görülmüştür. İzole edilen Candidaların tiplendirilmesi sonucu aşağıdaki türler
Synthesis and Antimicrobial Activity of Some New 2‐Phenyl‐N‐substituted Carboxamido‐1H‐benzimidazole Derivatives
Some 1H‐benzimidazole‐carboxamide derivatives were prepared and their antimicrobial activities ag... more Some 1H‐benzimidazole‐carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.
Native-polyacrylamide gel electrophoresis (N-PAGE) was used to characterize Candida albicans stra... more Native-polyacrylamide gel electrophoresis (N-PAGE) was used to characterize Candida albicans strains isolated from vaginal specimens of patients suffering from vaginitis in Ankara hospitals, Turkey. Three different protein band profiles were observed among these 38 C. albicans isolates when whole cell protein extracts of these strains were used in N-PAGE. 34 of the 38 isolates were shown to belong to a single group or clone with a dissemination percentage of 89, while three isolates belonged to another group with a percentage of 8. Furthermore only one C. albicans isolate was detected with a dissemination percentage of 3 and assigned to a third group. The results presented here also suggested that N-PAGE may be an efficacious method for differentiating between C. albicans strains.
Synthesis and microbiological activity of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides as the possible metabolites of antimicrobial active benzoxazoles
Synthesis of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and t... more Synthesis of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides (5a-k) were described in order to determine their in vitro antimicrobial activity against 3 Gram-positive, 3 Gram-negative bacteria and the fungus Candida albicans comparing with several control drugs. The derivative 5e was found active at a MIC value of 25 micrograms/ml against the whole tested Gram-positive bacteria strains and the Gram-negative microorganism Klebsiella pneumoniae. Moreover, the synthesized compounds 5a-k exhibited significant antibacterial activity against the enterobacter Pseudomonas aureginosae when compared to the control drugs. For the antifungal avtivity against C. albicans, the compound 5k was found more active than the other synthesized derivatives. On the other hand, the antimicrobial activity of some of these acetamide derivatives (5c, 5d, 5e, 5j and 5k) which are the possible metabolites of benzoxazoles, were also compared with their cyc...
Synthesis and antimicrobial activity of some new anilino benzimidazoles
Archiv der Pharmazie
A series of 2-(anilino or 2,6-dichloroanilino)-1,5(6)-disubstituted-1H-benzimidazoles (1-13) were... more A series of 2-(anilino or 2,6-dichloroanilino)-1,5(6)-disubstituted-1H-benzimidazoles (1-13) were prepared by reaction of several 2-chloro- or 2-chloromethyl-1H-benzimidazoles with aniline derivatives. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compounds 2, 8, and 9 exhibited the best activity.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Flavone-6-carboxaldehyde Oxime Ether Derivatives
ChemInform, 1999
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Piperidinyl Benzimidazoles
ChemInform, 1996
Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives
Archiv der Pharmazie, 2001
Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities ag... more Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.
Synthesis and antimicrobial activity of some new 4-hydroxy-2H- 1,4-benzoxazin-3(4H)-ones
Farmaco (Società chimica italiana : 1989)
Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobia... more Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus, Escherichia coli and Candida albicans. Compounds 9, and 10 exhibited the best activity against Candida albicans.
CCDC 723964: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 285666: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
CCDC 626234: Experimental Crystal Structure Determination
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Ankara Universitesi Eczacilik Fakultesi Dergisi, 2020
Synthesis and antimicrobial activity of some new piperidinyl benzimidazoles
Il Farmaco
A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepare... more A series of 2-(4-methylpiperidin-1-yl)-1,5(6)-disubstituted-1H-benzimidazoles (1-18) were prepared through the reaction of 2-chloro (or 2-chloromethyl)-1H-benzimidazole derivatives with 4-methylpiperidine. For the preparation of the individual isomers, compounds 7, 9 and 18 were synthesized by a multistep procedure. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compound 3 and 4 exhibited the best antifungal activity.
[Microbiological quality control of lipsticks which are on the market in our country]
Mikrobiyoloji bülteni, 1989
In this study, microbiological quality control of lipsticks has been investigated. In 81 samples,... more In this study, microbiological quality control of lipsticks has been investigated. In 81 samples, we found that 34 of them (42%) had total aerobic plate count and 19 of them (23.5%) were found to consist mold and yeast which are not allowed by the cosmetic regulations. In none of the samples, pathogen microorganisms such as S. aureus, P. aeruginosa, E.coli, Salmonella and Shigella were detected. Indeed, after carefully examining of the microbiological content of these lipsticks, their biostatistical efficiency was also determined. In each counting procedure, for different bacteria, it was found that only one sample was effective at the 3rd and 14th day. The remaining 9 lipstick samples (90%) were kept under investigation until the end of the testing procedure on the 28th day.
Zeitschrift für Naturforschung C, 2011
There has been an increasing importance of drug-resistant pathogens in clinical microbiological a... more There has been an increasing importance of drug-resistant pathogens in clinical microbiological and antibacterial research. Indoles and hydrazone-type compounds constitute important classes of compounds in the search for effective agents against multidrug-resistant microbial infections. In this study a series of 1-methylindole-3-carboxaldehyde hydrazone derivatives were evaluated for their in vitro antimicrobial activities using the twofold serial dilution technique against Staphylococcus aureus, methicillin-resistant S. aureus, methicillinresistant S. aureus isolate, Escherichia coli, Bacillus subtilis, and Candida albicans. The minimum inhibitory concentration (MIC) of the test compounds and the reference standards sultamicillin, ampicillin, fl uconazole, and ciprofl oxacin was determined. All compounds possessed a broad spectrum of activity having MIC values of 6.25-100 μg/ml against the tested microorganisms. Aromaticity and disubstitution of the phenyl ring with especially fl uorine and chlorine atoms were found to be signifi cant for the antimicrobial activity
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones
Bioorganic & Medicinal Chemistry, 2008
A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reactio... more A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
Reviewer List for the Year of 2004
fabad.org.tr
... Aydn, Erdem Baflaran, Nurflen Baykara, Tamer Bozkr, Asuman Caner, Biray Çalfl, Sema De¤im,... more ... Aydn, Erdem Baflaran, Nurflen Baykara, Tamer Bozkr, Asuman Caner, Biray Çalfl, Sema De¤im, Tuncer De¤im, Zelihagül Do¤ru, Bilgehan Dortunç, Betül Duydu, Yalçn Gö¤er, Nilgün Günden Gönül, Bilge Kr, Metin Kocabafl, Neslihan Aygün Özçelikay, Gülbin Özçelikay ...
DEGÍ § ÍK KLÍNlK ÖRNEKLERDEN IZÓLE EDÍLEN CANDIDA TÜRLERÍNÍN DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA § TIRILMASI
ANKEM …, 1999
... DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA§TIRILMASI* Nurten ALTANLAR/ Ali ERDEMOGLIP, Güro... more ... DAGILIMI VE ANTIFUNGAL DUYARLILIKLARININ ARA§TIRILMASI* Nurten ALTANLAR/ Ali ERDEMOGLIP, Gürol EMEKDAÇ2, Ömer KOCABEYOGLU2, Ahmet ... maddelere duyaihlik farklihklan nedeniyle mantar hastahklarm-da tcdavide ba§anyi artirmak amaciyla tur tanisi ve ...
Ankara Universitesi Eczacilik Fakultesi Dergisi, 1999
Vaginal akıntı kaşıntı yakınmalarıyla Ankara'da çeşitli sağlık ocağına başvuran değişik yaş grupl... more Vaginal akıntı kaşıntı yakınmalarıyla Ankara'da çeşitli sağlık ocağına başvuran değişik yaş gruplarından 354 hastanın vajinal sürüntü örnekleri fungal enfeksiyon varlığı bakımından incelenmeye alınmıştır. Vaginal numuneler Sabouraud Dextrose Agar (SDA) ve kanlı agara inoküle edilmiş ayrıca boyasız ve Gram ile boyanarak taze preparat incelenmiştir. Direkt preparat ve vajinal kültürler sonucunda numunelerin 78'inde (%22.30) maya varlığı belirlenmiştir. İzole edilen mayalar klasik tiplendirme yöntemleri ve ticari Fungichrom test kiti ile tiplendirilmiştir. Klasik yöntemler ile ticari kit sonuçlarının uyumlu olduğu görülmüştür. İzole edilen Candidaların tiplendirilmesi sonucu aşağıdaki türler
Synthesis and Antimicrobial Activity of Some New 2‐Phenyl‐N‐substituted Carboxamido‐1H‐benzimidazole Derivatives
Some 1H‐benzimidazole‐carboxamide derivatives were prepared and their antimicrobial activities ag... more Some 1H‐benzimidazole‐carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.
Native-polyacrylamide gel electrophoresis (N-PAGE) was used to characterize Candida albicans stra... more Native-polyacrylamide gel electrophoresis (N-PAGE) was used to characterize Candida albicans strains isolated from vaginal specimens of patients suffering from vaginitis in Ankara hospitals, Turkey. Three different protein band profiles were observed among these 38 C. albicans isolates when whole cell protein extracts of these strains were used in N-PAGE. 34 of the 38 isolates were shown to belong to a single group or clone with a dissemination percentage of 89, while three isolates belonged to another group with a percentage of 8. Furthermore only one C. albicans isolate was detected with a dissemination percentage of 3 and assigned to a third group. The results presented here also suggested that N-PAGE may be an efficacious method for differentiating between C. albicans strains.
Synthesis and microbiological activity of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides as the possible metabolites of antimicrobial active benzoxazoles
Synthesis of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and t... more Synthesis of some novel N-(2-hydroxyl-5-substitutedphenyl)benzacetamides, phenoxyacetamides and thiophenoxyacetamides (5a-k) were described in order to determine their in vitro antimicrobial activity against 3 Gram-positive, 3 Gram-negative bacteria and the fungus Candida albicans comparing with several control drugs. The derivative 5e was found active at a MIC value of 25 micrograms/ml against the whole tested Gram-positive bacteria strains and the Gram-negative microorganism Klebsiella pneumoniae. Moreover, the synthesized compounds 5a-k exhibited significant antibacterial activity against the enterobacter Pseudomonas aureginosae when compared to the control drugs. For the antifungal avtivity against C. albicans, the compound 5k was found more active than the other synthesized derivatives. On the other hand, the antimicrobial activity of some of these acetamide derivatives (5c, 5d, 5e, 5j and 5k) which are the possible metabolites of benzoxazoles, were also compared with their cyc...
Synthesis and antimicrobial activity of some new anilino benzimidazoles
Archiv der Pharmazie
A series of 2-(anilino or 2,6-dichloroanilino)-1,5(6)-disubstituted-1H-benzimidazoles (1-13) were... more A series of 2-(anilino or 2,6-dichloroanilino)-1,5(6)-disubstituted-1H-benzimidazoles (1-13) were prepared by reaction of several 2-chloro- or 2-chloromethyl-1H-benzimidazoles with aniline derivatives. The prepared compounds were screened for their in vitro antibacterial and antifungal activities. Compounds 2, 8, and 9 exhibited the best activity.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Flavone-6-carboxaldehyde Oxime Ether Derivatives
ChemInform, 1999
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Piperidinyl Benzimidazoles
ChemInform, 1996
Synthesis and antimicrobial activity of some new 2-phenyl-N-substituted carboxamido-1H-benzimidazole derivatives
Archiv der Pharmazie, 2001
Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities ag... more Some 1H-benzimidazole-carboxamide derivatives were prepared and their antimicrobial activities against Staphyloccus aureus, Escherichia coli and Candida albicans evaluated. Compounds 18, 22, and 25 exhibited the best activity against Candida albicans.
Synthesis and antimicrobial activity of some new 4-hydroxy-2H- 1,4-benzoxazin-3(4H)-ones
Farmaco (Società chimica italiana : 1989)
Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobia... more Some 4-hydroxy-2H-1,4-benzoxazin-3(4H)-ones were synthesized and evaluated for their antimicrobial activities against Staphylococcus aureus, Escherichia coli and Candida albicans. Compounds 9, and 10 exhibited the best activity against Candida albicans.