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Papers by Nourdin Aqodad
The American journal of gastroenterology, 2008
Patients with type 1 (HFE-related) genetic hemochromatosis are usually excluded from blood donati... more Patients with type 1 (HFE-related) genetic hemochromatosis are usually excluded from blood donation on the basis that this disease may facilitate bacterial infections. The aim of the present study was to evaluate the serum antibacterial effect against Salmonella enterica Typhimurium LT2 in relation to iron status. Serum samples were collected in 26 iron-overloaded (homozygous C282Y mutation) and 35 iron-depleted hemochromatosis patients and 33 healthy control subjects. The antibacterial activity of sera and iron parameters were tested for each patient. Serum from normal controls had an antibacterial effect against Salmonella Typhimurium LT2. The antibacterial effect decreased from the 1:2 to the 1:8 dilution and was always significantly lower in the iron-overloaded group. In both control and iron-depleted patients, a positive correlation was found between the decrease of antibacterial effect and the increase of both serum iron and transferrin saturation. These results (a) support th...
Gastroentérologie Clinique et Biologique, 2008
DOAJ (DOAJ: Directory of Open Access Journals), Feb 8, 2012
ABSTRACT Introduction Des différences épidémiologiques, étiologique voire pronostique des hémorra... more ABSTRACT Introduction Des différences épidémiologiques, étiologique voire pronostique des hémorragies digestives hautes (HDH) entre les deux sexes opposés ont été cité par différentes études. Méthodes Nous avons essayé de déceler ces différences à travers une analyse rétrospective nichée sur une étude prospective sur les hémorragies digestives hautes ayant inclus 945 patients. Résultats Six cents trente-sept patients étaient des hommes (67,4% Vs 32,6%). Un antécédent d'HDH était trouvé chez 24,2% des cas sans différence significative entre les deux sexes. L'âge de survenue de l'hémorragie était plus élevé chez les femmes que chez les hommes : 51,5 ans ± 18,8 Vs 47,8 ans ± 18,3 (p : 0,003). Les étiologies de l'HDH étaient différentes entre les deux sexes. Alors que l'hémorragie liée à l'HTP était la première cause chez la femme (38 % Vs 23,5 % chez l'homme, p<0,0001), c'est la pathologie ulcéreuse qui venait en premier chez l'homme (62 % Vs 36,7 % chez la femme, p<0,0001). Un besoin transfusionnel était noté chez 42,4 % des patients de sexe masculin contre 35,4 % des patientes avec un p = 0,03. Le taux de récidive et de décès global étaient de 7,5 % et de 5,7 % des cas respectivement, sans différence significative entre les deux sexes. Conclusion L'étude trouve un profil épidémiologique, clinique et étiologique différent selon le sexe des patients.
Elsevier Masson, Mar 26, 2008
Open Journal of Gastroenterology, 2022
For a long time, a combination of interferon and ribavirin has been used to treat viral hepatitis... more For a long time, a combination of interferon and ribavirin has been used to treat viral hepatitis C, but the sustained virological response was only achieved in 45% of cases and side effects were serious [1]. Direct acting antivirals (DAA) have provided a cure for almost everyone with hepatitis C, with few side effects. The Purpose of Our Work is to compare the results of treatment for viral hepatitis C before and after DAA. Patients and Methods: This is a retrospective study, bringing together all patients with chronic viral hepatitis C treated between January 2009 and March 2020 at the University Hospital Hassan II in Fez, Morocco. The epidemiological, clinical, biological, virological characteristics of the included patients were collected from the two groups: A, treated with interferon and ribavirin or by triple therapy and B, treated with DAA. Results: 162 patients were included, the average age was 55 y/o, with 90 women and 72 men. 88 patients (54.3%) were already cirrhotic, of which 61 were compensated and 27 were decompensated. Genotype 1 was dominant with a frequency of 71.6%, 107 patients (66%) initially treated with old HCV treatments and 55 (34%) treated with DAA. Sustained viral response was obtained in 59 cases (55.14%) in group A versus 54 cases (98.18%) in group B with a very significant difference (p < 0.0001). Treatment failure was observed in 14 patients (13.
International Journal of Advanced Research, 2022
Polycysticdisease of the pancreasis a rare disease most often seen in association with polycystic... more Polycysticdisease of the pancreasis a rare disease most often seen in association with polycystic kidney disease and Von Hippel Lindau syndrome. It is characterized by the presence of single or multiple simple congenital cysts in the pancreatic parenchyma. These cysts are benign in nature and do not communicate with the main pancreatic duct. We report a case of a young 31-year-old female patient incidentally detected to have multiple simple pancreatic cysts.
of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis*
Journal of Medical and Surgical Research, 2016
Introduction: The incidence of digestive bleedings secondary to the rupture of gastroduodenal var... more Introduction: The incidence of digestive bleedings secondary to the rupture of gastroduodenal varices ranges from 3 to 30%. They represent approximately 10 % of all the high bleedings associated with a portal hypertension. The purpose of this work is to estimate the therapeutic efficiency and the complications of the injection of chemical glue diluted with glucose solution5% as a technique for endoscopic hemostasis. Patients and methods: It’s a retrospective study concerning 15 patients between 2012 and 2014. All the patients were admitted for upper gastrointestinal bleeding. They all underwent oesogastro- duodenal endoscopy which objectified bleeding caused by rupture of gastroduodenal varices. Patient’s consent was mandatory. N-butyl-2-cyanoacrylate was associated with methacryl oxysulfolane (Glubran 2) prepared with glucose serum 5%. The endoscopic treatment was realized under sedation and consisted in the injection of chemical glue intravariceally. Results: The injection of glue...
Pan African Medical Journal, 2020
Primary Budd-Chiari syndrome is an hepatopathy characterized by obstruction of the hepatic venous... more Primary Budd-Chiari syndrome is an hepatopathy characterized by obstruction of the hepatic venous flow in the vascular space between the hepatic venules and the junction between the inferior vena cava and the right atrium, thus excluding the causes of upstream (sinusoidal obstruction syndrome) and downstream (cardiac causes). This endoluminal venous obstruction is mainly due to thrombosis or its fibrotic consequences. This is a rare disease, mainly affecting young adults. Clinical manifestations are extremely variable; it can be asymptomatic, acute, subacute or chronic. The diagnosis is mainly based on Doppler ultrasound and/or magnetic resonance imaging. Several causes have been identified, in particular, myeloproliferative syndrome, antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, inherited thrombotic disorders. Symptomatic and etiologic treatments are the commonly used approaches, treatment recommendations are organized in algorithm. Recent therapeutic advances can significantly improve the prognosis.
Pan African Medical Journal, 2020
Pan African Medical Journal, 2021
Liver damage during COVID-19 disease has been described in numerous studies. Its mechanism is poo... more Liver damage during COVID-19 disease has been described in numerous studies. Its mechanism is poorly understood. It is mainly reserved for severe forms and is manifested by abnormalities of the hepatic assessment and more particularly cytolysis. Particular attention must be paid to patients with chronic liver disease, both in terms of follow-up and treatment. We wanted to know the evolution of COVID-19 and its treatment, on the liver function of a 27-year-old patient followed for chronic noncirrhotic hepatitis B at the Hassan II University Hospital in Fez. Our patient had stopped the antiviral B treatment and presented COVID-19 infection with minimal to moderate impairment. The initial evaluation showed cytolysis at 4 times upper limit of normal (ULN). Management consisted in the immediate resumption of Tenofovir in combination with hydroxychloroquine (HCQ) and azythromycin with good clinical and biological evolution.
Open Journal of Gastroenterology, 2019
The achalasia is a rare primary esophageal motor disorder characterized by relaxation disorders o... more The achalasia is a rare primary esophageal motor disorder characterized by relaxation disorders of the lower esophageal sphincter and absence of the esophageal body peristalsis. Several studies suggest that the response to the endoscopic treatment depends on several predictors. The aim of our study was to evaluate the endoscopic treatment of esophageal achalasia and identify the predictive factors of endoscopic treatment response. Patients and Methods: This is a retrospective analytical study of 78 patients with achalasia, managed in the gastroenterology department of the university medical center Hassan II-Fez, during a period of 5 years (
Journal Africain du Cancer / African Journal of Cancer, 2013
![Research paper thumbnail of [Epidemiological differences in upper gastrointestinal bleeding between men and women]](https://attachments.academia-assets.com/99979537/thumbnails/1.jpg)
](The Pan African medical journal, 2012
La différence épidémiologique des hémorragies digestives hautes entre les hommes et les femmes
Open Journal of Gastroenterology, 2014
The occurrence of pregnancy is relatively rare in patients with portal hypertension, and has been... more The occurrence of pregnancy is relatively rare in patients with portal hypertension, and has been reported as clinical cases. However, few studies have evaluated the effectiveness of injecting histoacryl during pregnancy. The choice of treatment for varicose bleeding during pregnancy has been described in the literature based on the elastic ligature. We report the second case, to our knowledge, of treatment of bleeding gastric varices by injection of histoacryl with good maternal and fetal development.
Pan African Medical Journal, 2013
Hepatitis B virus infection is an uncommon cause of acute glomerulonephritis. We present a case o... more Hepatitis B virus infection is an uncommon cause of acute glomerulonephritis. We present a case of acute glomerulonephritis revealing a chronic viral hepatitis B. A 45 year-old man was admitted in the nephrology department of Hassan II university hospital (Fez, Morocco) for nephritic syndrome with advanced acute kidney injury. The investigations have revealed viral hepatitis B with a positive HBV-DNA and Others viral serology tests were negative. Renal biopsy showed a diffuse and global endocapillary proliferation without extra-capillary proliferation; and global deposits of C3 and Ig G On immunofluorescence. There wasn't any other infectious cause. We thus retained the diagnosis of hepatitis B virus-associated acute glomerulonephritis. He was given entecavir and corticosteroids. Three months later, the evolution was marked by the normalization of renal function, negativity of proteinuria and HBV DNA became undetectable. There was no relapse of glomerulonephritis and HBV viral load was still negative after one year follow-up.
Pan African Medical Journal, 2014
La sarcoïdose est une maladie systémique d'étiologie inconnue. Elle est caractérisée par la prése... more La sarcoïdose est une maladie systémique d'étiologie inconnue. Elle est caractérisée par la présence de lésions granulomateuses, non caséeuses, au niveau des organes atteints. La cirrhose biliaire primitive (CBP) est une hépatopathie cholestatique auto-immune chronique, caractérisée par une destruction des canalicules biliaires et la présence d'anticorps antimitchondries type M2. L'association sarcoïdose et CBP est rare. Nous rapportons un nouveau cas de cette association avec revue de la littérature.
Open Journal of Gastroenterology, 2014
Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in l... more Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in literature. Several studies have demonstrated independent predictors of mortality. The aim of this work is indeed to identify these predictors. Patients and Methods: We conducted a retrospective study of 1080 cirrhotic patients hospitalized in our department of gastroenterology and hepatology between January 2001 and August 2010. A descriptive study of the study population was performed, and a univariate analysis looking for an association between intra-hospital mortality, and clinical, biological, etiological and socio-demographic characteristics of our patients. Results: The average age of our patients was 54 years, with an equal number of men and women. 41.1% of patients had cirrhosis secondary to hepatitis C and 18.5% had cirrhosis secondary to hepatitis B. 26.1% of our patients were CHILD C. Intra-hospital mortality was 8.7% (97 deaths) with a mean of 23.4 ± 35.8 months. Univariate analysis showed that the intra-hospital mortality was significantly associated with higher age (p = 0.049) as well as the reasons for admissions like hepatic encephalopathy, and hematemesis (p < 0.0001), melena, jaundice and ascites (p = 0.001). Among the biological parameters analyzed in univariate analysis, significant associations with mortality were objectified for high white blood cell count (p = 0.035), and high serum bilirubin and creatinine (p < 0.0001); low rate of prothrombin time (PT) (p < 0.0001), of albumin (p = 0.0001) and of serum sodium (p < 0.0001). Among the complications analyzed, significant associations with mortality were objectified for jaundice, ascites (p = 0.001), hemorrhagic decompensation, hepatic encephalopathy, and spontaneous bacterial peritonitis (p < 0.001). Univariate analysis of the etiology of cirrhosis objectified significant associations for cirrhosis secondary to hepatitis B (p = 0.001) and hepatitis C (p = 0.022). Multivariate analysis objectified four independent predictors of mortality: hepatic encephalopathy, infection (hyper leukocytosis ≥ 10,000/mm 3), renal failure (serum creatinine ≥ 15 mg/l) and hyponatremia. Conclusion: In our series, we identified four independent predictors of intra-hospital mortality in cirrhotic patients: hepatic encephalopathy, infection, renal failure and hyponatremia.
The American journal of gastroenterology, 2008
Patients with type 1 (HFE-related) genetic hemochromatosis are usually excluded from blood donati... more Patients with type 1 (HFE-related) genetic hemochromatosis are usually excluded from blood donation on the basis that this disease may facilitate bacterial infections. The aim of the present study was to evaluate the serum antibacterial effect against Salmonella enterica Typhimurium LT2 in relation to iron status. Serum samples were collected in 26 iron-overloaded (homozygous C282Y mutation) and 35 iron-depleted hemochromatosis patients and 33 healthy control subjects. The antibacterial activity of sera and iron parameters were tested for each patient. Serum from normal controls had an antibacterial effect against Salmonella Typhimurium LT2. The antibacterial effect decreased from the 1:2 to the 1:8 dilution and was always significantly lower in the iron-overloaded group. In both control and iron-depleted patients, a positive correlation was found between the decrease of antibacterial effect and the increase of both serum iron and transferrin saturation. These results (a) support th...
Gastroentérologie Clinique et Biologique, 2008
DOAJ (DOAJ: Directory of Open Access Journals), Feb 8, 2012
ABSTRACT Introduction Des différences épidémiologiques, étiologique voire pronostique des hémorra... more ABSTRACT Introduction Des différences épidémiologiques, étiologique voire pronostique des hémorragies digestives hautes (HDH) entre les deux sexes opposés ont été cité par différentes études. Méthodes Nous avons essayé de déceler ces différences à travers une analyse rétrospective nichée sur une étude prospective sur les hémorragies digestives hautes ayant inclus 945 patients. Résultats Six cents trente-sept patients étaient des hommes (67,4% Vs 32,6%). Un antécédent d'HDH était trouvé chez 24,2% des cas sans différence significative entre les deux sexes. L'âge de survenue de l'hémorragie était plus élevé chez les femmes que chez les hommes : 51,5 ans ± 18,8 Vs 47,8 ans ± 18,3 (p : 0,003). Les étiologies de l'HDH étaient différentes entre les deux sexes. Alors que l'hémorragie liée à l'HTP était la première cause chez la femme (38 % Vs 23,5 % chez l'homme, p<0,0001), c'est la pathologie ulcéreuse qui venait en premier chez l'homme (62 % Vs 36,7 % chez la femme, p<0,0001). Un besoin transfusionnel était noté chez 42,4 % des patients de sexe masculin contre 35,4 % des patientes avec un p = 0,03. Le taux de récidive et de décès global étaient de 7,5 % et de 5,7 % des cas respectivement, sans différence significative entre les deux sexes. Conclusion L'étude trouve un profil épidémiologique, clinique et étiologique différent selon le sexe des patients.
Elsevier Masson, Mar 26, 2008
Open Journal of Gastroenterology, 2022
For a long time, a combination of interferon and ribavirin has been used to treat viral hepatitis... more For a long time, a combination of interferon and ribavirin has been used to treat viral hepatitis C, but the sustained virological response was only achieved in 45% of cases and side effects were serious [1]. Direct acting antivirals (DAA) have provided a cure for almost everyone with hepatitis C, with few side effects. The Purpose of Our Work is to compare the results of treatment for viral hepatitis C before and after DAA. Patients and Methods: This is a retrospective study, bringing together all patients with chronic viral hepatitis C treated between January 2009 and March 2020 at the University Hospital Hassan II in Fez, Morocco. The epidemiological, clinical, biological, virological characteristics of the included patients were collected from the two groups: A, treated with interferon and ribavirin or by triple therapy and B, treated with DAA. Results: 162 patients were included, the average age was 55 y/o, with 90 women and 72 men. 88 patients (54.3%) were already cirrhotic, of which 61 were compensated and 27 were decompensated. Genotype 1 was dominant with a frequency of 71.6%, 107 patients (66%) initially treated with old HCV treatments and 55 (34%) treated with DAA. Sustained viral response was obtained in 59 cases (55.14%) in group A versus 54 cases (98.18%) in group B with a very significant difference (p < 0.0001). Treatment failure was observed in 14 patients (13.
International Journal of Advanced Research, 2022
Polycysticdisease of the pancreasis a rare disease most often seen in association with polycystic... more Polycysticdisease of the pancreasis a rare disease most often seen in association with polycystic kidney disease and Von Hippel Lindau syndrome. It is characterized by the presence of single or multiple simple congenital cysts in the pancreatic parenchyma. These cysts are benign in nature and do not communicate with the main pancreatic duct. We report a case of a young 31-year-old female patient incidentally detected to have multiple simple pancreatic cysts.
of early rebleeding and mortality after acute variceal haemorrhage in patients with cirrhosis*
Journal of Medical and Surgical Research, 2016
Introduction: The incidence of digestive bleedings secondary to the rupture of gastroduodenal var... more Introduction: The incidence of digestive bleedings secondary to the rupture of gastroduodenal varices ranges from 3 to 30%. They represent approximately 10 % of all the high bleedings associated with a portal hypertension. The purpose of this work is to estimate the therapeutic efficiency and the complications of the injection of chemical glue diluted with glucose solution5% as a technique for endoscopic hemostasis. Patients and methods: It’s a retrospective study concerning 15 patients between 2012 and 2014. All the patients were admitted for upper gastrointestinal bleeding. They all underwent oesogastro- duodenal endoscopy which objectified bleeding caused by rupture of gastroduodenal varices. Patient’s consent was mandatory. N-butyl-2-cyanoacrylate was associated with methacryl oxysulfolane (Glubran 2) prepared with glucose serum 5%. The endoscopic treatment was realized under sedation and consisted in the injection of chemical glue intravariceally. Results: The injection of glue...
Pan African Medical Journal, 2020
Primary Budd-Chiari syndrome is an hepatopathy characterized by obstruction of the hepatic venous... more Primary Budd-Chiari syndrome is an hepatopathy characterized by obstruction of the hepatic venous flow in the vascular space between the hepatic venules and the junction between the inferior vena cava and the right atrium, thus excluding the causes of upstream (sinusoidal obstruction syndrome) and downstream (cardiac causes). This endoluminal venous obstruction is mainly due to thrombosis or its fibrotic consequences. This is a rare disease, mainly affecting young adults. Clinical manifestations are extremely variable; it can be asymptomatic, acute, subacute or chronic. The diagnosis is mainly based on Doppler ultrasound and/or magnetic resonance imaging. Several causes have been identified, in particular, myeloproliferative syndrome, antiphospholipid syndrome, paroxysmal nocturnal hemoglobinuria, inherited thrombotic disorders. Symptomatic and etiologic treatments are the commonly used approaches, treatment recommendations are organized in algorithm. Recent therapeutic advances can significantly improve the prognosis.
Pan African Medical Journal, 2020
Pan African Medical Journal, 2021
Liver damage during COVID-19 disease has been described in numerous studies. Its mechanism is poo... more Liver damage during COVID-19 disease has been described in numerous studies. Its mechanism is poorly understood. It is mainly reserved for severe forms and is manifested by abnormalities of the hepatic assessment and more particularly cytolysis. Particular attention must be paid to patients with chronic liver disease, both in terms of follow-up and treatment. We wanted to know the evolution of COVID-19 and its treatment, on the liver function of a 27-year-old patient followed for chronic noncirrhotic hepatitis B at the Hassan II University Hospital in Fez. Our patient had stopped the antiviral B treatment and presented COVID-19 infection with minimal to moderate impairment. The initial evaluation showed cytolysis at 4 times upper limit of normal (ULN). Management consisted in the immediate resumption of Tenofovir in combination with hydroxychloroquine (HCQ) and azythromycin with good clinical and biological evolution.
Open Journal of Gastroenterology, 2019
The achalasia is a rare primary esophageal motor disorder characterized by relaxation disorders o... more The achalasia is a rare primary esophageal motor disorder characterized by relaxation disorders of the lower esophageal sphincter and absence of the esophageal body peristalsis. Several studies suggest that the response to the endoscopic treatment depends on several predictors. The aim of our study was to evaluate the endoscopic treatment of esophageal achalasia and identify the predictive factors of endoscopic treatment response. Patients and Methods: This is a retrospective analytical study of 78 patients with achalasia, managed in the gastroenterology department of the university medical center Hassan II-Fez, during a period of 5 years (
Journal Africain du Cancer / African Journal of Cancer, 2013
The Pan African medical journal, 2012
La différence épidémiologique des hémorragies digestives hautes entre les hommes et les femmes
Open Journal of Gastroenterology, 2014
The occurrence of pregnancy is relatively rare in patients with portal hypertension, and has been... more The occurrence of pregnancy is relatively rare in patients with portal hypertension, and has been reported as clinical cases. However, few studies have evaluated the effectiveness of injecting histoacryl during pregnancy. The choice of treatment for varicose bleeding during pregnancy has been described in the literature based on the elastic ligature. We report the second case, to our knowledge, of treatment of bleeding gastric varices by injection of histoacryl with good maternal and fetal development.
Pan African Medical Journal, 2013
Hepatitis B virus infection is an uncommon cause of acute glomerulonephritis. We present a case o... more Hepatitis B virus infection is an uncommon cause of acute glomerulonephritis. We present a case of acute glomerulonephritis revealing a chronic viral hepatitis B. A 45 year-old man was admitted in the nephrology department of Hassan II university hospital (Fez, Morocco) for nephritic syndrome with advanced acute kidney injury. The investigations have revealed viral hepatitis B with a positive HBV-DNA and Others viral serology tests were negative. Renal biopsy showed a diffuse and global endocapillary proliferation without extra-capillary proliferation; and global deposits of C3 and Ig G On immunofluorescence. There wasn't any other infectious cause. We thus retained the diagnosis of hepatitis B virus-associated acute glomerulonephritis. He was given entecavir and corticosteroids. Three months later, the evolution was marked by the normalization of renal function, negativity of proteinuria and HBV DNA became undetectable. There was no relapse of glomerulonephritis and HBV viral load was still negative after one year follow-up.
Pan African Medical Journal, 2014
La sarcoïdose est une maladie systémique d'étiologie inconnue. Elle est caractérisée par la prése... more La sarcoïdose est une maladie systémique d'étiologie inconnue. Elle est caractérisée par la présence de lésions granulomateuses, non caséeuses, au niveau des organes atteints. La cirrhose biliaire primitive (CBP) est une hépatopathie cholestatique auto-immune chronique, caractérisée par une destruction des canalicules biliaires et la présence d'anticorps antimitchondries type M2. L'association sarcoïdose et CBP est rare. Nous rapportons un nouveau cas de cette association avec revue de la littérature.
Open Journal of Gastroenterology, 2014
Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in l... more Intra-hospital mortality in cirrhotic patients is variable depending on the studies reported in literature. Several studies have demonstrated independent predictors of mortality. The aim of this work is indeed to identify these predictors. Patients and Methods: We conducted a retrospective study of 1080 cirrhotic patients hospitalized in our department of gastroenterology and hepatology between January 2001 and August 2010. A descriptive study of the study population was performed, and a univariate analysis looking for an association between intra-hospital mortality, and clinical, biological, etiological and socio-demographic characteristics of our patients. Results: The average age of our patients was 54 years, with an equal number of men and women. 41.1% of patients had cirrhosis secondary to hepatitis C and 18.5% had cirrhosis secondary to hepatitis B. 26.1% of our patients were CHILD C. Intra-hospital mortality was 8.7% (97 deaths) with a mean of 23.4 ± 35.8 months. Univariate analysis showed that the intra-hospital mortality was significantly associated with higher age (p = 0.049) as well as the reasons for admissions like hepatic encephalopathy, and hematemesis (p < 0.0001), melena, jaundice and ascites (p = 0.001). Among the biological parameters analyzed in univariate analysis, significant associations with mortality were objectified for high white blood cell count (p = 0.035), and high serum bilirubin and creatinine (p < 0.0001); low rate of prothrombin time (PT) (p < 0.0001), of albumin (p = 0.0001) and of serum sodium (p < 0.0001). Among the complications analyzed, significant associations with mortality were objectified for jaundice, ascites (p = 0.001), hemorrhagic decompensation, hepatic encephalopathy, and spontaneous bacterial peritonitis (p < 0.001). Univariate analysis of the etiology of cirrhosis objectified significant associations for cirrhosis secondary to hepatitis B (p = 0.001) and hepatitis C (p = 0.022). Multivariate analysis objectified four independent predictors of mortality: hepatic encephalopathy, infection (hyper leukocytosis ≥ 10,000/mm 3), renal failure (serum creatinine ≥ 15 mg/l) and hyponatremia. Conclusion: In our series, we identified four independent predictors of intra-hospital mortality in cirrhotic patients: hepatic encephalopathy, infection, renal failure and hyponatremia.