N. Botross - Academia.edu (original) (raw)
Papers by N. Botross
Asian Pacific Journal of Cancer Prevention, 2015
Background: Even after completion of conventional treatment, breast cancer survivors continue to ... more Background: Even after completion of conventional treatment, breast cancer survivors continue to exhibit a variety of psychological and physical symptoms, affecting their quality of life. The study aimed to investigate the relationship between socio-demography, medical characteristics and health-related quality of life (HR-QOL) of a sample of breast cancer survivors in Malaysia. Materials and Methods: This pilot cross-sectional survey was conducted among breast cancer survivors (n=40) who were members of Breast Cancer Support Group Centre Johor Bahru. A validated self-administered questionnaire was used to identify the relationships between socio-demography, medical characteristics and HR-QOL of the participants. Results: Living with family and completion of treatment were significant predictive factors of self-rated QOL, while living with family and ever giving birth significantly predicted satisfaction with health and physical health. Psychological health had moderate correlations with number of children and early cancer stage. Survivors' higher personal income (>MYR4,500) was the only significant predictor of social relationship, while age, income more than MYR4,500 and giving birth significantly predicted environment domain score. Conclusions: The findings suggested the survivors coped better in all four HR-QOL domains if they were married, lived with family, had children and were employed.
Scottish Medical Journal, 2014
Introduction Gaucher’s disease is a lysosomal storage disorder caused by the deficiency of glucoc... more Introduction Gaucher’s disease is a lysosomal storage disorder caused by the deficiency of glucocerebrosidase. Gaucher’s disease has three clinical types: non-neuronopathic (Type 1), Acute Neuropathic (Type 2) and chronic neuronopathic (Type 3). The chronic neuronopathic (Type 3) is characterised by a variety of disease variants with onset in childhood with hepatomegaly, skeletal lesions and later slow horizontal saccades, treatment-resistant generalised tonic–clonic and myoclonic seizures, dementia, progressive spasticity, cognitive deterioration, ataxia and death in the second or third decade of life. Case presentation We describe a case of a 17-year-old girl who was born normally but subsequently developed treatment-refractory seizures at the age of nine with myoclonus, oculomotor apraxia, ataxia and cognitive decline. Enzyme activity of beta-glucocerebrosidase was found to be low without visceromegaly or bone involvement. Conclusion Screening for lysosomal enzyme activity should...
Asian Pacific journal of cancer prevention : APJCP, Jan 27, 2018
Background: There is a lack of evidence on the effectiveness of multifaceted group-based interven... more Background: There is a lack of evidence on the effectiveness of multifaceted group-based interventions to improve psychological well-being and health-related quality of life (HRQOL) of breast cancer (BCa) survivors in Malaysia. This study is aimed at assessing the effectiveness of such intervention program among the BCa survivors. Materials and Methods: This was a group-based intervention program with pre- and post-test design, carried out among BCa survivors (n=37) who were members of Breast Cancer Support Group Centre, Johor Bahru. A validated self-administered questionnaire was used to assess the impact of the program on psychosocial well-being and HRQOL of the participants. Results: The mean age of BCa survivors was 58.1 years (SD=9.7), with mean age at diagnosis of 49.9 years (SD=9.6). Majority of them were of Chinese ethnicity, married and had secondary level education, but were unemployed. More than 86% of them were diagnosed to have early BCa diagnosis and have since complet...
Multiple Sclerosis and Related Disorders
Background: There is a lack of evidence on the effectiveness of multifaceted group-based interven... more Background: There is a lack of evidence on the effectiveness of multifaceted group-based interventions to
improve psychological well-being and health-related quality of life (HRQOL) of breast cancer (BCa) survivors in
Malaysia. This study is aimed at assessing the effectiveness of such intervention program among the BCa survivors.
Materials and Methods: This was a group-based intervention program with pre- and post-test design, carried out
among BCa survivors (n=37) who were members of Breast Cancer Support Group Centre, Johor Bahru. A validated
self-administered questionnaire was used to assess the impact of the program on psychosocial well-being and HRQOL of
the participants. Results: The mean age of BCa survivors was 58.1 years (SD=9.7), with mean age at diagnosis of
49.9 years (SD=9.6). Majority of them were of Chinese ethnicity, married and had secondary level education, but
were unemployed. More than 86% of them were diagnosed to have early BCa diagnosis and have since completed
the treatment. There were significant decreases in median depression (p=0.001), anxiety (p<0.001) and stress (p<0.001)
scores at post-intervention. More than 85% of the participants rated themselves to have a good or very good QOL
at post-intervention, as opposed to 75.9% at pre-intervention. Significant improvements in several HR-QOL domain
scores were seen, with psychological score improving the most (p<0.001), followed by social relationship (p=0.002)
and physical health (p=0.004). Conclusions: Group-based multifaceted intervention can be a viable solution to improve
psychosocial well-being of BCa survivors.
Asian Pacific journal of cancer prevention : APJCP, 2015
Even after completion of conventional treatment, breast cancer survivors continue to exhibit a va... more Even after completion of conventional treatment, breast cancer survivors continue to exhibit a variety of psychological and physical symptoms, affecting their quality of life. The study aimed to investigate the relationship between socio-demography, medical characteristics and health-related quality of life (HR-QOL) of a sample of breast cancer survivors in Malaysia. This pilot cross-sectional survey was conducted among breast cancer survivors (n=40) who were members of Breast Cancer Support Group Centre Johor Bahru. A validated self-administered questionnaire was used to identify the relationships between socio-demography, medical characteristics and HR-QOL of the participants. Living with family and completion of treatment were significant predictive factors of self-rated QOL, while living with family and ever giving birth significantly predicted satisfaction with health and physical health. Psychological health had moderate correlations with number of children and early cancer st...
Scottish Medical Journal, 2014
Asian Pacific Journal of Cancer Prevention, 2015
Background: Even after completion of conventional treatment, breast cancer survivors continue to ... more Background: Even after completion of conventional treatment, breast cancer survivors continue to exhibit a variety of psychological and physical symptoms, affecting their quality of life. The study aimed to investigate the relationship between socio-demography, medical characteristics and health-related quality of life (HR-QOL) of a sample of breast cancer survivors in Malaysia. Materials and Methods: This pilot cross-sectional survey was conducted among breast cancer survivors (n=40) who were members of Breast Cancer Support Group Centre Johor Bahru. A validated self-administered questionnaire was used to identify the relationships between socio-demography, medical characteristics and HR-QOL of the participants. Results: Living with family and completion of treatment were significant predictive factors of self-rated QOL, while living with family and ever giving birth significantly predicted satisfaction with health and physical health. Psychological health had moderate correlations with number of children and early cancer stage. Survivors' higher personal income (>MYR4,500) was the only significant predictor of social relationship, while age, income more than MYR4,500 and giving birth significantly predicted environment domain score. Conclusions: The findings suggested the survivors coped better in all four HR-QOL domains if they were married, lived with family, had children and were employed.
Scottish Medical Journal, 2014
Introduction Gaucher’s disease is a lysosomal storage disorder caused by the deficiency of glucoc... more Introduction Gaucher’s disease is a lysosomal storage disorder caused by the deficiency of glucocerebrosidase. Gaucher’s disease has three clinical types: non-neuronopathic (Type 1), Acute Neuropathic (Type 2) and chronic neuronopathic (Type 3). The chronic neuronopathic (Type 3) is characterised by a variety of disease variants with onset in childhood with hepatomegaly, skeletal lesions and later slow horizontal saccades, treatment-resistant generalised tonic–clonic and myoclonic seizures, dementia, progressive spasticity, cognitive deterioration, ataxia and death in the second or third decade of life. Case presentation We describe a case of a 17-year-old girl who was born normally but subsequently developed treatment-refractory seizures at the age of nine with myoclonus, oculomotor apraxia, ataxia and cognitive decline. Enzyme activity of beta-glucocerebrosidase was found to be low without visceromegaly or bone involvement. Conclusion Screening for lysosomal enzyme activity should...
Asian Pacific journal of cancer prevention : APJCP, Jan 27, 2018
Background: There is a lack of evidence on the effectiveness of multifaceted group-based interven... more Background: There is a lack of evidence on the effectiveness of multifaceted group-based interventions to improve psychological well-being and health-related quality of life (HRQOL) of breast cancer (BCa) survivors in Malaysia. This study is aimed at assessing the effectiveness of such intervention program among the BCa survivors. Materials and Methods: This was a group-based intervention program with pre- and post-test design, carried out among BCa survivors (n=37) who were members of Breast Cancer Support Group Centre, Johor Bahru. A validated self-administered questionnaire was used to assess the impact of the program on psychosocial well-being and HRQOL of the participants. Results: The mean age of BCa survivors was 58.1 years (SD=9.7), with mean age at diagnosis of 49.9 years (SD=9.6). Majority of them were of Chinese ethnicity, married and had secondary level education, but were unemployed. More than 86% of them were diagnosed to have early BCa diagnosis and have since complet...
Multiple Sclerosis and Related Disorders
Background: There is a lack of evidence on the effectiveness of multifaceted group-based interven... more Background: There is a lack of evidence on the effectiveness of multifaceted group-based interventions to
improve psychological well-being and health-related quality of life (HRQOL) of breast cancer (BCa) survivors in
Malaysia. This study is aimed at assessing the effectiveness of such intervention program among the BCa survivors.
Materials and Methods: This was a group-based intervention program with pre- and post-test design, carried out
among BCa survivors (n=37) who were members of Breast Cancer Support Group Centre, Johor Bahru. A validated
self-administered questionnaire was used to assess the impact of the program on psychosocial well-being and HRQOL of
the participants. Results: The mean age of BCa survivors was 58.1 years (SD=9.7), with mean age at diagnosis of
49.9 years (SD=9.6). Majority of them were of Chinese ethnicity, married and had secondary level education, but
were unemployed. More than 86% of them were diagnosed to have early BCa diagnosis and have since completed
the treatment. There were significant decreases in median depression (p=0.001), anxiety (p<0.001) and stress (p<0.001)
scores at post-intervention. More than 85% of the participants rated themselves to have a good or very good QOL
at post-intervention, as opposed to 75.9% at pre-intervention. Significant improvements in several HR-QOL domain
scores were seen, with psychological score improving the most (p<0.001), followed by social relationship (p=0.002)
and physical health (p=0.004). Conclusions: Group-based multifaceted intervention can be a viable solution to improve
psychosocial well-being of BCa survivors.
Asian Pacific journal of cancer prevention : APJCP, 2015
Even after completion of conventional treatment, breast cancer survivors continue to exhibit a va... more Even after completion of conventional treatment, breast cancer survivors continue to exhibit a variety of psychological and physical symptoms, affecting their quality of life. The study aimed to investigate the relationship between socio-demography, medical characteristics and health-related quality of life (HR-QOL) of a sample of breast cancer survivors in Malaysia. This pilot cross-sectional survey was conducted among breast cancer survivors (n=40) who were members of Breast Cancer Support Group Centre Johor Bahru. A validated self-administered questionnaire was used to identify the relationships between socio-demography, medical characteristics and HR-QOL of the participants. Living with family and completion of treatment were significant predictive factors of self-rated QOL, while living with family and ever giving birth significantly predicted satisfaction with health and physical health. Psychological health had moderate correlations with number of children and early cancer st...
Scottish Medical Journal, 2014