Ng Hao wen - Academia.edu (original) (raw)
Papers by Ng Hao wen
IEEE Photonics Journal
All-optical control of silicon photonic devices plays a key role in on-chip all-optical computing... more All-optical control of silicon photonic devices plays a key role in on-chip all-optical computing, switching and signal processing. However, due to the weak intrinsic nonlinear effects of silicon, current integrated devices are limited by high power consumptions. Here, an all-optical controllable optomechanical microring resonator (OMMR) is proposed and fabricated on the silicon platform. Due to the mechanical Kerr effect induced by the optical gradient force (OGF), we realize seamless wavelength tuning over a range of 2.56 nm which is 61% of the free-spectral range, with a high tuning efficiency of 80 GHz/mW. By controlling the pump power, the OMMR indicates three working regions, which are the cutoff region, amplified region and saturate region. Accordingly, this function is similar to a transistor. Furthermore, the dynamic properties of the OMMR are investigated. By analyzing the dynamic responses, we demonstrate that the OMMR is driven by the OGF, rather than other nonlinear effects. The method simplifies the experimental setup, compared with measuring the intrinsic mechanical frequency of the OMMR. This all-silicon device is energy-efficient and compatible with complementary metal-oxide semiconductor (CMOS) processing. We believe that this work is important for on-chip all-optial signal processing and beneficial to futher studies on integrated optomechanics.
Remote Sensing
For quantitative precipitation estimation (QPE) based on polarimetric radar (PR) and rain gauges ... more For quantitative precipitation estimation (QPE) based on polarimetric radar (PR) and rain gauges (RGs), the quality of the radar data is crucial for estimation accuracy. This paper proposes a combined radar quality index (CRQI) to represent the quality of the radar data used for QPE and an algorithm that uses CRQI to improve the QPE performance. Nine heavy rainfall events that occurred in Guangdong Province, China, were used to evaluate the QPE performance in five contrast tests. The QPE performance was evaluated in terms of the overall statistics, spatial distribution, near real-time statistics, and microphysics. CRQI was used to identify good-quality data pairs (i.e., PR-based QPE and RG observation) for correcting estimators (i.e., relationships between the rainfall rate and the PR parameters) in real-time. The PR-based QPE performance was improved because estimators were corrected according to variations in the drop size distribution, especially for data corresponding to 1.1 mm ...
2021 IEEE 24th International Conference on Information Fusion (FUSION), 2021
Differentiable particle filters provide a flexible mechanism to adaptively train dynamic and meas... more Differentiable particle filters provide a flexible mechanism to adaptively train dynamic and measurement models by learning from observed data. However, most existing differentiable particle filters are within the bootstrap particle filtering framework and fail to incorporate the information from latest observations to construct better proposals. In this paper, we utilize conditional normalizing flows to construct proposal distributions for differentiable particle filters, enriching the distribution families that the proposal distributions can represent. In addition, normalizing flows are incorporated in the construction of the dynamic model, resulting in a more expressive dynamic model. We demonstrate the performance of the proposed conditional normalizing flow-based differentiable particle filters in a visual tracking task. Index Terms-Sequential Monte Carlo, Differentiable particle filters, Normalizing flows.
GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might... more GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might have at most six polarizations: plus- and cross-type (tensor-mode gravitons), x-, y-type (vector-mode), and b-, l-type (scalar-mode). Peak or partial peak regions of some of such GWs are just distributed in GHz or higher frequency band, which would be optimal band for electromagnetic(EM) response. In this paper we investigate EM response to such high-frequency GWs(HFGWs) having additional polarizations. For the first time we address:(1)concrete forms of analytic solutions for perturbed EM fields caused by HFGWs having all six possible polarizations in background stable EM fields; (2)perturbed EM signals of HFGWs with additional polarizations in three-dimensional-synchro-resonance-system(3DSR system) and in galactic-extragalactic background EM fields. These perturbative EM fields are actually EM counterparts of HFGWs, and such results provide a novel way to simultaneously distinguish and...
Remote Sensing, 2020
The quality of radar data is crucial for its application. In particular, before radar mosaic and ... more The quality of radar data is crucial for its application. In particular, before radar mosaic and quantitative precipitation estimation (QPE) can be conducted, it is necessary to know the quality of polarimetric parameters. The parameters include the horizontal reflectivity factor, ZH; the differential reflectivity factor, ZDR; the specific differential phase, KDP; and the correlation coefficient, ρHV. A novel radar data quality index (RQI) is specifically developed for the Chinese polarimetric radars. Not only the influences of partial beam blockages and bright band upon radar data quality, but also those of bright band correction performance, signal-to-noise ratio, and non-precipitation echoes are considered in the index. RQI can quantitatively describe the quality of various polarimetric parameters. A new radar mosaic QPE algorithm based on RQI is presented in this study, which can be used in different regions with the default values adjusted according to the characteristics of lo...
Applied Sciences, 2019
The rapid development of e-commerce makes the last-mile problem more and more prominent. To meet ... more The rapid development of e-commerce makes the last-mile problem more and more prominent. To meet the requirements of such a scenario, this paper proposes a robot with a decoupled mechanical structure. Such a hexapod robot is divided into a chassis frame with a pair of auxiliary wheel-legs for horizontal movement, a tetrapod for vertical movement, and a slide-and-rail mechanism to connect the former two parts. Such a structure is simple and, thus, cost-efficient; by managing the horizontal and vertical movements, such a robot can keep the balance and safety of the load in the various operation environments, such as roads, staircases, and even indoor ones. Meanwhile, a state-machine-based controller, which adapts well to the unique structure of the proposed robot, is also proposed, simplifying the sequential control of the robot. A prototype robot with 30-kg load ability was built, and the experimental results prove the validity of the design.
Chinese Physics C, 2017
Extremely powerful astrophysical electromagnetic (EM) systems could be possible sources of high-f... more Extremely powerful astrophysical electromagnetic (EM) systems could be possible sources of high-frequency gravitational waves (HFGWs). Here, based on properties of magnetars and gamma-ray bursts (GRBs), we address "Gamma-HFGWs" (with very high-frequency around 10 20 Hz) caused by ultra-strong EM radiation (in the radiation-dominated phase of GRB fireballs) interacting with super-high magnetar surface magnetic fields (∼ 10 11 T). By certain parameters of distance and power, the Gamma-HFGWs would have far field energy density Ω gw around 10 −6 , and they would cause perturbed signal EM waves of ∼ 10 −20 W/m 2 in a proposed HFGW detection system based on the EM response to GWs. Specially, Gamma-HFGWs would possess distinctive envelopes with characteristic shapes depending on the particular structures of surface magnetic fields of magnetars, which could be exclusive features helpful to distinguish them from background noise. Results obtained suggest that magnetars could be involved in possible astrophysical EM sources of GWs in the very high-frequency band, and Gamma-HFGWs could be potential targets for observations in the future.
OncoTargets and therapy, 2018
Oral carcinoma, one of the most commonly diagnosed cancers, has a poor prognosis and low survival... more Oral carcinoma, one of the most commonly diagnosed cancers, has a poor prognosis and low survival rate with treatment. In recent years, some studies reported the upregulation of miRNA-16 (miR-16) in the oral carcinoma, whereas some other studies confirmed the downregulation of miR-16. In the current study, we aimed to investigate the function of miR-16 in oral carcinoma. Cell proliferation assay was measured by MTT assay, quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate the expression of miR-16, and apoptosis was analyzed by flow cytometry. In addition, the expression of proteins was detected by Western blot. Moreover, xenograft tumor model was established to detect the effect of miR-16 in vivo. The results suggested that miR-16 was downregulated in the oral carcinoma tissues. Overexpression of miR-16 inhibited the growth and proliferation of oral squamous carcinoma cells (OSCCs) and induced apoptosis both in vitro and in vivo, which is due to the supp...
Parasite, 2018
Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by infection with the larva... more Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by infection with the larval stage of Echinococcus granulosus sensu lato. Thioredoxin peroxidase (TPx) may play an essential role in the antioxidant defence system of E. granulosus s.l. as neither catalase nor glutathione peroxidase activities have been detected in the parasite. However, it is not known whether TPx affects the survival and growth of E. granulosus s.l. during development. In this study, three fragments of siRNA specific for EgTPx (siRNA-1/2/3) were designed and transfected into protoscoleces of E. granulosus sensu stricto by electroporation. Quantitative real-time PCR and Western blotting analysis showed that siRNA-3 significantly reduced the expression of EgTPx. Coincidentally, knockdown of EgTPx expression in protoscoleces with siRNA-3 significantly reduced the viability of the parasite under oxidative stress induced by 0.6 mM H2O2. In vitro culture studies showed that protoscoleces treated with ...
![Research paper thumbnail of {"__content__"=>"Identification of functional MKK3/6 and MEK1/2homologs from and investigation of protoscolecidal activity of MAPK signaling pathway inhibitors and .", "i"=>[{"__content__"=>"Echinococcus granulosus"}, {"__content__"=>"in vitro"}, {"__content__"=>"in vivo"}]}](https://attachments.academia-assets.com/91773285/thumbnails/1.jpg)
](Antimicrobial agents and chemotherapy, Jan 22, 2018
Cystic echinococcosis is a zoonosis caused by the larval stage of There is an urgent need to deve... more Cystic echinococcosis is a zoonosis caused by the larval stage of There is an urgent need to develop new drugs for the treatment of this disease. In this study, we identified two new members of MAPK cascades, MKK3/6 and MEK1/2 homologs (termed EgMKK1 and EgMKK2, respectively), from Both EgMKK1 and EgMKK2 were expressed at the larval stages. As shown by yeast two-hybrid and co-immunoprecipitation analyses, EgMKK1 interacted with the previously identified Egp38 but not with EgERK. EgMKK2, on the other hand, interacted with EgERK. In addition, EgMKK1 and EgMKK2 displayed kinase activity toward the substrate, myelin basic protein. When sorafenib tosylate, PD184352 or U0126-EtOH were added to the medium for culture of protoscoleces (PSCs) or cysts, an inhibitory and cytolytic effect was observed via suppressed phosphorylation of EgMKKs and EgERK. Non-viability of PSCs treated with sorafenib tosylate or U0126-EtOH, and not with PD184352, was confirmed through bioassay, i.e. inoculation of...
Journal of experimental & clinical cancer research : CR, Jan 30, 2018
Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tu... more Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved signaling in GC metastasis. CHI3L1 expression was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), and enzyme linked immunosorbent assay (ELISA) (n = 150). The interactions between CD44 and CHI3L1 or Interleukin-13 receptor alpha 2 (IL-13Rα2) were analyzed by co-immunoprecipitation, immunofluorescence co-localization assay, ELISA, and bio-layer interferometry. The roles of CHI3L1/CD44 axis in GC metastasis were investigated in GC cell lines and experimental animal model by gain and loss of function. CHI3L1 upregulation occurred during GC development, and positively corr...
Experimental and therapeutic medicine, 2018
Alveolar echinococcosis (AE) is a prevalent epidemic in the northern hemisphere, especially in ce... more Alveolar echinococcosis (AE) is a prevalent epidemic in the northern hemisphere, especially in central Europe and western China. Serum diagnosis is important for patients with AE, especially during the first screening. The present study purified the recombinant Em18-GST (rEm18-GST), and detected its diagnostic performance in human alveolar echinococcosis patients of Xinjiang, China with immunoblotting (IB) and enzyme-linked immunosorbent assay (ELISA). Serum samples were collected from 50 patients with AE, 222 patients with cystic echinococcosis (CE), 158 patients with other unrelated infections and 106 healthy individuals. The IB results showed that serum samples of 47 patients with AE and 12 patients with CE were rEm18-positive. However, only one sample from patients with cancer showed a cross-reaction with rEm18 in IB. The overall sensitivity was 94%, and the total specificity was 96.58%. For the rEm18 results using ELISA, the sera of 46 patients with AE were positive, and the ov...
World journal of gastroenterology, Jan 7, 2017
To investigate a safer way to set up the disease model of cystic echinococcosis without contamina... more To investigate a safer way to set up the disease model of cystic echinococcosis without contamination risk and develop a novel experimental murine model of hepatic cystic echinococcosis. C57B/6 mice were injected with human protoscolices of three different concentrations the portal vein. The mice were followed for 10 mo by ultrasound, gross anatomy, and pathological and immunological examinations. The protoscolex migration in the portal vein, hydatid cyst growth, host immune reaction, and hepatic histopathology were examined periodically. The infection rates in the mice in the high, medium, and low concentration groups were 90%, 100%, and 63.6%, respectively. The protoscolices migrated in the portal vein with blood flow, settled in the liver, and developed into orthotopic hepatic hydatid cysts, resembling the natural infection route and course. We have established an improved experimental model of hepatic cystic echinococcosis with low biohazard risk but stable growing dynamics and ...
Scientific reports, Jan 13, 2018
Fluorodeoxyglucose (FDG) uptake by alveolar echinococcosis (AE) liver lesions is a signal of thei... more Fluorodeoxyglucose (FDG) uptake by alveolar echinococcosis (AE) liver lesions is a signal of their metabolic activity and of disease progression. In order to find a surrogate marker for this status, we investigated whether parameters of the peripheral and/or periparasitic immune responses were associated with metabolic activity in a prospective case-control study of 30 AE patients and 22 healthy controls. Levels of 18 cytokines and chemokines, representative of innate and adaptive immune responses, were assessed in plasma and peripheral cells of two groups of patients with (MAAE) and without (MIAE) metabolically active lesions, and in the liver of MAAE patients. Mixed cytokine profile was observed in the peripheral blood of AE patients, with a predominance of Th2, Th17 and Treg responses. Among the detected markers only plasma IL-5 and IL-23, more elevated in MAAE patients, were found discriminant. Discrimination between MAAE and MIAE patients obtained by using IL-23 was improved wh...
Gut, Nov 25, 2018
There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular... more There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Murr (Huaier granule) to address this unmet need. A total of 1044 patients were randomised in 2:1 ratio to receive either Huaier or no further treatment (controls) for a maximum of 96 weeks. The primary endpoint was RFS. Secondary endpoints included OS and tumour extrahepatic recurrence rate (ERR). The Huaier (n=686) and control groups (n=316) had a mean RFS of 75.5 weeks and 68.5 weeks, respectively (HR 0.67; 95% CI 0.55 to 0.81). The difference in the RFS rate between Huaier and control groups was 62.39% and 49.05% (95% CI 6.74 to 19.94; p=0.0001); this led to an OS rate in the Huaier and control groups of 95.19% and 91.46%, respectively (95% CI 0.26 to 7.21; p=0.0207). The tumour ERR betwee...
Oncology Letters, 2017
Expression of eukaryotic initiation factor 4A1 (eIF4A1) following brachytherapy has been reported... more Expression of eukaryotic initiation factor 4A1 (eIF4A1) following brachytherapy has been reported to predict improved radiosensitivity and tumor-specific survival in cervical cancer. Therefore, the present study investigated the function of eIF4A1 in cervical cancer and the mechanism by which eIF4A1 regulates cervical cancer radiosensitivity. It was determined that the downregulation of eIF4A1 in HeLa and SiHa cells notably attenuated cell proliferation, in addition to repressing cervical cancer migration and invasion, and promoting cell apoptosis. In vitro and in vivo studies have demonstrated that silencing eIF4A1 improves cervical cancer radiosensitivity. Detection of γ-H2AX using western blot analysis at 0, 0.5, 1, 6 and 24 h following the exposure of cervical cancer cells to X-rays illustrated that eIF4A1-knockdown results in postponed radiation-induced DNA double strand break (DSB) repair. Overall, the results of the present study demonstrated that downregulated eIF4A1 improves cervical cancer radiosensitivity by delaying cancer cell DSB repair. In conclusion, the data indicated that eIF4A1 performs a vital role in cervical cancer progression and radiosensitivity. Therefore, eIF4A1 may be a potential therapeutic target in patients with cervical cancer.
International Journal of Theoretical Physics, 2016
We consider a Gaussian Beam (GB) resonant system for high frequency gravitational waves (HFGWs) d... more We consider a Gaussian Beam (GB) resonant system for high frequency gravitational waves (HFGWs) detection. At present, we find the optimal signal strength in theory through setting the magnetic component of GB in a standard gaussian form. Under the synchro-resonance condition, we study the signal strength (i.e., transverse perturbative photon fluxes) from the relic HFGWs (predicted by ordinary inflationary model) and the braneworld HFGWs (from braneworld scenarios). Both of them would generate potentially detectable transverse perturbative photon fluxes (PPFs). Furthermore we find optimal system parameters and the relationship between frequency and effective width of energy fluxes accumulation.
PLOS ONE, 2017
Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, ... more Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages. We quantitatively analyzed and evaluated the different pathological characterizations of hepatic echinococcosis during the development of this disease via our PAD-based PPCT and especially provided evidence that hepatic alveolar echinococcosis invades the liver tissue and spreads through blood flow systems with abundant blood supply in the early stage. Additionally, the infiltration of tiny vesicles in HE lesions can be clearly observed by our PAD-PPCT technique due to the striking contrast-to-noise ratio (CNR) and mass density resolution, which cannot be found by the medical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound, in hospitals. The results demonstrated that our PAD-PPCT technique has a great potential for indicating the subtle structural information of pathological changes in soft biomedical specimens, especially helpful for the research of early micromorphology of diseases.
Parasitology Research, 2011
Eimeria acervulina was isolated from chicken at Hebei province, China. The gene of merozoite surf... more Eimeria acervulina was isolated from chicken at Hebei province, China. The gene of merozoite surface antigen 3-1E was amplified and cloned into pET28a(+) vector and then transformed into Escherichia coli BL21 strain. Results showed that 3-1E fusion protein band of about 22 kDa was identified by SDS-PAGE. Western blot analysis indicated that the recombinant protein specifically reacted with E. acervulina polyclonal antibody.
arXiv: General Physics, 2019
As a candidate of dark matter, and related to many fundamental physics issues, the primordial bla... more As a candidate of dark matter, and related to many fundamental physics issues, the primordial black hole (PBH) is a crucial topic. However, so far the existence of PBHs is still not confirmed, and currently running GW detectors are still not able to distinguish them from the normal astrophysical BHs. In this article, we propose that the GWs (of PBH binary mergers) could interact with the very widespread background galactic magnetic fields in the Milky way, to produce the perturbed electromagnetic waves (EMWs) with unique characteristics of frequencies, waveforms, spectra and polarizations. In order to be distinguished from astrophysical black holes, only the PBHs with masses less than the solarmass are considered here, and their binary mergers will radiate GWs in frequencies much higher above the plasma frequency of interstellar medium (ISM), so corresponding perturbed EMWs (in the same frequencies to such GWs) can propagate through the ISM until the Earth. Our estimations show that...
IEEE Photonics Journal
All-optical control of silicon photonic devices plays a key role in on-chip all-optical computing... more All-optical control of silicon photonic devices plays a key role in on-chip all-optical computing, switching and signal processing. However, due to the weak intrinsic nonlinear effects of silicon, current integrated devices are limited by high power consumptions. Here, an all-optical controllable optomechanical microring resonator (OMMR) is proposed and fabricated on the silicon platform. Due to the mechanical Kerr effect induced by the optical gradient force (OGF), we realize seamless wavelength tuning over a range of 2.56 nm which is 61% of the free-spectral range, with a high tuning efficiency of 80 GHz/mW. By controlling the pump power, the OMMR indicates three working regions, which are the cutoff region, amplified region and saturate region. Accordingly, this function is similar to a transistor. Furthermore, the dynamic properties of the OMMR are investigated. By analyzing the dynamic responses, we demonstrate that the OMMR is driven by the OGF, rather than other nonlinear effects. The method simplifies the experimental setup, compared with measuring the intrinsic mechanical frequency of the OMMR. This all-silicon device is energy-efficient and compatible with complementary metal-oxide semiconductor (CMOS) processing. We believe that this work is important for on-chip all-optial signal processing and beneficial to futher studies on integrated optomechanics.
Remote Sensing
For quantitative precipitation estimation (QPE) based on polarimetric radar (PR) and rain gauges ... more For quantitative precipitation estimation (QPE) based on polarimetric radar (PR) and rain gauges (RGs), the quality of the radar data is crucial for estimation accuracy. This paper proposes a combined radar quality index (CRQI) to represent the quality of the radar data used for QPE and an algorithm that uses CRQI to improve the QPE performance. Nine heavy rainfall events that occurred in Guangdong Province, China, were used to evaluate the QPE performance in five contrast tests. The QPE performance was evaluated in terms of the overall statistics, spatial distribution, near real-time statistics, and microphysics. CRQI was used to identify good-quality data pairs (i.e., PR-based QPE and RG observation) for correcting estimators (i.e., relationships between the rainfall rate and the PR parameters) in real-time. The PR-based QPE performance was improved because estimators were corrected according to variations in the drop size distribution, especially for data corresponding to 1.1 mm ...
2021 IEEE 24th International Conference on Information Fusion (FUSION), 2021
Differentiable particle filters provide a flexible mechanism to adaptively train dynamic and meas... more Differentiable particle filters provide a flexible mechanism to adaptively train dynamic and measurement models by learning from observed data. However, most existing differentiable particle filters are within the bootstrap particle filtering framework and fail to incorporate the information from latest observations to construct better proposals. In this paper, we utilize conditional normalizing flows to construct proposal distributions for differentiable particle filters, enriching the distribution families that the proposal distributions can represent. In addition, normalizing flows are incorporated in the construction of the dynamic model, resulting in a more expressive dynamic model. We demonstrate the performance of the proposed conditional normalizing flow-based differentiable particle filters in a visual tracking task. Index Terms-Sequential Monte Carlo, Differentiable particle filters, Normalizing flows.
GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might... more GWs from extra dimensions, very early universe, and some high-energy astrophysical process, might have at most six polarizations: plus- and cross-type (tensor-mode gravitons), x-, y-type (vector-mode), and b-, l-type (scalar-mode). Peak or partial peak regions of some of such GWs are just distributed in GHz or higher frequency band, which would be optimal band for electromagnetic(EM) response. In this paper we investigate EM response to such high-frequency GWs(HFGWs) having additional polarizations. For the first time we address:(1)concrete forms of analytic solutions for perturbed EM fields caused by HFGWs having all six possible polarizations in background stable EM fields; (2)perturbed EM signals of HFGWs with additional polarizations in three-dimensional-synchro-resonance-system(3DSR system) and in galactic-extragalactic background EM fields. These perturbative EM fields are actually EM counterparts of HFGWs, and such results provide a novel way to simultaneously distinguish and...
Remote Sensing, 2020
The quality of radar data is crucial for its application. In particular, before radar mosaic and ... more The quality of radar data is crucial for its application. In particular, before radar mosaic and quantitative precipitation estimation (QPE) can be conducted, it is necessary to know the quality of polarimetric parameters. The parameters include the horizontal reflectivity factor, ZH; the differential reflectivity factor, ZDR; the specific differential phase, KDP; and the correlation coefficient, ρHV. A novel radar data quality index (RQI) is specifically developed for the Chinese polarimetric radars. Not only the influences of partial beam blockages and bright band upon radar data quality, but also those of bright band correction performance, signal-to-noise ratio, and non-precipitation echoes are considered in the index. RQI can quantitatively describe the quality of various polarimetric parameters. A new radar mosaic QPE algorithm based on RQI is presented in this study, which can be used in different regions with the default values adjusted according to the characteristics of lo...
Applied Sciences, 2019
The rapid development of e-commerce makes the last-mile problem more and more prominent. To meet ... more The rapid development of e-commerce makes the last-mile problem more and more prominent. To meet the requirements of such a scenario, this paper proposes a robot with a decoupled mechanical structure. Such a hexapod robot is divided into a chassis frame with a pair of auxiliary wheel-legs for horizontal movement, a tetrapod for vertical movement, and a slide-and-rail mechanism to connect the former two parts. Such a structure is simple and, thus, cost-efficient; by managing the horizontal and vertical movements, such a robot can keep the balance and safety of the load in the various operation environments, such as roads, staircases, and even indoor ones. Meanwhile, a state-machine-based controller, which adapts well to the unique structure of the proposed robot, is also proposed, simplifying the sequential control of the robot. A prototype robot with 30-kg load ability was built, and the experimental results prove the validity of the design.
Chinese Physics C, 2017
Extremely powerful astrophysical electromagnetic (EM) systems could be possible sources of high-f... more Extremely powerful astrophysical electromagnetic (EM) systems could be possible sources of high-frequency gravitational waves (HFGWs). Here, based on properties of magnetars and gamma-ray bursts (GRBs), we address "Gamma-HFGWs" (with very high-frequency around 10 20 Hz) caused by ultra-strong EM radiation (in the radiation-dominated phase of GRB fireballs) interacting with super-high magnetar surface magnetic fields (∼ 10 11 T). By certain parameters of distance and power, the Gamma-HFGWs would have far field energy density Ω gw around 10 −6 , and they would cause perturbed signal EM waves of ∼ 10 −20 W/m 2 in a proposed HFGW detection system based on the EM response to GWs. Specially, Gamma-HFGWs would possess distinctive envelopes with characteristic shapes depending on the particular structures of surface magnetic fields of magnetars, which could be exclusive features helpful to distinguish them from background noise. Results obtained suggest that magnetars could be involved in possible astrophysical EM sources of GWs in the very high-frequency band, and Gamma-HFGWs could be potential targets for observations in the future.
OncoTargets and therapy, 2018
Oral carcinoma, one of the most commonly diagnosed cancers, has a poor prognosis and low survival... more Oral carcinoma, one of the most commonly diagnosed cancers, has a poor prognosis and low survival rate with treatment. In recent years, some studies reported the upregulation of miRNA-16 (miR-16) in the oral carcinoma, whereas some other studies confirmed the downregulation of miR-16. In the current study, we aimed to investigate the function of miR-16 in oral carcinoma. Cell proliferation assay was measured by MTT assay, quantitative real time polymerase chain reaction (qRT-PCR) was used to evaluate the expression of miR-16, and apoptosis was analyzed by flow cytometry. In addition, the expression of proteins was detected by Western blot. Moreover, xenograft tumor model was established to detect the effect of miR-16 in vivo. The results suggested that miR-16 was downregulated in the oral carcinoma tissues. Overexpression of miR-16 inhibited the growth and proliferation of oral squamous carcinoma cells (OSCCs) and induced apoptosis both in vitro and in vivo, which is due to the supp...
Parasite, 2018
Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by infection with the larva... more Cystic echinococcosis (CE) is a cosmopolitan parasitic disease caused by infection with the larval stage of Echinococcus granulosus sensu lato. Thioredoxin peroxidase (TPx) may play an essential role in the antioxidant defence system of E. granulosus s.l. as neither catalase nor glutathione peroxidase activities have been detected in the parasite. However, it is not known whether TPx affects the survival and growth of E. granulosus s.l. during development. In this study, three fragments of siRNA specific for EgTPx (siRNA-1/2/3) were designed and transfected into protoscoleces of E. granulosus sensu stricto by electroporation. Quantitative real-time PCR and Western blotting analysis showed that siRNA-3 significantly reduced the expression of EgTPx. Coincidentally, knockdown of EgTPx expression in protoscoleces with siRNA-3 significantly reduced the viability of the parasite under oxidative stress induced by 0.6 mM H2O2. In vitro culture studies showed that protoscoleces treated with ...
Antimicrobial agents and chemotherapy, Jan 22, 2018
Cystic echinococcosis is a zoonosis caused by the larval stage of There is an urgent need to deve... more Cystic echinococcosis is a zoonosis caused by the larval stage of There is an urgent need to develop new drugs for the treatment of this disease. In this study, we identified two new members of MAPK cascades, MKK3/6 and MEK1/2 homologs (termed EgMKK1 and EgMKK2, respectively), from Both EgMKK1 and EgMKK2 were expressed at the larval stages. As shown by yeast two-hybrid and co-immunoprecipitation analyses, EgMKK1 interacted with the previously identified Egp38 but not with EgERK. EgMKK2, on the other hand, interacted with EgERK. In addition, EgMKK1 and EgMKK2 displayed kinase activity toward the substrate, myelin basic protein. When sorafenib tosylate, PD184352 or U0126-EtOH were added to the medium for culture of protoscoleces (PSCs) or cysts, an inhibitory and cytolytic effect was observed via suppressed phosphorylation of EgMKKs and EgERK. Non-viability of PSCs treated with sorafenib tosylate or U0126-EtOH, and not with PD184352, was confirmed through bioassay, i.e. inoculation of...
Journal of experimental & clinical cancer research : CR, Jan 30, 2018
Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tu... more Enzymatically inactive chitinase-like protein CHI3L1 drives inflammatory response and promotes tumor progression. However, its role in gastric cancer (GC) tumorigenesis and metastasis has not yet been fully elucidated. We determined the significance of CHI3L1 expression in patients with GC. We also explored an as-yet unknown receptor of CHI3L1 and investigated the involved signaling in GC metastasis. CHI3L1 expression was evaluated by immunoblotting, tissue microarray-based immunohistochemistry analysis (n = 100), and enzyme linked immunosorbent assay (ELISA) (n = 150). The interactions between CD44 and CHI3L1 or Interleukin-13 receptor alpha 2 (IL-13Rα2) were analyzed by co-immunoprecipitation, immunofluorescence co-localization assay, ELISA, and bio-layer interferometry. The roles of CHI3L1/CD44 axis in GC metastasis were investigated in GC cell lines and experimental animal model by gain and loss of function. CHI3L1 upregulation occurred during GC development, and positively corr...
Experimental and therapeutic medicine, 2018
Alveolar echinococcosis (AE) is a prevalent epidemic in the northern hemisphere, especially in ce... more Alveolar echinococcosis (AE) is a prevalent epidemic in the northern hemisphere, especially in central Europe and western China. Serum diagnosis is important for patients with AE, especially during the first screening. The present study purified the recombinant Em18-GST (rEm18-GST), and detected its diagnostic performance in human alveolar echinococcosis patients of Xinjiang, China with immunoblotting (IB) and enzyme-linked immunosorbent assay (ELISA). Serum samples were collected from 50 patients with AE, 222 patients with cystic echinococcosis (CE), 158 patients with other unrelated infections and 106 healthy individuals. The IB results showed that serum samples of 47 patients with AE and 12 patients with CE were rEm18-positive. However, only one sample from patients with cancer showed a cross-reaction with rEm18 in IB. The overall sensitivity was 94%, and the total specificity was 96.58%. For the rEm18 results using ELISA, the sera of 46 patients with AE were positive, and the ov...
World journal of gastroenterology, Jan 7, 2017
To investigate a safer way to set up the disease model of cystic echinococcosis without contamina... more To investigate a safer way to set up the disease model of cystic echinococcosis without contamination risk and develop a novel experimental murine model of hepatic cystic echinococcosis. C57B/6 mice were injected with human protoscolices of three different concentrations the portal vein. The mice were followed for 10 mo by ultrasound, gross anatomy, and pathological and immunological examinations. The protoscolex migration in the portal vein, hydatid cyst growth, host immune reaction, and hepatic histopathology were examined periodically. The infection rates in the mice in the high, medium, and low concentration groups were 90%, 100%, and 63.6%, respectively. The protoscolices migrated in the portal vein with blood flow, settled in the liver, and developed into orthotopic hepatic hydatid cysts, resembling the natural infection route and course. We have established an improved experimental model of hepatic cystic echinococcosis with low biohazard risk but stable growing dynamics and ...
Scientific reports, Jan 13, 2018
Fluorodeoxyglucose (FDG) uptake by alveolar echinococcosis (AE) liver lesions is a signal of thei... more Fluorodeoxyglucose (FDG) uptake by alveolar echinococcosis (AE) liver lesions is a signal of their metabolic activity and of disease progression. In order to find a surrogate marker for this status, we investigated whether parameters of the peripheral and/or periparasitic immune responses were associated with metabolic activity in a prospective case-control study of 30 AE patients and 22 healthy controls. Levels of 18 cytokines and chemokines, representative of innate and adaptive immune responses, were assessed in plasma and peripheral cells of two groups of patients with (MAAE) and without (MIAE) metabolically active lesions, and in the liver of MAAE patients. Mixed cytokine profile was observed in the peripheral blood of AE patients, with a predominance of Th2, Th17 and Treg responses. Among the detected markers only plasma IL-5 and IL-23, more elevated in MAAE patients, were found discriminant. Discrimination between MAAE and MIAE patients obtained by using IL-23 was improved wh...
Gut, Nov 25, 2018
There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular... more There is little evidence that adjuvant therapy after radical surgical resection of hepatocellular carcinoma (HCC) improves recurrence-free survival (RFS) or overall survival (OS). We conducted a multicentre, randomised, controlled, phase IV trial evaluating the benefit of an aqueous extract of Murr (Huaier granule) to address this unmet need. A total of 1044 patients were randomised in 2:1 ratio to receive either Huaier or no further treatment (controls) for a maximum of 96 weeks. The primary endpoint was RFS. Secondary endpoints included OS and tumour extrahepatic recurrence rate (ERR). The Huaier (n=686) and control groups (n=316) had a mean RFS of 75.5 weeks and 68.5 weeks, respectively (HR 0.67; 95% CI 0.55 to 0.81). The difference in the RFS rate between Huaier and control groups was 62.39% and 49.05% (95% CI 6.74 to 19.94; p=0.0001); this led to an OS rate in the Huaier and control groups of 95.19% and 91.46%, respectively (95% CI 0.26 to 7.21; p=0.0207). The tumour ERR betwee...
Oncology Letters, 2017
Expression of eukaryotic initiation factor 4A1 (eIF4A1) following brachytherapy has been reported... more Expression of eukaryotic initiation factor 4A1 (eIF4A1) following brachytherapy has been reported to predict improved radiosensitivity and tumor-specific survival in cervical cancer. Therefore, the present study investigated the function of eIF4A1 in cervical cancer and the mechanism by which eIF4A1 regulates cervical cancer radiosensitivity. It was determined that the downregulation of eIF4A1 in HeLa and SiHa cells notably attenuated cell proliferation, in addition to repressing cervical cancer migration and invasion, and promoting cell apoptosis. In vitro and in vivo studies have demonstrated that silencing eIF4A1 improves cervical cancer radiosensitivity. Detection of γ-H2AX using western blot analysis at 0, 0.5, 1, 6 and 24 h following the exposure of cervical cancer cells to X-rays illustrated that eIF4A1-knockdown results in postponed radiation-induced DNA double strand break (DSB) repair. Overall, the results of the present study demonstrated that downregulated eIF4A1 improves cervical cancer radiosensitivity by delaying cancer cell DSB repair. In conclusion, the data indicated that eIF4A1 performs a vital role in cervical cancer progression and radiosensitivity. Therefore, eIF4A1 may be a potential therapeutic target in patients with cervical cancer.
International Journal of Theoretical Physics, 2016
We consider a Gaussian Beam (GB) resonant system for high frequency gravitational waves (HFGWs) d... more We consider a Gaussian Beam (GB) resonant system for high frequency gravitational waves (HFGWs) detection. At present, we find the optimal signal strength in theory through setting the magnetic component of GB in a standard gaussian form. Under the synchro-resonance condition, we study the signal strength (i.e., transverse perturbative photon fluxes) from the relic HFGWs (predicted by ordinary inflationary model) and the braneworld HFGWs (from braneworld scenarios). Both of them would generate potentially detectable transverse perturbative photon fluxes (PPFs). Furthermore we find optimal system parameters and the relationship between frequency and effective width of energy fluxes accumulation.
PLOS ONE, 2017
Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, ... more Propagation-based phase-contrast computed micro-tomography (PPCT) dominates the non-destructive, three-dimensional inner-structure measurement in synchrotron-based biomedical research due to its simple experimental setup. To quantitatively visualize tiny density variations in soft tissues and organs closely related to early pathological morphology, an experimental study of synchrotron-based X-ray PPCT combined with generalized phase and attenuation duality (PAD) phase retrieval was implemented with the hepatic echinococcosis (HE) infection rat model at different stages. We quantitatively analyzed and evaluated the different pathological characterizations of hepatic echinococcosis during the development of this disease via our PAD-based PPCT and especially provided evidence that hepatic alveolar echinococcosis invades the liver tissue and spreads through blood flow systems with abundant blood supply in the early stage. Additionally, the infiltration of tiny vesicles in HE lesions can be clearly observed by our PAD-PPCT technique due to the striking contrast-to-noise ratio (CNR) and mass density resolution, which cannot be found by the medical imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasound, in hospitals. The results demonstrated that our PAD-PPCT technique has a great potential for indicating the subtle structural information of pathological changes in soft biomedical specimens, especially helpful for the research of early micromorphology of diseases.
Parasitology Research, 2011
Eimeria acervulina was isolated from chicken at Hebei province, China. The gene of merozoite surf... more Eimeria acervulina was isolated from chicken at Hebei province, China. The gene of merozoite surface antigen 3-1E was amplified and cloned into pET28a(+) vector and then transformed into Escherichia coli BL21 strain. Results showed that 3-1E fusion protein band of about 22 kDa was identified by SDS-PAGE. Western blot analysis indicated that the recombinant protein specifically reacted with E. acervulina polyclonal antibody.
arXiv: General Physics, 2019
As a candidate of dark matter, and related to many fundamental physics issues, the primordial bla... more As a candidate of dark matter, and related to many fundamental physics issues, the primordial black hole (PBH) is a crucial topic. However, so far the existence of PBHs is still not confirmed, and currently running GW detectors are still not able to distinguish them from the normal astrophysical BHs. In this article, we propose that the GWs (of PBH binary mergers) could interact with the very widespread background galactic magnetic fields in the Milky way, to produce the perturbed electromagnetic waves (EMWs) with unique characteristics of frequencies, waveforms, spectra and polarizations. In order to be distinguished from astrophysical black holes, only the PBHs with masses less than the solarmass are considered here, and their binary mergers will radiate GWs in frequencies much higher above the plasma frequency of interstellar medium (ISM), so corresponding perturbed EMWs (in the same frequencies to such GWs) can propagate through the ISM until the Earth. Our estimations show that...