N. Thieriet - Academia.edu (original) (raw)
Papers by N. Thieriet
Tetrahedron Letters, 1997
The use of Alloc group in SPPS for the N t~ protection of amino acids is an alternative to the Bo... more The use of Alloc group in SPPS for the N t~ protection of amino acids is an alternative to the Boc and Fmoc protecting groups. The smooth removal of Alloc group in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3 as a scavenger for the allyl system permits orthogonality with the most common protecting groups. Furthermore, a tandem deprotection-coupling reaction allows the suppression of DKP formation in cases where this side reaction is troublesome.
ChemInform, 1995
ABSTRACT Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the pre... more ABSTRACT Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the presence of palladium catalyst and either phenyltrihydrosilane or N-methyl-N-(trimethylsilyl)-trifluoroacetamide. These reactions are totally compatible with the presence of Boc and, as far as phenyltrihydrosilane is concerned, Fmoc protections.
Tetrahedron Letters, 1995
... 212 (1993), pp. 303–310. Abstract | PDF (712 K) | View Record in Scopus | Cited By in Scopus ... more ... 212 (1993), pp. 303–310. Abstract | PDF (712 K) | View Record in Scopus | Cited By in Scopus (92). 2. c). P. Lloyd-Williams, A. Merzouk, F. Guibé, F. Albericio and E. Giralt. Tetrahedron Lett. 35 (1994), pp. ... 72 (1950), pp. 4702–4704. 5. E. Keinan and N. Greenspoon. Isr. J. Chem. ...
Journal of Nanomaterials, 2012
Organic Letters, 2000
[reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-tr... more [reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-trityl resin, an allyl ester as the temporary protecting group, and Cu(OBt)(2)/DIPCDI or HATU/DIEA as the coupling method is described. These conditions ensure good yields with minimal racemization of the C-terminal residue.
Journal of Physics: Conference Series, 2013
ABSTRACT Titanium and silicon dioxide nanoparticles (TiO2 and SiO2 NPs) are now in daily use in m... more ABSTRACT Titanium and silicon dioxide nanoparticles (TiO2 and SiO2 NPs) are now in daily use in many commercial products of which food, sunscreens, toothpastes or cosmetics. However, their effects on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether direct exposition of the brain to TiO2 and SiO2 NPs results in alternations in nervous system function. C57Bl6 mice were exposed to 5 and 10 μg doses of TiO2 and SiO2 NPs through intracerebroventricular administration using a stereotaxic approach. Then the neurologic effects were investigated using motor performance parameters, measured on a rotarod at 20 rpm or at an accelerating rod (from 4 to 40 rpm). Before and after injection, motor activity is registered individually for each mouse exposed, once a week, for 8 weeks. Besides, a group of 3 mice is culled at 1, 2, 3, 4 and 8 weeks after exposure in order to study the time dependant effect on the histopathology of the brain (gliosis, inflammatory process...). Both rotarod tests (accelerating and at 20 rpm) showed that TiO2 and SiO2 NPs exposure could significantly impair the motor performances, even several weeks after initial acute exposure. The first examination of the brain histopathology revealed microglial activation. As it appeared to grow throughout the brain in a time dependant manner this suggests the induction of a long lasting neuroinflammation. These primary findings indicated that exposure to TiO2 and SiO2 NPs could possibly impair the locomotor ability and this deficit may be possibly attributed at least to an inflammatory process maintained till 8 weeks after exposure in the mouse brain. To fully investigate the neurotoxicological consequences of TiO2 and SiO2 NPs exposure, brain contents in these NPs will be also investigated as well as other alterations like neurotransmitter levels. These preliminary data already underline the necessity of more in vivo studies to better characterize TiO2 and SiO2 NPs exposure effects especially on human brain for long-term and low-dose treatment.
Tetrahedron letters, 1999
... PhSiH3 carboxyactivated amino acid Nathalie Thieriet, Paloma GomezMartinez and Francois Guib6... more ... PhSiH3 carboxyactivated amino acid Nathalie Thieriet, Paloma GomezMartinez and Francois Guib6*l lnstitut de Chimie Molculaire d" Orsay, Laboratoire des Ractions Organiques Slectives, associ au ... Tetrahedron Letters Volume 40, Issue 13, 26 March 1999, Pages 2505-2508. ...
Archives des Maladies Professionnelles et de l'Environnement, 2012
Archives des Maladies Professionnelles et de l'Environnement, 2014
Tetrahedron Letters, 1997
The use of Alloc group in SPPS for the N t~ protection of amino acids is an alternative to the Bo... more The use of Alloc group in SPPS for the N t~ protection of amino acids is an alternative to the Boc and Fmoc protecting groups. The smooth removal of Alloc group in neutral conditions with catalytic amounts of Pd(PPh3)4 in the presence of PhSiH3 as a scavenger for the allyl system permits orthogonality with the most common protecting groups. Furthermore, a tandem deprotection-coupling reaction allows the suppression of DKP formation in cases where this side reaction is troublesome.
ChemInform, 1995
ABSTRACT Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the pre... more ABSTRACT Allyl carboxylates, carbamates and phenoxides may be cleaved or transacylated in the presence of palladium catalyst and either phenyltrihydrosilane or N-methyl-N-(trimethylsilyl)-trifluoroacetamide. These reactions are totally compatible with the presence of Boc and, as far as phenyltrihydrosilane is concerned, Fmoc protections.
Tetrahedron Letters, 1995
... 212 (1993), pp. 303–310. Abstract | PDF (712 K) | View Record in Scopus | Cited By in Scopus ... more ... 212 (1993), pp. 303–310. Abstract | PDF (712 K) | View Record in Scopus | Cited By in Scopus (92). 2. c). P. Lloyd-Williams, A. Merzouk, F. Guibé, F. Albericio and E. Giralt. Tetrahedron Lett. 35 (1994), pp. ... 72 (1950), pp. 4702–4704. 5. E. Keinan and N. Greenspoon. Isr. J. Chem. ...
Journal of Nanomaterials, 2012
Organic Letters, 2000
[reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-tr... more [reaction: see text] A new strategy for SPPS in the reverse direction based on the use of 2-Cl-trityl resin, an allyl ester as the temporary protecting group, and Cu(OBt)(2)/DIPCDI or HATU/DIEA as the coupling method is described. These conditions ensure good yields with minimal racemization of the C-terminal residue.
Journal of Physics: Conference Series, 2013
ABSTRACT Titanium and silicon dioxide nanoparticles (TiO2 and SiO2 NPs) are now in daily use in m... more ABSTRACT Titanium and silicon dioxide nanoparticles (TiO2 and SiO2 NPs) are now in daily use in many commercial products of which food, sunscreens, toothpastes or cosmetics. However, their effects on human body, especially on the central nervous system, are still unclear. The aim of this study was to determine whether direct exposition of the brain to TiO2 and SiO2 NPs results in alternations in nervous system function. C57Bl6 mice were exposed to 5 and 10 μg doses of TiO2 and SiO2 NPs through intracerebroventricular administration using a stereotaxic approach. Then the neurologic effects were investigated using motor performance parameters, measured on a rotarod at 20 rpm or at an accelerating rod (from 4 to 40 rpm). Before and after injection, motor activity is registered individually for each mouse exposed, once a week, for 8 weeks. Besides, a group of 3 mice is culled at 1, 2, 3, 4 and 8 weeks after exposure in order to study the time dependant effect on the histopathology of the brain (gliosis, inflammatory process...). Both rotarod tests (accelerating and at 20 rpm) showed that TiO2 and SiO2 NPs exposure could significantly impair the motor performances, even several weeks after initial acute exposure. The first examination of the brain histopathology revealed microglial activation. As it appeared to grow throughout the brain in a time dependant manner this suggests the induction of a long lasting neuroinflammation. These primary findings indicated that exposure to TiO2 and SiO2 NPs could possibly impair the locomotor ability and this deficit may be possibly attributed at least to an inflammatory process maintained till 8 weeks after exposure in the mouse brain. To fully investigate the neurotoxicological consequences of TiO2 and SiO2 NPs exposure, brain contents in these NPs will be also investigated as well as other alterations like neurotransmitter levels. These preliminary data already underline the necessity of more in vivo studies to better characterize TiO2 and SiO2 NPs exposure effects especially on human brain for long-term and low-dose treatment.
Tetrahedron letters, 1999
... PhSiH3 carboxyactivated amino acid Nathalie Thieriet, Paloma GomezMartinez and Francois Guib6... more ... PhSiH3 carboxyactivated amino acid Nathalie Thieriet, Paloma GomezMartinez and Francois Guib6*l lnstitut de Chimie Molculaire d" Orsay, Laboratoire des Ractions Organiques Slectives, associ au ... Tetrahedron Letters Volume 40, Issue 13, 26 March 1999, Pages 2505-2508. ...
Archives des Maladies Professionnelles et de l'Environnement, 2012
Archives des Maladies Professionnelles et de l'Environnement, 2014