Nenad Zornic - Academia.edu (original) (raw)

Papers by Nenad Zornic

European review for medical and pharmacological sciences, 2022

Sažetak Mehanicka ventilacija je dobro uspostavljen režim intenzivne terapije koja se koristi da ... more Sažetak Mehanicka ventilacija je dobro uspostavljen režim intenzivne terapije koja se koristi da podrži plucnu funkciju kod kriticno obolelih pacijenata. Pacijenti sa pneumonijom koji zahtevaju mehanicku ventilaciju najcesce su na jedinici intenzivnog lecenja opsteg tipa: hirurska jedinica intenzivnog lecenja i jedinica intenzivnog lecenja kao hospitalni deo Urgentnog centra. Kvalitet života pacijenata sa pneumonijom zavisi od komorbiditeta, starosti i teskih hronicnih bolesti. Primenom mehanicke ventilacije pluca, kod pacijenta se može razviti psiholoska simptomatologija koja je cesto zanemarena u jedinici intezivnog lecenja kao i smanjenje kvaliteta života nakon odvikavanja pacijenta od mehanickog ventilatora. Pacijenti koji borave u jedinici intenzivnog lecenja, a koji zahtevaju ventilatornu potporu (mehanicku ventilaciju) imaju niži kvalitet života od populacije iste starosne grupe koja nije zahtevala intenzivno lecenje, duže borave u jedinici intenzivnog lecenja uz vece troskov...

Journal of Personalized Medicine

This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY

Journal of Personalized Medicine, Jun 26, 2023

International Journal of Morphology, Jun 1, 2022

Atherosclerosis is a complex disease whose pathogenesis includes endothelial activation, accumula... more Atherosclerosis is a complex disease whose pathogenesis includes endothelial activation, accumulation of lipids in the subendothelium, formation of foam cells, fat bands and formation of atherosclerotic plaque. These complex mechanisms involve different cell populations in the intimate sub-endothelium, and the S-100 protein family plays a role in a number of extracellular and intracellular processes during the development of atherosclerotic lesions. The aim of this study was to determine the phenotypic characteristics of smooth muscle cells and the consequent expression of S100 protein in atherosclerotic altered coronary arteries in advanced stages of atherosclerosis. 19 samples of right atherosclerotic coronary arteries in stages of fibro atheroma (type V lesion) and complicated lesions (type VI lesion) have been analyzed. According to the standard protocol, the following primary antibodies have been used in the immunohistochemical analysis: a-smooth muscle actin (α-SMA), vimentin and S-100 protein. All analyzed samples have been in advanced stages of atherosclerosis, fibro atheroma (stage V lesions) and complicated lesions (type VI lesions). Most of them have had the structure of a complicated lesion with atheroma or fibro atheroma as a basis, subsequently complicated by disruption (subtype VI a), hemorrhage (subtype VI b) or thrombosis (subtype VI c), as well as by the presence of several complications on the same sample. Marked hypocellularity is present in the subendothelium of plaques. Cell population at plaque margins is characterized by immunoreactivity to α-SMA, vimentin, and S100 protein. Some of these cells accumulate lipids and look like foam cells. In the cell population at the margins of the plaques, smooth muscle cells of the synthetic phenotype are present, some of which accumulate lipids and demonstrate S100 immunoreactivity. Summarizing numerous literature data and our results, we could assume that smooth muscle cells, due to their synthetic and proliferative activity in the earlier stages of pathogenesis, as well as the consequent expression of S100 protein, could accumulate lipids in the earlier stages of atherosclerosis which, in advanced stages analyzed in this study, result in immunoreactivity of foam cells of smooth muscle origin to S100 protein.

$Research paper thumbnail of The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture$

Open Medicine, 2022

The aim of this study is to determine whether the use of tranexamic acid (TXA) in patients with h... more The aim of this study is to determine whether the use of tranexamic acid (TXA) in patients with hip fracture reduces intraoperative and postoperative blood loss, and on the other hand, whether it increases thromboembolic risk. The study was performed on patients with hip fracture for a period of one year. Patients were divided into two groups (1:1): the first group receiving TXA and the second group receiving placebo. The amount of blood aspiration during the surgery was measured as well as drainage in the postoperative period of 24 h. The occurrence of deep vein thrombosis (DVT) was monitored before and after the surgery by ultrasound of the lower extremities. The amount of total blood loss was two times lower in patients who received TXA (291.8 ± 65.5 mL of blood vs 634.7 ± 150.5 mL of blood). Among the patients who developed DVT, one patient was from the group that did not receive TXA, and two patients were from the group that received TXA. The use of TXA in patients with hip fracture significantly reduces intraoperative and postoperative blood loss, without a significant thromboembolic risk.

DOAJ (DOAJ: Directory of Open Access Journals), Feb 1, 2022

OBJECTIVE We aimed to create a clinically usable probability risk score for prediction of no-refl... more OBJECTIVE We aimed to create a clinically usable probability risk score for prediction of no-reflow (NRF) phenomenon prior to primary percutaneous coronary intervention (PPCI). PATIENTS AND METHODS This single-center and retrospective study included 1254 patients with acute ST-segment elevation myocardial infarction (STEMI) who underwent PPCI. Patients were randomly assigned into two groups in the ratio 2:1, the derivation dataset (n=840) and validation dataset (n=414). Independent predictors of NRF were identified and combined to create a prediction model using univariate and multivariate regression analysis in the derivation dataset. The risk score was tested and validated by calculating area under the receiver operating characteristic (ROC) curves in the derivation and validation datasets, respectively. RESULTS Five significant, independent predictors of NRF were identified: age ≥ 65 years (odds ratio [OR]: 2.473, 95% confidence interval [CI]: 0.389-1.484, p < 0.01), heart rate ≥ 89 bpm (odds ratio [OR]: 1.622, 95% confidence interval [CI]: 0.024-0.945, p < 0.05), Killip class ≥ II (odds ratio [OR]: 1.914, 95% confidence interval [CI]: 0.024-1.306, p < 0.01), total ischemic time ≥ 268 min (odds ratio [OR]: 2.652, 95% confidence interval [CI]: 0.493-1.565, p < 0.01), and thrombus burden G≥4 (odds ratio [OR]: 8.351, 95% confidence interval [CI]: 0.344-15.901, p < 0.01). The risk score was created combining these predictors with assigned points. The overall score ranged from 0 to 17 points. The optimal cutoff value of the risk score was 11 points (area under curve [AUC]: 0.772, 95% confidence interval [CI]: 0.729-0.815, sensitivity 71.21%, specificity 70.34%, positive predictive value 30.92%, negative predictive value 92.91%, p < 0.001). The ROC curve for the validation group showed good discriminant power. CONCLUSIONS We developed a novel risk score based on five clinical and angiographic parameters, which might be a useful clinical tool for prediction of NRF in STEMI patients prior to PPCI with an acceptable accuracy.

Serbian Journal of Experimental and Clinical Research, Mar 1, 2020

The quality of life and patient survival rate in terminal chronic renal insufficiency depends on ... more The quality of life and patient survival rate in terminal chronic renal insufficiency depends on the duration of vascular approaches. Dialysis catheters are used to establish an adequate vascular approach when emergency hemodialysis is indicated and when all approaches are exhausted. Complications of CVC can be classified into three categories: mechanical (hematoma, arterial puncture, pneumothorax, hemothorax, catheter misplacement, and stenosis), infectious (insertion site infection, CVC colonization, and bloodstream infection) and thrombotic (deep vein thrombosis). Despite the increasing prevalence of haemodialysis patients with complex access issues, there remains no consensus on the definition of vascular access failure or end-stage vascular access. The dilema in these cases remains whether the generalized vascular insufficiency is the cause or a complication of exhausted vascular accesses. This case report is one of the examples of combined complications with generalized vascular access insufficiency. During the year and a half of the chronic dialysis program, the patient had several changes of vascular approaches, and each approach became dysfunctional in certain time due to various causes. After six months of successful hemodialysis, the patient was admitted with signs of infection and during hospitalization was again subjected to multiple changes of the vascular approach due to infection, thrombosis, and vascular access failure.

Annals of Vascular Surgery, May 1, 2014

Antibiotics, Feb 9, 2023

Serbian Journal of Experimental and Clinical Research, Jun 1, 2014

Hepatorenal syndrome (HRS) involves reversible renal failure in patients with advanced cirrhosis ... more Hepatorenal syndrome (HRS) involves reversible renal failure in patients with advanced cirrhosis or acute liver failure. Th e aim of the study was to determine the pathogenetic mechanisms of the development of hepatorenal syndrome and to emphasise the clinical importance of early detection and timely treatment of patients with this condition. Th e one-year incidence rate of hepatorenal syndrome in patients with liver cirrhosis is 18-20%. Th e risk factors for the development of hepatorenal syndrome include the following: spontaneous bacterial peritonitis, gastrointestinal bleeding, nephrotoxic drugs, diuretics, non-steroidal anti-infl ammatory drugs, and hyponatraemia. Th e primary plan of treatment is a liver transplantation, while a secondary plan of treatment is the use of a vasoconstrictor in conjunction with albumin. Early diagnosis and prompt appropriate treatment can signifi cantly reduce the mortality rate of patients with hepatorenal syndrome.

Frontiers in Psychiatry, Jul 25, 2022

Objective: Many studies so far have shown that antipsychotic therapy may have an effect on the de... more Objective: Many studies so far have shown that antipsychotic therapy may have an effect on the development of metabolic syndrome in patients diagnosed with schizophrenia. Our goal was to determine whether our respondents are at risk for developing metabolic syndrome and who is more predisposed to it. Methods: In a stable phase, 60 patients diagnosed with schizophrenia were equally divided into three groups according to the drug (risperidone, clozapine, and aripiprazole monotherapy). Control group had 20 healthy examinees. Patients were evaluated first using The Positive and Negative Syndrome Scale (PANSS). Prolactin, lipid status, glycemia, insulin, cytokine values (IL-33, TGF-β, and TNF-α) and C-reactive protein (CRP) were measured. Also, Body mass index (BMI), Homeostatic Model Assesment for Insulin Resistance (HOMA index), waist and hip circumference (WHR) and blood pressure (TA) measurement were performed in the study.

Journal of Pakistan Medical Association, Feb 23, 2021

Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of man... more Fever of unknown origin (FUO) presents a major diagnostic challenge as it is a consequence of many infectious as well as malignant, rheumatologic and other diseases. Here we present the case of a woman with mediastinal and abdominal lymphadenopathy who was initially suspected to have lymphoproliferative disease, but our histopathologic examination revealed sarcoidosis. Sarcoidosis, especially chronic, is a rare cause of FUO, because it usually manifests as a febrile condition. A woman presented with shoulder and ankle joint pain, mediastinal and abdominal lymphadenopathy and fever at the Infectious Diseases Clinic. Physical examination identified the presence of lupus pernio and normal respiratory noise in the lungs, and later peripheral lymphadenopathy. Peripheral blood smear indicated conspicuous eosinophilia. Biopsy examination obtained by rigid bronchoscopy suggested pulmonary sarcoidosis. Sarcoidosis and lymphoma may have similar clinical manifestations; both present as mediastinal and abdominal lymphadenopathy with constitutional symptoms. Therefore, in the diagnosis of sarcoidosis, it is important to exclude lymphoproliferative diseases and other granulomatous diseases.

The Medicus, 2005

Lo cal anest he tics are wi dely used in anest he si o logy, mostly to pro vi de sur gi cal anest... more Lo cal anest he tics are wi dely used in anest he si o logy, mostly to pro vi de sur gi cal anest he sia and anal ge sia in perip he ral and cen tral ner vo us system ner ve blocks (spi nal anest he sia). Epi du ral in fu si ons of lo cal anest he tics are also used for in tra o pe ra ti ve and po sto pe ra ti ve anal ge sia. In the in te si ve ca re unit, li do ca i ne is fre qu ently used as an anti a rrythmic agent. Lo cal anest he tics are gi ven ro u ti nely to pa ti ents with al ready im pa i red pre o pe ra ti ve re nal function. Se ve ral in vi tro ex pe ri men tal stu di es sho wed that lo cal anest he tics in cre a se cell de ath via apop to sis in ne u ro nal and oste o bla stic cell li nes (1, 2). In ad di tion, so me authors ha ve re cently fo und that lo cal anest he tics in du ce apop to sis in hu man pro xi mal tu bu le (HK2) cells (3). More o ver, one in vi vo study sho wed that lo cal anest he tics wor sen re nal fun ction af ter ische mia-re per fu sion in jury in rats (4). Ba sed of the se ex pe ri men tal fin dings, we aimed to per form an ob ser va ti o nal cli ni cal study to de termi ne whet her lo cal anest he tics used in spi nal anest he sia chan ge a re nal fun ction in pa ti ents un der go ing sur gi cal pro ce du res. PA TI ENTS AND MET HOD The pro spec ti ve, ob ser va ti o nal study in clu ded 44 in pa ti ents, tre a ted at Cli ni cal Cen ter Kra gu je vac, du ring the period from Jun to Sep tem ber in 2004. All of them we re under go ing a sur gi cal pro ce du re in spi nal anest he sia. Bi oc he mi stry of re nal fun ction was mo ni to red a few days be fo re and af ter spi nal anest he sia in in te si ve ca re unit or in de part ment of sur gery. Du ring the study we as sem bled a de mo grap hic da ta, patient history, the type of sur gi cal pro ce du re, the type and do se of lo cal ane stet hics used in spi nal anest he sia, bi oc he mi stry of re nal fun ction (urea, cre a ti ni ne) and pla sma glu co se le vel. Ge ne rally, the re were no ex clu si on cri te ria. All da ta we re col lec ted by the physi cian (sur geon or anest hesio lo gist) wit hin or di nary cli ni cal and the ra pe u tic pro ce du re. We al so pro tected the pa ti ent iden tity, using only initi als in stead of the ir full names. The analysis of ex pe ri men tal da ta in clu ded the met hods of de scrip ti ve sta ti stics (the mean, the stan dard de vi a tion) and the hypot he sis te sting (5). The Stu dent's, t-test pro cedu re com pa res me ans for two gro ups of ca ses for the nume ric va ri a bles. De pen ding on the da ta type the in de pendent-sam ples and the pa i red-sam ples, re spec ti vely has been 86 Correspondence: Ass. dr De ja na Ru žiae-Zeèe viae De part ment of Phar ma co logy, Fa culty of Medicine, Uni ver sity of Kra gu je vac Sve to za ra Mar ko vi ca 69, PO Box 124 34000 Kra gu je vac, Ser bia and Montenegro Phone:

Open Access Macedonian Journal of Medical Sciences, Dec 15, 2014

In the presented case report, we evaluated the mechanism of the external iliac, the common femora... more In the presented case report, we evaluated the mechanism of the external iliac, the common femoral and the superficial femoral arterial thrombosis secondary to total hip arthroplasty. A 75year-old female sufferd from 5.5 cm shorter left lower limb and same sade coxarthritis. Next day after arthroplasty and eqalisation of the lower limbs, an acute ishemia of the treated leg was presented. Multyscan CT angiography revealed the presence of the external iliac, the common femoral and the superficial femoral arterial thrombosis. From the best of our knowledge, it seems to be the only case of this arterial segment thrombosis after total hip arthroplasty and equalistaion of the lower limbs reported.

Archives of Medical Science, 2017

Introduction: Acute aortic type III dissection is one of the most catastrophic events, with in-ho... more Introduction: Acute aortic type III dissection is one of the most catastrophic events, with in-hospital mortality ranging between 10% and 12%. The majority of patients are treated medically, but complicated dissections, which represent 15% to 20% of cases, require surgical or thoracic endovascular aortic repair (TEVAR). For the best outcomes adequate blood transfusion support is required. Interest in the relationship between blood type and vascular disease has been established. The aim of our study is to evaluate distribution of blood groups among patients with acute aortic type III dissection and to identify any kind of relationship between blood type and patient's survival. Material and methods: From January 2005 to December 2014, 115 patients with acute aortic type III dissection were enrolled at the Clinic of Vascular and Endovascular Surgery in Belgrade, Serbia and retrospectively analyzed. Patients were separated into two groups. The examination group consisted of patients with a lethal outcome, and the control group consisted of patients who survived. Results: The analysis of the blood groups and RhD typing between groups did not reveal a statistically significant difference (p = 0.220). Conclusions: Our results indicated no difference between different blood groups and RhD typing with respect to in-hospital mortality of patients with acute aortic dissection type III.

Antibiotics, Feb 9, 2023

Journal of Clinical Medicine

Adiponectin is one of the most important molecules in the body’s compensatory response to the dev... more Adiponectin is one of the most important molecules in the body’s compensatory response to the development of insulin resistance. By trying to maintain insulin sensitivity, increase insulin secretion and prevent inflammation, adiponectin tries to maintain glucose homeostasis. Interleukin-33, which belongs to the group of alarmins, also promotes insulin secretion. Interleukin-33 might be either pro-inflammatory or anti-inflammatory depending on the disease and the model. However, interleukin-33 has shown various protective effects in CVD, obesity and diabetes. The aim of our study was to investigate the association between adiponectin and interleukin-33 in patients with metabolic syndrome. As expected, all patients with metabolic syndrome had worse parameters that represent the hallmark of metabolic syndrome compared to the control group. In the subgroup of patients with low adiponectin, we observed less pronounced characteristics of metabolic syndrome simultaneously with significantl...

Frontiers in Public Health

Validation of the fear of introductionHigh levels of fear of COVID-19 may be associated with incr... more Validation of the fear of introductionHigh levels of fear of COVID-19 may be associated with increased levels of stress, anxiety, and depression, as well as decreased resilience and life expectancy.ObjectiveThis study aimed to translate and confirm the Serbian version of the Fear of COVID-19 scale as well as to investigate its psychometric properties.MethodsThe translation and intercultural adaptation of the Fear of COVID-19 scale was performed by the leading standard of the International Society for Pharmacoeconomics and Outcome Research. When the distribution was normal, the Kolmogorov-Smirnov test was used. The reliability of the Serbian version of FCV-19S was tested by measuring the internal consistency through the value of Cronbach's alpha.ResultsThe original version of the Fear of COVID-19 scale was tested on a sample of 256 subjects with a mean age of 25.38 ± 12.47. The Cronbach's alpha value was 0.864. We divided the scale by the split-half method (Spearman-Brown), a...

European review for medical and pharmacological sciences, 2022

Journal of Personalized Medicine

Journal of Personalized Medicine, Jun 26, 2023

International Journal of Morphology, Jun 1, 2022

$Research paper thumbnail of The effect of tranexamic acid on the reduction of intraoperative and postoperative blood loss and thromboembolic risk in patients with hip fracture$

Open Medicine, 2022

DOAJ (DOAJ: Directory of Open Access Journals), Feb 1, 2022

Serbian Journal of Experimental and Clinical Research, Mar 1, 2020

Annals of Vascular Surgery, May 1, 2014

Antibiotics, Feb 9, 2023

Serbian Journal of Experimental and Clinical Research, Jun 1, 2014

Frontiers in Psychiatry, Jul 25, 2022

Journal of Pakistan Medical Association, Feb 23, 2021

The Medicus, 2005

Open Access Macedonian Journal of Medical Sciences, Dec 15, 2014

Archives of Medical Science, 2017

Antibiotics, Feb 9, 2023

Journal of Clinical Medicine

Frontiers in Public Health