Nadiya Boyko - Academia.edu (original) (raw)
Papers by Nadiya Boyko
Agrofor, Oct 7, 2019
Nowadays, there are a number of projects tackling on challenges around which this study is based.... more Nowadays, there are a number of projects tackling on challenges around which this study is based. For instance, the ultimate goal of the current project SKIN is to create a permanent stakeholders' association on short food supply chain (SFSC) that works on the joint economic growth of the agricultural sector through the exchange of local food practices and through coaching sessions stimulating innovation. It creates a European network of best practices in SFSC that addresses the fragmentation of knowledge in the agricultural sector and supports bottom-up innovation initiatives. No doubts, boosting innovation through that project in local areas will lead to economic growth in the regions. But, for its sustainable development, it is crucial to create the agricultural extension and advisory services (AEAS), particularly in EU countries and also to modify their role using bottom-up approaches. Despite the fact that the role of AEAS in the EU countries is transforming in the last few years, from a technology transfer paradigm to a demand-driven model, there are still two challenges that should be tackled in the global agenda: 1) facilitate linking of local agricultural sector and nutrition; 2) build a sustainable network of advisors in the EU for improving knowledge flows in national and regional agricultural knowledge and innovation systems (AKIS). According also to the findings of the SKIN project and to our recently developed concept (FENIX), the launch of new initiatives will enable AEAS by gathering of a large amount of information and knowledge from local areas and population, helping all types of stakeholders to improve health, environmental, and economic sectors in targeted regions.
Фізика і хімія твердого тіла, Dec 15, 2019
The article deals with chemical properties of honey as well as wax and beeglue before and after t... more The article deals with chemical properties of honey as well as wax and beeglue before and after the process of caramelization. The research has been done to study chemical reactions of caramelization of honey and other bee products; the biochemical properties of the obtained substances have been investigated. It has been revealed that biological activity of the compound after thermochemical heating of honey in the presence of special catalysts was discovered. Infrared spectra, moisture, viscosity, size and distribution of nanoparticles, elemental composition, oxymethylfurfural content, diastase number of caramelized honey have been investigated. The difference between the sizes of nanoparticles of raw and caramelized honey has been revealed, namely caramelized honey (1.5-2.0 times) of smaller size encourages their biochemical activity. On the basis of the results obtained from caramelized honey, wax and beeglue as well as their properties, the chewing gum with biologically active components for the prevention and treatment of periodontal tissue diseases (gingivitis, periodontitis and periodontal disease) was invented. Clinical studies on chewing gum with honey, wax, and beeglue have confirmed that it provides health benefits among 72 % of patients.
Biological Trace Element Research, Aug 19, 2020
Consumption of edible plants satisfies a significant part of human body needs in macro-and micron... more Consumption of edible plants satisfies a significant part of human body needs in macro-and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the content of macro-and micronutrients and biologically active substances. We determined polyphenol and anthocyanin content in 22 species of local edible plants using modified spectrophotometric method with Folin-Ciocalteu reagent as well as chemical elements' content in a mixture of edible plants from 13 regions using standard procedures. We performed correlational analysis of the obtained data and analysis of the main components in OriginLab, developed regional models of chemical elements' content for a mixture of edible plants, and conducted cluster analysis using common tools in Python. The results of biologically active substances' study demonstrated that the highest content of polyphenolic compounds and anthocyanins was found in grape meal of Vitis vinifera L. The study of chemical elements' content demonstrated that edible plants from lowland areas are the best and revealed clear dependences of the elements on each other and geographical conditions. The analysis of the principal components confirmed this finding. Based on the obtained data, a number of regional models of chemical elements' content in a mixture of edible plants were built, tested, and evaluated. Obtained results are the basis for designing various diets, filling composite databases of the region's food, and creating the newest biologics-pharmabiotics.
Acta horticulturae, 2014
Topics variability, varieties growing systems uses / traditional products composition 10th Intern... more Topics variability, varieties growing systems uses / traditional products composition 10th International Symposium on Vaccinium and Other Superfruits June 17-22, 2012, Maastricht, The Netherlands Cornelian cherry variability • Reproduction from seed for centuries • Wide wild variability • Wild botanic varieties: var. typica Sanadze, var. macrocarpa Sanadze, var. flava Sanadze, var. pyriformis Sanadze • Local selection varieties developed by people in many countries Surveys on natural populations, in situ observations and collection Evaluation, Selection and Breeding
Journal of Biotechnology, Nov 1, 2010
The Journal of Allergy and Clinical Immunology, Feb 1, 2023
Springer eBooks, 2021
Type 2 diabetes is one of the most common noncommunicable diseases in the world. Recent studies s... more Type 2 diabetes is one of the most common noncommunicable diseases in the world. Recent studies suggest a link between type 2 diabetes and microbiota, as well as the ability to treat and prevent it using personalized approaches to nutrition. In this work, we conducted clinical studies on the effects of a personalized diet on 56 female patients. Biochemical, physical, and immunological parameters were measured by standard methods on days 1 and 18 of the experiment. Gut and oral microbiota studies were performed in dynamics on days 1, 7, 11, and 18 using real-time polymerase chain reaction. With the help of the developed information system, a personalized diet was developed for each participant of the experiment. In the group of patients following personalized diets a statistically significant decreasing levels of glucose, thymol test, creatinine, very low-density lipoprotein, urea, secretory IgA, and tumour necrosis factor-α, and improvement in all physical parameters were observed. There was a statistically significant increase in uric acid, sodium, and magnesium. Statistically significant changes in gut microbiota were observed in Enterococcus faecalis, Escherichia coli (lac+, lac-), Lactobacillus spp., and Candida spp. Such microorganisms of oral microbiota as E. faecalis, Lactobacillus spp., Pseudomonas aeruginosa, and Candida spp. demonstrated statistically significant changes. All these changes indicate an improvement in the patients' condition in the experimental group compared to the control group. Our algorithm used for the development of personalized diets for patients with diabetes type 2 demonstrated clinical efficacy of its implementation.
The aim of the work was to use the in vivo model to reveal main changes in gut microbiota of immu... more The aim of the work was to use the in vivo model to reveal main changes in gut microbiota of immune competent mice in dynamic and find out the specificity of immunomodulation action (activity) of traditional foods ingredients - edible plants extracts on local mucosal cytokines to its oral administration.Materials and methods. In this study, seven groups of immunocompetent BALB/c mice were formed. All experimental mice had been fed orally by plants’ extracts (15mg/200 µl/mouse) for the 14th days. The extracts of edible plants - ingredients of traditional food such as kale leaves, persimmon, pomegranate, dill, Sideritis scardica, and nettle were obtained as described and orally administrated to experimental animals. For microbiological analysis of gut microbiota changes, the colon content has been investigated, the key microbial representatives were isolated by plating of its serial dilution on selected chromogenic medium, identified serologically and biochemically. The production of ...
Microbiome, Immunity, Digestive Health and Nutrition
Journal of Ecosystem & Ecography, Jul 27, 2018
Microbiome of soil, plants and humans, the ways and mechanisms of their interrelation, role in P4... more Microbiome of soil, plants and humans, the ways and mechanisms of their interrelation, role in P4 and IT-medicine Statement of the Problem: The fact that our host changes are more likely occur due to the modification of gene expression, rather than the alteration of the genetic code itself reverse/refresh our vision, and finally led to prognostic personified and preventive medicine and sustainable agriculture consistent with cyclic bioeconomy. Methodology & Theoretical Orientation: In vitro and in vivo models, in situ monitoring, limited clinical trials, mathematical modeling, GIS.
ScienceRise: Biological Science
Journal of Ecosystem & Ecography, Jul 27, 2018
To strengthen European citizens to make dietary choices as the healthy diet, which is sustainable... more To strengthen European citizens to make dietary choices as the healthy diet, which is sustainable and affordable using local goods that are produced in the environmentally responsible way for further improving food systems. Methodology & Theoretical Orientation: Clinical trials, cohort studies, in vitro and in vivo experiments (cells, animal models: CNV vs. GF and k.o. mice, etc.), mathematical modeling, IT tools. Findings: We are currently testing is the personalized nutrition algorithm (PNA). However, it is being tested only for specific diseases, which limits the use of those approaches for personalized nutrition to only those cases. FENIX proposes to exploit an easy-to-use coherent tool to make recommendations for PN requirements that meet the precise needs of EU citizens. Proposed by FENIX tool is based on measurements and an innovative bioinformatics approach for interpretation of individual microbiome data with other relevant and crucial factors (evidence-based and correlated biomarkers, calculating age, gender and indicating personal health status, personal nutritional requirements, food composition data, lifestyle specificity, cultural preferences, environment conditions) and also consider the available source and analytical characteristics of ethnic foods and innovative food processing approach of further individualisation proposed for local farmers and food producers. Conclusion & Significance: All NCDs, allergies, other so-called "metabolic disorders" correlate with human microbiome status. Normal microbiome depends on the region where a person lives. In fact, the project presents a new way of the understanding microbiome-function. FENIX will also consider the origin of food taking into account its nutritional value and unique composition since different food affects different people in different ways, as well as the different origin of one product, affect the same person differently.
HEALTH OF WOMAN
The article shows the research results of vaginal microbiome correction of pregnant women with ba... more The article shows the research results of vaginal microbiome correction of pregnant women with bacterial vaginosis before and after oral using of synbiotic Bifiten. This biopreparation differs from others recommended for vaginal microbiome correction by its combined anti-inflammatory and specific pro- and antimicrobial activity. The aim of research is to define the clinical efficacy of oral administration of the non-medicinal biological (synbiotic) preparation Bifiten to pregnant women with bacterial vaginosis. Materials and Methods. Clinical and statistical analysis of pregnant women's individual cards, childbirth stories had been held. Vaginal microbiome had been studied by using classic microbiological methods and qRT-PCR. Immune parameters of vagina secrets had been detected by immunosorbent assay (ELISA). Results. A positive dynamics of subjective and objective state of pregnant women had been observed. It was shown that following to the oral administration of Bifiten mucou...
Medicina, 2022
The intestinal microbiota plays an important role in maintaining human health, and its alteration... more The intestinal microbiota plays an important role in maintaining human health, and its alteration is now associated with the development of various gastrointestinal (ulcerative colitis, irritable bowel syndrome, constipation, etc.) and extraintestinal diseases, such as cancer, metabolic syndrome, neuropsychiatric diseases. In this context, it is not surprising that gut microbiota modification methods may constitute a therapy whose potential has not yet been fully investigated. In this regard, the most interesting method is thought to be fecal microbiota transplantation, which consists of the simultaneous replacement of the intestinal microbiota of a sick recipient with fecal material from a healthy donor. This review summarizes the most interesting findings on the application of fecal microbiota transplantation in gastrointestinal and extraintestinal pathologies.
Ukrainian chemistry journal, 2021
Based on the screening of some heavy metals (HMs) content in the humus soil horizon of the Transc... more Based on the screening of some heavy metals (HMs) content in the humus soil horizon of the Transcarpathian region, the regularities of the distribution of HMs in the soils of different landscape zones have been established. It is shown that increasing of the terrain height, the content of HMs in soils decreases (except for Mn and Hg) and for the total HMs content the values of the Spearman correlation coefficient are: Cu – (-0.84); Zn – (-0.83); Mn 0.77; Mo – (-0.91); Co – (-0.82); Pb – (-0.83); Hg – absent; for the content of acid-soluble forms: Cu – absent; Zn – (-0.72); Mn 0.75; Mo – (-0.89); Co – (-0.86); Pb – (-0.77); Hg is absent. This pattern is associated with the tectonic and geological features of the different landscape zones. The calculation of the migration coefficient (the ratio of the content of acid-soluble forms to the gross content) has been shown that in mountainous regions this indicator has the highest value for Zn, Pb, and Cu. That means the potential danger ...
Georgian medical news, 2020
A side effect of treating children with fixed orthodontic equipment (FOE) is the deterioration of... more A side effect of treating children with fixed orthodontic equipment (FOE) is the deterioration of the oral microbiota and, as a typical consequence, a significant increase in the risk of chronic catarrhal gingivitis (CCG). The problem is to calculate the specified risk for each specific child, and its modern solution using models subjected to the machine learning procedure requires the identification of microbial and other markers of the process of formation of oral microbiota in the presence of FOE in healthy children and children with CCG. The identification of such markers was the main goal of this study. The experiment consisted in monitoring this process by four dental and nineteen microbial parameters at the third, sixth and twelfth month of orthodontic treatment of 30 non-sick and 32 patients with CCG having healthy periodontal tissues before the FOE. Markers were detected by correlation, principal component (PCA), factor and cluster analyzes of the obtained experimental data...
This work is funded under the EU FP7 Theme 2: “Food, Agriculture, Fisheries, and Biotechnology”, ... more This work is funded under the EU FP7 Theme 2: “Food, Agriculture, Fisheries, and Biotechnology”, Grant Agreement no.227118
Poster publicado em: BaSeFood Newsletter - Special Issue n.o7, October 2012 - Traditional Food In... more Poster publicado em: BaSeFood Newsletter - Special Issue n.o7, October 2012 - Traditional Food International 2012, p. 35. ISBN: 978-88-902152-6-1
Agrofor, Oct 7, 2019
Nowadays, there are a number of projects tackling on challenges around which this study is based.... more Nowadays, there are a number of projects tackling on challenges around which this study is based. For instance, the ultimate goal of the current project SKIN is to create a permanent stakeholders' association on short food supply chain (SFSC) that works on the joint economic growth of the agricultural sector through the exchange of local food practices and through coaching sessions stimulating innovation. It creates a European network of best practices in SFSC that addresses the fragmentation of knowledge in the agricultural sector and supports bottom-up innovation initiatives. No doubts, boosting innovation through that project in local areas will lead to economic growth in the regions. But, for its sustainable development, it is crucial to create the agricultural extension and advisory services (AEAS), particularly in EU countries and also to modify their role using bottom-up approaches. Despite the fact that the role of AEAS in the EU countries is transforming in the last few years, from a technology transfer paradigm to a demand-driven model, there are still two challenges that should be tackled in the global agenda: 1) facilitate linking of local agricultural sector and nutrition; 2) build a sustainable network of advisors in the EU for improving knowledge flows in national and regional agricultural knowledge and innovation systems (AKIS). According also to the findings of the SKIN project and to our recently developed concept (FENIX), the launch of new initiatives will enable AEAS by gathering of a large amount of information and knowledge from local areas and population, helping all types of stakeholders to improve health, environmental, and economic sectors in targeted regions.
Фізика і хімія твердого тіла, Dec 15, 2019
The article deals with chemical properties of honey as well as wax and beeglue before and after t... more The article deals with chemical properties of honey as well as wax and beeglue before and after the process of caramelization. The research has been done to study chemical reactions of caramelization of honey and other bee products; the biochemical properties of the obtained substances have been investigated. It has been revealed that biological activity of the compound after thermochemical heating of honey in the presence of special catalysts was discovered. Infrared spectra, moisture, viscosity, size and distribution of nanoparticles, elemental composition, oxymethylfurfural content, diastase number of caramelized honey have been investigated. The difference between the sizes of nanoparticles of raw and caramelized honey has been revealed, namely caramelized honey (1.5-2.0 times) of smaller size encourages their biochemical activity. On the basis of the results obtained from caramelized honey, wax and beeglue as well as their properties, the chewing gum with biologically active components for the prevention and treatment of periodontal tissue diseases (gingivitis, periodontitis and periodontal disease) was invented. Clinical studies on chewing gum with honey, wax, and beeglue have confirmed that it provides health benefits among 72 % of patients.
Biological Trace Element Research, Aug 19, 2020
Consumption of edible plants satisfies a significant part of human body needs in macro-and micron... more Consumption of edible plants satisfies a significant part of human body needs in macro-and micronutrients while biologically active substances contain strong antioxidant properties and reduce the risk of a number of diseases. Balanced nutrition and design of personalized diets and treatment rely on the data on the content of macro-and micronutrients and biologically active substances. We determined polyphenol and anthocyanin content in 22 species of local edible plants using modified spectrophotometric method with Folin-Ciocalteu reagent as well as chemical elements' content in a mixture of edible plants from 13 regions using standard procedures. We performed correlational analysis of the obtained data and analysis of the main components in OriginLab, developed regional models of chemical elements' content for a mixture of edible plants, and conducted cluster analysis using common tools in Python. The results of biologically active substances' study demonstrated that the highest content of polyphenolic compounds and anthocyanins was found in grape meal of Vitis vinifera L. The study of chemical elements' content demonstrated that edible plants from lowland areas are the best and revealed clear dependences of the elements on each other and geographical conditions. The analysis of the principal components confirmed this finding. Based on the obtained data, a number of regional models of chemical elements' content in a mixture of edible plants were built, tested, and evaluated. Obtained results are the basis for designing various diets, filling composite databases of the region's food, and creating the newest biologics-pharmabiotics.
Acta horticulturae, 2014
Topics variability, varieties growing systems uses / traditional products composition 10th Intern... more Topics variability, varieties growing systems uses / traditional products composition 10th International Symposium on Vaccinium and Other Superfruits June 17-22, 2012, Maastricht, The Netherlands Cornelian cherry variability • Reproduction from seed for centuries • Wide wild variability • Wild botanic varieties: var. typica Sanadze, var. macrocarpa Sanadze, var. flava Sanadze, var. pyriformis Sanadze • Local selection varieties developed by people in many countries Surveys on natural populations, in situ observations and collection Evaluation, Selection and Breeding
Journal of Biotechnology, Nov 1, 2010
The Journal of Allergy and Clinical Immunology, Feb 1, 2023
Springer eBooks, 2021
Type 2 diabetes is one of the most common noncommunicable diseases in the world. Recent studies s... more Type 2 diabetes is one of the most common noncommunicable diseases in the world. Recent studies suggest a link between type 2 diabetes and microbiota, as well as the ability to treat and prevent it using personalized approaches to nutrition. In this work, we conducted clinical studies on the effects of a personalized diet on 56 female patients. Biochemical, physical, and immunological parameters were measured by standard methods on days 1 and 18 of the experiment. Gut and oral microbiota studies were performed in dynamics on days 1, 7, 11, and 18 using real-time polymerase chain reaction. With the help of the developed information system, a personalized diet was developed for each participant of the experiment. In the group of patients following personalized diets a statistically significant decreasing levels of glucose, thymol test, creatinine, very low-density lipoprotein, urea, secretory IgA, and tumour necrosis factor-α, and improvement in all physical parameters were observed. There was a statistically significant increase in uric acid, sodium, and magnesium. Statistically significant changes in gut microbiota were observed in Enterococcus faecalis, Escherichia coli (lac+, lac-), Lactobacillus spp., and Candida spp. Such microorganisms of oral microbiota as E. faecalis, Lactobacillus spp., Pseudomonas aeruginosa, and Candida spp. demonstrated statistically significant changes. All these changes indicate an improvement in the patients' condition in the experimental group compared to the control group. Our algorithm used for the development of personalized diets for patients with diabetes type 2 demonstrated clinical efficacy of its implementation.
The aim of the work was to use the in vivo model to reveal main changes in gut microbiota of immu... more The aim of the work was to use the in vivo model to reveal main changes in gut microbiota of immune competent mice in dynamic and find out the specificity of immunomodulation action (activity) of traditional foods ingredients - edible plants extracts on local mucosal cytokines to its oral administration.Materials and methods. In this study, seven groups of immunocompetent BALB/c mice were formed. All experimental mice had been fed orally by plants’ extracts (15mg/200 µl/mouse) for the 14th days. The extracts of edible plants - ingredients of traditional food such as kale leaves, persimmon, pomegranate, dill, Sideritis scardica, and nettle were obtained as described and orally administrated to experimental animals. For microbiological analysis of gut microbiota changes, the colon content has been investigated, the key microbial representatives were isolated by plating of its serial dilution on selected chromogenic medium, identified serologically and biochemically. The production of ...
Microbiome, Immunity, Digestive Health and Nutrition
Journal of Ecosystem & Ecography, Jul 27, 2018
Microbiome of soil, plants and humans, the ways and mechanisms of their interrelation, role in P4... more Microbiome of soil, plants and humans, the ways and mechanisms of their interrelation, role in P4 and IT-medicine Statement of the Problem: The fact that our host changes are more likely occur due to the modification of gene expression, rather than the alteration of the genetic code itself reverse/refresh our vision, and finally led to prognostic personified and preventive medicine and sustainable agriculture consistent with cyclic bioeconomy. Methodology & Theoretical Orientation: In vitro and in vivo models, in situ monitoring, limited clinical trials, mathematical modeling, GIS.
ScienceRise: Biological Science
Journal of Ecosystem & Ecography, Jul 27, 2018
To strengthen European citizens to make dietary choices as the healthy diet, which is sustainable... more To strengthen European citizens to make dietary choices as the healthy diet, which is sustainable and affordable using local goods that are produced in the environmentally responsible way for further improving food systems. Methodology & Theoretical Orientation: Clinical trials, cohort studies, in vitro and in vivo experiments (cells, animal models: CNV vs. GF and k.o. mice, etc.), mathematical modeling, IT tools. Findings: We are currently testing is the personalized nutrition algorithm (PNA). However, it is being tested only for specific diseases, which limits the use of those approaches for personalized nutrition to only those cases. FENIX proposes to exploit an easy-to-use coherent tool to make recommendations for PN requirements that meet the precise needs of EU citizens. Proposed by FENIX tool is based on measurements and an innovative bioinformatics approach for interpretation of individual microbiome data with other relevant and crucial factors (evidence-based and correlated biomarkers, calculating age, gender and indicating personal health status, personal nutritional requirements, food composition data, lifestyle specificity, cultural preferences, environment conditions) and also consider the available source and analytical characteristics of ethnic foods and innovative food processing approach of further individualisation proposed for local farmers and food producers. Conclusion & Significance: All NCDs, allergies, other so-called "metabolic disorders" correlate with human microbiome status. Normal microbiome depends on the region where a person lives. In fact, the project presents a new way of the understanding microbiome-function. FENIX will also consider the origin of food taking into account its nutritional value and unique composition since different food affects different people in different ways, as well as the different origin of one product, affect the same person differently.
HEALTH OF WOMAN
The article shows the research results of vaginal microbiome correction of pregnant women with ba... more The article shows the research results of vaginal microbiome correction of pregnant women with bacterial vaginosis before and after oral using of synbiotic Bifiten. This biopreparation differs from others recommended for vaginal microbiome correction by its combined anti-inflammatory and specific pro- and antimicrobial activity. The aim of research is to define the clinical efficacy of oral administration of the non-medicinal biological (synbiotic) preparation Bifiten to pregnant women with bacterial vaginosis. Materials and Methods. Clinical and statistical analysis of pregnant women's individual cards, childbirth stories had been held. Vaginal microbiome had been studied by using classic microbiological methods and qRT-PCR. Immune parameters of vagina secrets had been detected by immunosorbent assay (ELISA). Results. A positive dynamics of subjective and objective state of pregnant women had been observed. It was shown that following to the oral administration of Bifiten mucou...
Medicina, 2022
The intestinal microbiota plays an important role in maintaining human health, and its alteration... more The intestinal microbiota plays an important role in maintaining human health, and its alteration is now associated with the development of various gastrointestinal (ulcerative colitis, irritable bowel syndrome, constipation, etc.) and extraintestinal diseases, such as cancer, metabolic syndrome, neuropsychiatric diseases. In this context, it is not surprising that gut microbiota modification methods may constitute a therapy whose potential has not yet been fully investigated. In this regard, the most interesting method is thought to be fecal microbiota transplantation, which consists of the simultaneous replacement of the intestinal microbiota of a sick recipient with fecal material from a healthy donor. This review summarizes the most interesting findings on the application of fecal microbiota transplantation in gastrointestinal and extraintestinal pathologies.
Ukrainian chemistry journal, 2021
Based on the screening of some heavy metals (HMs) content in the humus soil horizon of the Transc... more Based on the screening of some heavy metals (HMs) content in the humus soil horizon of the Transcarpathian region, the regularities of the distribution of HMs in the soils of different landscape zones have been established. It is shown that increasing of the terrain height, the content of HMs in soils decreases (except for Mn and Hg) and for the total HMs content the values of the Spearman correlation coefficient are: Cu – (-0.84); Zn – (-0.83); Mn 0.77; Mo – (-0.91); Co – (-0.82); Pb – (-0.83); Hg – absent; for the content of acid-soluble forms: Cu – absent; Zn – (-0.72); Mn 0.75; Mo – (-0.89); Co – (-0.86); Pb – (-0.77); Hg is absent. This pattern is associated with the tectonic and geological features of the different landscape zones. The calculation of the migration coefficient (the ratio of the content of acid-soluble forms to the gross content) has been shown that in mountainous regions this indicator has the highest value for Zn, Pb, and Cu. That means the potential danger ...
Georgian medical news, 2020
A side effect of treating children with fixed orthodontic equipment (FOE) is the deterioration of... more A side effect of treating children with fixed orthodontic equipment (FOE) is the deterioration of the oral microbiota and, as a typical consequence, a significant increase in the risk of chronic catarrhal gingivitis (CCG). The problem is to calculate the specified risk for each specific child, and its modern solution using models subjected to the machine learning procedure requires the identification of microbial and other markers of the process of formation of oral microbiota in the presence of FOE in healthy children and children with CCG. The identification of such markers was the main goal of this study. The experiment consisted in monitoring this process by four dental and nineteen microbial parameters at the third, sixth and twelfth month of orthodontic treatment of 30 non-sick and 32 patients with CCG having healthy periodontal tissues before the FOE. Markers were detected by correlation, principal component (PCA), factor and cluster analyzes of the obtained experimental data...
This work is funded under the EU FP7 Theme 2: “Food, Agriculture, Fisheries, and Biotechnology”, ... more This work is funded under the EU FP7 Theme 2: “Food, Agriculture, Fisheries, and Biotechnology”, Grant Agreement no.227118
Poster publicado em: BaSeFood Newsletter - Special Issue n.o7, October 2012 - Traditional Food In... more Poster publicado em: BaSeFood Newsletter - Special Issue n.o7, October 2012 - Traditional Food International 2012, p. 35. ISBN: 978-88-902152-6-1