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Papers by Nagendra Singh

Research paper thumbnail of Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

Journal of Clinical Investigation, 2007

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunor... more A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO + pDCs directly activate resting CD4 + CD25 + Foxp3 + Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor-draining LNs were constitutively activated and suppressed antigen-specific T cells immediately ex vivo. In vitro, IDO + pDCs from

Research paper thumbnail of Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase

Journal of Clinical Investigation, 2007

A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunor... more A small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO). We show that these IDO + pDCs directly activate resting CD4 + CD25 + Foxp3 + Tregs for potent suppressor activity. In vivo, Tregs isolated from tumor-draining LNs were constitutively activated and suppressed antigen-specific T cells immediately ex vivo. In vitro, IDO + pDCs from

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