Naghmeh Mirhosseini - Academia.edu (original) (raw)

Papers by Naghmeh Mirhosseini

Research paper thumbnail of The Effect of a Novel Combination of Vitamin D and Probiotic on Clinical Symptoms, Biomarkers of Oxidative Stress and Cardio-Metabolic Risk in Patients with Chronic Schizophrenia: A Randomized, Double-Blinded, Placebo-Controlled Trial

Social Science Research Network, 2018

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD — CORRIGENDUM

British Journal of Nutrition, Sep 4, 2019

Research paper thumbnail of The Effects of Statin Use on Inflammatory Markers Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Social Science Research Network, 2018

Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD... more Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD) through reducing LDL cholesterol and decreasing inflammation. Metabolic syndrome (MetS) is usually associated with increased inflammatory markers and increased risk of CVD. We conducted a systematic review and meta-analysis to determine the effect of statin use on inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1 (IL-1) among patients with MetS and related disorders. PubMed, EMBASE, Web of Science databases, and Cochrane Library were searched for randomized controlled trials (RCTs) through April 2018. Three independent investigators evaluated study eligibilities, extracted data, and assessed study quality using the Cochrane Collaboration risk of bias tool and Jadad's quality scales. Heterogeneity was determined using Cochran's Q statistic and I-square (I 2) test. Based on the heterogeneity results, we pooled data using random-effect or fixed effect models presented as standardized mean differences (SMD) and corresponding 95% confidence intervals (CI). One hundred thirteen RCTs (19,644 patients) were included in our meta-analysis. The pooled results using random effects model showed that statin use statistically significantly decreased CRP level (SMD=-0.97; 95% CI,-1.10,-0.85; P < 0.001; I 2 : 95.1%), TNF-α (SMD=-1.88; 95% CI,-2.40,-1.38; P < 0.001; I 2 : 97.2%), IL-6 (SMD=-1.67; 95% CI,-1.98,-1.34; P < 0.001; I 2 : 96.5%), and IL-1 concentrations (SMD=-8.35; 95% CI,-10.49,-6.22; P < 0.001; I 2 : 98.4%) among patients with MetS and related disorders. Our meta-analysis showed beneficial effects of statin use on reducing inflammatory markers in patients with MetS and related disorders. creases the risk of metabolic disorders including type 2 diabetes mellitus (T2DM) [3]. Reduced adiponectin levels occur in patients with T2DM

Research paper thumbnail of An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial

Journal of Nutrition, Nov 1, 2020

Research paper thumbnail of An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial

The Journal of Nutrition, 2020

Research paper thumbnail of Body fat distribution and its association with cardiovascular risk factors in adolescent Iranian girls

PubMed, Jun 1, 2012

Objective: The relationships between body fat distribution, lipid profile and blood pressure, hav... more Objective: The relationships between body fat distribution, lipid profile and blood pressure, have not been studied extensively in young population. This study was designed to evaluate the association between measures of adiposity and established cardiovascular risk factors in adolescent girls. Methods: A total of 477 adolescent girls aged 15 to 18 years were recruited from Mashhad high schools. Socio-demographic characteristics were assessed using a self-administered questionnaire. Anthropometric assessments, blood pressure measurement and biochemical assessment were performed. Total and regional fat mass were determined by bio-impedance analysis. Cardiovascular disease risk factors were assessed in relation to body fat measures with adjustment for confounder factors including age and family socioeconomic status. Findings: The prevalence of overweight and obesity was 14.6% and 3.4% respectively; 16% of study population had greater fat mass compared to its ideal distribution. The majority of cardiovascular risk factors, especially systolic and diastolic blood pressure, triglyceride concentration, CRP and fasting blood sugar were significantly higher in group with a high body fat when compared to those with normal and low values. All anthropometric indices showed significant correlation with fat mass, fat free mass, total and regional body fat percent (P<0.001). After adjustment for age and family socioeconomic status, a high fat mass especially, truncal fat, was positively associated with triglyceride and blood pressure. Conclusion: Adiposity, especially truncal adiposity, which can be assessed by simple measures such as Body Mass Index (BMI) and Waist Circumference (WC) may predispose adolescent girls for demonstration of metabolic abnormalities and consequently cardiovascular diseases.

Research paper thumbnail of Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Diabetology & Metabolic Syndrome

Background Vitamin D supplementation exerts several supporting effects on improving glycemic stat... more Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11...

Research paper thumbnail of Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting

Dermato-Endocrinology, 2017

Supplementation by the general public with vitamin D at doses above the Tolerable Upper Level of ... more Supplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a community-based program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community program for whom there were blood measurements at program entry and at follow-up within 6-18 months between 2013 and 2015. Participants were supplemented with a wide range of vitamin D doses (1,000-15,000 IU/d) aimed at achieving serum 25-hydroxyvitamin D [25(OH) D] levels of at least 100 nmol/L. Serum 25(OH)D concentrations up to 300 nmol/L were achieved without perturbation of calcium homeostasis or incidence of toxicity. Hypercalcemia and hypercalciuria were not related to an increase in 25(OH)D concentrations nor vitamin D dose. To achieve serum 25(OH)D levels >100 nmol/L on average, required vitamin D intakes of 6,000 IU/d for normal Body Mass Index (BMI), 7,000 IU/d for overweight and 8,000 IU/d for obese. Doses of vitamin D in excess of 6,000 IU/d were required to achieve serum 25(OH)D concentrations above 100 nmol/L, especially in individuals who were overweight or obese without any evidence of toxicity. Serum 25(OH)D concentrations up to 300 nmol/L were found to be safe.

Research paper thumbnail of An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2015

An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption Following the report of... more An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption Following the report of two Canadian Aboriginal patients with severe hepatic failure by Mhanni et al. (2006), 1 suffering from hyperammonemia, hyperornithinemia, and hyperhomocitrullinuria (HHH) syndrome, to the best of our knowledge, we are presenting the third and the oldest Aboriginal patient with HHH syndrome. Our patient, a 34-year-old male of Métis descent, with chronic cognitive dysfunction, presented with acute inappropriate behavior and recurrent hostility. Previously, he was healthy with no seizure or vascular risk factor. He complained of an inability to "think right" and impaired concentration. On assessment, his vital signs were normal. He was alert, moderately cooperative, and his language was normal. Motor examination including muscle tone was normal. Deep tendon reflexes were brisk and left plantar response was extensor. Sensation, coordination, and gait were normal. There was no meningismus or asterixis. During the first week in the hospital, the patient had episodes of aggression and disorientation requiring physical restraint occurred. The episodes were refractory to quetiapine and occurred in the evenings. During the day, he was calm and oriented. On reassessment, his Montreal Cognitive Assessment score was 12/30, visuospatial skills were impaired (Figure 1A), deep tendon reflexes were brisk, plantar responses were extensor, coordination was impaired, and gait was unsteady. Subsequently, he became unconscious with intermittent colonic movements of the extremities that were treated with intravenous lorazepam and phenytoin load. Blood work was normal on admission, which included complete blood count, electrolytes, Ca 2 + , Mg 2 + , Po 4 2 + , glucose, creatine kinase, liver enzymes, and bilirubin. Further investigation showed negative vasculitis panel (antinuclear antibody, antineutrophil cytoplasmic antibody, extractable nuclear antigen, rheumatoid factor, and C-reactive protein) and thrombophilia workup, negative urine toxicology on several occasions, hypodensities in the right frontal lobe on cranial computed tomography scan, slow electroencephalogram background, negative cerebrospinal fluid, including polymerase chain reaction for herpes simplex virus. His brain magnetic resonance imaging (MRI) was suspicious for acute demyelinating encephalomyelitis or vasculitis (Figure 2A). The vasculitis workup, hepatitis panel, Venereal Disease Research Laboratory, and HIV tests were all negative. Repeated brain MRI revealed infarcts in the cingulate and insular cortices bilaterally (Figure 2B). Magnetic resonance angiogram and stroke workup including 24-hour Holter monitoring were negative. Left ventricular ejection fraction was decreased (45% to 50%) on echocardiogram. A repeated electroencephalogram taken while the patient was comatose showed diffuse slowing with no epileptiform discharges or triphasic waves. Arterial blood gas showed respiratory alkalosis (pH: 7.47 [7.38-7.46]; bicarbonate: 24 mmol/L [21-28]; partial pressure of carbon dioxide: low at 33 mmHg [35-48], partial pressure of oxygen: 91 mmHg), and blood ammonia level was markedly elevated at 291 µmol/L.

Research paper thumbnail of The effects of magnesium supplementation on gene expression related to inflammatory markers, vascular endothelial growth factor, and pregnancy outcomes in patients with gestational diabetes

Magnesium has been introduced as one of the micronutrients with several metabolic benefits, mainl... more Magnesium has been introduced as one of the micronutrients with several metabolic benefits, mainly anti-inflammatory properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression of inflammatory markers, vascular endothelial growth factor (VEGF), and pregnancy outcomes in women diagnosed with gestational diabetes mellitus (GDM). This randomized, double-blinded, placebo-controlled trial was conducted among 36 women, aged 18-40 years old, diagnosed with GDM. Study participants were randomly allocated into two groups to receive either 250 mg/day magnesium oxide (n = 18) or placebo (n = 18) for six weeks. Gene expression related to inflammatory markers and VEGF was assessed using peripheral blood mononuclear cells (PBMCs) of women with GDM, via RT-PCR method. Quantitative results of RT-PCR demonstrated that magnesium supplementation downregulated gene expression levels of interleukin-8 (IL-8) (P = 0.03) and tumor necrosis factor-α (TNF-α) ...

Research paper thumbnail of The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

EXCLI Journal, 2019

The loss of muscle mass and its strength is one of the most critical changes in aging which is as... more The loss of muscle mass and its strength is one of the most critical changes in aging which is associated with an increased risk of falls, osteoporotic fractures and mobility disability. Vitamin D, with its extra-skeletal benefits, might improve muscle function in elderly. The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize available relevant data and determine the effect of vitamin D supplementation on muscle function among postmenopausal women. We reached databases including; Cochrane library, Embase, PubMed, and Web of Science database until the end of May 2018 to identify relevant published RCTs. Heterogeneity among included studies was assessed using Q-test and I2 statistics. Random-effect model was applied to pool data and weighted mean difference (WMD) was calculated representing summary effect size. Outcomes of interest included the effects of vitamin D supplementation on hand grip strength (HGS), back muscle stre...

Research paper thumbnail of Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial – Expression of concern

British Journal of Nutrition

This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), g... more This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P&lt;0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=-9·42 pmol/l; 95% CI -14·94, -3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=-0·56; 95 % CI -0·89, -0·24; P=0·001) and HbA1c (β=-0·74 %; 95 % CI -1·10, -0·39; P&lt;0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=-0·30 mmol/l; 95% CI -0·56, -0·04; P=0·02), LDL-cholesterol (β=-0·29 mmol/l; 95% CI -0·52, -0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P&lt;0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P&lt;0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD – Expression of concern

British Journal of Nutrition

Research paper thumbnail of Association between miRNAs Expression and Signaling Pathways of Oxidative Stress in Polycystic Ovary Syndrome

Critical Reviews in Eukaryotic Gene Expression

Research paper thumbnail of Correction: The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials

Journal of Human Hypertension

Research paper thumbnail of The Effects of Vitamin D Supplementation on Markers Related to Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Hormone and Metabolic Research

This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to... more This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to summarize the effect of vitamin D supplementation on endothelial function among people with metabolic syndrome and related disorders. Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published up 20th May 2018. To check heterogeneity a Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Twenty-two trials of 931 potential citations were found to be eligible for current meta-analysis. The pooled findings by using random effects model indicated that vitamin D supplementation to individuals with MetS and related disorders significantly increased flow-mediated dilatation (FMD) (SMD=1.10; 95% CI, 0.38, 1.81, p=0.003). However, it did not affect pulse-wave velocity (PWV) (SMD=0.04; 95% CI, –0.25, 0.33, p=0.80) and augmentation index...

Research paper thumbnail of The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

Reproductive Biology and Endocrinology

Background: Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarka... more Background: Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It is hypothesized that vitamin D supplementation influences metabolic profile of these patients and indirectly might affect fertility and the outcomes. Therefore, this study was conducted to determine the effects of vitamin D supplementation on the levels of anti-Müllerian hormone (AMH), metabolic profiles, and gene expression of insulin and lipid metabolism in infertile women with PCOS who were candidate for in vitro fertilization (IVF). Methods: This study was a randomized, double-blinded, placebo-controlled trial conducted among 40 infertile women, aged 18-40 years, diagnosed with PCOS and was candidate for IVF. Participants were randomly assigned into two intervention groups for receiving either 50,000 IU vitamin D or placebo (n = 20 each group) every other week for 8 weeks. Gene expression for insulin and lipid metabolism was conducted using peripheral blood mononuclear cells (PBMCs) of women with PCOS, via RT-PCR method. Results: Vitamin D supplementation led to a significant reduction in serum AMH (− 0.7 ± 1.2 vs. − 0.1 ± 0.5 ng/mL, P = 0.02), insulin levels (− 1.4 ± 1.6 vs.-0.3 ± 0.9 μIU/mL, P = 0.007), homeostatic model of assessment for insulin resistance (− 0.3 ± 0.3 vs.-0.1 ± 0.2, P = 0.008), and a significant increase in quantitative insulin sensitivity check index (+ 0.009 ± 0.01 vs. + 0.001 ± 0.004, P = 0.04), compared with the placebo. Moreover, following vitamin D supplementation there was a significant decrease in serum total-(− 5.1 ± 12.6 vs. + 2.9 ± 10.9 mg/dL, P = 0.03) and LDL-cholesterol levels (− 4.5 ± 10.3 vs. + 2.5 ± 10.6 mg/dL, P = 0.04) compared with the placebo. Conclusion: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. Trial registration: This study was retrospectively registered in the Iranian website (www.irct.ir) for clinical trials registration (http://www.irct.ir: IRCT20170513033941N27).

Research paper thumbnail of Could circRNA be a new biomarker for pre‐eclampsia?

Molecular Reproduction and Development

Research paper thumbnail of The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials

Journal of Diabetes & Metabolic Disorders

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

British Journal of Nutrition

This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementa... more This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·0...

Research paper thumbnail of The Effect of a Novel Combination of Vitamin D and Probiotic on Clinical Symptoms, Biomarkers of Oxidative Stress and Cardio-Metabolic Risk in Patients with Chronic Schizophrenia: A Randomized, Double-Blinded, Placebo-Controlled Trial

Social Science Research Network, 2018

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD — CORRIGENDUM

British Journal of Nutrition, Sep 4, 2019

Research paper thumbnail of The Effects of Statin Use on Inflammatory Markers Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Social Science Research Network, 2018

Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD... more Current evidence suggests that statin use decreases the incidence of cardiovascular diseases (CVD) through reducing LDL cholesterol and decreasing inflammation. Metabolic syndrome (MetS) is usually associated with increased inflammatory markers and increased risk of CVD. We conducted a systematic review and meta-analysis to determine the effect of statin use on inflammatory markers including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1 (IL-1) among patients with MetS and related disorders. PubMed, EMBASE, Web of Science databases, and Cochrane Library were searched for randomized controlled trials (RCTs) through April 2018. Three independent investigators evaluated study eligibilities, extracted data, and assessed study quality using the Cochrane Collaboration risk of bias tool and Jadad's quality scales. Heterogeneity was determined using Cochran's Q statistic and I-square (I 2) test. Based on the heterogeneity results, we pooled data using random-effect or fixed effect models presented as standardized mean differences (SMD) and corresponding 95% confidence intervals (CI). One hundred thirteen RCTs (19,644 patients) were included in our meta-analysis. The pooled results using random effects model showed that statin use statistically significantly decreased CRP level (SMD=-0.97; 95% CI,-1.10,-0.85; P < 0.001; I 2 : 95.1%), TNF-α (SMD=-1.88; 95% CI,-2.40,-1.38; P < 0.001; I 2 : 97.2%), IL-6 (SMD=-1.67; 95% CI,-1.98,-1.34; P < 0.001; I 2 : 96.5%), and IL-1 concentrations (SMD=-8.35; 95% CI,-10.49,-6.22; P < 0.001; I 2 : 98.4%) among patients with MetS and related disorders. Our meta-analysis showed beneficial effects of statin use on reducing inflammatory markers in patients with MetS and related disorders. creases the risk of metabolic disorders including type 2 diabetes mellitus (T2DM) [3]. Reduced adiponectin levels occur in patients with T2DM

Research paper thumbnail of An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial

Journal of Nutrition, Nov 1, 2020

Research paper thumbnail of An Expression of Concern from The Journal of Nutrition's Editorial Office about: High-dose ω-3 Fatty Acid Plus Vitamin D3 Supplementation Affects Clinical Symptoms and Metabolic Status of Patients with Multiple Sclerosis: A Randomized Controlled Clinical Trial

The Journal of Nutrition, 2020

Research paper thumbnail of Body fat distribution and its association with cardiovascular risk factors in adolescent Iranian girls

PubMed, Jun 1, 2012

Objective: The relationships between body fat distribution, lipid profile and blood pressure, hav... more Objective: The relationships between body fat distribution, lipid profile and blood pressure, have not been studied extensively in young population. This study was designed to evaluate the association between measures of adiposity and established cardiovascular risk factors in adolescent girls. Methods: A total of 477 adolescent girls aged 15 to 18 years were recruited from Mashhad high schools. Socio-demographic characteristics were assessed using a self-administered questionnaire. Anthropometric assessments, blood pressure measurement and biochemical assessment were performed. Total and regional fat mass were determined by bio-impedance analysis. Cardiovascular disease risk factors were assessed in relation to body fat measures with adjustment for confounder factors including age and family socioeconomic status. Findings: The prevalence of overweight and obesity was 14.6% and 3.4% respectively; 16% of study population had greater fat mass compared to its ideal distribution. The majority of cardiovascular risk factors, especially systolic and diastolic blood pressure, triglyceride concentration, CRP and fasting blood sugar were significantly higher in group with a high body fat when compared to those with normal and low values. All anthropometric indices showed significant correlation with fat mass, fat free mass, total and regional body fat percent (P<0.001). After adjustment for age and family socioeconomic status, a high fat mass especially, truncal fat, was positively associated with triglyceride and blood pressure. Conclusion: Adiposity, especially truncal adiposity, which can be assessed by simple measures such as Body Mass Index (BMI) and Waist Circumference (WC) may predispose adolescent girls for demonstration of metabolic abnormalities and consequently cardiovascular diseases.

Research paper thumbnail of Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Diabetology & Metabolic Syndrome

Background Vitamin D supplementation exerts several supporting effects on improving glycemic stat... more Background Vitamin D supplementation exerts several supporting effects on improving glycemic status, however, results are inconclusive. Thus, in the present study, we aimed to conduct an umbrella of meta-analysis regarding the impact of vitamin D on type 2 diabetes (T2DM) biomarkers. Methods The Scopus, PubMed, Web of Science, Embase, and Google Scholar online databases were searched up to March 2022. All meta-analyses evaluating the impact of vitamin D supplementation on T2DM biomarkers were considered eligible. Overall, 37 meta-analyses were included in this umbrella meta-analysis. Results Our findings indicated that vitamin D supplementation significantly decreased fasting blood sugar (FBS) (WMD = − 3.08; 95% CI: − 3.97, − 2.19, p < 0.001, and SMD = − 0.26; 95% CI: − 0.38, − 0.14, p < 0.001), hemoglobin A1c (HbA1c) (WMD = − 0.05; 95% CI: − 0.10, − 0.01, p = 0.016, and SMD = − 0.16; 95% CI: − 0.27, − 0.05, p = 0.004), insulin concentrations (WMD = − 2.62; 95% CI: − 4.11...

Research paper thumbnail of Evaluation of vitamin D3 intakes up to 15,000 international units/day and serum 25-hydroxyvitamin D concentrations up to 300 nmol/L on calcium metabolism in a community setting

Dermato-Endocrinology, 2017

Supplementation by the general public with vitamin D at doses above the Tolerable Upper Level of ... more Supplementation by the general public with vitamin D at doses above the Tolerable Upper Level of Intake (UL) is becoming quite common. The objective of the current analysis was to characterize the effect of vitamin D supplementation at doses up to 15,000 IU/d in a community-based program on vitamin D status, calcium homeostasis as well as on kidney, liver and immune function. We evaluated data collected for 3,882 participants in a community program for whom there were blood measurements at program entry and at follow-up within 6-18 months between 2013 and 2015. Participants were supplemented with a wide range of vitamin D doses (1,000-15,000 IU/d) aimed at achieving serum 25-hydroxyvitamin D [25(OH) D] levels of at least 100 nmol/L. Serum 25(OH)D concentrations up to 300 nmol/L were achieved without perturbation of calcium homeostasis or incidence of toxicity. Hypercalcemia and hypercalciuria were not related to an increase in 25(OH)D concentrations nor vitamin D dose. To achieve serum 25(OH)D levels >100 nmol/L on average, required vitamin D intakes of 6,000 IU/d for normal Body Mass Index (BMI), 7,000 IU/d for overweight and 8,000 IU/d for obese. Doses of vitamin D in excess of 6,000 IU/d were required to achieve serum 25(OH)D concentrations above 100 nmol/L, especially in individuals who were overweight or obese without any evidence of toxicity. Serum 25(OH)D concentrations up to 300 nmol/L were found to be safe.

Research paper thumbnail of An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption

Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, 2015

An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption Following the report of... more An Acute Encephalopathy Accelerated by a Large Amount of Milk Consumption Following the report of two Canadian Aboriginal patients with severe hepatic failure by Mhanni et al. (2006), 1 suffering from hyperammonemia, hyperornithinemia, and hyperhomocitrullinuria (HHH) syndrome, to the best of our knowledge, we are presenting the third and the oldest Aboriginal patient with HHH syndrome. Our patient, a 34-year-old male of Métis descent, with chronic cognitive dysfunction, presented with acute inappropriate behavior and recurrent hostility. Previously, he was healthy with no seizure or vascular risk factor. He complained of an inability to "think right" and impaired concentration. On assessment, his vital signs were normal. He was alert, moderately cooperative, and his language was normal. Motor examination including muscle tone was normal. Deep tendon reflexes were brisk and left plantar response was extensor. Sensation, coordination, and gait were normal. There was no meningismus or asterixis. During the first week in the hospital, the patient had episodes of aggression and disorientation requiring physical restraint occurred. The episodes were refractory to quetiapine and occurred in the evenings. During the day, he was calm and oriented. On reassessment, his Montreal Cognitive Assessment score was 12/30, visuospatial skills were impaired (Figure 1A), deep tendon reflexes were brisk, plantar responses were extensor, coordination was impaired, and gait was unsteady. Subsequently, he became unconscious with intermittent colonic movements of the extremities that were treated with intravenous lorazepam and phenytoin load. Blood work was normal on admission, which included complete blood count, electrolytes, Ca 2 + , Mg 2 + , Po 4 2 + , glucose, creatine kinase, liver enzymes, and bilirubin. Further investigation showed negative vasculitis panel (antinuclear antibody, antineutrophil cytoplasmic antibody, extractable nuclear antigen, rheumatoid factor, and C-reactive protein) and thrombophilia workup, negative urine toxicology on several occasions, hypodensities in the right frontal lobe on cranial computed tomography scan, slow electroencephalogram background, negative cerebrospinal fluid, including polymerase chain reaction for herpes simplex virus. His brain magnetic resonance imaging (MRI) was suspicious for acute demyelinating encephalomyelitis or vasculitis (Figure 2A). The vasculitis workup, hepatitis panel, Venereal Disease Research Laboratory, and HIV tests were all negative. Repeated brain MRI revealed infarcts in the cingulate and insular cortices bilaterally (Figure 2B). Magnetic resonance angiogram and stroke workup including 24-hour Holter monitoring were negative. Left ventricular ejection fraction was decreased (45% to 50%) on echocardiogram. A repeated electroencephalogram taken while the patient was comatose showed diffuse slowing with no epileptiform discharges or triphasic waves. Arterial blood gas showed respiratory alkalosis (pH: 7.47 [7.38-7.46]; bicarbonate: 24 mmol/L [21-28]; partial pressure of carbon dioxide: low at 33 mmHg [35-48], partial pressure of oxygen: 91 mmHg), and blood ammonia level was markedly elevated at 291 µmol/L.

Research paper thumbnail of The effects of magnesium supplementation on gene expression related to inflammatory markers, vascular endothelial growth factor, and pregnancy outcomes in patients with gestational diabetes

Magnesium has been introduced as one of the micronutrients with several metabolic benefits, mainl... more Magnesium has been introduced as one of the micronutrients with several metabolic benefits, mainly anti-inflammatory properties. The aim of this study was to evaluate the effects of magnesium supplementation on gene expression of inflammatory markers, vascular endothelial growth factor (VEGF), and pregnancy outcomes in women diagnosed with gestational diabetes mellitus (GDM). This randomized, double-blinded, placebo-controlled trial was conducted among 36 women, aged 18-40 years old, diagnosed with GDM. Study participants were randomly allocated into two groups to receive either 250 mg/day magnesium oxide (n = 18) or placebo (n = 18) for six weeks. Gene expression related to inflammatory markers and VEGF was assessed using peripheral blood mononuclear cells (PBMCs) of women with GDM, via RT-PCR method. Quantitative results of RT-PCR demonstrated that magnesium supplementation downregulated gene expression levels of interleukin-8 (IL-8) (P = 0.03) and tumor necrosis factor-α (TNF-α) ...

Research paper thumbnail of The effects of vitamin D supplementation on muscle function among postmenopausal women: a systematic review and meta-analysis of randomized controlled trials

EXCLI Journal, 2019

The loss of muscle mass and its strength is one of the most critical changes in aging which is as... more The loss of muscle mass and its strength is one of the most critical changes in aging which is associated with an increased risk of falls, osteoporotic fractures and mobility disability. Vitamin D, with its extra-skeletal benefits, might improve muscle function in elderly. The current systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize available relevant data and determine the effect of vitamin D supplementation on muscle function among postmenopausal women. We reached databases including; Cochrane library, Embase, PubMed, and Web of Science database until the end of May 2018 to identify relevant published RCTs. Heterogeneity among included studies was assessed using Q-test and I2 statistics. Random-effect model was applied to pool data and weighted mean difference (WMD) was calculated representing summary effect size. Outcomes of interest included the effects of vitamin D supplementation on hand grip strength (HGS), back muscle stre...

Research paper thumbnail of Effects of magnesium supplementation on carotid intima–media thickness and metabolic profiles in diabetic haemodialysis patients: a randomised, double-blind, placebo-controlled trial – Expression of concern

British Journal of Nutrition

This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), g... more This study evaluated the effects of Mg administration on carotid intima-media thickness (CIMT), glycaemic control and markers of cardio-metabolic risk in diabetic haemodialysis (HD) patients. This randomised, double-blind, placebo-controlled clinical trial was conducted in fifty-four diabetic HD patients. Participants were randomly divided into two groups to take either 250 mg/d Mg as magnesium oxide (n 27) or placebo (n 27) for 24 weeks. Mg supplementation resulted in a significant reduction in mean (P&lt;0·001) and maximum levels of left CIMT (P=0·02) and mean levels of right CIMT (P=0·004) compared with the placebo. In addition, taking Mg supplements significantly reduced serum insulin levels (β=-9·42 pmol/l; 95% CI -14·94, -3·90; P=0·001), homoeostasis model of assessment-insulin resistance (β=-0·56; 95 % CI -0·89, -0·24; P=0·001) and HbA1c (β=-0·74 %; 95 % CI -1·10, -0·39; P&lt;0·001) and significantly increased the quantitative insulin sensitivity check index (β=0·008; 95 % CI 0·002, 0·01; P=0·002) compared with the placebo. In addition, Mg administration led to a significant reduction in serum total cholesterol (β=-0·30 mmol/l; 95% CI -0·56, -0·04; P=0·02), LDL-cholesterol (β=-0·29 mmol/l; 95% CI -0·52, -0·05; P=0·01), high-sensitivity C-reactive protein (hs-CRP) (P&lt;0·001) and plasma malondialdehyde (MDA) (P=0·04) and a significant rise in plasma total antioxidant capacity (TAC) levels (P&lt;0·001) compared with the placebo. Overall, we found that taking Mg for 24 weeks by diabetic HD patients significantly improved mean and maximum levels of left and mean levels of right CIMT, insulin metabolism, HbA1c, total cholesterol and LDL-cholesterol, hs-CRP, TAC and MDA levels.

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD – Expression of concern

British Journal of Nutrition

Research paper thumbnail of Association between miRNAs Expression and Signaling Pathways of Oxidative Stress in Polycystic Ovary Syndrome

Critical Reviews in Eukaryotic Gene Expression

Research paper thumbnail of Correction: The effects of melatonin supplementation on blood pressure in patients with metabolic disorders: a systematic review and meta-analysis of randomized controlled trials

Journal of Human Hypertension

Research paper thumbnail of The Effects of Vitamin D Supplementation on Markers Related to Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-Analysis of Clinical Trials

Hormone and Metabolic Research

This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to... more This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to summarize the effect of vitamin D supplementation on endothelial function among people with metabolic syndrome and related disorders. Cochrane library, Embase, PubMed, and Web of Science database were searched to identify related RCTs published up 20th May 2018. To check heterogeneity a Q-test and I2 statistics were used. Data were pooled by using the random-effect model and standardized mean difference (SMD) was considered as summary effect size. Twenty-two trials of 931 potential citations were found to be eligible for current meta-analysis. The pooled findings by using random effects model indicated that vitamin D supplementation to individuals with MetS and related disorders significantly increased flow-mediated dilatation (FMD) (SMD=1.10; 95% CI, 0.38, 1.81, p=0.003). However, it did not affect pulse-wave velocity (PWV) (SMD=0.04; 95% CI, –0.25, 0.33, p=0.80) and augmentation index...

Research paper thumbnail of The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization

Reproductive Biology and Endocrinology

Background: Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarka... more Background: Vitamin D deficiency in women diagnosed with polycystic ovary syndrome (PCOS) remarkably decreases the chance of pregnancy, which might be related to its impact on metabolic abnormalities in these patients. It is hypothesized that vitamin D supplementation influences metabolic profile of these patients and indirectly might affect fertility and the outcomes. Therefore, this study was conducted to determine the effects of vitamin D supplementation on the levels of anti-Müllerian hormone (AMH), metabolic profiles, and gene expression of insulin and lipid metabolism in infertile women with PCOS who were candidate for in vitro fertilization (IVF). Methods: This study was a randomized, double-blinded, placebo-controlled trial conducted among 40 infertile women, aged 18-40 years, diagnosed with PCOS and was candidate for IVF. Participants were randomly assigned into two intervention groups for receiving either 50,000 IU vitamin D or placebo (n = 20 each group) every other week for 8 weeks. Gene expression for insulin and lipid metabolism was conducted using peripheral blood mononuclear cells (PBMCs) of women with PCOS, via RT-PCR method. Results: Vitamin D supplementation led to a significant reduction in serum AMH (− 0.7 ± 1.2 vs. − 0.1 ± 0.5 ng/mL, P = 0.02), insulin levels (− 1.4 ± 1.6 vs.-0.3 ± 0.9 μIU/mL, P = 0.007), homeostatic model of assessment for insulin resistance (− 0.3 ± 0.3 vs.-0.1 ± 0.2, P = 0.008), and a significant increase in quantitative insulin sensitivity check index (+ 0.009 ± 0.01 vs. + 0.001 ± 0.004, P = 0.04), compared with the placebo. Moreover, following vitamin D supplementation there was a significant decrease in serum total-(− 5.1 ± 12.6 vs. + 2.9 ± 10.9 mg/dL, P = 0.03) and LDL-cholesterol levels (− 4.5 ± 10.3 vs. + 2.5 ± 10.6 mg/dL, P = 0.04) compared with the placebo. Conclusion: Overall, the findings of this trial supported that 50,000 IU vitamin D supplementation every other week for 8 weeks had beneficial effects on insulin metabolism, and lipid profile of infertile women with PCOS who are candidate for IVF. These benefits might not be evident upon having sufficient vitamin D levels. Trial registration: This study was retrospectively registered in the Iranian website (www.irct.ir) for clinical trials registration (http://www.irct.ir: IRCT20170513033941N27).

Research paper thumbnail of Could circRNA be a new biomarker for pre‐eclampsia?

Molecular Reproduction and Development

Research paper thumbnail of The effects of alpha-lipoic acid supplementation on fasting glucose and lipid profiles among patients with stroke: a systematic review and meta-analysis of randomized controlled trials

Journal of Diabetes & Metabolic Disorders

Research paper thumbnail of Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

British Journal of Nutrition

This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementa... more This study was performed to evaluate the effects of vitamin D and n-3 fatty acids’ co-supplementation on markers of cardiometabolic risk in diabetic patients with CHD. This randomised, double-blinded, placebo-controlled trial was conducted among sixty-one vitamin D-deficient diabetic patients with CHD. At baseline, the range of serum 25-hydroxyvitamin D levels in study participants was 6·3–19·9 ng/ml. Subjects were randomly assigned into two groups either taking 50 000 IU vitamin D supplements every 2 weeks plus 2× 1000 mg/d n-3 fatty acids from flaxseed oil (n 30) or placebo (n 31) for 6 months. Vitamin D and n-3 fatty acids’ co-supplementation significantly reduced mean (P = 0·01) and maximum levels of left carotid intima–media thickness (CIMT) (P = 0·004), and mean (P = 0·02) and maximum levels of right CIMT (P = 0·003) compared with the placebo. In addition, co-supplementation led to a significant reduction in fasting plasma glucose (β −0·40 mmol/l; 95 % CI −0·77, −0·03; P = 0·0...