Suprava Naik - Academia.edu (original) (raw)

Papers by Suprava Naik

Cureus

Systemic malignancy can induce hypercoagulation and can cause retinal vein occlusion (RVO). Altho... more Systemic malignancy can induce hypercoagulation and can cause retinal vein occlusion (RVO). Although RVO has been reported in association with breast, renal, lung, prostate, and ovarian malignancies, it has not been reported in brain tumors. We are reporting a case of bilateral central retinal vein occlusion (CRVO) associated with recurrent frontal lobe gliosarcoma. The association was established after ruling out all other systemic causes that can produce bilateral CRVO. The importance of this case report lies in the fact that, while evaluating bilateral CRVO cases, these rare associations should also be kept in mind.

Ovarian fibroma is a rare entity and a diagnostic dilemma due to its solid nature and ultrasound ... more Ovarian fibroma is a rare entity and a diagnostic dilemma due to its solid nature and ultrasound findings being similar to uterine fibroid. Ovarian fibroma being parasitic is extremely rare. We report the case of a 35-year-old multiparous woman who presented with a ‘wandering’ abdominal mass of 6 months duration. Clinical examination revealed a 16 weeks size solid, firm, well defined mass in the right lumbar and iliac regions, separate from the uterus on bimanual examination, suggestive of pedunculated subserous fibroid uterus. Ultrasound abdomen with color Doppler evaluation was suggestive of a non-uterine origin of the tumor, probably gastrointestinal stromal tumor. In view of the diagnostic dilemma, MRI was done which showed that the lesion had features characteristic of ovarian fibroma, however bilateral ovaries were normally visualised. Exploratory laparotomy was performed. There was a solid parasitic tumor adherent to the bladder peritoneum and attached to the right ovary by a...

Autopsy Case Reports, 2021

Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade s... more Primary malignant giant cell tumor (PMGCT) is a diagnosis based on the presence of a high-grade sarcomatous component along with a typical benign giant cell tumor (GCT). We report the first case of PMGCT of the sternum in a 28-year-old male with painless swelling over the manubrium sterni. The differential diagnoses of PMGCT and giant cell-rich osteosarcoma were considered. Surgical resection was performed, and the reconstruction was done with a neosternum using polymethyl methacrylate and prolene mesh. At 30 months follow-up, the patient is disease-free.

Asian Journal of Neurosurgery, 2020

Intracranial infantile hemangiopericytoma (HPC) is a rare, sparsely documented neoplasm with a re... more Intracranial infantile hemangiopericytoma (HPC) is a rare, sparsely documented neoplasm with a relatively favorable prognosis than its adult counterpart. We describe a neonatal extradural, intracranial, infantile HPC managed with near-total excision.

Advances in Respiratory Medicine, 2020

A 20-year old female presented to our department with complaints of sudden-onset dyspnea and righ... more A 20-year old female presented to our department with complaints of sudden-onset dyspnea and right-sided chest pain for the last month [...]

Monaldi Archives for Chest Disease, 2020

Tubercular splenic abscess is rare, particularly in immunocompetent patients. Diagnostic difficul... more Tubercular splenic abscess is rare, particularly in immunocompetent patients. Diagnostic difficulties usually arise in patients with tubercular splenic abscess because of its non-specific presentation. We report an elderly male who presented with cough and fever and had pulmonary infiltrates suspicious of tuberculosis. Bronchoalveolar lavage microbiology including XpertMTB/Rif assay was non-contributory. Contrast enhanced computed tomography scan of abdomen revealed multiple non-enhancing lesions in the spleen. Ultrasound guided splenic aspirate revealed pus that was positive for Mycobacterium tuberculosis in XpertMTB/Rif assay confirming the diagnosis of tuberculosis.

Journal of Thoracic Oncology, 2017

those models is not evident since assessment of the model accuracy and validity should be perform... more those models is not evident since assessment of the model accuracy and validity should be performed before generalizing to other populations. Therefore, the aim of this study was to clinically validate the two NTCP-models to predict acute esophagus toxicity in NSCLC patients treated with CCRT. Method: To validate the NTCP-models, clinical data of 274 inoperable NSCLC patients receiving CCRT using IMRT was used. The planned V50Gy and V60Gy and the prospectively scored grade 2 AET (CTC-AE) were retrieved and independently reviewed. The grade 2 AET probability for the V50Gy and V60Gy was calculated as; [1/ 1+ exp [-0.515 + (0.027 * V50 ] and [1/1+ exp [-0.701 + (0.029 * V60 ]]. Validity of the model was assessed with the ability to predict the number of grade 2 AET events (calibration) and the ability to distinguish between those who develop grade 2 AET from those who do not (discrimination, area under the curve (AUC)). Furthermore, sensitivity and specificity for different cutoff points were determined. Result: From the 274 NSCLC patients, 125 (45.6%) patients developed grade 2 AET (93.8% grade 2, 6.2% grade 3), median V50Gy 23% (interquartile range 10.1-35.6%), median V60Gy 4.3% (interquartile range 0-20.5%). Calibration showed that the V50 overestimated the risk of developing grade 2 AET in low-risk patients while the V60 underestimated the risk of developing grade 2 AET in high-risk patients. Discrimination of both algorithms demonstrated a similar moderate fit (AUC 0.70 95%CI 0.64 to 0.76 and AUC 0.69 95%CI 0.63 to 0.76 for the V50Gy and V60Gy, respectively). For V50Gy, a cutoff point of more than 40% probability of developing grade 2 AET resulted in the most favorable sensitivity of 95.8% for grade 2 and 100% for grade 3, with specificity scores of 54.6% and 40.7% respectively. For V60Gy, a cutoff point of more than 60% resulted in the most favorable sensitivity of 95.1% for grade 2 and 100% for grade 3, with remarkably low specificity scores of 9.1% and 18.8%, respectively. Conclusion: The NTCP-models to predict acute esophagus toxicity in NSCLC patients both showed good predictive accuracy. For clinical practice, the V50Gy seems to be the most sensitive without compromising safety and efficacy.

Journal of Thoracic Oncology, 2018

Result: Of 22 patients on first-line afatinib, the starting dose was 40 mg od in 12 patients and ... more Result: Of 22 patients on first-line afatinib, the starting dose was 40 mg od in 12 patients and 30 mg od in 10 patients (Figure 1). Among the 12 patients started on afatinib 40mg od, 4 (33.3%) did not require dose adjustment, 4 (33.3%) needed dose reduction to 30mg od, 2 (16.7%) needed dose reduction to 20mg od, and 2 (16.7%) had dose escalation to 50mg od. Among 10 patients started on afatinib 30mg od, 6 (60%) did not require dose adjustment, 1 (10%) needed dose reduction to 25mg od and 3 (30%) had dose escalation to 40mg od. Dose reduction was to reduce the cost of treatment in 1 patient and to reduce drugrelated side-effects in the rest. Dose escalation was exclusively to improve disease control. The overall response rate and disease control rate was 80% (8/10) and 90% (9/10) in patients who did not require dose adjustment; while the respective rates were 85.7% (6/7) and 100% (7/7) in patients who had dose reduction. The optimal dose of afatinib defined by good disease control and tolerable side-effects was 50mg od in 9.1% (2/22), 40mg od in 31.8% (7/22), 30mg od in 31.8% (7/22), 25mg od in 13.6% (3/22) and 20mg od in 13.6% (3/22) of patients. Conclusion: We suggest starting afatinib at 30mg od and adjust the dose accordingly because dose adjustment is not required in most cases on this starting dose and it is the commonest optimal dose.

Journal of Neurosciences in Rural Practice, 2016

Letters to the Editor as hypothesized by Minassian et al. [3] The association between HZ and stro... more Letters to the Editor as hypothesized by Minassian et al. [3] The association between HZ and stroke has been clearly revealed in recent large case studies, however underlying pathogenesis has not been clarified yet. [2,4] Gathering these knowledges, this report constitutes a considerably rare, detailed clinical-neuroimaging illustration of this co-occurrence. Thus, this case may probably give important points regarding the pathogenesis of stroke in association with acute HZ. However, future prospective studies including results of conventional angiography and pathological investigations need to be conducted to clarify this issue. Finally, through this demonstrative case, I would again point out the importance of HZ among etiological factors of stroke and remark keeping in mind HZ during the routine evaluation process of stroke patients. Financial support and sponsorship Nil. Conflicts of interest There are no conflicts of interest.

Annals of Indian Academy of Neurology

Neurology India, 2021

Intracranial hypotension due to multiple spinal epidural cerebrospinal fluid (CSF) leak is rare a... more Intracranial hypotension due to multiple spinal epidural cerebrospinal fluid (CSF) leak is rare and has multiple etiologies. These patients require epidural blood patches (EBP). We report a patient with recurrent paraplegia due to intracranial hypotension following recurrent epidural CSF leak. Cerebrospinal fluid leak was noted at D1, D10, D11, and L2 levels. Autologous epidural blood patch (EBP) at lower thoracic (3 ml) and lumbar region (4 ml) was performed. The patient developed paraplegia with sensory level at D2 for which 3 ml of EBP was done at D1 level after two months. Following EBP, the patient developed quadriplegia and root pain, which recovered in one month. The patient was free of symptoms for 18 months. Spinal epidural CSF leak should be suspected in patients with features of low pressure headache and recurrent paraplegia at multiple levels. Nuclear scintigraphy and CT myelography help in localizing the site of leak.

Indian Journal of Rheumatology, 2018

Journal of Pediatric Neurosciences, 2019

Dear Editor, Syringomyelia is a rare delayed complication of tubercular meningitis (TBM) and deve... more Dear Editor, Syringomyelia is a rare delayed complication of tubercular meningitis (TBM) and develops 7–28 years after the occurrence of TBM.[1] Early syringomyelia during active disease or while continuing antituberculosis therapy (ATT) is even rarer.[2] Multiseptated syringomyelia has been reported in the literature in association with trauma and after spinal surgical procedures for extramedullary lesions and meningomyelocele but not with TBM.[3,4]

Neurological Sciences, 2019

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Journal of Medical Science And clinical Research, 2018