Namita Pandey - Academia.edu (original) (raw)

Papers by Namita Pandey

12.5% are detected at an early stage (http://icmr.nic.in/ icmrsql/archive/2016/4.pdf), diminishin... more 12.5% are detected at an early stage (http://icmr.nic.in/ icmrsql/archive/2016/4.pdf), diminishing the chances of disease-free progression considerably. Therefore, there is an urgent need to identify predisposing genetic factors along with other preventive health measures, to help decrease the disease burden in different populations. Unfortunately, despite its incidence there are very few Abstract Background: The 15q24-25 loci contain genes (CHRNA5 and CHRNA3) encoding nicotinic acetylcholine receptor subunits. We here determined for the first time the association of genetic variants rs16969968 and rs3743074 in CHRNA5 and CHRNA3, respectively, on nicotine dependence and lung cancer risk in a North Indian population by a case-control approach. Methods: Venous blood samples were obtained from 324 participants (108 lung cancer patients and 216 healthy individuals). DNA was extracted and PCR amplified with primers flanking the SNPs rs16969968 and rs3743074. Amplicons were subjected to s...

In this we report radiation pattern of some important antennas as well as area covered by them. T... more In this we report radiation pattern of some important antennas as well as area covered by them. The paper starts by giving the reader a refresher on antenna pattern parameters and then shows typical patterns for the most common antennas used in EMC. As the improvements on the communication and navigation systems of aircrafts go on, new edge cutting technologies are developed and new approaches to the system components are required. The antenna represents the interface between the transmitted and/or received microwaves traveling on free space and the signal processing hardware and software. Optimizing the antenna characteristics can lead to great improvements to the overall system performance, like lower noise figures, suppressed multipath and interference signals and higher signal levels, i.e. better accuracy, better aerodynamics, lighter weight, etc. The peak value of radiation for A1 dipole L/2 antenna is typically 63.2 dB μA at 95. For A6 telescopic antenna the value of high radi...

High incident of lung cancer among never smokers and their disease pathogenesis is an unexplained... more High incident of lung cancer among never smokers and their disease pathogenesis is an unexplained phenomenon. We have analyzed 1727 lung cancer patient data to understand the impact of smoking on overall survival of lung cancer patients and have observed a difference of only 47 days between smokers and never smokers in adenocarcinoma patients suggesting that the disease is equally fatal in never-smokers irrespective of gender. In this study, we have investigated the possible collaboration between the nAChR and hypoxia signaling pathway to elucidate a mechanism of disease progression in never-smokers. We report a previously unidentified increase in both acetylcholine and nAChR-α7 levels in non small cell lung cancer cells in hypoxia. Similar increase in ubiquitously expressed nAChR-α7 transcripts was also observed in other cancer lines. A direct binding of HIF-1α with the hypoxia response element (HRE) present at -48 position preceding the transcriptional start site in nAChR-α7 promo...

SSRN Electronic Journal

In this research, one of the prominent Shareholder Value Metric, Market Value Added (MVA) is used... more In this research, one of the prominent Shareholder Value Metric, Market Value Added (MVA) is used to measure shareholder value. The primary Objective of this research is to objectively and empirically identify the profit variants which maximize shareholders’ value on a long term. This paper focuses on bridging this gap in the present research in finance. A sample of 50 listed companies comprising the NIFTY Index in India has been chosen. Multiple Regression Analysis was primarily conducted in order to observe the causal influence of profit variants, viz., the average figures of Earnings Before Interest, Taxes, Depreciation and Amortization, (EBITDA), Earnings After Taxes(EAT), Free Cash Flows(FCFs), Cash From Operations(CFOs) and Dividend Pay-out Ratio(D/P Ratio) on Shareholders’ Value. The data pertaining to the above has been collected for a period of nine years (FY 2009-10 to FY 2017-18). Multiple Regression Results reveal that the prominent profit indicators which contribute significantly towards the determination of MVA are EAT, D/P Ratio and CFOs. This indicates that MVA of the companies comprising the NIFTY INDEX is fairly determined by the net profits (after taxes) or EAT, D/P Ratio and by CFOs.

Cellular Physiology and Biochemistry

This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 I... more This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND). Usage and distribution for commercial purposes as well as any distribution of modified material requires written permission.

Journal of Applied Pharmaceutical Science, Aug 1, 2018

Indole and its derivatives are gaining importance because of their anti-cancer activity. Here, we... more Indole and its derivatives are gaining importance because of their anti-cancer activity. Here, we have reported the synthesis and characterization of novel polymeric poly D, L-lactide-co-glycolide (PLGA) indole nanoparticles, and investigated their cytotoxic potential against A549 lung cancer cells. Materials and methods: Nanoparticles were synthesized by solvent emulsion-diffusion-evaporation method. Size determination was done by Transmission Electron Microscopy (TEM), encapsulation efficiency using UV-Vis spectra, release kinetics using dialysis, measurement of drug-polymer interaction by Fourier Transform Infra Red Spectroscopy (FTIR) and surface charge by zeta potential. Cell viability of lung cancer cells (A549) was determined by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and morphological analysis. Results: Nanoparticles were spherical in shape with an average diameter of 65 nm, encapsulation efficiency was found to be about 78% and zeta potential was −15.2mV. Drug-loaded nanoparticles showed sustained release kinetics fitting well in exponential Higuchi and Zero order Model. FTIR studies showed a broadening of the peak of PLGA indole nanoparticles at 2100-3400 cm-1 indicating the formation of drug-loaded nanoparticles. These nanoparticles showed about 95% cytotoxicity against A549 lung cancer cell lines. Results were supported by visible morphological changes in cells. Conclusion: PLGA encapsulated Indole nanoparticles were stable, having sustained release and good cytotoxic potential.

Oncotarget, 2016

Non-small cell lung cancer (NSCLC), comprising 85% of lung cancer cases, has been associated with... more Non-small cell lung cancer (NSCLC), comprising 85% of lung cancer cases, has been associated with resistance to chemo/radiotherapy. The hypoxic tumor microenvironment, where insufficient vasculature results in poor drug penetrance and suboptimal chemotherapy in the tumor interiors contributes heavily to this resistance. Additionally, epigenetic changes in tumorigenic cells also change their response to different forms of therapy. In our study, we have investigated the effectiveness of a combination of cisplatin with scriptaid [a pan-Histone Deacetylase inhibitor (HDACi)] in a model that mimics the tumor microenvironment of hypoxia and sublethal chemotherapy. Scriptaid synergistically increases the efficacy of cisplatin in normoxia as well as hypoxia, accompanied with reduced metastasis and enhanced DNA damage. Addition of scriptaid also overcomes the cisplatin resistance exhibited in lung cancer cells with stabilized hypoxia inducible factor 1 (HIF1)-α (mutant) and mutant p53. Molecular studies showed that the combination treatment increased apoptotic cell death in both normoxia and hypoxia with a dual role of p38MAPK. Together, our results suggest that the combination of low dose cisplatin and scriptaid is cytotoxic to NSCLC lines, can overcome hypoxia induced resistance and mutant p53-induced instability often associated with this cancer, and has the potential to be an effective therapeutic modality.

Chemico-Biological Interactions, 2016

BACKGROUND The transition metal oxide nanoparticles are in focus for their anti-cancer potential.... more BACKGROUND The transition metal oxide nanoparticles are in focus for their anti-cancer potential. In this study we have synthesized and characterized CuO, NiO and Fe2O3 nanoparticles and, investigated their cytotoxic potential in the heterogeneous tumour microenvironment. METHODS Nanoparticles were synthesized by aqueous precipitation method and characterized with UV-Visible spectrophotometer, Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and X-ray diffraction (XRD). Cell viability of lung cancer cells (A549) grown in normoxia (18%O2) and hypoxia (1%O2) was determined for all nanoparticles. The mechanism of cell death was assessed by nuclear morphological analysis, flow cytometry analysis and western blotting. Generation of intracellular ROS in treated cells and its contribution to cell viability was determined. RESULTS The synthesized metal oxide nanoparticles were successfully characterized with SEM, spectroscopy and X-ray diffraction patterns. Cell viability of lung cancer cells was compromised in both normoxia and hypoxia. ROS generation was shown to contribute to cellular toxicity in CuO, but not NiO and Fe2O3. CONCLUSION We have shown the therapeutic potential of CuO, NiO and Fe2O3 nanoparticles in non small cell lung cancer cells cultured in hypoxia, a relevant feature of solid tumors along with normoxia. The newly synthesized nanoparticles showed efficacy in both conditions. GENERAL SIGNIFICANCE Hypoxia drives metabolic alterations and epigenetic modifications in the tumor microenvironment. By using conditions that mimic tumour microenvironment, this study expands the possibility of using metal oxide nanoparticles as a therapeutic agent for lung cancer treatment.

Indian Journal of Engineering Materials Sciences, 2008

An oxygen deficient ceramic oxide having perovskite structure has been prepared by the convention... more An oxygen deficient ceramic oxide having perovskite structure has been prepared by the conventional solid state reaction method. X-ray diffraction studies have confirmed the sample formation in single phase polycrystalline form. The scanning electron micrographs have confirmed polycrystalline texture of the material alongwith indications of porous microstructure. The temperature dependence of the dielectric properties (permittivity/loss tangent) in the sub-ambient and ambient temperature region suggests the possibility of a strong dipolar ordering. The appearance of maxima in both the permittivity and loss factor pattern at a very close temperature range (ε max~1 879 at 29 o C, tan δ max~9 .7 at 35 o C at a common frequency of 10 kHz) supports the presence of dipolar interaction in CaMnO 3-δ. It has been attributed to a strong interaction of the oxide ion-oxygen vacancy pair in the crystal lattice of an oxygen deficient perovskite (CaMnO 3-δ) that in turn reduces the net mobility of oxygen ion at lower temperatures and imparts it a higher dielectric permittivity as well as high loss factor close to room temperature. A decrease in the permittivity and monotonous increase in loss factor with rise in temperature above the ambient value suggest a thermally activated weakening of the dipolar ordering in the system. In view of a very high value of loss factor at and above room temperature, it would be premature to conclude the existence of ferroelectric ordering in the material system just by the presence of a peak in both the permittivity and loss factor pattern.

ABSTRACT Conduction behavior of nanocrystalline oxygen deficient ceramic-SrMnO3-δ(δ̃0.14) has bee... more ABSTRACT Conduction behavior of nanocrystalline oxygen deficient ceramic-SrMnO3-δ(δ̃0.14) has been studied. The structural analysis of nano-SrMnO2.86 follows hexagonal unit cell structure with P63/mmc (194) space group belonging to 6/mmm point group with 4H - layered type hexagonal-cubic layers. The system have lattice parameters; a = 5.437(92) Å, c = 9.072(92) Å, c/ã1.66 (85) with α =90° γ= 120° and cell volume, V= 232.35(18). The relaxation times estimated from complex impedance and modulus relaxation spectrum, show the thermally activated system with corresponding activation energies as 0.66 eV and 0.51 eV The stretching factor `β' from the scaled modulus spectrum shows the poly-dispersive non-Debye nature of the system. The hopping number `n' shows the influence of ionic charge carriers which controls the conduction mechanism of nano-SrMnO2.86.

An Antenna is an essential terminal device in all types of communication and radar system. All co... more An Antenna is an essential terminal device in all types of communication and radar system. All communication and radar system requires an antenna in one form or the other. Without an antenna there would be no communication system and no radar system. The antenna is a source as well as a sensor of electromagnetic wave. In this paper an attempt has been made to receive the fundamental characteristics of different types of antenna with diagram. Further again it has been elaborated comprehensively its applications.

Advances in Applied Ceramics, 2010

Asian Pacific journal of cancer prevention : APJCP, Nov 26, 2017

Background: The 15q24-25 loci contain genes (CHRNA5 and CHRNA3) encoding nicotinic acetylcholine ... more Background: The 15q24-25 loci contain genes (CHRNA5 and CHRNA3) encoding nicotinic acetylcholine receptor subunits. We here determined for the first time the association of genetic variants rs16969968 and rs3743074 in CHRNA5 and CHRNA3, respectively, on nicotine dependence and lung cancer risk in a North Indian population by a case-control approach. Methods: Venous blood samples were obtained from 324 participants (108 lung cancer patients and 216 healthy individuals). DNA was extracted and PCR amplified with primers flanking the SNPs rs16969968 and rs3743074. Amplicons were subjected to sequencing and logistic regression was used to analyze association between variables. Results: The risk variant SNP rs16969968 in both heterozygous and homozygous forms appeared to exert a significant effect on nicotine dependence [GA (OR=2.77) and AA (OR=2.53)]. As expected, smoking was strongly associated with lung cancer (OR= 2.62). Risk allele rs16969968 in CHRNA5 also showed a significant assoc...

Critical Care Medicine, 2002

To report a case of hepatitis E-induced fulminant hepatic failure associated with typhoid fever, ... more To report a case of hepatitis E-induced fulminant hepatic failure associated with typhoid fever, diagnosed with the Widal test. Case report. Eight-bed medical/surgical intensive care unit of a university hospital. A 15-yr-old, 50-kg male with grade IV hepatic encephalopathy was admitted to the intensive care unit for ventilatory support. On admission to the intensive care unit he had had fever associated with loss of appetite and nausea for 15 days, jaundice for 4 days, and altered sensorium for 2 days. He was intubated and kept on elective ventilation. Tracheal aspirate, blood, urine, and stool were sterile. Anti-coma measures were instituted in the form of 20 degrees head elevation; mannitol, lactulose, and ampicillin through a nasogastric tube; and bowel wash. The mainstay of fluid therapy was 20% dextrose. Viral marker was positive for hepatitis E. He showed a favorable recovery but continued to have high-grade fever (39-40 degrees C). On investigation, peripheral blood smear was negative for malarial parasite, and Widal was positive. Fever responded to treatment with Ceftazidime. The patient recovered with anti-coma and anti-typhoid therapy. In viral hepatitis, fever is usually present in the prodromal phase but subsides before appearance of the icteric phase. In endemic areas, if fever is present in the icteric phase of hepatitis, typhoid also should be considered in the differential diagnosis of fever, even in the absence of positive cultures for Salmonella typhi. The Widal test may be helpful in reaching a diagnosis.

We study an effective theory of QCD in which the fundamental variables are dual magnetic potentia... more We study an effective theory of QCD in which the fundamental variables are dual magnetic potentials coupled to the topological fields (monopole and dyon). The color confinement is realized through the dynamical breaking of magnetic symmetry, which leads to the magnetic condensation of QCD vacuum. The flux tube structure of SU(2) QCD vacuum is investigated which gaurantees the dual superconducting nature of the QCD vacuum. Finally, it is shown that the dyonically condensed phase of QCD vacuum seems to be more favorable for the absolute confinement of color isocharges in QCD.