Nasreen Khalil - Academia.edu (original) (raw)

Papers by Nasreen Khalil

Research paper thumbnail of Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease

The European respiratory journal, 2018

Research paper thumbnail of Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease

The European respiratory journal, May 1, 2017

Research paper thumbnail of Generalizability of Pharmaceutical Randomized Controlled Trials for Idiopathic Pulmonary Fibrosis

Research paper thumbnail of Monocyte Count and Transplant-free Survival in Patients With Fibrotic Interstitial Lung Disease

Research paper thumbnail of INCREASE IN THE BETA CHAIN OF HEPATOCYTE GROWTH FACTOR (HGFβ) PRECEDES c-Met EXPRESSION AFTER BLEOMYCIN-INDUCED LUNG INJURY IN THE RAT

Experimental Lung Research, 2002

Research paper thumbnail of Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation

Canadian Respiratory Journal, 2012

Research paper thumbnail of Minimal Important Difference for Physical Activity and Validity of the International Physical Activity Questionnaire in Interstitial Lung Disease

Annals of the American Thoracic Society, 2019

Research paper thumbnail of Differential Expression of Transforming Growth Factor-Β Type I and II Receptors by Pulmonary Cells in Bleomycin-Induced Lung Injury: Correlation with Repair and Fibrosis

Experimental Lung Research, 2002

In a rat model of lung injury induced bythe antineoplastic antibiotic, bleomycin, there is loss o... more In a rat model of lung injury induced bythe antineoplastic antibiotic, bleomycin, there is loss of type I alveolar epithelial cells (AECs) followed by infiltration of activated inflammatory cells, type II AEC proliferation, and fibrosis. At 4 and 7 days after bleomycin administration alveolar macrophages have increased production and release of active transforming growth factor (TGF)- β 1, an inhibitor of epithelial cell proliferation. Paradoxically at these same time intervals there is a concomitant induction of type II AEC proliferation. For TGF- β -mediated signal transduction to occur, the expression of both TGF- β receptor types I (T β R-I) and II (T β R-II) must be present. Using immunohistochemistry and in situ hybridization, 4 and 7 days after bleomycin administration the expression of T β R-I on AECs was reduced whereas that of T β R-II was unaltered. However, 14 and 28 days after bleomycin injury, when there is decreased proliferation and induction of differentiation of type II AECs, there was a return of T β R-I expression on AECs. In contrast, T β R-I and T β R-II were observed on interstitial fibroblasts at all time intervals after bleomycin administration. Because both T β R-I and T β R-II are required for signal transduction, the reduction of T β R-I levels on the alveolar epithelium may alter the sensitivity of AECs to the antiproliferative effects of TGF- β 1 present in increased quantities following bleomycin injury. The loss of an antiproliferative response to TGF- β 1 may be important for the regeneration of the alveolar epithelium by proliferation while the expression of both receptors on fibroblasts would result in TGF- β 1 signaling for the synthesis of connective tissue proteins. Our findings suggest that during bleomycin-induced pulmonary fibrosis, the effects of TGF- β 1 on cells may be regulated by the expression of T β Rs.

Research paper thumbnail of Role of a Regional Multidisciplinary Conference in the Diagnosis of Interstitial Lung Disease

Annals of the American Thoracic Society, Apr 1, 2019

Research paper thumbnail of GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-β receptors

American Journal of Physiology-lung Cellular and Molecular Physiology, Mar 1, 2003

Research paper thumbnail of Dyspnea During Sexual Activity in Patients With Fibrotic Interstitial Lung Disease

Research paper thumbnail of Progressive Fibrotic Interstitial Lung Disease in Autoimmune Inflammatory Myopathy

Research paper thumbnail of Environmental, Inhaled and Ingested Causes of Pulmonary Fibrosis

Toxicologic Pathology, 2007

Research paper thumbnail of Integration and application of radiologic patterns from clinical practice guidelines on idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis

Research paper thumbnail of POS1242 COMPUTED Tomography Findings in Connective Tissue Disease Related Interstitial Lung Disease

Annals of the Rheumatic Diseases

BackgroundLung imaging findings vary among subtypes of connective tissue disease-associated inter... more BackgroundLung imaging findings vary among subtypes of connective tissue disease-associated interstitial lung disease (CTD-ILD), leading to both diagnostic and therapeutic challenges.ObjectivesWe performed a comprehensive assessment of ILD morphology across CTD-ILD subtypes by examining the presence of overall imaging patterns and specific morphological features.MethodsHigh-resolution chest computed tomography (HRCT) of patients with CTD-ILD enrolled in the multicentre Canadian Registry for Pulmonary Fibrosis from their first ILD clinic visit were re-reviewed in standardized multidisciplinary discussion. All CTD diagnoses were rheumatologist-confirmed. An experienced chest radiologist blinded to clinical data quantified the percentage of lung parenchyma affected by honeycombing, reticulation, ground glass opacity (GGO), hypoattenuating lobules, consolidation, and emphysema. Gas trapping was evaluated on expiratory CT. Each case was categorized into an overall disease pattern includi...

Research paper thumbnail of POS0123 ASSOCIATION of Lung Imaging Pattern with Prognosis and Immunosuppression Response in Connective Tissue Disease Associated Interstitial Lung Disease

Annals of the Rheumatic Diseases

BackgroundPrognosis in connective tissue disease associated interstitial lung disease (CTD-ILD) i... more BackgroundPrognosis in connective tissue disease associated interstitial lung disease (CTD-ILD) is influenced by the underlying diagnosis and chest imaging pattern. Usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), and fibrotic hypersensitivity pneumonitis (fHP) patterns can be found across all CTD-ILD subtypes although their impact on disease evolution and treatment response is unclear.ObjectivesOur goal was to examine the association of lung imaging pattern with CTD-ILD progression, mortality, and immunosuppression response.Methods615 patients with CTD-ILD enrolled in the Canadian Registry for Pulmonary Fibrosis had high-resolution chest computed tomography (HRCT) from their first ILD clinic visit reviewed in standardized multidisciplinary discussion. All CTD diagnoses were rheumatologist-confirmed. Experienced chest radiologists blinded to clinical data categorized each case into five groups: UIP, NSIP, organizing pneumonia (OP), fHP, and other patte...

Research paper thumbnail of Neighborhood-Level Disadvantage Impacts on Lung Function in Patients with Sarcoidosis

D22. ADDRESSING HEALTH DISPARITIES IN LUNG DISEASE

Research paper thumbnail of Real World' Therapeutic Approach and Associations with FVC Decline in IPF Patients Treated with Antifibrotics

Research paper thumbnail of TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases

Respiratory Research, Jan 3, 2006

Research paper thumbnail of Radiologic Patterns and Leading Clinical Diagnoses in Unclassifiable Interstitial Lung Disease

Research paper thumbnail of Neurophysiological mechanisms of exertional dyspnoea in fibrotic interstitial lung disease

The European respiratory journal, 2018

Research paper thumbnail of Effects of hyperoxia on dyspnoea and exercise endurance in fibrotic interstitial lung disease

The European respiratory journal, May 1, 2017

Research paper thumbnail of Generalizability of Pharmaceutical Randomized Controlled Trials for Idiopathic Pulmonary Fibrosis

Research paper thumbnail of Monocyte Count and Transplant-free Survival in Patients With Fibrotic Interstitial Lung Disease

Research paper thumbnail of INCREASE IN THE BETA CHAIN OF HEPATOCYTE GROWTH FACTOR (HGFβ) PRECEDES c-Met EXPRESSION AFTER BLEOMYCIN-INDUCED LUNG INJURY IN THE RAT

Experimental Lung Research, 2002

Research paper thumbnail of Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation

Canadian Respiratory Journal, 2012

Research paper thumbnail of Minimal Important Difference for Physical Activity and Validity of the International Physical Activity Questionnaire in Interstitial Lung Disease

Annals of the American Thoracic Society, 2019

Research paper thumbnail of Differential Expression of Transforming Growth Factor-Β Type I and II Receptors by Pulmonary Cells in Bleomycin-Induced Lung Injury: Correlation with Repair and Fibrosis

Experimental Lung Research, 2002

In a rat model of lung injury induced bythe antineoplastic antibiotic, bleomycin, there is loss o... more In a rat model of lung injury induced bythe antineoplastic antibiotic, bleomycin, there is loss of type I alveolar epithelial cells (AECs) followed by infiltration of activated inflammatory cells, type II AEC proliferation, and fibrosis. At 4 and 7 days after bleomycin administration alveolar macrophages have increased production and release of active transforming growth factor (TGF)- β 1, an inhibitor of epithelial cell proliferation. Paradoxically at these same time intervals there is a concomitant induction of type II AEC proliferation. For TGF- β -mediated signal transduction to occur, the expression of both TGF- β receptor types I (T β R-I) and II (T β R-II) must be present. Using immunohistochemistry and in situ hybridization, 4 and 7 days after bleomycin administration the expression of T β R-I on AECs was reduced whereas that of T β R-II was unaltered. However, 14 and 28 days after bleomycin injury, when there is decreased proliferation and induction of differentiation of type II AECs, there was a return of T β R-I expression on AECs. In contrast, T β R-I and T β R-II were observed on interstitial fibroblasts at all time intervals after bleomycin administration. Because both T β R-I and T β R-II are required for signal transduction, the reduction of T β R-I levels on the alveolar epithelium may alter the sensitivity of AECs to the antiproliferative effects of TGF- β 1 present in increased quantities following bleomycin injury. The loss of an antiproliferative response to TGF- β 1 may be important for the regeneration of the alveolar epithelium by proliferation while the expression of both receptors on fibroblasts would result in TGF- β 1 signaling for the synthesis of connective tissue proteins. Our findings suggest that during bleomycin-induced pulmonary fibrosis, the effects of TGF- β 1 on cells may be regulated by the expression of T β Rs.

Research paper thumbnail of Role of a Regional Multidisciplinary Conference in the Diagnosis of Interstitial Lung Disease

Annals of the American Thoracic Society, Apr 1, 2019

Research paper thumbnail of GM-CSF increases airway smooth muscle cell connective tissue expression by inducing TGF-β receptors

American Journal of Physiology-lung Cellular and Molecular Physiology, Mar 1, 2003

Research paper thumbnail of Dyspnea During Sexual Activity in Patients With Fibrotic Interstitial Lung Disease

Research paper thumbnail of Progressive Fibrotic Interstitial Lung Disease in Autoimmune Inflammatory Myopathy

Research paper thumbnail of Environmental, Inhaled and Ingested Causes of Pulmonary Fibrosis

Toxicologic Pathology, 2007

Research paper thumbnail of Integration and application of radiologic patterns from clinical practice guidelines on idiopathic pulmonary fibrosis and fibrotic hypersensitivity pneumonitis

Research paper thumbnail of POS1242 COMPUTED Tomography Findings in Connective Tissue Disease Related Interstitial Lung Disease

Annals of the Rheumatic Diseases

BackgroundLung imaging findings vary among subtypes of connective tissue disease-associated inter... more BackgroundLung imaging findings vary among subtypes of connective tissue disease-associated interstitial lung disease (CTD-ILD), leading to both diagnostic and therapeutic challenges.ObjectivesWe performed a comprehensive assessment of ILD morphology across CTD-ILD subtypes by examining the presence of overall imaging patterns and specific morphological features.MethodsHigh-resolution chest computed tomography (HRCT) of patients with CTD-ILD enrolled in the multicentre Canadian Registry for Pulmonary Fibrosis from their first ILD clinic visit were re-reviewed in standardized multidisciplinary discussion. All CTD diagnoses were rheumatologist-confirmed. An experienced chest radiologist blinded to clinical data quantified the percentage of lung parenchyma affected by honeycombing, reticulation, ground glass opacity (GGO), hypoattenuating lobules, consolidation, and emphysema. Gas trapping was evaluated on expiratory CT. Each case was categorized into an overall disease pattern includi...

Research paper thumbnail of POS0123 ASSOCIATION of Lung Imaging Pattern with Prognosis and Immunosuppression Response in Connective Tissue Disease Associated Interstitial Lung Disease

Annals of the Rheumatic Diseases

BackgroundPrognosis in connective tissue disease associated interstitial lung disease (CTD-ILD) i... more BackgroundPrognosis in connective tissue disease associated interstitial lung disease (CTD-ILD) is influenced by the underlying diagnosis and chest imaging pattern. Usual interstitial pneumonia (UIP), non-specific interstitial pneumonia (NSIP), and fibrotic hypersensitivity pneumonitis (fHP) patterns can be found across all CTD-ILD subtypes although their impact on disease evolution and treatment response is unclear.ObjectivesOur goal was to examine the association of lung imaging pattern with CTD-ILD progression, mortality, and immunosuppression response.Methods615 patients with CTD-ILD enrolled in the Canadian Registry for Pulmonary Fibrosis had high-resolution chest computed tomography (HRCT) from their first ILD clinic visit reviewed in standardized multidisciplinary discussion. All CTD diagnoses were rheumatologist-confirmed. Experienced chest radiologists blinded to clinical data categorized each case into five groups: UIP, NSIP, organizing pneumonia (OP), fHP, and other patte...

Research paper thumbnail of Neighborhood-Level Disadvantage Impacts on Lung Function in Patients with Sarcoidosis

D22. ADDRESSING HEALTH DISPARITIES IN LUNG DISEASE

Research paper thumbnail of Real World' Therapeutic Approach and Associations with FVC Decline in IPF Patients Treated with Antifibrotics

Research paper thumbnail of TGF-β1 increases proliferation of airway smooth muscle cells by phosphorylation of map kinases

Respiratory Research, Jan 3, 2006

Research paper thumbnail of Radiologic Patterns and Leading Clinical Diagnoses in Unclassifiable Interstitial Lung Disease