Natalija Snovak - Academia.edu (original) (raw)

Uploads

Papers by Natalija Snovak

Research paper thumbnail of AB124. SOH21AS106. Balloon dilatation of subglottic stenosis related to granulomatosis with polyangiitis-long term follow up of four patients and their outcomes

Mesentery and peritoneum, Apr 1, 2021

Background: Subglottic stenosis is a well-known potentially life-threatening presentation of gran... more Background: Subglottic stenosis is a well-known potentially life-threatening presentation of granulomatosis with polyangiitis (GPA). Circumferential scarring and critical narrowing of the airway at the level of cricoid cartilage and/or upper tracheal rings appears in 10-16% of patients with GPA. Symptoms range from cough and shortness of breath to life-threatening dyspnoea with stridor. Majority of patients need tracheostomy at the moment of diagnosis. Surgical treatment consists of endoscopic surgery, complex resection of the stenotic segment followed by reconstruction and stenting. Surgical therapy usually has to be repeated due to restenosis of the airway despite ongoing medical treatment. Endoscopic balloon dilatation is a procedure of choice in our institution in a long term management of those patients with good postoperative results. We present four patients with a long history of GPA complicated by airway obstruction and their management. Methods: Retrospective chart review of four patients with a long history of GPA and airway obstruction treated in our institution. Results: All four patients present with a complex history of airway obstruction. All of them have had a tracheostomy tube for a period of time or long term, and one of the patients have had a laryngotracheal reconstruction. Endoscopic balloon dilatation has been carried out as an elective procedure in the management of GPA related subglottic stenosis for two main indications, voice improvement in long term tracheostomy patients and airway obstruction in non-tracheostomy patients. Conclusions: Elective endoscopic balloon dilatation is an optimal procedure in long term management of subglottic stenosis related to GPA.

Research paper thumbnail of AB124. SOH21AS106. Balloon dilatation of subglottic stenosis related to granulomatosis with polyangiitis-long term follow up of four patients and their outcomes

Mesentery and Peritoneum, 2021

Background: Subglottic stenosis is a well-known potentially life-threatening presentation of gran... more Background: Subglottic stenosis is a well-known potentially life-threatening presentation of granulomatosis with polyangiitis (GPA). Circumferential scarring and critical narrowing of the airway at the level of cricoid cartilage and/or upper tracheal rings appears in 10-16% of patients with GPA. Symptoms range from cough and shortness of breath to life-threatening dyspnoea with stridor. Majority of patients need tracheostomy at the moment of diagnosis. Surgical treatment consists of endoscopic surgery, complex resection of the stenotic segment followed by reconstruction and stenting. Surgical therapy usually has to be repeated due to restenosis of the airway despite ongoing medical treatment. Endoscopic balloon dilatation is a procedure of choice in our institution in a long term management of those patients with good postoperative results. We present four patients with a long history of GPA complicated by airway obstruction and their management. Methods: Retrospective chart review of four patients with a long history of GPA and airway obstruction treated in our institution. Results: All four patients present with a complex history of airway obstruction. All of them have had a tracheostomy tube for a period of time or long term, and one of the patients have had a laryngotracheal reconstruction. Endoscopic balloon dilatation has been carried out as an elective procedure in the management of GPA related subglottic stenosis for two main indications, voice improvement in long term tracheostomy patients and airway obstruction in non-tracheostomy patients. Conclusions: Elective endoscopic balloon dilatation is an optimal procedure in long term management of subglottic stenosis related to GPA.

Research paper thumbnail of Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial

Clinical Nutrition, 2010

Background & aims: The aim of our study was to investigate the role of Lactobacillus GG (LGG) in ... more Background & aims: The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers. Methods: We conducted a randomized, double-blind, placebo-controlled trial in 281 children who attend day care centers. They were randomly allocated to receive LGG at a dose of 10 9 colony-forming units in 100 ml of a fermented milk product (LGG group, n ¼ 139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n ¼ 142) during the 3-month intervention period. Results: Compared to the placebo group, children in the LGG group had a significantly reduced risk of upper respiratory tract infections (RR 0.66, 95% CI 0.52 to 0.82, NNT 5, 95% CI 4 to 10), a reduced risk of respiratory tract infections lasting longer than 3 days (RR 0.57, 95% CI 0.41 to 0.78, NNT 5, 95% CI 4 to 11), and a significantly lower number of days with respiratory symptoms (p < 0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p ¼ 0.063). Conclusion: LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.

Research paper thumbnail of AB124. SOH21AS106. Balloon dilatation of subglottic stenosis related to granulomatosis with polyangiitis-long term follow up of four patients and their outcomes

Mesentery and peritoneum, Apr 1, 2021

Background: Subglottic stenosis is a well-known potentially life-threatening presentation of gran... more Background: Subglottic stenosis is a well-known potentially life-threatening presentation of granulomatosis with polyangiitis (GPA). Circumferential scarring and critical narrowing of the airway at the level of cricoid cartilage and/or upper tracheal rings appears in 10-16% of patients with GPA. Symptoms range from cough and shortness of breath to life-threatening dyspnoea with stridor. Majority of patients need tracheostomy at the moment of diagnosis. Surgical treatment consists of endoscopic surgery, complex resection of the stenotic segment followed by reconstruction and stenting. Surgical therapy usually has to be repeated due to restenosis of the airway despite ongoing medical treatment. Endoscopic balloon dilatation is a procedure of choice in our institution in a long term management of those patients with good postoperative results. We present four patients with a long history of GPA complicated by airway obstruction and their management. Methods: Retrospective chart review of four patients with a long history of GPA and airway obstruction treated in our institution. Results: All four patients present with a complex history of airway obstruction. All of them have had a tracheostomy tube for a period of time or long term, and one of the patients have had a laryngotracheal reconstruction. Endoscopic balloon dilatation has been carried out as an elective procedure in the management of GPA related subglottic stenosis for two main indications, voice improvement in long term tracheostomy patients and airway obstruction in non-tracheostomy patients. Conclusions: Elective endoscopic balloon dilatation is an optimal procedure in long term management of subglottic stenosis related to GPA.

Research paper thumbnail of AB124. SOH21AS106. Balloon dilatation of subglottic stenosis related to granulomatosis with polyangiitis-long term follow up of four patients and their outcomes

Mesentery and Peritoneum, 2021

Background: Subglottic stenosis is a well-known potentially life-threatening presentation of gran... more Background: Subglottic stenosis is a well-known potentially life-threatening presentation of granulomatosis with polyangiitis (GPA). Circumferential scarring and critical narrowing of the airway at the level of cricoid cartilage and/or upper tracheal rings appears in 10-16% of patients with GPA. Symptoms range from cough and shortness of breath to life-threatening dyspnoea with stridor. Majority of patients need tracheostomy at the moment of diagnosis. Surgical treatment consists of endoscopic surgery, complex resection of the stenotic segment followed by reconstruction and stenting. Surgical therapy usually has to be repeated due to restenosis of the airway despite ongoing medical treatment. Endoscopic balloon dilatation is a procedure of choice in our institution in a long term management of those patients with good postoperative results. We present four patients with a long history of GPA complicated by airway obstruction and their management. Methods: Retrospective chart review of four patients with a long history of GPA and airway obstruction treated in our institution. Results: All four patients present with a complex history of airway obstruction. All of them have had a tracheostomy tube for a period of time or long term, and one of the patients have had a laryngotracheal reconstruction. Endoscopic balloon dilatation has been carried out as an elective procedure in the management of GPA related subglottic stenosis for two main indications, voice improvement in long term tracheostomy patients and airway obstruction in non-tracheostomy patients. Conclusions: Elective endoscopic balloon dilatation is an optimal procedure in long term management of subglottic stenosis related to GPA.

Research paper thumbnail of Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: A randomized, double-blind, placebo-controlled trial

Clinical Nutrition, 2010

Background & aims: The aim of our study was to investigate the role of Lactobacillus GG (LGG) in ... more Background & aims: The aim of our study was to investigate the role of Lactobacillus GG (LGG) in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers. Methods: We conducted a randomized, double-blind, placebo-controlled trial in 281 children who attend day care centers. They were randomly allocated to receive LGG at a dose of 10 9 colony-forming units in 100 ml of a fermented milk product (LGG group, n ¼ 139) or placebo that was the same post-pasteurized fermented milk product without LGG (placebo group, n ¼ 142) during the 3-month intervention period. Results: Compared to the placebo group, children in the LGG group had a significantly reduced risk of upper respiratory tract infections (RR 0.66, 95% CI 0.52 to 0.82, NNT 5, 95% CI 4 to 10), a reduced risk of respiratory tract infections lasting longer than 3 days (RR 0.57, 95% CI 0.41 to 0.78, NNT 5, 95% CI 4 to 11), and a significantly lower number of days with respiratory symptoms (p < 0.001). There was no risk reduction in regard to lower respiratory tract infections (RR 0.82, 95% CI 0.24 to 2.76). Compared with the placebo group, children in the LGG group had no significant reduction in the risk of gastrointestinal infections (RR 0.63, 95% CI 0.38 to 1.06), vomiting episodes (RR 0.60, 95% CI 0.29 to 1.24), and diarrheal episodes (RR 0.63, 95% CI 0.35 to 1.11) as well as no reduction in the number of days with gastrointestinal symptoms (p ¼ 0.063). Conclusion: LGG administration can be recommended as a valid measure for decreasing the risk of upper respiratory tract infections in children attending day care centers.