Nathaniel Rogers - Profile on Academia.edu (original) (raw)
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Papers by Nathaniel Rogers
Frontiers in Immunology, 2022
Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing i... more Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co-stimulatory signals required for complete activation. Activated CTLs secrete lytic granules containing enzymes that trigger target cell death at the CTL-target contact, also known as the immune synapse (IS). The actin and microtubule cytoskeletons are instrumental in the killing of CTL targets. Lytic granules are transported along microtubules to the IS, where granule secretion is facilitated by actin depletion and recovery. Furthermore, actomyosin contractility promotes target cell death by mediating mechanical force exertion at the IS. Recent studies have shown that inflammatory cytokines produced by APCs, such as interleukin-12 (IL-12), act as a third signal for CTL activation and enhance CTL proliferation and effector function. However,...
Exploring a role for the proximity to the plasma membrane miscibility phase transition in the gating of two temperature sensing channels
Biophysical Journal, 2022
Investigating allosteric regulation by membrane domains of two pentameric ligand-gated ion channels
Biophysical Journal
Frontiers in Immunology, 2022
Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing i... more Cytotoxic T lymphocytes (CTLs) play an integral role in the adaptive immune response by killing infected cells. Antigen presenting cells (APCs), such as dendritic cells, present pathogenic peptides to the T cell receptor on the CTL surface and co-stimulatory signals required for complete activation. Activated CTLs secrete lytic granules containing enzymes that trigger target cell death at the CTL-target contact, also known as the immune synapse (IS). The actin and microtubule cytoskeletons are instrumental in the killing of CTL targets. Lytic granules are transported along microtubules to the IS, where granule secretion is facilitated by actin depletion and recovery. Furthermore, actomyosin contractility promotes target cell death by mediating mechanical force exertion at the IS. Recent studies have shown that inflammatory cytokines produced by APCs, such as interleukin-12 (IL-12), act as a third signal for CTL activation and enhance CTL proliferation and effector function. However,...
Exploring a role for the proximity to the plasma membrane miscibility phase transition in the gating of two temperature sensing channels
Biophysical Journal, 2022
Investigating allosteric regulation by membrane domains of two pentameric ligand-gated ion channels
Biophysical Journal