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Papers by Naveen Kannekanti

Research paper thumbnail of Gut-Lung Axis: The Relationship Between Parenteral Nutrition and Moderate to Severe Bronchopulmonary Dysplasia

Research paper thumbnail of Atypical Presentation of Coronary Artery Fistula: Case Report and Review of the Literature

Cureus, 2020

Chest pain is one of the common complaints a patient presents to the healthcare provider. It need... more Chest pain is one of the common complaints a patient presents to the healthcare provider. It needs prompt evaluation to determine the cause and origin. Angina occurs when myocardial oxygen demand exceeds oxygen supply; the clinical manifestation is often chest discomfort. Atherosclerotic disease is the major cause of angina. However, several non-atherosclerotic conditions have been studied and reported in the literature that causes angina in rarity. We describe a case of coronary artery fistula (CAF) likely causing angina.

Research paper thumbnail of Risk Factors for the Isolation of Vancomycin-Resistant Enterococcus Faecalis from Wound Site: A Case-Case Control Analysis

American Journal of Infection Control, 2012

... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya... more ... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya Govindavarjhulla, MBBS; Ashwini Mallad, MBBS; Kevin Ho, BA; Deepika Reddy Abbadi, MBBS; Deepti Chowdary, MBBS; Hari Kakarlapudi, MBBS; Harish Guddati, MBBS ...

Research paper thumbnail of Postnatal glucocorticoid use impacts renal function in VLBW neonates

Pediatric Research, 2021

BACKGROUND: Preterm neonates often require glucocorticoids to manage refractory hypotension, prev... more BACKGROUND: Preterm neonates often require glucocorticoids to manage refractory hypotension, prevent, and treat bronchopulmonary dysplasia. We have investigated the effect of cumulative dose and duration of glucocorticoids on blood pressure and renal function in VLBW infants. METHODS: In this retrospective cohort study, medical records of infants (GA ≤ 35 weeks) born January 2015 to December 2019 were reviewed to extract demographic and clinical characteristics, dose and duration of steroids, blood pressure (BP), and creatinine at the time of discharge from the neonatal intensive care unit. RESULTS: Two hundred and eighty-three neonates with average GA (28 ± 3 weeks) and birthweight (1060±381 g). Twenty-eight percent (33/116) of infants who received postnatal steroids developed hypertension versus 16% (27/167) of controls (OR = 2.0, p = 0.011). There was a correlation between the cumulative dosage of postnatal steroids and systolic BP (R 2 = 0.06, p < 0.001). With increasing steroid dose and total steroid days, there was a significant increase in creatinine clearance at the time of discharge (R 2 = 0.13, p < 0.001; R 2 = 0.13, p < 0.001, respectively). CONCLUSIONS: Cumulative dose of postnatal steroids and duration of use is associated with increased systolic BP in premature infants. Postnatal steroids should be used prudently to prevent long-term cardiovascular and renal morbidity.

Research paper thumbnail of The urea cycle is transcriptionally controlled by hypoxia-inducible factors

Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-indu... more Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-inducible factors (HIFs) and demonstrate a hepatic HIF dependent increase in urea cycle activity.

Research paper thumbnail of Risk factors for vancomycin-resistant enterococci infection and mortality in colonized patients on intensive care unit admission

American Journal of Infection Control, 2012

Research paper thumbnail of Epidemiology of Vancomycin-Resistant Enterococcus faecalis: a Case-Case-Control Study

Antimicrobial Agents and Chemotherapy, 2013

Research paper thumbnail of Risk factors for vancomycin-resistant enterococci infection and mortality in colonized patients on intensive care unit admission

American Journal of Infection Control, 2012

This study examined the incidence of and risk factors for development of vancomycin-resistant ent... more This study examined the incidence of and risk factors for development of vancomycin-resistant enterococci (VRE) infection and death in VRE-colonized patients in a medical intensive care unit. VRE colonization was identified in 184 patients (17.6%) in whom VRE perianal swab cultures were obtained. Of these, 28 (11.9%) developed VRE infection. Control of infectious sources is crucial to decrease development of VRE infections and optimize the survival of VRE-colonized patients.

Research paper thumbnail of Risk Factors for the Isolation of Vancomycin-Resistant Enterococcus Faecalis from Wound Site: A Case-Case Control Analysis

American Journal of Infection Control, 2012

... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya... more ... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya Govindavarjhulla, MBBS; Ashwini Mallad, MBBS; Kevin Ho, BA; Deepika Reddy Abbadi, MBBS; Deepti Chowdary, MBBS; Hari Kakarlapudi, MBBS; Harish Guddati, MBBS ...

Research paper thumbnail of Gut-Lung Axis: The Relationship Between Parenteral Nutrition and Moderate to Severe Bronchopulmonary Dysplasia

Research paper thumbnail of Atypical Presentation of Coronary Artery Fistula: Case Report and Review of the Literature

Cureus, 2020

Chest pain is one of the common complaints a patient presents to the healthcare provider. It need... more Chest pain is one of the common complaints a patient presents to the healthcare provider. It needs prompt evaluation to determine the cause and origin. Angina occurs when myocardial oxygen demand exceeds oxygen supply; the clinical manifestation is often chest discomfort. Atherosclerotic disease is the major cause of angina. However, several non-atherosclerotic conditions have been studied and reported in the literature that causes angina in rarity. We describe a case of coronary artery fistula (CAF) likely causing angina.

Research paper thumbnail of Risk Factors for the Isolation of Vancomycin-Resistant Enterococcus Faecalis from Wound Site: A Case-Case Control Analysis

American Journal of Infection Control, 2012

... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya... more ... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya Govindavarjhulla, MBBS; Ashwini Mallad, MBBS; Kevin Ho, BA; Deepika Reddy Abbadi, MBBS; Deepti Chowdary, MBBS; Hari Kakarlapudi, MBBS; Harish Guddati, MBBS ...

Research paper thumbnail of Postnatal glucocorticoid use impacts renal function in VLBW neonates

Pediatric Research, 2021

BACKGROUND: Preterm neonates often require glucocorticoids to manage refractory hypotension, prev... more BACKGROUND: Preterm neonates often require glucocorticoids to manage refractory hypotension, prevent, and treat bronchopulmonary dysplasia. We have investigated the effect of cumulative dose and duration of glucocorticoids on blood pressure and renal function in VLBW infants. METHODS: In this retrospective cohort study, medical records of infants (GA ≤ 35 weeks) born January 2015 to December 2019 were reviewed to extract demographic and clinical characteristics, dose and duration of steroids, blood pressure (BP), and creatinine at the time of discharge from the neonatal intensive care unit. RESULTS: Two hundred and eighty-three neonates with average GA (28 ± 3 weeks) and birthweight (1060±381 g). Twenty-eight percent (33/116) of infants who received postnatal steroids developed hypertension versus 16% (27/167) of controls (OR = 2.0, p = 0.011). There was a correlation between the cumulative dosage of postnatal steroids and systolic BP (R 2 = 0.06, p < 0.001). With increasing steroid dose and total steroid days, there was a significant increase in creatinine clearance at the time of discharge (R 2 = 0.13, p < 0.001; R 2 = 0.13, p < 0.001, respectively). CONCLUSIONS: Cumulative dose of postnatal steroids and duration of use is associated with increased systolic BP in premature infants. Postnatal steroids should be used prudently to prevent long-term cardiovascular and renal morbidity.

Research paper thumbnail of The urea cycle is transcriptionally controlled by hypoxia-inducible factors

Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-indu... more Here, we demonstrate transcriptional regulation of urea cycle genes CPS1 and ARG1 by hypoxia-inducible factors (HIFs) and demonstrate a hepatic HIF dependent increase in urea cycle activity.

Research paper thumbnail of Risk factors for vancomycin-resistant enterococci infection and mortality in colonized patients on intensive care unit admission

American Journal of Infection Control, 2012

Research paper thumbnail of Epidemiology of Vancomycin-Resistant Enterococcus faecalis: a Case-Case-Control Study

Antimicrobial Agents and Chemotherapy, 2013

Research paper thumbnail of Risk factors for vancomycin-resistant enterococci infection and mortality in colonized patients on intensive care unit admission

American Journal of Infection Control, 2012

This study examined the incidence of and risk factors for development of vancomycin-resistant ent... more This study examined the incidence of and risk factors for development of vancomycin-resistant enterococci (VRE) infection and death in VRE-colonized patients in a medical intensive care unit. VRE colonization was identified in 184 patients (17.6%) in whom VRE perianal swab cultures were obtained. Of these, 28 (11.9%) developed VRE infection. Control of infectious sources is crucial to decrease development of VRE infections and optimize the survival of VRE-colonized patients.

Research paper thumbnail of Risk Factors for the Isolation of Vancomycin-Resistant Enterococcus Faecalis from Wound Site: A Case-Case Control Analysis

American Journal of Infection Control, 2012

... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya... more ... Manit Singla, MBBS; Mayan Ajamoughli, MD; Pradeep Bathina, MBBS; Khaled Alshabani, MD; Aditya Govindavarjhulla, MBBS; Ashwini Mallad, MBBS; Kevin Ho, BA; Deepika Reddy Abbadi, MBBS; Deepti Chowdary, MBBS; Hari Kakarlapudi, MBBS; Harish Guddati, MBBS ...