Navgeet Kaur - Academia.edu (original) (raw)

Papers by Navgeet Kaur

Research paper thumbnail of A Review on Current Status of Blood Disorder: Thalassemia and its Treatment

Journal of Advanced Zoology, Oct 23, 2023

Research paper thumbnail of Synthesis and In-Vitro Antimicrobial Activity of Pyrimidine Derivatives

International Journal of Pharmaceutical Sciences and Drug Research, Jul 1, 2012

In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the... more In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the 4-position is described. These unreported compounds are obtained starting from commercially available dehydroacetic acid (DHA), aromatic aldehydes and S-benzylisothiouronium chloride (SBT). A series of compounds (3a-j) were prepared and tested for their antimicrobial activity. These synthesized compounds showed mild activity against gram +ve bacteria and very less activity against gram -ve bacteria. Compounds 3b, 3i, 3j showed mild activity against gram +ve Bacillus subtilis bacteria while against gram -ve Pseudomonas aeruginosa compound 3i showed minor activity.

Research paper thumbnail of Plant‐Based Vaccines: Challenges and Opportunities

Herbal Drugs for the Management of Infectious Diseases

Research paper thumbnail of Basics and Fundamentals of X‐Rays

X‐Ray Fluorescence in Biological Sciences

Research paper thumbnail of Toxic and Essential Elemental Studies of Human Organs Using X‐Ray Fluorescence

X‐Ray Fluorescence in Biological Sciences

Research paper thumbnail of Synthesis and In-Vitro Antimicrobial Activity of Pyrimidine Derivatives

International Journal of Pharmaceutical Sciences and Drug Research, 2012

In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the... more In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the 4-position is described. These unreported compounds are obtained starting from commercially available dehydroacetic acid (DHA), aromatic aldehydes and S-benzylisothiouronium chloride (SBT). A series of compounds (3a-j) were prepared and tested for their antimicrobial activity. These synthesized compounds showed mild activity against gram +ve bacteria and very less activity against gram -ve bacteria. Compounds 3b, 3i, 3j showed mild activity against gram +ve Bacillus subtilis bacteria while against gram -ve Pseudomonas aeruginosa compound 3i showed minor activity.

Research paper thumbnail of Synthesis and Biological Aspects of Pyrimidine Derivatives

This book is intended to be an introduction to pharmacy students regarding 'Synthesis and Bio... more This book is intended to be an introduction to pharmacy students regarding 'Synthesis and Biological Aspects of Pyrimidine Derivatives'. Pyrimidine and its derivatives are demonstrated as a pharmacologically active and important scaffold which possesses all kind of pharmacological activities such as analgesic, anticonvulsant, anti-depressive, antipyretic, sedative, antiviral, anti-HIV, anti-inflammatory, antimicrobial and anti-tumor activities. Upon completion of the course the students shall be able to know about the various types of pharmacological application and synthesis scheme for pyrimidines.

Research paper thumbnail of An Appraisal on Synthetic and Medicinal Aspects of Fused Pyrimidines as Anti Neoplastic Agents

Anti-Cancer Agents in Medicinal Chemistry

: Heterocyclic compounds are recognized to possess a high grade of structural diversity and a bro... more : Heterocyclic compounds are recognized to possess a high grade of structural diversity and a broad spectrum of therapeutic properties. About two-thirds of the New Chemical Entities approved by the FDA against cancer entail heterocyclic rings and are the foundation stone of medicinal chemistry. Pyrimidine being a major heterocyclic compound and a crucial base component of the genetic material, has emerged as the key structural component against cancer, the deadliest disease worldwide. Though many drugs are marketed against cancer, researchers are still investigating the more promising moieties against various malignancies due to the severity of this disease. In this review, an attempt has been made to assemble the reported literature of the previous five years on various synthetic procedures and the anti-cancer potential of various classes of fused pyrimidine analogs, which would help the researchers in designing new potent derivatives. Besides this, the review intends to focus on the comprehensive discussion on biological targets, modes of action, and structure-activity relationships of each class of fused pyrimidines as potential anticancer agents.

Research paper thumbnail of A Review on Current Status of Blood Disorder: Thalassemia and its Treatment

Journal of Advanced Zoology, Oct 23, 2023

Research paper thumbnail of Synthesis and In-Vitro Antimicrobial Activity of Pyrimidine Derivatives

International Journal of Pharmaceutical Sciences and Drug Research, Jul 1, 2012

In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the... more In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the 4-position is described. These unreported compounds are obtained starting from commercially available dehydroacetic acid (DHA), aromatic aldehydes and S-benzylisothiouronium chloride (SBT). A series of compounds (3a-j) were prepared and tested for their antimicrobial activity. These synthesized compounds showed mild activity against gram +ve bacteria and very less activity against gram -ve bacteria. Compounds 3b, 3i, 3j showed mild activity against gram +ve Bacillus subtilis bacteria while against gram -ve Pseudomonas aeruginosa compound 3i showed minor activity.

Research paper thumbnail of Plant‐Based Vaccines: Challenges and Opportunities

Herbal Drugs for the Management of Infectious Diseases

Research paper thumbnail of Basics and Fundamentals of X‐Rays

X‐Ray Fluorescence in Biological Sciences

Research paper thumbnail of Toxic and Essential Elemental Studies of Human Organs Using X‐Ray Fluorescence

X‐Ray Fluorescence in Biological Sciences

Research paper thumbnail of Synthesis and In-Vitro Antimicrobial Activity of Pyrimidine Derivatives

International Journal of Pharmaceutical Sciences and Drug Research, 2012

In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the... more In the present work an easy access to a series of pyrimidines bearing a pyronyl side chain in the 4-position is described. These unreported compounds are obtained starting from commercially available dehydroacetic acid (DHA), aromatic aldehydes and S-benzylisothiouronium chloride (SBT). A series of compounds (3a-j) were prepared and tested for their antimicrobial activity. These synthesized compounds showed mild activity against gram +ve bacteria and very less activity against gram -ve bacteria. Compounds 3b, 3i, 3j showed mild activity against gram +ve Bacillus subtilis bacteria while against gram -ve Pseudomonas aeruginosa compound 3i showed minor activity.

Research paper thumbnail of Synthesis and Biological Aspects of Pyrimidine Derivatives

This book is intended to be an introduction to pharmacy students regarding 'Synthesis and Bio... more This book is intended to be an introduction to pharmacy students regarding 'Synthesis and Biological Aspects of Pyrimidine Derivatives'. Pyrimidine and its derivatives are demonstrated as a pharmacologically active and important scaffold which possesses all kind of pharmacological activities such as analgesic, anticonvulsant, anti-depressive, antipyretic, sedative, antiviral, anti-HIV, anti-inflammatory, antimicrobial and anti-tumor activities. Upon completion of the course the students shall be able to know about the various types of pharmacological application and synthesis scheme for pyrimidines.

Research paper thumbnail of An Appraisal on Synthetic and Medicinal Aspects of Fused Pyrimidines as Anti Neoplastic Agents

Anti-Cancer Agents in Medicinal Chemistry

: Heterocyclic compounds are recognized to possess a high grade of structural diversity and a bro... more : Heterocyclic compounds are recognized to possess a high grade of structural diversity and a broad spectrum of therapeutic properties. About two-thirds of the New Chemical Entities approved by the FDA against cancer entail heterocyclic rings and are the foundation stone of medicinal chemistry. Pyrimidine being a major heterocyclic compound and a crucial base component of the genetic material, has emerged as the key structural component against cancer, the deadliest disease worldwide. Though many drugs are marketed against cancer, researchers are still investigating the more promising moieties against various malignancies due to the severity of this disease. In this review, an attempt has been made to assemble the reported literature of the previous five years on various synthetic procedures and the anti-cancer potential of various classes of fused pyrimidine analogs, which would help the researchers in designing new potent derivatives. Besides this, the review intends to focus on the comprehensive discussion on biological targets, modes of action, and structure-activity relationships of each class of fused pyrimidines as potential anticancer agents.