Nedim Hamzagic - Academia.edu (original) (raw)

Papers by Nedim Hamzagic

Diagnostics

Chest X-ray has verified its role as a crucial tool in COVID-19 assessment due to its practicabil... more Chest X-ray has verified its role as a crucial tool in COVID-19 assessment due to its practicability, especially in emergency units, and Brixia score has proven as a useful tool for COVID-19 pneumonia grading. The aim of our study was to investigate correlations between main laboratory parameters, vaccination status, and Brixia score, as well as to confirm if Brixia score is a significant independent predictor of unfavorable outcome (death) in COVID-19 patients. The study was designed as a cross-sectional multicentric study. It included patients with a diagnosed COVID-19 infection who were hospitalized. This study included a total of 279 patients with a median age of 62 years. The only significant predictor of unfavorable outcome (death) was Brixia score (adjusted odds ratio 1.148, p = 0.022). In addition, the results of the multiple linear regression analysis (R2 = 0.334, F = 19.424, p < 0.001) have shown that male gender (B = 0.903, p = 0.046), severe COVID-19 (B = 1.970, p &lt...

Anemija je cesta komplikacija kod bolesnika na hemodijalizi. Na lecenje anemije uticu: nedostatak... more Anemija je cesta komplikacija kod bolesnika na hemodijalizi. Na lecenje anemije uticu: nedostatak gvožđa, nedovoljna doza eritropoetina, mikroinflamacija, nedostatak vitamina D, povecana koncentracija iPTH i neadekvatna hemodijaliza. U ostale uzroke anemije kod ovih bolesnika spadaju: gubitak krvi (okultno gastrointestinalno krvarenje zbog uremijskog gastritisa, stvaranje krvnih ugrusaka u vantelesnoj cirkulaciji, cesta uzorkovanja krvi za laboratorijske analize. Rad je imao za cilj da utvrdi prevalencu ciljne koncentracije hemoglobina u krvi bolesnika koji se lece redovnom hemodijalizom, utvrditi prevalencu „apsolutnog„ i „funkcionalnog“ nedostatka gvožđa kod bolesnika koji se lece redovnom hemodijalizom. Rad je imao za cilj da utvrdi prevalencu mikroinflamacije, kao i da ispita njen uticaj na koncentraciju hemoglobina u krvi, status gvožđa, vitamin D, adekvatnost hemodijalize i dozu eritropoetina kod bolesnika koji se lece redovnom hemodijalizom. Da utvrdi prevalencu nedostatka vi...

Vojnosanitetski pregled, 2018

Background/Aim. Anemia is a common complication in hemodialysis patients. Treatment of anemia is ... more Background/Aim. Anemia is a common complication in hemodialysis patients. Treatment of anemia is affected by iron deficiency, insufficient dose of erythropoietin, microinflammation, vitamin D deficiency, increased intact parathyroid hormone concentration and inadequate hemodialysis. The aim of the study was to determine the prevalence of vitamin D deficiency and its impact on hemoglobin con-centration, iron status, microinflammation, malnutrition, dialysis adequacy and erythropoietin dose in patients on regular hemodialysis. Methods. The study involved 120 patients divided into three groups: severely deficient of vitamin D: 25- hydroxyvitamin D[25(OH)D] < 10 ng/mL; deficient ? 25(OH)D within range of 10?20 ng/mL, and insufficient ? 25(OH)D > 20 ng/mL. For statistical analysis Kolmogorov- Smirnov test, the single-factor parametric analysis of variance ? ANOVA and Kruskal-Wallis test were used. Results. The prevalence of vitamin D deficiency in patients on regular hemodialysis w...

Vojnosanitetski pregled, 2020

Background/Aim. The use of cisplatin as a chemotherapeutic opened the door to the new metal-based... more Background/Aim. The use of cisplatin as a chemotherapeutic opened the door to the new metal-based drug research. New complexes containing metals such as platinum, palladium, ruthenium and gold have recently been analyzed as potential antitumor agents. The aim of the study was to investigate the cytotoxicity of Au(III) complexes with pincer-type ligands against cervical carcinoma cells (HeLa), breast cancer cells (MDA-MB-231 and 4T1) and colon carcinoma cells (HCT116 and CT26), as well as to examine the type and mechanism of cell death that these complexes induced in cancer cells. Methods. The cytotoxicity of Au(III) complexes was investigated by MTT assay. The apoptosis of the treated cancer cells was measured by flow cytometry and applying Annexin V/7AAD staining. The expressions of active proapoptotic protein Bax, antiapoptotic protein Bcl-2 and the percentage of cells containing cleaved caspase-3 in the treated cancer cells were determined by flow cytometry. Results. Complex 1 sh...

Timocki medicinski glasnik, 2018

Sepsis is the main cause of the development of acute kidney injury in critical ill patients in in... more Sepsis is the main cause of the development of acute kidney injury in critical ill patients in intensive care units. A reinforced and uncontrolled response of the host immune system to bacterial infection has a significant role in the pathogenesis of acute kidney injury in patients with sepsis. Early target therapy, early administration of antibiotics, optimal control of the site of infection, and kidney replacement therapy play a key role in the treatment of patients with sepsis. Continuous dialysis modalities are indicated in hemodynamically unstable patients with severe sepsis, septic shock and acute renal injury. Continuous veno-venous hemodiafiltration with the modified AN69ST membrane provides homeostasis of the immune system's response to bacterial infection, hemodynamic stability of the patient, improved kidney function and a higher survival rate for patients with septic shock and acute renal failure.

Acta Facultatis Medicae Naissensis, 2019

Summary Anemia is defined as blood hemoglobin concentration of less than 120 g/l in women and les... more Summary Anemia is defined as blood hemoglobin concentration of less than 120 g/l in women and less than 130 g/l in men. The main cause of the development of anemia in patients treated with regular hemodialysis is the lack of endogenous erythropoietin, and its main clinical consequences are: progressive decline in residual renal function, development of cardiovascular disorders, disorders of cognitive functions and a decrease in the quality of life of these patients. Despite the administration of an appropriate dose of erythropoietin, in 5-10% of patients treated with regular hemodialysis, there is resistance to erythropoietin activity. The main risk factors for the development of resistance to the effects of erythropoietin are: iron deficiency, microinflammation, deficiency of vitamin D, secondary hyperparathyroidism, deficiency of vitamin C, and inadequate hemodialysis. The main side effects of erythropoietin are: hypertension, thrombosis of the vascular approach to hemodialysis, a...

Serbian Journal of Experimental and Clinical Research, 2019

The compound cis-diamminedichloroplatinum(II) (cisplatin) is the most widely used anticancer drug... more The compound cis-diamminedichloroplatinum(II) (cisplatin) is the most widely used anticancer drug, but due to its serious side effects (including gastrointestinal symptoms, renal tubular injury, neuromuscular complications, and ototoxicity), clinical applications of cisplatin are limited. Therefore, these limitations have provided an encouragement for further research into other transition metal complexes, with an aim to overcome the disadvantages related with cisplatin therapy. In the search for effective complexes that can be targeted against tumor cells, many research groups synthesized various ruthenium( II) complexes with different ligands. Also, newly synthesized ruthenium(II) complexes showed selective anticancer activity against different types of cancer cells. Activity of ruthenium(II) complexes in some cases was even higher than that of cisplatin against the same cells. Precise mechanism of action of ruthenium(II) complexes is not fully understood. The different examples m...

Serbian Journal of Experimental and Clinical Research, 2018

Anemia is a common complication among the patients with end-stage kidney disease. Management of a... more Anemia is a common complication among the patients with end-stage kidney disease. Management of anemia is influenced by several factors: iron deficiency, subtherapeutic dosage of erythropoietin, microinflammation, vitamin D deficiency, increased iPTH levels and inadequate hemodialysis. The aim of the study was to examine impact of dialysis modality on blood hemoglobin level as well as status of iron, status of vitamin D, hemodialysis adequacy and erythropoietin dose. The study included 120 patients which were divided into two groups: the group of patients treated with hemodiafiltration and the group of patients treated with standard hemo-dialysis. For statistical analysis Kolmogorov-Smirnov test, Student’s t-test and Mann-Whitney U-test were used. Blood hemoglobin level and parameters of hemodialysis adequacy (Kt/V index, spKt/V index, URR index), hematocrit ad protein catabolic rate (nPCR) were statisticaly significant lower in patients treated with regular hemodialysis compared to...

Serbian Journal of Experimental and Clinical Research, 2017

Acute damage to the kidney is a serious complication in patients in intensive care units. Th e ca... more Acute damage to the kidney is a serious complication in patients in intensive care units. Th e causes of acute kidney damage in these patients may be prerenal, renal and postrenal. Sepsis is the most common cause of the development of acute kidney damage in intensive care units. For the defi nition and classifi cation of acute kidney damage in clinical practice, the RIFLE, AKIN and KDIGO classifi cations are used. Th ere is a complex link between acute kidney damage and other organs. Acute kidney damage is induced by complex pathophysiological mechanisms that cause acute damage and functional disorders of the heart (acute heart failure, acute coronary syndrome and cardiac arrhythmias), brain (whole body cramps, ischaemic stroke and coma), lung (acute damage to the lung and acute respiratory distress syndrome) and liver (hypoxic hepatitis and acute hepatic insuffi ciency). New biomarkers, colour Doppler ultrasound diagnosis and kidney biopsy have signifi cant roles in the diagnosis o...

Serbian Journal of Experimental and Clinical Research, 2016

Pseudomembranous colitis is a frequent nosocomial infection associated with significant morbidity... more Pseudomembranous colitis is a frequent nosocomial infection associated with significant morbidity and mortality. Clostridium difficile infection incidence most frequently increases due to unreasonable antibiotic use and the appearance of new hypervirulent bacterial strains, which leads to prolonged hospitalization and an increase in the total cost of hospital treatment.This is a retrospective design study conducted at Clinical Centre Kragujevac from January to December 2014. The patient data were obtained from the protocol of the Virological Laboratory and from medical documentation. All statistical analyses were performed using the computer program SPSS. The descriptive statistical data are expressed as percentage values. Continuous variables are expressed as the arithmetic mean with the standard deviation.Clostridium difficile infection occurred more frequently with elderly patients (123 patients were over 65 years old). Out of 154 patients on antibiotic treatment, 110 patients we...

Serbian Journal of Experimental and Clinical Research, 2015

Primary infection with Epstein-Barr virus (EBV) usually occurs in early childhood and often does ... more Primary infection with Epstein-Barr virus (EBV) usually occurs in early childhood and often does not present clinical symptoms. More than 90% of adults are infected with this virus. A primary infection that occurs in adolescence or adulthood is usually clinically presented as infectious mononucleosis with a triad of symptoms: fever, lymphadenopathy and pharyngitis. Our retrospective study included 51 patients with a median age of 17 (9-23) years and serologically confirmed infectious mononucleosis. All patients with infectious mononucleosis were treated at the Clinic for Infectious Diseases at the Clinical Center in Kragujevac during 2013. We analysed the clinical, haematological and laboratory parameters of patients. The aspartate-aminotransferase levels were increased in 40 patients, with a mean value of 116.24 (±93.22); the alanine-aminotransferase levels were increased in 44 patients, with a mean value of 189.24 (±196.69). Lymphadenopathy was the most common clinical feature upo...

Acta Facultatis Medicae Naissensis, 2015

SummaryThe aim of this study was to analyze the reasons why the guidelines for post-splenectomy v... more SummaryThe aim of this study was to analyze the reasons why the guidelines for post-splenectomy vaccination are not being followed. Considering that vaccination reduces the risk of overwhelming post-splenectomy infection, it is important to determine the reasons for inadequate vaccination after splenectomy.Our research was a qualitative study based on interviews with six surgeons, one general practitioner and three patients who underwent splenectomy, and on the review of patient’s medical charts and discharge summaries.This study has shown that health care team and patients lack sufficient knowledge about postsplenectomy vaccination. In addition, the study has shown that splenectomy registers, medical bracelets and up-to-date vaccination cards still have not become part of our current practice.Our study has shown that patient education and health care team education is crucial to follow the guidelines for post-splenectomy vaccination, which is similar to most other reports.In order ...