Neelam Sood - Academia.edu (original) (raw)

Papers by Neelam Sood

Research paper thumbnail of Correlation of CK5 and EGFR with Clinicopathological Profile of Triple-Negative Breast Cancer

Pathology Research International, 2014

Purpose.Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and ... more Purpose.Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neuexpressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters.Materials and Methods.Thirty-six female patients with TNBC based on ER, PR, and the HER2neunegativities were studied by immunohistochemistry for EGFR, CK5, and Ki-67 expression. Statistical analysis was done using the SPSS software version 20.Results.The mean and median ages were 45.18 years and 46.70 years, respectively. Infiltrating ductal carcinoma NOS was the predominant histopathological type (29/36 [80.6%]). The commonest histological grade was grade 2 (17/36 [47.2%]). Tumour necrosis was seen in 16/36 (44.4%) patients. Infiltrative margins were shown in 69.44% (25/36) cases. Ki-67 was positive in 80.56% (29/36) cases, 61.11% (22/36) were C...

Research paper thumbnail of Small cell extraskeletal osteosarcoma: a rare case report

Rare Tumors, 2014

Extraskeletal osteosarcoma is a rare malignant mesenchymal neoplasm and its small cell variant is... more Extraskeletal osteosarcoma is a rare malignant mesenchymal neoplasm and its small cell variant is one among the rarest variant. This article describes a 60-year-old woman presenting with a large, lobulated, painful mass in left thigh with associated history of trauma since 18 months. Her magnetic resonance imaging showed a variegated mixed intensity lesion with associated cystic degeneration, necrosis and matrix arborizing nearby muscles. Fine needle aspiration cytology showed a small cell lesion with very scant osteoid. Tumor was excised and histopathological diagnosis was small cell osteosarcoma involving adjacent muscles and fat with sparing of lymph nodes. The aim of this article is to present the clinical, radiological, cyto-histological and immunohistochemical features of this extremely rare lesion.

Research paper thumbnail of Hibernoma like lipoblastoma

Indian journal of pathology & microbiology, 2007

Research paper thumbnail of Pinna with synchronous chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) - A rare presentation of Amelanotic melanoma (Desmoplastic variant)

The Southeast Asian Journal of Case Report and Review, 2015

Research paper thumbnail of Superficial Spreading Squamous Cell Carcinoma Endometrium andIcthyosis Uteri with CINIII with p 16 Expression : Report of 2 Unusual Cases

We report two interesting and rare case reports, a 60 year old with well differentiated squamous ... more We report two interesting and rare case reports, a 60 year old with well differentiated squamous cell carcinoma of cervix with superficial spreading into the endometrium, other female of 70 year old with features of CIN III also involving the endometrium with multilfocal epidermidization consistent with icthyosis uteri, involving cervix and endometrium. p16 was used as a surrogate marker which was positive for neoplastic cells in both the cases, showing HPV aetiology. Superficial spreading squamous cell carcinoma of the cervix is a rare entity, with less than 30 cases reported in the literature. Primary endometrial squamous cell carcinoma usually occurs in postmenopausal women with mean age of presentation being 67 years. It is postulated that tumour may arise from ichthyosis uteri. Demonstration of p16 positivity in tumour cells helps in revealing HPV aetiology was also confirmed thus signifying its usefulness. Hence, we report these rare entities.

Research paper thumbnail of Dermal Lymphatic Invasion: A Rare Feature in Benign Intradermal Nevus

The present case describes classical intradermal nevus with intralymphatic nevus cell emboli. A 1... more The present case describes classical intradermal nevus with intralymphatic nevus cell emboli. A 13-year-old boy presented with black colored macule on the shin 1 cm in diameter which was gradually increasing in size. Histopathology of the lesion was typical of an intradermal melanocytic nevus. The most notable feature of this case, however, was an occasional aggregate of nevus cells within a lymphatic vessel of the upper dermis. The nevus cells within lymphatic lumen had morphological features of type A nevus cells. The cells were roundtocuboidal, exhibited abundant cytoplasm with welldefined cell borders and formed nests. These nevus cell aggregates were surrounded by flattened endothelial cells. Due to its rarity, a lymphatic nevus cell embolus creates diagnostic issues for pathologists. This observation must not be interpreted as evidence of malignancy but significant as a rare histological feature. In other words, the nevus cells might have been transported through the lymphatic...

Research paper thumbnail of Nonparameningeal alveolar rhabdomyosarcoma, with cytohistological features: A case report

Indian Journal of Pathology and Microbiology

Rhabdomyosarcoma (RMS) is a tumor arising from primitive mesenchymal cell with tendency for myoge... more Rhabdomyosarcoma (RMS) is a tumor arising from primitive mesenchymal cell with tendency for myogenesis. WHO classification categorizes this entity as embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes removing botryoid as a separate entity. The alveolar variant has worse prognosis and the cytological features of this entity are similar to embryonal type with little variations. This case report describes the cytohistological features of alveolar RMSfrom a 9-year-old child with nonparameningeal location.

Research paper thumbnail of Multinodular adult rhabdomyoma in female: A rare case report

Journal of Oral and Maxillofacial Pathology

Rhabdomyomas are rare benign mesenchymal tumors of striated muscle origin. These are classified a... more Rhabdomyomas are rare benign mesenchymal tumors of striated muscle origin. These are classified as cardiac and extracardiac types. Extracardiac type is further classified as adult, fetal and genital types. Adult rhabdomyoma represents <2% of all muscular tumors. It mostly occurs in adults (median: 60 years). Males are more commonly affected (M:F = 3:1) and usually present as solitary lesion. We report a rare case of multinodular adult rhabdomyoma arising from the floor of the mouth. A 55-year-old female presented with a painless, soft, mobile, nontender and multinodular swelling in the right submandibular region and the floor of the mouth for 2 months. Fine-needle aspiration cytology showed cellular smears of large elongated to round cells with abundant eosinophilic granular cytoplasm, small nuclei and occasionally prominent nucleoli. Histology revealed partially encapsulated lesion showing sheets of large, oval to polygonal cells with abundant deeply eosinophilic and granular cytoplasm, with small peripherally placed nuclei with few cells showing prominent nucleoli. Prominent cytoplasmic vacuolations (periodic acid–Schiff positive) were present. The cells were positive for desmin and myogenin. This case is an extremely rare presentation of multinodular adult rhabdomyoma in a female. The correct identification of this lesion is important to avoid an unnecessarily aggressive resection, yet providing potentially curative therapy.

Research paper thumbnail of Knowledge, Practice, and Skills in Cytology-Based Cervical Cancer Screening: Impact Assessment of Training Workshop for the Pathologists

Journal of Cancer Education

Research paper thumbnail of Invasive solid papillary carcinoma: Report of the first case presenting as an occult breast carcinoma in a male

Indian Journal of Pathology and Microbiology

Research paper thumbnail of Metaplastic carcinoma of breast: Case series with cytohistological correlation

Indian Journal of Medical and Paediatric Oncology

Research paper thumbnail of Masson’s Tumour: Two Case Reports with a Brief Review of Literature

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Research paper thumbnail of Superficial acral fibromyxoma: A cytohistopathological correlation in a recurrent, nonperiungual, acral lesion

Indian Journal of Pathology and Microbiology

Research paper thumbnail of Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Research paper thumbnail of Metaplastic Carcinoma of Breast: a diagnostic challenge on fine needle aspiration cytology

Cytopathology : official journal of the British Society for Clinical Cytology, Jan 25, 2018

A 28-year female presented with a lump in the left breast for three months. She was non- lactatin... more A 28-year female presented with a lump in the left breast for three months. She was non- lactating and had no family history of breast malignancy. Local examination showed a 3 cm firm mass in the upper inner quadrant of left breast. The mass was mobile and not fixed to the overlying skin or underlying muscle. This article is protected by copyright. All rights reserved.

Research paper thumbnail of Warthins tumor: Cyto histological spectrum with emphasis on diagnostic difficulties

Diagnostic cytopathology, Jan 5, 2018

Warthins tumour is characterized by the presence of epithelial proliferation in a lymphoid stroma... more Warthins tumour is characterized by the presence of epithelial proliferation in a lymphoid stroma. It has been categorized as Sieferts types: 1-4, depending on the proportions of the 2 components. Although FNA is fairly accurate in establishing the diagnosis, the cytologic diagnosis of this tumor has potential sources of error. This retrospective study was conducted in the Department of Pathology and Lab Medicine, of a tertiary care hospital. Cytology and surgical pathology records of past 15 years were screened. A total of 1200 FNAC cases of salivary gland lesions in the past 15 years were retrieved. 36 cases with presumptive cytodiagnosis of WT were identified and histopathological correlation was done. Histopathological correlation could be done in 24 cases. 19 out of 24 cases, were confirmed as WT. The 5 cases with discordance were analyzed for potential diagnostic pitfalls. The most common discordance was in the category of papillary proliferation with minimal lymphoid infiltra...

Research paper thumbnail of Squamous cell carcinoma-like giant keratoacanthoma with delayed presentation in a known case of xeroderma pigmentosum

OA Case Reports

Introduction Keratoacanthomas are rapidly growing cutaneous tumours, which usually resolve leavin... more Introduction Keratoacanthomas are rapidly growing cutaneous tumours, which usually resolve leaving an atrophic scar. The term 'giant keratoacanthoma' is applied to a lesion greater than 2-3 cm in diameter. This case report discusses squamous cell carcinoma-like giant keratoacanthoma with delayed presentation in a known case of xeroderma pigmentosum. Case report A 50-year-old female patient, a known case of xeroderma pigmentosum, presented with a large, domeshaped, crateriform lesion over her right cheek that had persisted for the last four months. Histological examination showed an exophytic lesion with a large central keratin-filled crater surrounded by deep bulbous nodules of proliferating squamous cells that had abundant keratin with a lip of normal epidermis. The demarcation was discrete except for tiny foci of deep infiltration at the periphery. However, immunohistochemistry for p53 revealed strong positivity only in the basal layer of the infiltrating islands, weak Ki-67 and desmoglein positivity, along with down regulation of Bcl-2 and E-cadherin. Followup for 18 months did not reveal any site recurrence or metastasis. Conclusion This case highlights the uncommon, delayed, adult onset presentation of giant keratoacanthoma with borderline histological features that mimic squamous cell carcinoma but show negative immunohistochemistry.

Research paper thumbnail of A Case Report of a Giant Cholesteatoma

Journal of clinical and diagnostic research : JCDR, 2017

Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive ke... more Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive keratinisation. Keratoma and epidermoid cyst are other possibly more accurate names suggested to describe the same. It can be classified as congenital or acquired. Its management is often complicated by its tendency to recidivism/recurrence. Long standing cholesteatomas can be a precursor for squamous cell carcinoma. We hereby present a case of giant cholesteatoma in a 45-year-old female with radiological involvement of the left temporal region, periauricular region and infratemporal fossa with lytic destruction of left middle ear ossicles, mastoid and squamous part of temporal bone with intracranial extension. The enormity of the present lesion along with its bony erosions raised the strong clinical suspicion of malignancy. The underlying case report highlights the relevance of exhaustive sectioning and immunohistochemistry to reach the diagnosis.

Research paper thumbnail of Primary adenocarcinoma (intestinal type) of nasal septum--a case report

Indian Journal of Pathology and Microbiology, May 1, 2004

Primary nasal septal adenocarcinoma is a rare lesion. A sporadic case of septal adenocarcinoma in... more Primary nasal septal adenocarcinoma is a rare lesion. A sporadic case of septal adenocarcinoma in a 22 years old male is being described along with review of literature.

Research paper thumbnail of Squamous cell carcinoma arising in a mature cystic teratoma

Indian J Pathol Microbiol, 2009

Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complic... more Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complication. Squamous cell carcinoma is the most common transformation. We describe a new case of squamous cell carcinoma arising in a mature cystic teratoma. Case Report. A premenopausal 52-year-old female patient is diagnosed with vaginal bleeding. According to examination made on the women and the pelvic scanning, 7 cm mass is found on the right adnexa of the patient. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, and debulking were the treatments completed on the patient. According to histopathological diagnosis, squamous cell carcinoma arising in a mature cystic teratoma is diagnosed as a reason for the mass in the right adnexa of the patient. Conclusion. The prognosis of the malign transformation of MCT depends on surgery stage; however it is extremely poor. The patient should receive chemotherapy regardless of stage. We have decided to administer second cycle carboplatin and paclitaxel treatments on the patient.

Research paper thumbnail of Correlation of CK5 and EGFR with Clinicopathological Profile of Triple-Negative Breast Cancer

Pathology Research International, 2014

Purpose.Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and ... more Purpose.Triple-negative breast cancer (TNBC) is defined by the loss of expression of ER, PR, and Her2neuexpressions. The aim of this study was to examine the expression of the EGFR, CK5, and Ki-67 among triple-negative breast cancer cases and to correlate the expression of the basal markers with the clinicopathological prognostic parameters.Materials and Methods.Thirty-six female patients with TNBC based on ER, PR, and the HER2neunegativities were studied by immunohistochemistry for EGFR, CK5, and Ki-67 expression. Statistical analysis was done using the SPSS software version 20.Results.The mean and median ages were 45.18 years and 46.70 years, respectively. Infiltrating ductal carcinoma NOS was the predominant histopathological type (29/36 [80.6%]). The commonest histological grade was grade 2 (17/36 [47.2%]). Tumour necrosis was seen in 16/36 (44.4%) patients. Infiltrative margins were shown in 69.44% (25/36) cases. Ki-67 was positive in 80.56% (29/36) cases, 61.11% (22/36) were C...

Research paper thumbnail of Small cell extraskeletal osteosarcoma: a rare case report

Rare Tumors, 2014

Extraskeletal osteosarcoma is a rare malignant mesenchymal neoplasm and its small cell variant is... more Extraskeletal osteosarcoma is a rare malignant mesenchymal neoplasm and its small cell variant is one among the rarest variant. This article describes a 60-year-old woman presenting with a large, lobulated, painful mass in left thigh with associated history of trauma since 18 months. Her magnetic resonance imaging showed a variegated mixed intensity lesion with associated cystic degeneration, necrosis and matrix arborizing nearby muscles. Fine needle aspiration cytology showed a small cell lesion with very scant osteoid. Tumor was excised and histopathological diagnosis was small cell osteosarcoma involving adjacent muscles and fat with sparing of lymph nodes. The aim of this article is to present the clinical, radiological, cyto-histological and immunohistochemical features of this extremely rare lesion.

Research paper thumbnail of Hibernoma like lipoblastoma

Indian journal of pathology & microbiology, 2007

Research paper thumbnail of Pinna with synchronous chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) - A rare presentation of Amelanotic melanoma (Desmoplastic variant)

The Southeast Asian Journal of Case Report and Review, 2015

Research paper thumbnail of Superficial Spreading Squamous Cell Carcinoma Endometrium andIcthyosis Uteri with CINIII with p 16 Expression : Report of 2 Unusual Cases

We report two interesting and rare case reports, a 60 year old with well differentiated squamous ... more We report two interesting and rare case reports, a 60 year old with well differentiated squamous cell carcinoma of cervix with superficial spreading into the endometrium, other female of 70 year old with features of CIN III also involving the endometrium with multilfocal epidermidization consistent with icthyosis uteri, involving cervix and endometrium. p16 was used as a surrogate marker which was positive for neoplastic cells in both the cases, showing HPV aetiology. Superficial spreading squamous cell carcinoma of the cervix is a rare entity, with less than 30 cases reported in the literature. Primary endometrial squamous cell carcinoma usually occurs in postmenopausal women with mean age of presentation being 67 years. It is postulated that tumour may arise from ichthyosis uteri. Demonstration of p16 positivity in tumour cells helps in revealing HPV aetiology was also confirmed thus signifying its usefulness. Hence, we report these rare entities.

Research paper thumbnail of Dermal Lymphatic Invasion: A Rare Feature in Benign Intradermal Nevus

The present case describes classical intradermal nevus with intralymphatic nevus cell emboli. A 1... more The present case describes classical intradermal nevus with intralymphatic nevus cell emboli. A 13-year-old boy presented with black colored macule on the shin 1 cm in diameter which was gradually increasing in size. Histopathology of the lesion was typical of an intradermal melanocytic nevus. The most notable feature of this case, however, was an occasional aggregate of nevus cells within a lymphatic vessel of the upper dermis. The nevus cells within lymphatic lumen had morphological features of type A nevus cells. The cells were roundtocuboidal, exhibited abundant cytoplasm with welldefined cell borders and formed nests. These nevus cell aggregates were surrounded by flattened endothelial cells. Due to its rarity, a lymphatic nevus cell embolus creates diagnostic issues for pathologists. This observation must not be interpreted as evidence of malignancy but significant as a rare histological feature. In other words, the nevus cells might have been transported through the lymphatic...

Research paper thumbnail of Nonparameningeal alveolar rhabdomyosarcoma, with cytohistological features: A case report

Indian Journal of Pathology and Microbiology

Rhabdomyosarcoma (RMS) is a tumor arising from primitive mesenchymal cell with tendency for myoge... more Rhabdomyosarcoma (RMS) is a tumor arising from primitive mesenchymal cell with tendency for myogenesis. WHO classification categorizes this entity as embryonal, alveolar, spindle cell/sclerosing, and pleomorphic subtypes removing botryoid as a separate entity. The alveolar variant has worse prognosis and the cytological features of this entity are similar to embryonal type with little variations. This case report describes the cytohistological features of alveolar RMSfrom a 9-year-old child with nonparameningeal location.

Research paper thumbnail of Multinodular adult rhabdomyoma in female: A rare case report

Journal of Oral and Maxillofacial Pathology

Rhabdomyomas are rare benign mesenchymal tumors of striated muscle origin. These are classified a... more Rhabdomyomas are rare benign mesenchymal tumors of striated muscle origin. These are classified as cardiac and extracardiac types. Extracardiac type is further classified as adult, fetal and genital types. Adult rhabdomyoma represents <2% of all muscular tumors. It mostly occurs in adults (median: 60 years). Males are more commonly affected (M:F = 3:1) and usually present as solitary lesion. We report a rare case of multinodular adult rhabdomyoma arising from the floor of the mouth. A 55-year-old female presented with a painless, soft, mobile, nontender and multinodular swelling in the right submandibular region and the floor of the mouth for 2 months. Fine-needle aspiration cytology showed cellular smears of large elongated to round cells with abundant eosinophilic granular cytoplasm, small nuclei and occasionally prominent nucleoli. Histology revealed partially encapsulated lesion showing sheets of large, oval to polygonal cells with abundant deeply eosinophilic and granular cytoplasm, with small peripherally placed nuclei with few cells showing prominent nucleoli. Prominent cytoplasmic vacuolations (periodic acid–Schiff positive) were present. The cells were positive for desmin and myogenin. This case is an extremely rare presentation of multinodular adult rhabdomyoma in a female. The correct identification of this lesion is important to avoid an unnecessarily aggressive resection, yet providing potentially curative therapy.

Research paper thumbnail of Knowledge, Practice, and Skills in Cytology-Based Cervical Cancer Screening: Impact Assessment of Training Workshop for the Pathologists

Journal of Cancer Education

Research paper thumbnail of Invasive solid papillary carcinoma: Report of the first case presenting as an occult breast carcinoma in a male

Indian Journal of Pathology and Microbiology

Research paper thumbnail of Metaplastic carcinoma of breast: Case series with cytohistological correlation

Indian Journal of Medical and Paediatric Oncology

Research paper thumbnail of Masson’s Tumour: Two Case Reports with a Brief Review of Literature

JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH

Research paper thumbnail of Superficial acral fibromyxoma: A cytohistopathological correlation in a recurrent, nonperiungual, acral lesion

Indian Journal of Pathology and Microbiology

Research paper thumbnail of Cytological evaluation in males presenting with bloody nipple discharge, with or without breast mass: Report of two cases depicting two poles of the disease spectrum

Research paper thumbnail of Metaplastic Carcinoma of Breast: a diagnostic challenge on fine needle aspiration cytology

Cytopathology : official journal of the British Society for Clinical Cytology, Jan 25, 2018

A 28-year female presented with a lump in the left breast for three months. She was non- lactatin... more A 28-year female presented with a lump in the left breast for three months. She was non- lactating and had no family history of breast malignancy. Local examination showed a 3 cm firm mass in the upper inner quadrant of left breast. The mass was mobile and not fixed to the overlying skin or underlying muscle. This article is protected by copyright. All rights reserved.

Research paper thumbnail of Warthins tumor: Cyto histological spectrum with emphasis on diagnostic difficulties

Diagnostic cytopathology, Jan 5, 2018

Warthins tumour is characterized by the presence of epithelial proliferation in a lymphoid stroma... more Warthins tumour is characterized by the presence of epithelial proliferation in a lymphoid stroma. It has been categorized as Sieferts types: 1-4, depending on the proportions of the 2 components. Although FNA is fairly accurate in establishing the diagnosis, the cytologic diagnosis of this tumor has potential sources of error. This retrospective study was conducted in the Department of Pathology and Lab Medicine, of a tertiary care hospital. Cytology and surgical pathology records of past 15 years were screened. A total of 1200 FNAC cases of salivary gland lesions in the past 15 years were retrieved. 36 cases with presumptive cytodiagnosis of WT were identified and histopathological correlation was done. Histopathological correlation could be done in 24 cases. 19 out of 24 cases, were confirmed as WT. The 5 cases with discordance were analyzed for potential diagnostic pitfalls. The most common discordance was in the category of papillary proliferation with minimal lymphoid infiltra...

Research paper thumbnail of Squamous cell carcinoma-like giant keratoacanthoma with delayed presentation in a known case of xeroderma pigmentosum

OA Case Reports

Introduction Keratoacanthomas are rapidly growing cutaneous tumours, which usually resolve leavin... more Introduction Keratoacanthomas are rapidly growing cutaneous tumours, which usually resolve leaving an atrophic scar. The term 'giant keratoacanthoma' is applied to a lesion greater than 2-3 cm in diameter. This case report discusses squamous cell carcinoma-like giant keratoacanthoma with delayed presentation in a known case of xeroderma pigmentosum. Case report A 50-year-old female patient, a known case of xeroderma pigmentosum, presented with a large, domeshaped, crateriform lesion over her right cheek that had persisted for the last four months. Histological examination showed an exophytic lesion with a large central keratin-filled crater surrounded by deep bulbous nodules of proliferating squamous cells that had abundant keratin with a lip of normal epidermis. The demarcation was discrete except for tiny foci of deep infiltration at the periphery. However, immunohistochemistry for p53 revealed strong positivity only in the basal layer of the infiltrating islands, weak Ki-67 and desmoglein positivity, along with down regulation of Bcl-2 and E-cadherin. Followup for 18 months did not reveal any site recurrence or metastasis. Conclusion This case highlights the uncommon, delayed, adult onset presentation of giant keratoacanthoma with borderline histological features that mimic squamous cell carcinoma but show negative immunohistochemistry.

Research paper thumbnail of A Case Report of a Giant Cholesteatoma

Journal of clinical and diagnostic research : JCDR, 2017

Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive ke... more Cholesteatoma is a well demarcated, non-neoplastic, temporal bone cystic lesion with extensive keratinisation. Keratoma and epidermoid cyst are other possibly more accurate names suggested to describe the same. It can be classified as congenital or acquired. Its management is often complicated by its tendency to recidivism/recurrence. Long standing cholesteatomas can be a precursor for squamous cell carcinoma. We hereby present a case of giant cholesteatoma in a 45-year-old female with radiological involvement of the left temporal region, periauricular region and infratemporal fossa with lytic destruction of left middle ear ossicles, mastoid and squamous part of temporal bone with intracranial extension. The enormity of the present lesion along with its bony erosions raised the strong clinical suspicion of malignancy. The underlying case report highlights the relevance of exhaustive sectioning and immunohistochemistry to reach the diagnosis.

Research paper thumbnail of Primary adenocarcinoma (intestinal type) of nasal septum--a case report

Indian Journal of Pathology and Microbiology, May 1, 2004

Primary nasal septal adenocarcinoma is a rare lesion. A sporadic case of septal adenocarcinoma in... more Primary nasal septal adenocarcinoma is a rare lesion. A sporadic case of septal adenocarcinoma in a 22 years old male is being described along with review of literature.

Research paper thumbnail of Squamous cell carcinoma arising in a mature cystic teratoma

Indian J Pathol Microbiol, 2009

Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complic... more Introduction. Malignant transformation in a mature cystic teratoma of the ovary is a rare complication. Squamous cell carcinoma is the most common transformation. We describe a new case of squamous cell carcinoma arising in a mature cystic teratoma. Case Report. A premenopausal 52-year-old female patient is diagnosed with vaginal bleeding. According to examination made on the women and the pelvic scanning, 7 cm mass is found on the right adnexa of the patient. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic lymph node dissection, and debulking were the treatments completed on the patient. According to histopathological diagnosis, squamous cell carcinoma arising in a mature cystic teratoma is diagnosed as a reason for the mass in the right adnexa of the patient. Conclusion. The prognosis of the malign transformation of MCT depends on surgery stage; however it is extremely poor. The patient should receive chemotherapy regardless of stage. We have decided to administer second cycle carboplatin and paclitaxel treatments on the patient.