Neelottama Kushwaha - Academia.edu (original) (raw)

Papers by Neelottama Kushwaha

Current drug therapy, Jan 24, 2024

Research journal of pharmacy and technology, Jan 25, 2022

A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4... more A series of 6-(chloromethyl)-N2-(1-(4-substituted phenyl)-3-phenyl-1H-pyrazol-4-yl) methylene)-N4-aryl-1, 3, 5-triazine - 2, 4-diamine 7(Aa-Gd) were synthesized using the appropriate synthetic procedure and characterized by spectral analysis. All the synthesized compounds were evaluated for their antibacterial and antifungal activities. The antibacterial activity was evaluated against Gram-positive strains (Staphylococcus aureus, Streptococcus aureus) and Gram-negative strains (Escherichia coli, Pseudomonas aeruginosa) using benzyl penicillin and streptomycin as standard drugs. Further, these compounds were studied for antifungal activity against three strains of fungi (Candida albicans, Aspergillus fumigate and Aspergillus flavus) using Ketoconazole as a standard drug. In the presented study all the synthesized compounds showed significant antibacterial and antifungal activities.

Archives of Applied Science Research, 2010

The efficacy and safety of any pharmaceutical product is determined by the compounds (desired and... more The efficacy and safety of any pharmaceutical product is determined by the compounds (desired and undesired) which it contains. The purpose of quality control is to ensure that each dosage unit of the drug product delivers the same amount of active ingredients and is, as far as possible, free of impurities. As herbal medicinal products are complex mixtures which originate from biological sources, great efforts are necessary to guarantee a constant and adequate quality. By carefully selecting the plant material and a standardized manufacturing process the pattern and concentration of constituents of herbal medicinal products should be kept as constant as possible as this is a prerequisite for reproducible therapeutic results.

Current cosmetic science, Jul 31, 2023

: The confluence of three key fields, namely, cosmetics, pharmaceutics, and the chemistry of cosm... more : The confluence of three key fields, namely, cosmetics, pharmaceutics, and the chemistry of cosmetic items with the human body system, is known as cosmeceutical chemistry. The most remarkable logical knowledge and innovation are incorporated into cosmetology, including science, pharmacology, subatomic physics and nervous system science, etc. Cosmetics are items created to beautify, protect, and change the appearance of our bodies' external features. Water, emulsifiers, preservatives, thickeners, moisturizing agents, colors, and perfumes are the main components found in the majority of cosmetics. Ingredients may be synthetic or naturally occurring, but how they may affect our health mostly depends on the chemical substances they are made of. The concentrations of potentially harmful compounds present in cosmetics are thought to be too low to endanger human health. Nowadays, various types of cosmetics are available in the market such as lotions, lipstick, colognes, nail paints, and other products. After using the base cream, various cosmetics, such as face powder, provide skin luster. To achieve detergency, wetting, emulsifying, re-coloring, and moderating effects, cosmetic fixings/excipients are used. Some unfriendly synthetic reactions in the preparation of cosmetics cause serious dangerous effects on people and the environment. The usage of several cosmetics has restorative effects. Once more, each population has a specific makeup of cosmetic users. The distinction between cosmetic and medical research is becoming increasingly blurred as a result of this growing application of science to beauty. Leading cosmetic companies' laboratories conduct cutting-edge research in areas like grid science, cell reinforcements, and mature forms. Their manufacturing, marketing, and delivery should all be subject to proper rules and regulations in addition to pricing.

Journal of pharmaceutical care, Oct 3, 2022

The review on diverticulitis disease, is the most prevalent non-cancerous pathology of the colon ... more The review on diverticulitis disease, is the most prevalent non-cancerous pathology of the colon is diverticular disease and diverticulitis. It has long been thought to be a disease of the elderly, linked to cultural and dietary patterns. Our understanding of this condition, as well as the therapy protocols, has progressed. To give an updated assessment of the epidemiology, pathophysiology, and classification of diverticulitis, as well as to highlight developments in medicinal and surgical management. Treatment of Diverticular Disease represented an important challenge in clinical practice, especially concerning the management of symptomatic uncomplicated diverticular disease (SUDD) and the primary and secondary prevention of acute diverticular disease (AD). Antibiotics and supportive treatments are the mainstays of non-operative treatment, while antibiotics may be skipped in moderate cases. Acute surgery is required for the most severe and refractory cases, whereas elective resections should be considered for chronic, smoldering, or recurrent forms, as well as their associated complications (stricture, fistula, etc.) and patients with factors that are highly predictive of recurrent attacks. Diverticulitis isn't just a condition that affects the elderly. Our growing understanding of diverticulitis as a clinical entity has resulted in a more nuanced approach to its medicinal and surgical therapy. For more than 70% of patients, non-surgical care is still the best option. In the acute, chronic, or elective-prophylactic environment, a segmental colectomy remains the most effective surgical treatment for those with non-relenting, persistent, or recurrent symptoms, as well as those with severe disease and sequelae.

Journal of chemical and pharmaceutical research, 2015

Hetrocyclic systems are one of the most important classes of organic compounds present in nature ... more Hetrocyclic systems are one of the most important classes of organic compounds present in nature or synthesized in laboratory. These compound posses several interesting biological activity and are imployed in the treatment of various commonly occurring diseases. The biological significance of the 1, 3-oxathiolan-5-one derivative has promoted us to synthesize a series of its analogical derivative. In continuation of interest on the synthesis of 1,3oxathiolan-5-one derivatives herein an easy, practical and efficient cost effective ,time saving procedure for the synthesis of 1,3-oxathiolan-5-one derivatives by using aromatic aldehyde, mercaptoacetic acid dehydrating/ cyclising agent. All the compounds have been screened for their antimicrobial activity against three Gram-ve bacteria (Eschericha Coli, Staphylococcus aureus and Klebsiella pneumoniae three Gram +ve(Seratia reticulata, Bacillus subtilis and Streptococcus pneumoniae) and two fungal strains (P. aeruginosa and C.albicans). In the primary screening, the compounds exhibited appreciable activity. The structures of the synthesized compounds 3a-3l have been established on the basis of elemental analysis and spectral data.

journal of applied pharmaceutical science, 2016

Among bicyclic non-aromatic nitrogen heterocycles, phthalimides are an interesting class of compo... more Among bicyclic non-aromatic nitrogen heterocycles, phthalimides are an interesting class of compounds with a large range of applications. Phthalimide contains an imide functional group and may be considered as nitrogen analogues of anhydrides or as diacyl derivatives of ammonia. They are lipophilic and neutral compounds and can therefore easily cross biological membranes in vivo and showing different pharmacological activities. In the present work compounds containing phthalimide subunit have been described as a scaffold to design new prototypes drug candidates with different biological activities and are used in different diseases as, for example AIDS, tumor, diabetes, multiple myeloma, convulsion, inflammation, pain, bacterial infection among others.

Mini-reviews in Medicinal Chemistry, Jan 14, 2021

Triazine is the six-membered heterocyclic ring containing three nitrogens, which replace the carb... more Triazine is the six-membered heterocyclic ring containing three nitrogens, which replace the carbon-hydrogen unit in the benzene ring. Based on nitrogen position present in the ring system, it is categorized in three isomeric forms, i.e., 1, 2, 3-triazine (vicinal triazine), 1, 2, 4-triazine (asymmetrical triazine or isotriazine) and 1, 3, 5-triazine (symmetrical or s-triazine or cyanidine). Triazines have a weakly basic property. Their isomers have much weaker resonance energy than benzene structure, so nucleophilic substitution reactions are more preferred than electrophilic substitution reactions. Triazine isomers and their derivatives are known to play important roles possessing various activities in medicinal and agricultural fields such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal, antimalarial and antimicrobial agents.

International journal of pharmaceutical investigation, Oct 10, 2020

Different barriers like a blood-brain barrier in the brain restrict the transport of potential th... more Different barriers like a blood-brain barrier in the brain restrict the transport of potential therapeutic elements for direct entry into the brain. For delivery of a wide range of therapeutic drugs directly to the brain can be achieved by direct targeting the brain via an olfactory and trigeminal neural pathway which bypasses the blood-brain barrier hence has gained more importance and considered as an accurate route of drug targeting to brain. Intranasal route transports the drug by delivering it directly to the brain and avoiding the systemic absorption which also avoids the side effect of enhancing the efficacy of nano therapeutics. As these types of drug delivery commonly targeted drug delivery to the brain via nose are complex. Different strategies applied for overcoming these challenges has been covered. Drugs to be transported through this system are usually carried out through nano particulate system known as nanotechnology which helps in transportation of drug particles directly to the central nervous system and participates in drug release through a carrier-mediated system called nano particulate system have been extensively covered within the article. Parallel to this recent advancement in brain targeted drug delivery has been thoroughly explained and characterized. Although direct drug delivery to the brain is a vital challenge for researchers which can be overcome by using different types of strategies that have been covered under this article.

International journal of current research and review, 2021

Experimental animals are the animals that we are used for our research purpose to determine the d... more Experimental animals are the animals that we are used for our research purpose to determine the different activities of Drugs (Table 1). Mainly developing and testing medicines and vaccines for humans and other animals, studying how animals and human bodies function, Assessing the safety of chemical such as pesticides for their possible effect on human health or the environment. 6

Der Pharmacia Lettre, 2021

This presented study aims to design the drugs which reduce various types of side effect and toxic... more This presented study aims to design the drugs which reduce various types of side effect and toxicity and also give the potent anticonvulsant activity. Epilepsy is a central nervous system (CNS) disorder characterized by the existence of more than one epileptic seizure which is associated with neurobiological, cognitive, psychological, and social disturbances. The medicine used to treat epilepsy in the past had various side effects such as ataxia, drowsiness, gastrointestinal disturbances etc. Owing to these side effects, we had an interest in the development of anticonvulsant drugs. To design and synthesize some N-containing heterocyclic moieties i.e. triazinone derivatives which may enhance the anticonvulsant activity of compounds to some extent. A series of 2-(2-amino-3-phenylpropanoyl)-5-((1, 5-disubstituted-1Hpyrazol-4-yl) methylene)-3-phenyl-1, 2-dihydro-1, 2, 4-triazin-6(5H)-one derivatives were designed and synthesized using the appropriate synthetic route and keeping all the view in the structural requirements of pharmacophoric pattern and evaluated for anticonvulsant activity and CNS activities.

Der Pharma Chemica, 2014

The new Ru II chloroquine complexes [Ru(η 6-arene)(CQ)Cl 2 ] (CQ) chloroquine; arene) p-cymene 1,... more The new Ru II chloroquine complexes [Ru(η 6-arene)(CQ)Cl 2 ] (CQ) chloroquine; arene) p-cymene 1, benzene 2), [Ru(η 6-p-cymene)(CQ)(H 2 O) 2 ][BF 4 ] 2 (3), [Ru(η 6-p-cymene)(CQ)(en)][PF 6 ] 2 (en) ethylenediamine) (4), and [Ru(η 6p-cymene)(η 6-CQDP)][BF 4 ] 2 (5, CQDP) chloroquine diphosphate) have been synthesized and characterized by use of a combination of NMR and FTIR spectroscopy with DFT calculations. Each complex is formed as a single coordination isomer: In 1-4, chloroquine binds to ruthenium in the η 1-N mode through the quinoline nitrogen atom, whereas in 5 an unprecedented η 6 bonding through the carbocyclic ring is observed. 1, 2, 3, and 5 are active against CQ-resistant (Dd2, K1, and W2) and CQ-sensitive (FcB1, PFB, F32, and 3D7) malaria parasites (Plasmodium falciparum); importantly, the potency of these complexes against resistant parasites is consistently higher than that of the standard drug chloroquine diphosphate. 1 and 5 also inhibit the growth of colon cancer cells, independently of the p53 status and of liposarcoma tumor cell lines with the latter showing increased sensitivity, especially to 1 (IC 50 8 µM); this is significant because this type of tumor does not respond to currently employed chemotherapies.

Thiadiazole and its derivatives are important organic reaction intermediates and they have been w... more Thiadiazole and its derivatives are important organic reaction intermediates and they have been widely used as anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, antiviral, diuretic and muscles relaxant activity. Generally, synthesis of the thiadiazole derivations needs high temperature (≥ 100 0 C) or low temperature (< 0 0 C) or high pressure (at least higher than 1 atmospheric pressure), and the yields of those reactions are low. Otherwise, they could be synthesized by reacting thiocarbonyl dichloride with dithizone. A series of thiadiazole have been synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data.

Bulletin of Pharmaceutical Sciences, Nov 29, 2022

BioNanoScience, Oct 21, 2020

Bulletin of Pharmaceutical Sciences. Assiut

Journal of Pharmaceutical Care

Letters in Applied NanoBioScience

The objective of this paper is to summarize the current aspects related to nanoparticle targeted ... more The objective of this paper is to summarize the current aspects related to nanoparticle targeted delivery via lipid nanoparticulate drug carrier systeM. tuberculosis ranks IInd most fatal disease after AIDS, and thus WHO declared it as “A Global Health Emergency”. Mycobacterium species source of tuberculosis infection; infects the lungs primarily and some other part of the body after infection is thoroughly spread. Antitubercular agents are classified according to their therapeutic action and safety. In this, an overview is provided on WHO-recommended treatment regimens. The study summarizes antitubercular delivery to the targeted site, i.e., macrophages via; nanoparticulate drug delivery system. Thus, the study was conducted to provide concise knowledge about nanoparticulate, solid lipid nanoparticles: introduction, advantages, components, types, preparation methods, models, parameters, characteristics, mechanism of drug release, and applications in the antitubercular delivery fiel...

Research Journal of Pharmacy and Technology, 2022